3 recherche sur le mot-clé '*electroencephalography'

Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome / Elizabeth BERRY-KRAVIS ; Mark D. HARNETT ; Scott A. REINES ; Melody A REESE ; Abigail H OUTTERSON ; Claire MICHALAK ; Jeremiah FURMAN ; Mark E. GURNEY ; Lauren E ETHRIDGE in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 47 Titre : Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome Type de document : texte imprimé Auteurs : Elizabeth BERRY-KRAVIS, Auteur ; Mark D. HARNETT, Auteur ; Scott A. REINES, Auteur ; Melody A REESE, Auteur ; Abigail H OUTTERSON, Auteur ; Claire MICHALAK, Auteur ; Jeremiah FURMAN, Auteur ; Mark E. GURNEY, Auteur ; Lauren E ETHRIDGE, Auteur Article en page(s) : 47 Langues : Anglais (eng) Mots-clés : Adult  Humans  Male  Middle Aged  Young Adult  Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism  *Electroencephalography  Evoked Potentials  Evoked Potentials, Auditory/drug effects  *Fragile X Syndrome/blood/drug therapy/physiopathology  Biomarker  Eeg  Fragile X syndrome  Pharmacokinetics  Zatolmilast  interests. M.D.H.and S.D.R. are paid consultants to Tetra Therapeutics. M.E.G. is  an employee of TetraTherapeutics, which is a wholly owned subsidiary of Shionogi  & Co., Ltd that has a financial interest in BPN14770. Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by a CGG repeat expansion ? 200 repeats in 5' untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including in the domain of communication. A recent phase 2a clinical trial testing BPN14770, a phosphodiesterase 4D inhibitor, showed improved cognition in 30 adult males with FXS on drug relative to placebo. The initial study found significant improvements in clinical measures assessing cognition, language, and daily functioning in addition to marginal improvements in electroencephalography (EEG) results for the amplitude of the N1 event-related potential (ERP) component. These EEG results suggest BPN14770 improved neural hyperexcitability in FXS. The current study investigated the relationship between BPN14770 pharmacokinetics and the amplitude of the N1 ERP component from the initial data. Consistent with the original group-level finding post-period 1 of the study, participants who received BPN14770 in period 1 showed a significant correlation between N1 amplitude and serum concentration of BPN14770 measured at the end of period 1. These findings strengthen the validity of the original result, indicating that BPN14770 improves cognitive performance by modulating neural hyperexcitability. This study represents the first report of a significant correlation between a reliably abnormal EEG marker and serum concentration of a novel pharmaceutical in FXS. En ligne : https://dx.doi.org/10.1186/s13229-024-00626-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome [texte imprimé] / Elizabeth BERRY-KRAVIS, Auteur ; Mark D. HARNETT, Auteur ; Scott A. REINES, Auteur ; Melody A REESE, Auteur ; Abigail H OUTTERSON, Auteur ; Claire MICHALAK, Auteur ; Jeremiah FURMAN, Auteur ; Mark E. GURNEY, Auteur ; Lauren E ETHRIDGE, Auteur . - 47. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 47 Mots-clés : Adult  Humans  Male  Middle Aged  Young Adult  Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism  *Electroencephalography  Evoked Potentials  Evoked Potentials, Auditory/drug effects  *Fragile X Syndrome/blood/drug therapy/physiopathology  Biomarker  Eeg  Fragile X syndrome  Pharmacokinetics  Zatolmilast  interests. M.D.H.and S.D.R. are paid consultants to Tetra Therapeutics. M.E.G. is  an employee of TetraTherapeutics, which is a wholly owned subsidiary of Shionogi  & Co., Ltd that has a financial interest in BPN14770. Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by a CGG repeat expansion ? 200 repeats in 5' untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including in the domain of communication. A recent phase 2a clinical trial testing BPN14770, a phosphodiesterase 4D inhibitor, showed improved cognition in 30 adult males with FXS on drug relative to placebo. The initial study found significant improvements in clinical measures assessing cognition, language, and daily functioning in addition to marginal improvements in electroencephalography (EEG) results for the amplitude of the N1 event-related potential (ERP) component. These EEG results suggest BPN14770 improved neural hyperexcitability in FXS. The current study investigated the relationship between BPN14770 pharmacokinetics and the amplitude of the N1 ERP component from the initial data. Consistent with the original group-level finding post-period 1 of the study, participants who received BPN14770 in period 1 showed a significant correlation between N1 amplitude and serum concentration of BPN14770 measured at the end of period 1. These findings strengthen the validity of the original result, indicating that BPN14770 improves cognitive performance by modulating neural hyperexcitability. This study represents the first report of a significant correlation between a reliably abnormal EEG marker and serum concentration of a novel pharmaceutical in FXS. En ligne : https://dx.doi.org/10.1186/s13229-024-00626-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Alpha electroencephalogram (EEG) asymmetry among toddlers in foster care / Kellyn N. BLAISDELL in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1743-1753 Titre : Alpha electroencephalogram (EEG) asymmetry among toddlers in foster care Type de document : texte imprimé Auteurs : Kellyn N. BLAISDELL, Auteur ; Tyson V. BARKER, Auteur ; Ryan J. GIULIANO, Auteur ; Philip A. FISHER, Auteur Article en page(s) : p.1743-1753 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  *Electroencephalography  *Foster Home Care  Frontal Lobe  Humans  *alpha asymmetry  *child maltreatment  *early adversity  *foster care Index. décimale : PER Périodiques Résumé : The majority of children living in foster care in the United States have a history of maltreatment and/or disrupted caregiving. Maltreatment in early childhood adversely affects development at many levels, including neurobiology and behavior. One neurobiological measure associated with maltreatment is alpha electroencephalogram (EEG) asymmetry. Prior research has found greater right frontal asymmetry among children with a history of maltreatment. However, little research has been extended developmentally downward to examine alpha asymmetry and its behavioral correlates among toddlers in foster care; this was the purpose of the present study. Differences in EEG asymmetry were examined between a sample of foster toddlers (mean age = 3.21 years, n = 38) and a community comparison, low-income sample without a history of foster care (mean age = 3.04 years, n = 16). The toddlers in the foster care group exhibited greater right alpha asymmetry, primarily driven by differences in parietal asymmetry. Neither frontal nor parietal asymmetry were clearly related to internalizing or externalizing behaviors, measured concurrently or at previous time points. These findings reveal differences in alpha EEG asymmetry among toddlers in foster care, and highlight the need to better understand associations between neurobiological and behavioral functioning following early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Alpha electroencephalogram (EEG) asymmetry among toddlers in foster care [texte imprimé] / Kellyn N. BLAISDELL, Auteur ; Tyson V. BARKER, Auteur ; Ryan J. GIULIANO, Auteur ; Philip A. FISHER, Auteur . - p.1743-1753. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1743-1753 Mots-clés : Child  Child, Preschool  *Electroencephalography  *Foster Home Care  Frontal Lobe  Humans  *alpha asymmetry  *child maltreatment  *early adversity  *foster care Index. décimale : PER Périodiques Résumé : The majority of children living in foster care in the United States have a history of maltreatment and/or disrupted caregiving. Maltreatment in early childhood adversely affects development at many levels, including neurobiology and behavior. One neurobiological measure associated with maltreatment is alpha electroencephalogram (EEG) asymmetry. Prior research has found greater right frontal asymmetry among children with a history of maltreatment. However, little research has been extended developmentally downward to examine alpha asymmetry and its behavioral correlates among toddlers in foster care; this was the purpose of the present study. Differences in EEG asymmetry were examined between a sample of foster toddlers (mean age = 3.21 years, n = 38) and a community comparison, low-income sample without a history of foster care (mean age = 3.04 years, n = 16). The toddlers in the foster care group exhibited greater right alpha asymmetry, primarily driven by differences in parietal asymmetry. Neither frontal nor parietal asymmetry were clearly related to internalizing or externalizing behaviors, measured concurrently or at previous time points. These findings reveal differences in alpha EEG asymmetry among toddlers in foster care, and highlight the need to better understand associations between neurobiological and behavioral functioning following early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Prediction of social behavior in autism spectrum disorders: Explicit versus implicit social cognition / Cara M. KEIFER in Autism, 24-7 (October 2020)  

Public ISBD [article]  inAutism > 24-7 (October 2020) . - p.1758-1772 Titre : Prediction of social behavior in autism spectrum disorders: Explicit versus implicit social cognition Type de document : texte imprimé Auteurs : Cara M. KEIFER, Auteur ; Amori Yee MIKAMI, Auteur ; James P. MORRIS, Auteur ; Erin J. LIBSACK, Auteur ; Matthew D. LERNER, Auteur Article en page(s) : p.1758-1772 Langues : Anglais (eng) Mots-clés : *autism spectrum disorder  *electroencephalography  *event-related potential  *partial least squares regression  *social cognition  *social perception  interest. Amori Mikami declares that she has no conflict of interest. James Morris  declares that he has no conflict of interest. Erin Libsack declares that she has no  conflict of interest. Matthew Lerner declares that he has no conflict of interest. Index. décimale : PER Périodiques Résumé : Difficulties with social communication and interaction are a hallmark feature of autism spectrum disorder. These difficulties may be the result of problems with explicit social cognition (effortful and largely conscious processes) such as learning and recalling social norms or rules. Alternatively, social deficits may stem from problems with implicit social cognition (rapid and largely unconscious processes) such as the efficient integration of social information. The goal of this study was to determine how problems in explicit and implicit social cognition relate to social behavior in 34 youth with autism spectrum disorder. We measured aspects of implicit and explicit social cognition abilities in the laboratory using behavioral, cognitive, and brain (electrophysiological) measures. We then used those measures to predict "real-world" social behavior as reported by parents, clinicians, and independent observers. Results showed that overall better aspects of implicit and explicit social cognition predicted more competent social behavior. In addition, the ability to fluidly integrate social information (implicit social cognition) was more frequently related to competent social behavior that merely knowing what to do in social situations (explicit social cognition). These findings may help with the development of interventions focusing on improving social deficits. En ligne : http://dx.doi.org/10.1177/1362361320922058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Prediction of social behavior in autism spectrum disorders: Explicit versus implicit social cognition [texte imprimé] / Cara M. KEIFER, Auteur ; Amori Yee MIKAMI, Auteur ; James P. MORRIS, Auteur ; Erin J. LIBSACK, Auteur ; Matthew D. LERNER, Auteur . - p.1758-1772. Langues : Anglais (eng) in Autism > 24-7 (October 2020) . - p.1758-1772 Mots-clés : *autism spectrum disorder  *electroencephalography  *event-related potential  *partial least squares regression  *social cognition  *social perception  interest. Amori Mikami declares that she has no conflict of interest. James Morris  declares that he has no conflict of interest. Erin Libsack declares that she has no  conflict of interest. Matthew Lerner declares that he has no conflict of interest. Index. décimale : PER Périodiques Résumé : Difficulties with social communication and interaction are a hallmark feature of autism spectrum disorder. These difficulties may be the result of problems with explicit social cognition (effortful and largely conscious processes) such as learning and recalling social norms or rules. Alternatively, social deficits may stem from problems with implicit social cognition (rapid and largely unconscious processes) such as the efficient integration of social information. The goal of this study was to determine how problems in explicit and implicit social cognition relate to social behavior in 34 youth with autism spectrum disorder. We measured aspects of implicit and explicit social cognition abilities in the laboratory using behavioral, cognitive, and brain (electrophysiological) measures. We then used those measures to predict "real-world" social behavior as reported by parents, clinicians, and independent observers. Results showed that overall better aspects of implicit and explicit social cognition predicted more competent social behavior. In addition, the ability to fluidly integrate social information (implicit social cognition) was more frequently related to competent social behavior that merely knowing what to do in social situations (explicit social cognition). These findings may help with the development of interventions focusing on improving social deficits. En ligne : http://dx.doi.org/10.1177/1362361320922058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431