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2 recherche sur le mot-clé '*Head circumference'
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No evidence of early head circumference enlargements in children later diagnosed with autism in Israel / I. DINSTEIN in Molecular Autism, 8 (2017)
[article]
Titre : No evidence of early head circumference enlargements in children later diagnosed with autism in Israel Type de document : Texte imprimé et/ou numérique Auteurs : I. DINSTEIN, Auteur ; S. HAAR, Auteur ; S. ATSMON, Auteur ; H. SCHTAERMAN, Auteur Article en page(s) : 15p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/*diagnosis Body Height Body Weight Cephalometry/*methods Child, Preschool Female Head/*growth & development Humans Infant Israel Male Retrospective Studies *Autism *Biomarker *Early detection *Head circumference *Neuroanatomy Index. décimale : PER Périodiques Résumé : BACKGROUND: Large controversy exists regarding the potential existence and clinical significance of larger brain volumes in toddlers who later develop autism. Assessing this relationship is important for determining the clinical utility of early head circumference (HC) measures and for assessing the validity of the early overgrowth hypothesis of autism, which suggests that early accelerated brain development may be a hallmark of the disorder. METHODS: We performed a retrospective comparison of HC, height, and weight measurements between 66 toddlers who were later diagnosed with autism and 66 matched controls. These toddlers represent an unbiased regional sample from a single health service provider in the southern district of Israel. On average, participating toddlers had >8 measurements between birth and the age of two, which enabled us to characterize individual HC, height, and weight development with high precision and fit a negative exponential growth model to the data of each toddler with exceptional accuracy. RESULTS: The analyses revealed that HC sizes and growth rates were not significantly larger in toddlers with autism even when stratifying the autism group based on verbal capabilities at the time of diagnosis. In addition, there were no significant correlations between ADOS scores at the time of diagnosis and HC at any time-point during the first 2 years of life. CONCLUSIONS: These negative results add to accumulating evidence, which suggest that brain volume is not necessarily larger in toddlers who develop autism. We believe that conflicting results reported in other studies are due to small sample sizes, use of misleading population norms, changes in the clinical definition of autism over time, and/or inclusion of individuals with syndromic autism. While abnormally large brains may be evident in some individuals with autism and more clearly visible in MRI scans, converging evidence from this and other studies suggests that enlarged HC is not a common etiology of the entire autism population. Early HC measures, therefore, offer very limited clinical utility for assessment of autism risk in the general population. En ligne : http://dx.doi.org/10.1186/s13229-017-0129-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 15p.[article] No evidence of early head circumference enlargements in children later diagnosed with autism in Israel [Texte imprimé et/ou numérique] / I. DINSTEIN, Auteur ; S. HAAR, Auteur ; S. ATSMON, Auteur ; H. SCHTAERMAN, Auteur . - 15p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 15p.
Mots-clés : Autistic Disorder/*diagnosis Body Height Body Weight Cephalometry/*methods Child, Preschool Female Head/*growth & development Humans Infant Israel Male Retrospective Studies *Autism *Biomarker *Early detection *Head circumference *Neuroanatomy Index. décimale : PER Périodiques Résumé : BACKGROUND: Large controversy exists regarding the potential existence and clinical significance of larger brain volumes in toddlers who later develop autism. Assessing this relationship is important for determining the clinical utility of early head circumference (HC) measures and for assessing the validity of the early overgrowth hypothesis of autism, which suggests that early accelerated brain development may be a hallmark of the disorder. METHODS: We performed a retrospective comparison of HC, height, and weight measurements between 66 toddlers who were later diagnosed with autism and 66 matched controls. These toddlers represent an unbiased regional sample from a single health service provider in the southern district of Israel. On average, participating toddlers had >8 measurements between birth and the age of two, which enabled us to characterize individual HC, height, and weight development with high precision and fit a negative exponential growth model to the data of each toddler with exceptional accuracy. RESULTS: The analyses revealed that HC sizes and growth rates were not significantly larger in toddlers with autism even when stratifying the autism group based on verbal capabilities at the time of diagnosis. In addition, there were no significant correlations between ADOS scores at the time of diagnosis and HC at any time-point during the first 2 years of life. CONCLUSIONS: These negative results add to accumulating evidence, which suggest that brain volume is not necessarily larger in toddlers who develop autism. We believe that conflicting results reported in other studies are due to small sample sizes, use of misleading population norms, changes in the clinical definition of autism over time, and/or inclusion of individuals with syndromic autism. While abnormally large brains may be evident in some individuals with autism and more clearly visible in MRI scans, converging evidence from this and other studies suggests that enlarged HC is not a common etiology of the entire autism population. Early HC measures, therefore, offer very limited clinical utility for assessment of autism risk in the general population. En ligne : http://dx.doi.org/10.1186/s13229-017-0129-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 Head circumference trends in autism between 0 and 100 months / Joel CRUCITTI in Autism, 24-7 (October 2020)
[article]
Titre : Head circumference trends in autism between 0 and 100 months Type de document : Texte imprimé et/ou numérique Auteurs : Joel CRUCITTI, Auteur ; Christian HYDE, Auteur ; Peter G. ENTICOTT, Auteur ; Mark A. STOKES, Auteur Article en page(s) : p.1726-1739 Langues : Anglais (eng) Mots-clés : *age *autism *head circumference *sex Index. décimale : PER Périodiques Résumé : Summaries of studies that have measured head size in those with autism, known as meta-analyses, currently exist. However, this approach does not adequately explain extreme cases (such as those with extremely small, or extremely large, head size). Because of this, we obtained all available published data measuring head size (12 studies). The data from each study were then combined to make a larger dataset. We found that females with autism aged 12-17?months had, on average, smaller head sizes. Otherwise, average head size was not atypical in autism. However, we found that males with autism were more likely to have extreme head sizes at birth and between 60 and 100?months, a small head between 6 and 11?months, and a large head between 12 and 17?months. Females with autism were more likely to have extreme head sizes between 36 and 59?months and were less likely at birth. Our approach was able to measure the influence of age and biological sex on head size in autism, as well as the frequency of extreme cases of head size in autism. These results add to what we already know about head size in autism. En ligne : http://dx.doi.org/10.1177/1362361320921037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431
in Autism > 24-7 (October 2020) . - p.1726-1739[article] Head circumference trends in autism between 0 and 100 months [Texte imprimé et/ou numérique] / Joel CRUCITTI, Auteur ; Christian HYDE, Auteur ; Peter G. ENTICOTT, Auteur ; Mark A. STOKES, Auteur . - p.1726-1739.
Langues : Anglais (eng)
in Autism > 24-7 (October 2020) . - p.1726-1739
Mots-clés : *age *autism *head circumference *sex Index. décimale : PER Périodiques Résumé : Summaries of studies that have measured head size in those with autism, known as meta-analyses, currently exist. However, this approach does not adequately explain extreme cases (such as those with extremely small, or extremely large, head size). Because of this, we obtained all available published data measuring head size (12 studies). The data from each study were then combined to make a larger dataset. We found that females with autism aged 12-17?months had, on average, smaller head sizes. Otherwise, average head size was not atypical in autism. However, we found that males with autism were more likely to have extreme head sizes at birth and between 60 and 100?months, a small head between 6 and 11?months, and a large head between 12 and 17?months. Females with autism were more likely to have extreme head sizes between 36 and 59?months and were less likely at birth. Our approach was able to measure the influence of age and biological sex on head size in autism, as well as the frequency of extreme cases of head size in autism. These results add to what we already know about head size in autism. En ligne : http://dx.doi.org/10.1177/1362361320921037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431