1 recherche sur le mot-clé '*childhood adversity'

Challenges in researching the immune pathways between early life adversity and psychopathology / Brie REID in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1597-1624 Titre : Challenges in researching the immune pathways between early life adversity and psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Brie REID, Auteur ; Andrea DANESE, Auteur Article en page(s) : p.1597-1624 Langues : Anglais (eng) Mots-clés : Biomarkers  Child  Humans  Inflammation  *Psychopathology  Risk Factors  *Stress, Psychological  *childhood adversity  *immunity  *inflammation  *maltreatment  *psychiatric disorders Index. décimale : PER Périodiques Résumé : Exposure to childhood adversity is a critical risk factor for the development of psychopathology. A growing field of research examines how exposure to childhood adversity is translated into biological risk for psychopathology through alterations in immune system functioning, most notably heightened levels of inflammation biomarkers. Though our knowledge about how childhood adversity can instantiate biological risk for psychopathology is growing, there remain many challenges and gaps in the field to understand how inflammation from childhood adversity contributes to psychopathology. This paper reviews research on the inflammatory outcomes arising from childhood adversity and presents four major challenges that future research must address: (a) the measurement of childhood adversity, (b) the measurement of inflammation, (c) the identification of mediators between childhood adversity and inflammation, and (d) the identification of moderators of inflammatory outcomes following childhood adversity. We discuss synergies and inconsistencies in the literature to summarize the current understanding of the association between childhood adversity, a proinflammatory phenotype, and the biological risk for psychopathology. We discuss the clinical implications of the inflammatory links between childhood adversity and psychopathology, including possibilities for intervention. Finally, this review conclude by delineates future directions for research, including issues of how best to detect, prevent, and understand these "hidden wounds" of childhood adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Challenges in researching the immune pathways between early life adversity and psychopathology [Texte imprimé et/ou numérique] / Brie REID, Auteur ; Andrea DANESE, Auteur . - p.1597-1624. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1597-1624 Mots-clés : Biomarkers  Child  Humans  Inflammation  *Psychopathology  Risk Factors  *Stress, Psychological  *childhood adversity  *immunity  *inflammation  *maltreatment  *psychiatric disorders Index. décimale : PER Périodiques Résumé : Exposure to childhood adversity is a critical risk factor for the development of psychopathology. A growing field of research examines how exposure to childhood adversity is translated into biological risk for psychopathology through alterations in immune system functioning, most notably heightened levels of inflammation biomarkers. Though our knowledge about how childhood adversity can instantiate biological risk for psychopathology is growing, there remain many challenges and gaps in the field to understand how inflammation from childhood adversity contributes to psychopathology. This paper reviews research on the inflammatory outcomes arising from childhood adversity and presents four major challenges that future research must address: (a) the measurement of childhood adversity, (b) the measurement of inflammation, (c) the identification of mediators between childhood adversity and inflammation, and (d) the identification of moderators of inflammatory outcomes following childhood adversity. We discuss synergies and inconsistencies in the literature to summarize the current understanding of the association between childhood adversity, a proinflammatory phenotype, and the biological risk for psychopathology. We discuss the clinical implications of the inflammatory links between childhood adversity and psychopathology, including possibilities for intervention. Finally, this review conclude by delineates future directions for research, including issues of how best to detect, prevent, and understand these "hidden wounds" of childhood adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437