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Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children / Stacey E. ALEXEEFF in Journal of Autism and Developmental Disorders, 47-7 (July 2017)
[article]
Titre : Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children Type de document : Texte imprimé et/ou numérique Auteurs : Stacey E. ALEXEEFF, Auteur ; Vincent YAU, Auteur ; Yinge QIAN, Auteur ; Meghan N. DAVIGNON, Auteur ; Frances LYNCH, Auteur ; Phillip M. CRAWFORD, Auteur ; Robert DAVIS, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.2067-2079 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Comorbidity Medical conditions Index. décimale : PER Périodiques Résumé : This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0–23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1–3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification. Our findings provide new evidence indicating that children with ASD have a disproportionate burden of certain medical conditions preceding ASD diagnosis. En ligne : https://doi.org/10.1007/s10803-017-3130-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313
in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2067-2079[article] Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children [Texte imprimé et/ou numérique] / Stacey E. ALEXEEFF, Auteur ; Vincent YAU, Auteur ; Yinge QIAN, Auteur ; Meghan N. DAVIGNON, Auteur ; Frances LYNCH, Auteur ; Phillip M. CRAWFORD, Auteur ; Robert DAVIS, Auteur ; Lisa A. CROEN, Auteur . - p.2067-2079.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2067-2079
Mots-clés : Autism spectrum disorder Comorbidity Medical conditions Index. décimale : PER Périodiques Résumé : This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0–23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1–3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification. Our findings provide new evidence indicating that children with ASD have a disproportionate burden of certain medical conditions preceding ASD diagnosis. En ligne : https://doi.org/10.1007/s10803-017-3130-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313 Subgrouping school-aged children on the autism spectrum based on co-occurring psychiatric symptoms / Antonia M. H. PIERGIES in Research in Autism Spectrum Disorders, 95 (July 2022)
[article]
Titre : Subgrouping school-aged children on the autism spectrum based on co-occurring psychiatric symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Antonia M. H. PIERGIES, Auteur ; Tomoya HIROTA, Auteur ; Rei MONDEN, Auteur ; Shuting ZHENG, Auteur Article en page(s) : 101983 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Latent class analysis Co-occurring psychiatric symptoms Nonverbal IQ Atypical sleep duration Medical conditions Index. décimale : PER Périodiques Résumé : Background Phenotypic heterogeneity along the autism spectrum is compounded by co-occurring psychiatric conditions. Deriving subgroups of autistic individuals based on symptoms of these conditions could better our understanding of psychiatric symptom patterns existing within this population. This study?s goals were to derive subgroups of school-aged autistic children based on co-occurring psychiatric symptoms while controlling for age and sex and to examine correlates of subgroup membership while controlling for the degree of ASD-related diagnostic features. Method Latent class models were estimated in a sample from the Simons Simplex Collection (n = 2087) using ?borderline/clinical? versus ?normative? range data from five of the DSM-Oriented Scales from the CBCL/6?18 as indicator variables. We evaluated the predictive value of NVIQ < 70, atypical sleep duration, allergies/autoimmune conditions, gastrointestinal conditions, and neurological conditions on subgroup membership using multinomial logistic regression. Results Four subgroups emerged: Low Psychiatric Symptoms (41.02%), Externalizing Symptoms (12.36%), Internalizing Symptoms (31.58%), and High Psychiatric Symptoms (15.05%). Key findings were that NVIQ < 70 was associated with decreased odds of belonging to the Internalizing Symptoms and High Psychiatric Symptoms subgroups over the Low Psychiatric Symptoms subgroup, while atypical sleep duration and gastrointestinal conditions were associated with increased odds of belonging to the Externalizing Symptoms and High Psychiatric Symptoms subgroups. Neurological conditions were also associated with increased odds of belonging to the Externalizing Symptoms subgroup. Conclusion Distinct patterns of psychiatric symptoms exist within school-aged autistic children and are correlated with NVIQ < 70, atypical sleep duration, and medical conditions, providing insights for clinical practice and etiology-driven research. En ligne : https://doi.org/10.1016/j.rasd.2022.101983 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
in Research in Autism Spectrum Disorders > 95 (July 2022) . - 101983[article] Subgrouping school-aged children on the autism spectrum based on co-occurring psychiatric symptoms [Texte imprimé et/ou numérique] / Antonia M. H. PIERGIES, Auteur ; Tomoya HIROTA, Auteur ; Rei MONDEN, Auteur ; Shuting ZHENG, Auteur . - 101983.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 95 (July 2022) . - 101983
Mots-clés : Autism spectrum disorder Latent class analysis Co-occurring psychiatric symptoms Nonverbal IQ Atypical sleep duration Medical conditions Index. décimale : PER Périodiques Résumé : Background Phenotypic heterogeneity along the autism spectrum is compounded by co-occurring psychiatric conditions. Deriving subgroups of autistic individuals based on symptoms of these conditions could better our understanding of psychiatric symptom patterns existing within this population. This study?s goals were to derive subgroups of school-aged autistic children based on co-occurring psychiatric symptoms while controlling for age and sex and to examine correlates of subgroup membership while controlling for the degree of ASD-related diagnostic features. Method Latent class models were estimated in a sample from the Simons Simplex Collection (n = 2087) using ?borderline/clinical? versus ?normative? range data from five of the DSM-Oriented Scales from the CBCL/6?18 as indicator variables. We evaluated the predictive value of NVIQ < 70, atypical sleep duration, allergies/autoimmune conditions, gastrointestinal conditions, and neurological conditions on subgroup membership using multinomial logistic regression. Results Four subgroups emerged: Low Psychiatric Symptoms (41.02%), Externalizing Symptoms (12.36%), Internalizing Symptoms (31.58%), and High Psychiatric Symptoms (15.05%). Key findings were that NVIQ < 70 was associated with decreased odds of belonging to the Internalizing Symptoms and High Psychiatric Symptoms subgroups over the Low Psychiatric Symptoms subgroup, while atypical sleep duration and gastrointestinal conditions were associated with increased odds of belonging to the Externalizing Symptoms and High Psychiatric Symptoms subgroups. Neurological conditions were also associated with increased odds of belonging to the Externalizing Symptoms subgroup. Conclusion Distinct patterns of psychiatric symptoms exist within school-aged autistic children and are correlated with NVIQ < 70, atypical sleep duration, and medical conditions, providing insights for clinical practice and etiology-driven research. En ligne : https://doi.org/10.1016/j.rasd.2022.101983 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study / Ju-Wei HSU in Autism Research, 15-11 (November 2022)
[article]
Titre : Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Ju-Wei HSU, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : p.2192-2199 Langues : Anglais (eng) Mots-clés : Child Adolescent Humans Autism Spectrum Disorder/drug therapy Longitudinal Studies Analgesics, Opioid/adverse effects Chronic Pain/complications/drug therapy Prescriptions autism medical conditions mental disorders prescription opioids Index. décimale : PER Périodiques Résumé : Whether children and adolescents with autism spectrum disorder (ASD) are more likely to be exposed to prescription opioids than others remains unknown. The Taiwan National Health Insurance Research Database was employed, and 14,849 children and adolescents with ASD and 148,490 age- and sex-matched non-ASD controls were enrolled between 2001 and 2009 and followed up till the end of 2011. Those exposed to prescription opioids during the follow-up period were identified. Patients with ASD were more likely to be exposed to prescription opioids (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 4.50-5.45), including intravenous or intramuscular opioids (HR: 5.80, 95% CI: 5.23-6.43) and oral or transcutaneous opioids (HR: 2.32, 95% CI: 1.87-2.89), than were non-ASD controls. Furthermore, the ASD cohort had the increased likelihood of cumulative exposure of>14 days (HR: 6.19, 95% CI: 4.91-7.79) and>30 days (HR: 7.17, 95% CI: 5.19-9.90) to prescription opioids compared with the control cohort. ASD was a risk factor for exposure to prescription opioids. Close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. We found that patients with ASD were more likely to be exposed to prescription opioids, including intravenous or intramuscular opioids and oral or transcutaneous opioids, than were non-ASD controls. We suggest that close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. En ligne : http://dx.doi.org/10.1002/aur.2806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-11 (November 2022) . - p.2192-2199[article] Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study [Texte imprimé et/ou numérique] / Ju-Wei HSU, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - p.2192-2199.
Langues : Anglais (eng)
in Autism Research > 15-11 (November 2022) . - p.2192-2199
Mots-clés : Child Adolescent Humans Autism Spectrum Disorder/drug therapy Longitudinal Studies Analgesics, Opioid/adverse effects Chronic Pain/complications/drug therapy Prescriptions autism medical conditions mental disorders prescription opioids Index. décimale : PER Périodiques Résumé : Whether children and adolescents with autism spectrum disorder (ASD) are more likely to be exposed to prescription opioids than others remains unknown. The Taiwan National Health Insurance Research Database was employed, and 14,849 children and adolescents with ASD and 148,490 age- and sex-matched non-ASD controls were enrolled between 2001 and 2009 and followed up till the end of 2011. Those exposed to prescription opioids during the follow-up period were identified. Patients with ASD were more likely to be exposed to prescription opioids (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 4.50-5.45), including intravenous or intramuscular opioids (HR: 5.80, 95% CI: 5.23-6.43) and oral or transcutaneous opioids (HR: 2.32, 95% CI: 1.87-2.89), than were non-ASD controls. Furthermore, the ASD cohort had the increased likelihood of cumulative exposure of>14 days (HR: 6.19, 95% CI: 4.91-7.79) and>30 days (HR: 7.17, 95% CI: 5.19-9.90) to prescription opioids compared with the control cohort. ASD was a risk factor for exposure to prescription opioids. Close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. We found that patients with ASD were more likely to be exposed to prescription opioids, including intravenous or intramuscular opioids and oral or transcutaneous opioids, than were non-ASD controls. We suggest that close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. En ligne : http://dx.doi.org/10.1002/aur.2806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488