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Détail de l'auteur
Auteur E. S. CARLSON |
Documents disponibles écrits par cet auteur (2)
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Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology / Michael K. GEORGIEFF in Development and Psychopathology, 30-3 (August 2018)
[article]
Titre : Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Michael K. GEORGIEFF, Auteur ; P. V. TRAN, Auteur ; E. S. CARLSON, Auteur Article en page(s) : p.1063-1086 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Accumulating evidence indicates that the fetal environment plays an important role in brain development and sets the brain on a trajectory across the life span. An abnormal fetal environment results when factors that should be present during a critical period of development are absent or when factors that should not be in the developing brain are present. While these factors may acutely disrupt brain function, the real cost to society resides in the long-term effects, which include important mental health issues. We review the effects of three factors, fetal alcohol exposure, teratogen exposure, and nutrient deficiencies, on the developing brain and the consequent risk for developmental psychopathology. Each is reviewed with respect to the evidence found in epidemiological and clinical studies in humans as well as preclinical molecular and cellular studies that explicate mechanisms of action. En ligne : http://dx.doi.org/10.1017/s0954579418000500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367
in Development and Psychopathology > 30-3 (August 2018) . - p.1063-1086[article] Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology [Texte imprimé et/ou numérique] / Michael K. GEORGIEFF, Auteur ; P. V. TRAN, Auteur ; E. S. CARLSON, Auteur . - p.1063-1086.
Langues : Anglais (eng)
in Development and Psychopathology > 30-3 (August 2018) . - p.1063-1086
Index. décimale : PER Périodiques Résumé : Accumulating evidence indicates that the fetal environment plays an important role in brain development and sets the brain on a trajectory across the life span. An abnormal fetal environment results when factors that should be present during a critical period of development are absent or when factors that should not be in the developing brain are present. While these factors may acutely disrupt brain function, the real cost to society resides in the long-term effects, which include important mental health issues. We review the effects of three factors, fetal alcohol exposure, teratogen exposure, and nutrient deficiencies, on the developing brain and the consequent risk for developmental psychopathology. Each is reviewed with respect to the evidence found in epidemiological and clinical studies in humans as well as preclinical molecular and cellular studies that explicate mechanisms of action. En ligne : http://dx.doi.org/10.1017/s0954579418000500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems / E. S. CARLSON in Journal of Neurodevelopmental Disorders, 2-3 (September 2010)
[article]
Titre : Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems Type de document : Texte imprimé et/ou numérique Auteurs : E. S. CARLSON, Auteur ; S. J. FRETHAM, Auteur ; E. UNGER, Auteur ; M. O'CONNOR, Auteur ; A. PETRYK, Auteur ; T. SCHALLERT, Auteur ; R. RAO, Auteur ; I. TKAC, Auteur ; Michael K. GEORGIEFF, Auteur Article en page(s) : p.133-43 Langues : Anglais (eng) Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy Hippocampus Iron deficiency Memory systems Morris water maze Procedural memory Spatial memory Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342
in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43[article] Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems [Texte imprimé et/ou numérique] / E. S. CARLSON, Auteur ; S. J. FRETHAM, Auteur ; E. UNGER, Auteur ; M. O'CONNOR, Auteur ; A. PETRYK, Auteur ; T. SCHALLERT, Auteur ; R. RAO, Auteur ; I. TKAC, Auteur ; Michael K. GEORGIEFF, Auteur . - p.133-43.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43
Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy Hippocampus Iron deficiency Memory systems Morris water maze Procedural memory Spatial memory Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342