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Résultat de la recherche
3 recherche sur le mot-clé '*maltreatment'




Immediate and longitudinal effects of maltreatment on systemic inflammation in young children / Sonja ENTRINGER in Development and Psychopathology, 32-5 (December 2020)
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[article]
Titre : Immediate and longitudinal effects of maltreatment on systemic inflammation in young children Type de document : Texte imprimé et/ou numérique Auteurs : Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1725-1731 Langues : Anglais (eng) Mots-clés : C-Reactive Protein Child *Child Abuse Child, Preschool Cross-Sectional Studies Female Humans Infant Inflammation Male Retrospective Studies *crp *early life stress *inflammation *maltreatment *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731[article] Immediate and longitudinal effects of maltreatment on systemic inflammation in young children [Texte imprimé et/ou numérique] / Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1725-1731.
Langues : Anglais (eng)
in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731
Mots-clés : C-Reactive Protein Child *Child Abuse Child, Preschool Cross-Sectional Studies Female Humans Infant Inflammation Male Retrospective Studies *crp *early life stress *inflammation *maltreatment *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation / Adrienne A. VANZOMEREN in Development and Psychopathology, 32-5 (December 2020)
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[article]
Titre : Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation Type de document : Texte imprimé et/ou numérique Auteurs : Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1838-1853 Langues : Anglais (eng) Mots-clés : Adolescent African Americans Child *Depression Humans Hydrocortisone *Hypothalamo-Hypophyseal System Pituitary-Adrenal System Saliva *African American youth *HPA axis *maltreatment *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Development and Psychopathology > 32-5 (December 2020) . - p.1838-1853[article] Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation [Texte imprimé et/ou numérique] / Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur . - p.1838-1853.
Langues : Anglais (eng)
in Development and Psychopathology > 32-5 (December 2020) . - p.1838-1853
Mots-clés : Adolescent African Americans Child *Depression Humans Hydrocortisone *Hypothalamo-Hypophyseal System Pituitary-Adrenal System Saliva *African American youth *HPA axis *maltreatment *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 Challenges in researching the immune pathways between early life adversity and psychopathology / Brie REID in Development and Psychopathology, 32-5 (December 2020)
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[article]
Titre : Challenges in researching the immune pathways between early life adversity and psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Brie REID, Auteur ; Andrea DANESE, Auteur Article en page(s) : p.1597-1624 Langues : Anglais (eng) Mots-clés : Biomarkers Child Humans Inflammation *Psychopathology Risk Factors *Stress, Psychological *childhood adversity *immunity *inflammation *maltreatment *psychiatric disorders Index. décimale : PER Périodiques Résumé : Exposure to childhood adversity is a critical risk factor for the development of psychopathology. A growing field of research examines how exposure to childhood adversity is translated into biological risk for psychopathology through alterations in immune system functioning, most notably heightened levels of inflammation biomarkers. Though our knowledge about how childhood adversity can instantiate biological risk for psychopathology is growing, there remain many challenges and gaps in the field to understand how inflammation from childhood adversity contributes to psychopathology. This paper reviews research on the inflammatory outcomes arising from childhood adversity and presents four major challenges that future research must address: (a) the measurement of childhood adversity, (b) the measurement of inflammation, (c) the identification of mediators between childhood adversity and inflammation, and (d) the identification of moderators of inflammatory outcomes following childhood adversity. We discuss synergies and inconsistencies in the literature to summarize the current understanding of the association between childhood adversity, a proinflammatory phenotype, and the biological risk for psychopathology. We discuss the clinical implications of the inflammatory links between childhood adversity and psychopathology, including possibilities for intervention. Finally, this review conclude by delineates future directions for research, including issues of how best to detect, prevent, and understand these "hidden wounds" of childhood adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Development and Psychopathology > 32-5 (December 2020) . - p.1597-1624[article] Challenges in researching the immune pathways between early life adversity and psychopathology [Texte imprimé et/ou numérique] / Brie REID, Auteur ; Andrea DANESE, Auteur . - p.1597-1624.
Langues : Anglais (eng)
in Development and Psychopathology > 32-5 (December 2020) . - p.1597-1624
Mots-clés : Biomarkers Child Humans Inflammation *Psychopathology Risk Factors *Stress, Psychological *childhood adversity *immunity *inflammation *maltreatment *psychiatric disorders Index. décimale : PER Périodiques Résumé : Exposure to childhood adversity is a critical risk factor for the development of psychopathology. A growing field of research examines how exposure to childhood adversity is translated into biological risk for psychopathology through alterations in immune system functioning, most notably heightened levels of inflammation biomarkers. Though our knowledge about how childhood adversity can instantiate biological risk for psychopathology is growing, there remain many challenges and gaps in the field to understand how inflammation from childhood adversity contributes to psychopathology. This paper reviews research on the inflammatory outcomes arising from childhood adversity and presents four major challenges that future research must address: (a) the measurement of childhood adversity, (b) the measurement of inflammation, (c) the identification of mediators between childhood adversity and inflammation, and (d) the identification of moderators of inflammatory outcomes following childhood adversity. We discuss synergies and inconsistencies in the literature to summarize the current understanding of the association between childhood adversity, a proinflammatory phenotype, and the biological risk for psychopathology. We discuss the clinical implications of the inflammatory links between childhood adversity and psychopathology, including possibilities for intervention. Finally, this review conclude by delineates future directions for research, including issues of how best to detect, prevent, and understand these "hidden wounds" of childhood adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437