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Auteur R. A. LUNDWALL |
Documents disponibles écrits par cet auteur (2)
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Functional MRI connectivity of children with autism and low verbal and cognitive performance / T. P. GABRIELSEN in Molecular Autism, 9 (2018)
[article]
Titre : Functional MRI connectivity of children with autism and low verbal and cognitive performance Type de document : Texte imprimé et/ou numérique Auteurs : T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Adolescent Autistic Disorder/*diagnostic imaging/physiopathology Case-Control Studies Child *Cognition Female Humans Intelligence *Language Development Magnetic Resonance Imaging Male *Autism spectrum disorder *Functional connectivity *Imaging methodology *Intelligence *Language Institutional Review Board, protocol #F25403. Written informed consent was obtained from parents, with assent obtained from participants following video review of procedures.The boy who modeled the MRI procedures in the video modeling procedure was filmed, and the final video was shared, with written permission of both of his parents and with his own assent.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 9 (2018) . - 67 p.[article] Functional MRI connectivity of children with autism and low verbal and cognitive performance [Texte imprimé et/ou numérique] / T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur . - 67 p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 67 p.
Mots-clés : Adolescent Autistic Disorder/*diagnostic imaging/physiopathology Case-Control Studies Child *Cognition Female Humans Intelligence *Language Development Magnetic Resonance Imaging Male *Autism spectrum disorder *Functional connectivity *Imaging methodology *Intelligence *Language Institutional Review Board, protocol #F25403. Written informed consent was obtained from parents, with assent obtained from participants following video review of procedures.The boy who modeled the MRI procedures in the video modeling procedure was filmed, and the final video was shared, with written permission of both of his parents and with his own assent.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Not So Fast: Autistic traits and Anxious Apprehension in Real-World Visual Search Scenarios / N. C. C. RUSSELL in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
[article]
Titre : Not So Fast: Autistic traits and Anxious Apprehension in Real-World Visual Search Scenarios Type de document : Texte imprimé et/ou numérique Auteurs : N. C. C. RUSSELL, Auteur ; S. G. LUKE, Auteur ; R. A. LUNDWALL, Auteur ; M. SOUTH, Auteur Article en page(s) : p.1795-1806 Langues : Anglais (eng) Mots-clés : Anxiety Autism Contextual integration Eye tracking Visual search Index. décimale : PER Périodiques Résumé : Autistic individuals have shown superior performance in simple, albeit difficult, visual search tasks. We compared eye movements and behavioral markers across two visual search tasks based on real-world scenes in young adults. Context-aided search increased speed and accuracy for all groups. Autistic adults (n = 29) were on average consistently slower and less accurate than a non-anxious neurotypical comparison group (n = 48), but similar to neurotypical adults with elevated anxious apprehension (n = 26). Dimensional analyses suggest that autism traits, not anxious apprehension, are most associated with search efficiency of naturalistic stimuli suggesting that autistic individuals can effectively integrate contextual information to aid visual search, but that advantages in less visually complex tasks, reported in previous studies, may not transfer to situations involving real-world scenes. En ligne : http://dx.doi.org/10.1007/s10803-018-03874-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1795-1806[article] Not So Fast: Autistic traits and Anxious Apprehension in Real-World Visual Search Scenarios [Texte imprimé et/ou numérique] / N. C. C. RUSSELL, Auteur ; S. G. LUKE, Auteur ; R. A. LUNDWALL, Auteur ; M. SOUTH, Auteur . - p.1795-1806.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1795-1806
Mots-clés : Anxiety Autism Contextual integration Eye tracking Visual search Index. décimale : PER Périodiques Résumé : Autistic individuals have shown superior performance in simple, albeit difficult, visual search tasks. We compared eye movements and behavioral markers across two visual search tasks based on real-world scenes in young adults. Context-aided search increased speed and accuracy for all groups. Autistic adults (n = 29) were on average consistently slower and less accurate than a non-anxious neurotypical comparison group (n = 48), but similar to neurotypical adults with elevated anxious apprehension (n = 26). Dimensional analyses suggest that autism traits, not anxious apprehension, are most associated with search efficiency of naturalistic stimuli suggesting that autistic individuals can effectively integrate contextual information to aid visual search, but that advantages in less visually complex tasks, reported in previous studies, may not transfer to situations involving real-world scenes. En ligne : http://dx.doi.org/10.1007/s10803-018-03874-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393