Editorial Perspective: Extending IPDMA methodology to drive treatment personalisation in child mental health / Lizél-Antoinette BERTIE in Journal of Child Psychology and Psychiatry, 65-11 (November 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1546-1550 Titre : Editorial Perspective: Extending IPDMA methodology to drive treatment personalisation in child mental health Type de document : Texte imprimé et/ou numérique Auteurs : Lizél-Antoinette BERTIE, Auteur ; Maaike H. NAUTA, Auteur ; Bas KOOIMAN, Auteur ; Wenting CHEN, Auteur ; Jennifer L. HUDSON, Auteur Article en page(s) : p.1546-1550 Langues : Anglais (eng) Mots-clés : Large data  treatment trials  prediction  methodology Index. décimale : PER Périodiques Résumé : To improve outcomes for youth who do not respond optimally to existing treatments, we need to identify robust predictors, moderators, and mediators that are ideal targets for personalisation in mental health care. We propose a solution to leverage the Individual Patient Data Meta-analysis (IPDMA) approach to allow broader access to individual-level data while maintaining methodological rigour. Such a resource has the potential to answer questions that are unable to be addressed by single studies, reduce researcher burden, and enable the application of newer statistical techniques, all to provide data-driven strategies for clinical decision-making. Using childhood anxiety as the worked example, the editorial perspective outlines the rationale for leveraging IPDMA methodology to build a data repository, the Platform for Anxiety Disorder Data in Youth. We also include recommendations to address the methods and challenges inherent in this endeavour. En ligne : https://doi.org/10.1111/jcpp.14025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Editorial Perspective: Extending IPDMA methodology to drive treatment personalisation in child mental health [Texte imprimé et/ou numérique] / Lizél-Antoinette BERTIE, Auteur ; Maaike H. NAUTA, Auteur ; Bas KOOIMAN, Auteur ; Wenting CHEN, Auteur ; Jennifer L. HUDSON, Auteur . - p.1546-1550. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1546-1550 Mots-clés : Large data  treatment trials  prediction  methodology Index. décimale : PER Périodiques Résumé : To improve outcomes for youth who do not respond optimally to existing treatments, we need to identify robust predictors, moderators, and mediators that are ideal targets for personalisation in mental health care. We propose a solution to leverage the Individual Patient Data Meta-analysis (IPDMA) approach to allow broader access to individual-level data while maintaining methodological rigour. Such a resource has the potential to answer questions that are unable to be addressed by single studies, reduce researcher burden, and enable the application of newer statistical techniques, all to provide data-driven strategies for clinical decision-making. Using childhood anxiety as the worked example, the editorial perspective outlines the rationale for leveraging IPDMA methodology to build a data repository, the Platform for Anxiety Disorder Data in Youth. We also include recommendations to address the methods and challenges inherent in this endeavour. En ligne : https://doi.org/10.1111/jcpp.14025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Patterns of sub-optimal change following CBT for childhood anxiety / Lizél-Antoinette BERTIE in Journal of Child Psychology and Psychiatry, 65-12 (December 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-12 (December 2024) . - p.1612-1623 Titre : Patterns of sub-optimal change following CBT for childhood anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Lizél-Antoinette BERTIE, Auteur ; Kristian ARENDT, Auteur ; Jonathan R. I. COLEMAN, Auteur ; Peter COOPER, Auteur ; Cathy CRESWELL, Auteur ; Thalia C. ELEY, Auteur ; Catharina HARTMAN, Auteur ; Einar R. HEIERVANG, Auteur ; Tina IN-ALBON, Auteur ; Karen KRAUSE, Auteur ; Kathryn J. LESTER, Auteur ; Carla E. MARIN, Auteur ; Maaike NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Silvia SCHNEIDER, Auteur ; Carolyn SCHNIERING, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Polly WAITE, Auteur ; Gro Janne WERGELAND, Auteur ; Jennifer L. HUDSON, Auteur Article en page(s) : p.1612-1623 Langues : Anglais (eng) Mots-clés : Anxiety  childhood  cognitive behavioural therapy  sub-optimal response  response patterns Index. décimale : PER Périodiques Résumé : Background Children and adolescents demonstrate diverse patterns of symptom change and disorder remission following cognitive behavioural therapy (CBT) for anxiety disorders. To better understand children who respond sub-optimally to CBT, this study investigated youths (N?=?1,483) who continued to meet criteria for one or more clinical anxiety diagnosis immediately following treatment or at any point during the 12?months following treatment. Methods Data were collected from 10 clinical sites with assessments at pre-and post-treatment and at least once more at 3, 6 or 12-month follow-up. Participants were assigned to one of three groups based on diagnostic status for youths who: (a) retained an anxiety diagnosis from post to end point (minimal responders); (b) remitted anxiety diagnoses at post but relapsed by end point (relapsed responders); and (c) retained a diagnosis at post but remitted to be diagnosis free at end point (delayed responders). Growth curve models assessed patterns of change over time for the three groups and examined predictors associated with these patterns including demographic, clinical and parental factors, as well as treatment factors. Results Higher primary disorder severity, being older, having a greater number of anxiety disorders, having social anxiety disorder, as well as higher maternal psychopathology differentiated the minimal responders from the delayed and relapsed responders at the baseline. Results from the growth curve models showed that severity of the primary disorder and treatment modality differentiated patterns of linear change only. Higher severity was associated with significantly less improvement over time for the minimal and relapsed response groups, as was receiving group CBT, when compared to the delayed response group. Conclusions Sub-optimal response patterns can be partially differentiated using variables assessed at pre-treatment. Increased understanding of different patterns of change following treatment may provide direction for clinical decision-making and for tailoring treatments to specific groups of clinically anxious youth. Future research may benefit from assessing progress during treatment to detect emerging response patterns earlier. En ligne : https://doi.org/10.1111/jcpp.14009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542 [article] Patterns of sub-optimal change following CBT for childhood anxiety [Texte imprimé et/ou numérique] / Lizél-Antoinette BERTIE, Auteur ; Kristian ARENDT, Auteur ; Jonathan R. I. COLEMAN, Auteur ; Peter COOPER, Auteur ; Cathy CRESWELL, Auteur ; Thalia C. ELEY, Auteur ; Catharina HARTMAN, Auteur ; Einar R. HEIERVANG, Auteur ; Tina IN-ALBON, Auteur ; Karen KRAUSE, Auteur ; Kathryn J. LESTER, Auteur ; Carla E. MARIN, Auteur ; Maaike NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Silvia SCHNEIDER, Auteur ; Carolyn SCHNIERING, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Polly WAITE, Auteur ; Gro Janne WERGELAND, Auteur ; Jennifer L. HUDSON, Auteur . - p.1612-1623. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-12 (December 2024) . - p.1612-1623 Mots-clés : Anxiety  childhood  cognitive behavioural therapy  sub-optimal response  response patterns Index. décimale : PER Périodiques Résumé : Background Children and adolescents demonstrate diverse patterns of symptom change and disorder remission following cognitive behavioural therapy (CBT) for anxiety disorders. To better understand children who respond sub-optimally to CBT, this study investigated youths (N?=?1,483) who continued to meet criteria for one or more clinical anxiety diagnosis immediately following treatment or at any point during the 12?months following treatment. Methods Data were collected from 10 clinical sites with assessments at pre-and post-treatment and at least once more at 3, 6 or 12-month follow-up. Participants were assigned to one of three groups based on diagnostic status for youths who: (a) retained an anxiety diagnosis from post to end point (minimal responders); (b) remitted anxiety diagnoses at post but relapsed by end point (relapsed responders); and (c) retained a diagnosis at post but remitted to be diagnosis free at end point (delayed responders). Growth curve models assessed patterns of change over time for the three groups and examined predictors associated with these patterns including demographic, clinical and parental factors, as well as treatment factors. Results Higher primary disorder severity, being older, having a greater number of anxiety disorders, having social anxiety disorder, as well as higher maternal psychopathology differentiated the minimal responders from the delayed and relapsed responders at the baseline. Results from the growth curve models showed that severity of the primary disorder and treatment modality differentiated patterns of linear change only. Higher severity was associated with significantly less improvement over time for the minimal and relapsed response groups, as was receiving group CBT, when compared to the delayed response group. Conclusions Sub-optimal response patterns can be partially differentiated using variables assessed at pre-treatment. Increased understanding of different patterns of change following treatment may provide direction for clinical decision-making and for tailoring treatments to specific groups of clinically anxious youth. Future research may benefit from assessing progress during treatment to detect emerging response patterns earlier. En ligne : https://doi.org/10.1111/jcpp.14009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542

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