[article]
Titre : |
Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
M. H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Sepideh SAROUKHANI, Auteur ; M. LEE, Auteur ; J. ZHANG, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; M. L. GROVE, Auteur ; K. A. LOVELAND, Auteur |
Article en page(s) : |
p.1953-1965 |
Langues : |
Anglais (eng) |
Mots-clés : |
African Americans Autism Spectrum Disorder/blood/genetics Case-Control Studies Child Child, Preschool Genetic Predisposition to Disease Genotype Glutathione S-Transferase pi Glutathione Transferase/genetics Humans Male Manganese/blood Polymorphism, Genetic Autism spectrum disorder (ASD) Blood manganese concentrations (BMC) Conditional logistic regression (CLR) Glutathione S-transferase (GST) genes Interaction Jamaica interest. Maureen Samms-Vaughan declares that she has no conflict of interest. Sepideh Saroukhani declares that she has no conflict of interest. MinJae Lee declares that she has no conflict of interest. Jing Zhang declares that she has no conflict of interest. Jan Bressler declares that she has no conflict of interest. Manouchehr Hessabi declares that he has no conflict of interest. Sydonnie Shakespeare-Pellington declares that she has no conflict of interest. Megan L. Grove declares that she has no conflict of interest. Katherine A. Loveland declares that she has no conflict of interest. |
Index. décimale : |
PER Périodiques |
Résumé : |
Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2-8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P?=?0.02, P?=?0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC?>?12 vs.???8.3 ?g/L, respectively. Replication in other populations is warranted. |
En ligne : |
http://dx.doi.org/10.1007/s10803-020-04677-z |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 |
in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.1953-1965
[article] Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children [Texte imprimé et/ou numérique] / M. H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Sepideh SAROUKHANI, Auteur ; M. LEE, Auteur ; J. ZHANG, Auteur ; Jan BRESSLER, Auteur ; M. HESSABI, Auteur ; S. SHAKESPEARE-PELLINGTON, Auteur ; M. L. GROVE, Auteur ; K. A. LOVELAND, Auteur . - p.1953-1965. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.1953-1965 |