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Détail de l'auteur
Auteur S. E. MOUS |
Documents disponibles écrits par cet auteur (2)
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Attention and motor deficits index non-specific background liabilities that predict autism recurrence in siblings / S. E. MOUS in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)
[article]
Titre : Attention and motor deficits index non-specific background liabilities that predict autism recurrence in siblings Type de document : Texte imprimé et/ou numérique Auteurs : S. E. MOUS, Auteur ; A. JIANG, Auteur ; Arpana AGRAWAL, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.32 Langues : Anglais (eng) Mots-clés : Adhd Autism Family studies Motor coordination Sibling recurrence Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent research has demonstrated that subclinical autistic traits of parents amplify the effects of deleterious mutations in the causation of autism spectrum disorder (ASD) in their offspring. Here, we examined the extent to which two neurodevelopmental traits that are non-specific to ASD-inattention/hyperactivity and motor coordination-might contribute to ASD recurrence in siblings of ASD probands. METHODS: Data from a quantitative trait study of 114 ASD probands and their brothers, 26% of whom also had ASD, were analyzed. Autistic trait severity was ascertained using the Social Responsiveness Scale-2, attention/hyperactivity problems using the Achenbach System of Empirically Based Assessment, and motor coordination (in a subset of participants) using the Developmental Coordination Disorder Questionnaire. RESULTS: Among siblings (affected and unaffected), both categorical recurrence of ASD (Nagelkerke R (2) = 0.53) and quantitative ASD trait burden (R (2) = 0.55) were predicted by sibling ADHD and motor coordination impairment scores, even though these traits, on average, were not elevated among the unaffected siblings. CONCLUSIONS: These findings in a clinical family cohort confirm observations from general population studies that inattention/hyperactivity and motor impairment-axes of behavioral development that are non-specific to ASD, and often appreciable before ASD is typically diagnosed-jointly account for over 50% of the variation in autistic impairment of siblings, whether ascertained quantitatively or categorically. This finding within a sibling design suggests that background ASD susceptibilities that are inherited but non-specific ("BASINS") may contribute to additive genetic liability in the same manner that ASD-specific susceptibilities (such as parental subclinical ASD traits and deleterious mutations) engender ASD risk. En ligne : http://dx.doi.org/10.1186/s11689-017-9212-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.32[article] Attention and motor deficits index non-specific background liabilities that predict autism recurrence in siblings [Texte imprimé et/ou numérique] / S. E. MOUS, Auteur ; A. JIANG, Auteur ; Arpana AGRAWAL, Auteur ; John N. CONSTANTINO, Auteur . - p.32.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.32
Mots-clés : Adhd Autism Family studies Motor coordination Sibling recurrence Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent research has demonstrated that subclinical autistic traits of parents amplify the effects of deleterious mutations in the causation of autism spectrum disorder (ASD) in their offspring. Here, we examined the extent to which two neurodevelopmental traits that are non-specific to ASD-inattention/hyperactivity and motor coordination-might contribute to ASD recurrence in siblings of ASD probands. METHODS: Data from a quantitative trait study of 114 ASD probands and their brothers, 26% of whom also had ASD, were analyzed. Autistic trait severity was ascertained using the Social Responsiveness Scale-2, attention/hyperactivity problems using the Achenbach System of Empirically Based Assessment, and motor coordination (in a subset of participants) using the Developmental Coordination Disorder Questionnaire. RESULTS: Among siblings (affected and unaffected), both categorical recurrence of ASD (Nagelkerke R (2) = 0.53) and quantitative ASD trait burden (R (2) = 0.55) were predicted by sibling ADHD and motor coordination impairment scores, even though these traits, on average, were not elevated among the unaffected siblings. CONCLUSIONS: These findings in a clinical family cohort confirm observations from general population studies that inattention/hyperactivity and motor impairment-axes of behavioral development that are non-specific to ASD, and often appreciable before ASD is typically diagnosed-jointly account for over 50% of the variation in autistic impairment of siblings, whether ascertained quantitatively or categorically. This finding within a sibling design suggests that background ASD susceptibilities that are inherited but non-specific ("BASINS") may contribute to additive genetic liability in the same manner that ASD-specific susceptibilities (such as parental subclinical ASD traits and deleterious mutations) engender ASD risk. En ligne : http://dx.doi.org/10.1186/s11689-017-9212-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 Autism Spectrum Disorder in an Unselected Cohort of Children with Neurofibromatosis Type 1 (NF1) / S. EIJK in Journal of Autism and Developmental Disorders, 48-7 (July 2018)
[article]
Titre : Autism Spectrum Disorder in an Unselected Cohort of Children with Neurofibromatosis Type 1 (NF1) Type de document : Texte imprimé et/ou numérique Auteurs : S. EIJK, Auteur ; S. E. MOUS, Auteur ; G. C. DIELEMAN, Auteur ; Bram DIERCKX, Auteur ; A. B. RIETMAN, Auteur ; P. F. A. DE NIJS, Auteur ; L. W. TEN HOOPEN, Auteur ; R. VAN MINKELEN, Auteur ; Y. ELGERSMA, Auteur ; Coriene E. CATSMAN-BERREVOETS, Auteur ; R. OOSTENBRINK, Auteur ; J. S. LEGERSTEE, Auteur Article en page(s) : p.2278-2285 Langues : Anglais (eng) Mots-clés : Autism diagnostic observation schedule Autism spectrum disorder Autistic traits Neurofibromatosis type 1 Prevalence Social responsiveness scale Index. décimale : PER Périodiques Résumé : In a non-selected sample of children with Neurofibromatosis type 1 (NF1) the prevalence rate of autism spectrum disorder (ASD) and predictive value of an observational (ADOS)-and questionnaire-based screening instrument were assessed. Complete data was available for 128 children. The prevalence rate for clinical ASD was 10.9%, which is clearly higher than in the general population. This prevalence rate is presumably more accurate than in previous studies that examined children with NF1 with an ASD presumption or solely based on screening instruments. The combined observational- and screening based classifications demonstrated the highest positive predictive value for DSM-IV diagnosis, highlighting the importance of using both instruments in children with NF1. En ligne : http://dx.doi.org/10.1007/s10803-018-3478-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367
in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2278-2285[article] Autism Spectrum Disorder in an Unselected Cohort of Children with Neurofibromatosis Type 1 (NF1) [Texte imprimé et/ou numérique] / S. EIJK, Auteur ; S. E. MOUS, Auteur ; G. C. DIELEMAN, Auteur ; Bram DIERCKX, Auteur ; A. B. RIETMAN, Auteur ; P. F. A. DE NIJS, Auteur ; L. W. TEN HOOPEN, Auteur ; R. VAN MINKELEN, Auteur ; Y. ELGERSMA, Auteur ; Coriene E. CATSMAN-BERREVOETS, Auteur ; R. OOSTENBRINK, Auteur ; J. S. LEGERSTEE, Auteur . - p.2278-2285.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2278-2285
Mots-clés : Autism diagnostic observation schedule Autism spectrum disorder Autistic traits Neurofibromatosis type 1 Prevalence Social responsiveness scale Index. décimale : PER Périodiques Résumé : In a non-selected sample of children with Neurofibromatosis type 1 (NF1) the prevalence rate of autism spectrum disorder (ASD) and predictive value of an observational (ADOS)-and questionnaire-based screening instrument were assessed. Complete data was available for 128 children. The prevalence rate for clinical ASD was 10.9%, which is clearly higher than in the general population. This prevalence rate is presumably more accurate than in previous studies that examined children with NF1 with an ASD presumption or solely based on screening instruments. The combined observational- and screening based classifications demonstrated the highest positive predictive value for DSM-IV diagnosis, highlighting the importance of using both instruments in children with NF1. En ligne : http://dx.doi.org/10.1007/s10803-018-3478-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367