Adaptive Profiles in Autism and Other Neurodevelopmental Disorders / Susana MOUGA in Journal of Autism and Developmental Disorders, 45-4 (April 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1001-1012 Titre : Adaptive Profiles in Autism and Other Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Susana MOUGA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur Article en page(s) : p.1001-1012 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Adaptive behaviour  Functional profile  Vineland Adaptive Behaviour Scale Index. décimale : PER Périodiques Résumé : We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale (VABS) in communication, daily living skills, socialization and adaptive behaviour composite. Pearson-correlation analysis was performed between each domain of VABS and Full-Scale, Verbal and Performance IQ, and chronological age (CA). Results indicated that impairment in adaptive behaviour within the domain of socialization skills remains a distinctive factor of ASD versus OND, independently of intellectual disability (ID). Co-occurring ID result in further debilitating effects on overall functioning, especially in ASD. CA is negatively associated with VABS scores. En ligne : http://dx.doi.org/10.1007/s10803-014-2256-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Adaptive Profiles in Autism and Other Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / Susana MOUGA, Auteur ; Joana ALMEIDA, Auteur ; Cátia CAFÉ, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur . - p.1001-1012. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1001-1012 Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Adaptive behaviour  Functional profile  Vineland Adaptive Behaviour Scale Index. décimale : PER Périodiques Résumé : We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale (VABS) in communication, daily living skills, socialization and adaptive behaviour composite. Pearson-correlation analysis was performed between each domain of VABS and Full-Scale, Verbal and Performance IQ, and chronological age (CA). Results indicated that impairment in adaptive behaviour within the domain of socialization skills remains a distinctive factor of ASD versus OND, independently of intellectual disability (ID). Co-occurring ID result in further debilitating effects on overall functioning, especially in ASD. CA is negatively associated with VABS scores. En ligne : http://dx.doi.org/10.1007/s10803-014-2256-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Bumetanide oral solution for the treatment of children and adolescents with autism spectrum disorder: Results from two randomized phase III studies / Joaquin FUENTES in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.2021-2034 Titre : Bumetanide oral solution for the treatment of children and adolescents with autism spectrum disorder: Results from two randomized phase III studies Type de document : Texte imprimé et/ou numérique Auteurs : Joaquin FUENTES, Auteur ; Mara PARELLADA, Auteur ; Christina GEORGOULA, Auteur ; Guiomar OLIVEIRA, Auteur ; Stéphane MARRET, Auteur ; Véronique CRUTEL, Auteur ; Cristina ALBARRAN, Auteur ; Estelle LAMBERT, Auteur ; Pierre-François PÉNÉLAUD, Auteur ; Denis RAVEL, Auteur ; Yehezkel BEN ARI, Auteur Article en page(s) : p.2021-2034 Index. décimale : PER Périodiques Résumé : Abstract The efficacy and safety of bumetanide oral solution for the treatment of autism spectrum disorder (ASD) in children and adolescents was evaluated in two international, multi-center, randomized, double-blind, placebo-controlled phase III trials; one enrolled patients aged 7-17?years (SIGN 1 trial) and the other enrolled younger patients aged 2-6?years (SIGN 2). In both studies, patients were randomized to receive bumetanide oral solution twice daily (BID) or placebo BID during a 6-month double-blind treatment period. The primary endpoint was change in Childhood Autism Rating Scale 2 (CARS2) total raw score from baseline to Week 26. Key secondary endpoints included changes in Social Responsiveness Scale-2, Clinical Global Impression Scale, and Vineland Adaptive Behavior Scale. Each study enrolled 211 patients (bumetanide, n?=?107; placebo, n?=?104). Both studies were terminated early due to absence of any significant difference between bumetanide and placebo in the overall studied populations. In both studies, CARS2 total raw score decreased from baseline to Week 26 in the bumetanide and placebo groups, with no statistically significant difference between groups. No differences were observed between treatment groups for any of the secondary efficacy endpoints in either study. In both studies, treatment-emergent adverse events that occurred more frequently with bumetanide than placebo included thirst, polyuria, hypokalemia, and dry mouth. These large phase III trials failed to demonstrate a benefit of bumetanide for the treatment of pediatric ASD compared with placebo. Consequently, the sponsor has discontinued the development of bumetanide for the treatment of this condition. Trial registration: https://clinicaltrials.gov: SIGN 1: NCT03715166; SIGN 2: NCT03715153. En ligne : https://doi.org/10.1002/aur.3005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Bumetanide oral solution for the treatment of children and adolescents with autism spectrum disorder: Results from two randomized phase III studies [Texte imprimé et/ou numérique] / Joaquin FUENTES, Auteur ; Mara PARELLADA, Auteur ; Christina GEORGOULA, Auteur ; Guiomar OLIVEIRA, Auteur ; Stéphane MARRET, Auteur ; Véronique CRUTEL, Auteur ; Cristina ALBARRAN, Auteur ; Estelle LAMBERT, Auteur ; Pierre-François PÉNÉLAUD, Auteur ; Denis RAVEL, Auteur ; Yehezkel BEN ARI, Auteur . - p.2021-2034. in Autism Research > 16-10 (October 2023) . - p.2021-2034 Index. décimale : PER Périodiques Résumé : Abstract The efficacy and safety of bumetanide oral solution for the treatment of autism spectrum disorder (ASD) in children and adolescents was evaluated in two international, multi-center, randomized, double-blind, placebo-controlled phase III trials; one enrolled patients aged 7-17?years (SIGN 1 trial) and the other enrolled younger patients aged 2-6?years (SIGN 2). In both studies, patients were randomized to receive bumetanide oral solution twice daily (BID) or placebo BID during a 6-month double-blind treatment period. The primary endpoint was change in Childhood Autism Rating Scale 2 (CARS2) total raw score from baseline to Week 26. Key secondary endpoints included changes in Social Responsiveness Scale-2, Clinical Global Impression Scale, and Vineland Adaptive Behavior Scale. Each study enrolled 211 patients (bumetanide, n?=?107; placebo, n?=?104). Both studies were terminated early due to absence of any significant difference between bumetanide and placebo in the overall studied populations. In both studies, CARS2 total raw score decreased from baseline to Week 26 in the bumetanide and placebo groups, with no statistically significant difference between groups. No differences were observed between treatment groups for any of the secondary efficacy endpoints in either study. In both studies, treatment-emergent adverse events that occurred more frequently with bumetanide than placebo included thirst, polyuria, hypokalemia, and dry mouth. These large phase III trials failed to demonstrate a benefit of bumetanide for the treatment of pediatric ASD compared with placebo. Consequently, the sponsor has discontinued the development of bumetanide for the treatment of this condition. Trial registration: https://clinicaltrials.gov: SIGN 1: NCT03715166; SIGN 2: NCT03715153. En ligne : https://doi.org/10.1002/aur.3005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders / Susana MOUGA in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2940-2955 Titre : Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Susana MOUGA, Auteur ; Cátia CAFÉ, Auteur ; Joana ALMEIDA, Auteur ; Carla MARQUES, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur Article en page(s) : p.2940-2955 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Intellectual profiles  Cognitive ability  Wechsler Intelligence Scale for Children-III Index. décimale : PER Périodiques Résumé : The influence of specific autism spectrum disorder (ASD) deficits in Intelligence Quotients (IQ), Indexes and subtests from the Wechsler Intelligence Scale for Children-III was investigated in 445 school-aged children: ASD (N = 224) and other neurodevelopmental disorders (N = 221), matched by Full-Scale IQ and chronological age. ASD have lower scores in the VIQ than PIQ. The core distinctive scores between groups are Processing Speed Index and “Comprehension” and “Coding” subtests with lower results in ASD. ASD group with normal/high IQ showed highest score on “Similarities” subtest whereas the lower IQ group performed better on “Object Assembly”. The results replicated our previous work on adaptive behaviour, showing that adaptive functioning is positively correlated with intellectual profile, especially with the Communication domain in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2838-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Intellectual Profiles in the Autism Spectrum and Other Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / Susana MOUGA, Auteur ; Cátia CAFÉ, Auteur ; Joana ALMEIDA, Auteur ; Carla MARQUES, Auteur ; Frederico DUQUE, Auteur ; Guiomar OLIVEIRA, Auteur . - p.2940-2955. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2940-2955 Mots-clés : Autism spectrum disorder  Neurodevelopmental disorders  Intellectual profiles  Cognitive ability  Wechsler Intelligence Scale for Children-III Index. décimale : PER Périodiques Résumé : The influence of specific autism spectrum disorder (ASD) deficits in Intelligence Quotients (IQ), Indexes and subtests from the Wechsler Intelligence Scale for Children-III was investigated in 445 school-aged children: ASD (N = 224) and other neurodevelopmental disorders (N = 221), matched by Full-Scale IQ and chronological age. ASD have lower scores in the VIQ than PIQ. The core distinctive scores between groups are Processing Speed Index and “Comprehension” and “Coding” subtests with lower results in ASD. ASD group with normal/high IQ showed highest score on “Similarities” subtest whereas the lower IQ group performed better on “Object Assembly”. The results replicated our previous work on adaptive behaviour, showing that adaptive functioning is positively correlated with intellectual profile, especially with the Communication domain in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2838-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

Motor stereotypies in autism spectrum disorder: Clinical randomized study and classification proposal / ClAudia MELO in Autism, 27-2 (February 2023)  

Public ISBD [article]  inAutism > 27-2 (February 2023) . - p.456-471 Titre : Motor stereotypies in autism spectrum disorder: Clinical randomized study and classification proposal Type de document : Texte imprimé et/ou numérique Auteurs : ClAudia MELO, Auteur ; Tiago Pinto RIBEIRO, Auteur ; Catarina PRIOR, Auteur ; Camila GESTA, Auteur ; Vânia MARTINS, Auteur ; Guiomar OLIVEIRA, Auteur ; Teresa TEMUDO, Auteur Article en page(s) : p.456-471 Langues : Anglais (eng) Mots-clés : autism  epidemiologic determinants  intellectual disability  prevalence  stereotypies Index. décimale : PER Périodiques Résumé : Motor stereotypies are frequently reported in individuals with autism spectrum disorder, but determinants of stereotypies remain poorly understood. In this study, a randomized sample of children with diagnosis of autism spectrum disorder was investigated to identify the prevalence and determinants of stereotypies. A total of 134 children who carried the diagnosis of autism spectrum disorder were included (aged 2.3 “17.6 years; 79.1% male). Stereotypies were classified during a standardized protocol with video recording. The prevalence of stereotypies was 56.7%. Among 1198 captured stereotypies, hand/arm stereotypies were the most frequent. Thirty-five morphology patterns were identified, the most frequent being hand flapping, tapping, and jumping. In univariate analysis, an association was found between stereotypies and younger age (odds ratio=0.74), developmental delay, or intellectual disability (odds ratio=5.25), being nonverbal (odds ratio=0.06), epilepsy (odds ratio=3.89), Autism Diagnostic Interview “Revised-A score (odds ratio=1.17), Autism Diagnostic Interview “Revised-C score (odds ratio=1.25), and Autism Diagnostic Observation Schedule “2 score (odds ratio=1.65). After multivariate analysis, only younger age, being nonverbal, and Autism Diagnostic Interview “Revised-A and Autism Diagnostic Observation Schedule “2 scores remained as determinants of stereotypies. The prevalence of stereotypies in autism spectrum disorder was close to the values obtained in a previous meta-analysis and seems to represent a valid value. The combination of younger age, being nonverbal, and autism severity seems to increase the odds of stereotypies. En ligne : http://dx.doi.org/10.1177/13623613221105479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Motor stereotypies in autism spectrum disorder: Clinical randomized study and classification proposal [Texte imprimé et/ou numérique] / ClAudia MELO, Auteur ; Tiago Pinto RIBEIRO, Auteur ; Catarina PRIOR, Auteur ; Camila GESTA, Auteur ; Vânia MARTINS, Auteur ; Guiomar OLIVEIRA, Auteur ; Teresa TEMUDO, Auteur . - p.456-471. Langues : Anglais (eng) in Autism > 27-2 (February 2023) . - p.456-471 Mots-clés : autism  epidemiologic determinants  intellectual disability  prevalence  stereotypies Index. décimale : PER Périodiques Résumé : Motor stereotypies are frequently reported in individuals with autism spectrum disorder, but determinants of stereotypies remain poorly understood. In this study, a randomized sample of children with diagnosis of autism spectrum disorder was investigated to identify the prevalence and determinants of stereotypies. A total of 134 children who carried the diagnosis of autism spectrum disorder were included (aged 2.3 “17.6 years; 79.1% male). Stereotypies were classified during a standardized protocol with video recording. The prevalence of stereotypies was 56.7%. Among 1198 captured stereotypies, hand/arm stereotypies were the most frequent. Thirty-five morphology patterns were identified, the most frequent being hand flapping, tapping, and jumping. In univariate analysis, an association was found between stereotypies and younger age (odds ratio=0.74), developmental delay, or intellectual disability (odds ratio=5.25), being nonverbal (odds ratio=0.06), epilepsy (odds ratio=3.89), Autism Diagnostic Interview “Revised-A score (odds ratio=1.17), Autism Diagnostic Interview “Revised-C score (odds ratio=1.25), and Autism Diagnostic Observation Schedule “2 score (odds ratio=1.65). After multivariate analysis, only younger age, being nonverbal, and Autism Diagnostic Interview “Revised-A and Autism Diagnostic Observation Schedule “2 scores remained as determinants of stereotypies. The prevalence of stereotypies in autism spectrum disorder was close to the values obtained in a previous meta-analysis and seems to represent a valid value. The combination of younger age, being nonverbal, and autism severity seems to increase the odds of stereotypies. En ligne : http://dx.doi.org/10.1177/13623613221105479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Prevalence and determinants of motor stereotypies in autism spectrum disorder: A systematic review and meta-analysis / Claudia MELO in Autism, 24-3 (April 2020)  

Public ISBD [article]  inAutism > 24-3 (April 2020) . - p.569-590 Titre : Prevalence and determinants of motor stereotypies in autism spectrum disorder: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Claudia MELO, Auteur ; Luis RUANO, Auteur ; Joana JORGE, Auteur ; Tiago PINTO RIBEIRO, Auteur ; Guiomar OLIVEIRA, Auteur ; Luis AZEVEDO, Auteur ; Teresa TEMUDO, Auteur Article en page(s) : p.569-590 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  meta-analysis  prevalence  stereotypies Index. décimale : PER Périodiques Résumé : Stereotypies are frequently reported in people with autism spectrum disorder (ASD) but remain one of the less explained phenomena. We aimed to describe, through a systematic review and a meta-analysis, the prevalence of motor stereotypies in ASD and study the factors that influence this prevalence. Our literature search included MEDLINE, Scopus, and PsycINFO databases. Quality and risk of bias were assessed. Thirty-seven studies were included and the median prevalence of motor stereotypies in ASD was 51.8%, ranging from 21.9% to 97.5%. The most frequent determinants associated with a higher number of stereotypies in ASD were a younger age, lower intelligence quotient, and a greater severity of ASD. Moreover, gender did not seem to influence the prevalence of stereotypies. Meta-analytic analysis showed that lower IQ and autism diagnosis (independent of IQ) are associated with a higher prevalence of motor stereotypies (odds ratio = 2.5 and 4.7, respectively). Limitations of the reviewed literature include the use of convenience samples, with small sizes and heterogeneous inclusion criteria, and the predominance of high-functioning autism individuals. En ligne : http://dx.doi.org/10.1177/1362361319869118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Prevalence and determinants of motor stereotypies in autism spectrum disorder: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Claudia MELO, Auteur ; Luis RUANO, Auteur ; Joana JORGE, Auteur ; Tiago PINTO RIBEIRO, Auteur ; Guiomar OLIVEIRA, Auteur ; Luis AZEVEDO, Auteur ; Teresa TEMUDO, Auteur . - p.569-590. Langues : Anglais (eng) in Autism > 24-3 (April 2020) . - p.569-590 Mots-clés : autism spectrum disorder  meta-analysis  prevalence  stereotypies Index. décimale : PER Périodiques Résumé : Stereotypies are frequently reported in people with autism spectrum disorder (ASD) but remain one of the less explained phenomena. We aimed to describe, through a systematic review and a meta-analysis, the prevalence of motor stereotypies in ASD and study the factors that influence this prevalence. Our literature search included MEDLINE, Scopus, and PsycINFO databases. Quality and risk of bias were assessed. Thirty-seven studies were included and the median prevalence of motor stereotypies in ASD was 51.8%, ranging from 21.9% to 97.5%. The most frequent determinants associated with a higher number of stereotypies in ASD were a younger age, lower intelligence quotient, and a greater severity of ASD. Moreover, gender did not seem to influence the prevalence of stereotypies. Meta-analytic analysis showed that lower IQ and autism diagnosis (independent of IQ) are associated with a higher prevalence of motor stereotypies (odds ratio = 2.5 and 4.7, respectively). Limitations of the reviewed literature include the use of convenience samples, with small sizes and heterogeneous inclusion criteria, and the predominance of high-functioning autism individuals. En ligne : http://dx.doi.org/10.1177/1362361319869118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders / Catarina T. CORREIA in Molecular Autism, (April 2014)  

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The Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses / Joseph D. BUXBAUM in Molecular Autism, (May 2014)  

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Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / Bruno DIREITO in Autism, 26-6 (August 2022)  

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Use of early intervention for young children with autism spectrum disorder across Europe / Erica SALOMONE in Autism, 20-2 (February 2016)  

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Virtual Reality Immersion Rescales Regulation of Interpersonal Distance in Controls but not in Autism Spectrum Disorder / Marco SIMÕES in Journal of Autism and Developmental Disorders, 50-12 (December 2020)  

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