4 recherche sur le mot-clé 'Pupil'

Idiosyncratic pupil regulation in autistic children / Isabel H. BLEIMEISTER in Autism Research, 17-12 (December 2024)  

Public ISBD [article]  inAutism Research > 17-12 (December 2024) . - p.2503-2513 Titre : Idiosyncratic pupil regulation in autistic children Type de document : texte imprimé Auteurs : Isabel H. BLEIMEISTER, Auteur ; Inbar AVNI, Auteur ; Michael C. GRANOVETTER, Auteur ; Gal MEIRI, Auteur ; Michal ILAN, Auteur ; Analya MICHAELOVSKI, Auteur ; Idan MENASHE, Auteur ; Marlene BEHRMANN, Auteur ; Ilan DINSTEIN, Auteur Article en page(s) : p.2503-2513 Langues : Anglais (eng) Mots-clés : Autism  idiosyncrasy  inter-subject  naturalistic  pupil  pupillometry Index. décimale : PER Périodiques Résumé : Abstract Recent neuroimaging and eye-tracking studies have suggested that children with autism exhibit more variable and idiosyncratic brain responses and eye movements than typically developing (TD) children. Here, we extended this research to pupillometry recordings. We successfully acquired pupillometry recordings from 111 children (74 with autism), 4.5-years-old on average, who viewed three 90 s movies, twice. We extracted their pupillary time-course for each movie, capturing their stimulus evoked pupillary responses. We then computed the correlation between the time-course of each child and those of all others in their group as well as between each autistic child and all children in the TD group. This yielded an average inter-subject correlation value per child, representing how similar their pupillary responses were to all others in their group or the comparison group. Children with autism exhibited significantly weaker inter-subject correlations than TD children in all comparisons. These differences were independent of previously reported differences in gaze inter-subject correlations and were largest in responses to a naturalistic movie containing footage of a social interaction between two TD children. The results demonstrate the utility of measuring the idiosyncrasy of pupil regulation, which can be performed with passive viewing of movies even by young children with co-occurring intellectual disability. These findings reveal that a considerable number of children with autism have significantly less stable, idiosyncratic pupil regulation than TD children, indicative of more variable, weakly regulated, underlying neural activity. En ligne : https://dx.doi.org/10.1002/aur.3234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] Idiosyncratic pupil regulation in autistic children [texte imprimé] / Isabel H. BLEIMEISTER, Auteur ; Inbar AVNI, Auteur ; Michael C. GRANOVETTER, Auteur ; Gal MEIRI, Auteur ; Michal ILAN, Auteur ; Analya MICHAELOVSKI, Auteur ; Idan MENASHE, Auteur ; Marlene BEHRMANN, Auteur ; Ilan DINSTEIN, Auteur . - p.2503-2513. Langues : Anglais (eng) in Autism Research > 17-12 (December 2024) . - p.2503-2513 Mots-clés : Autism  idiosyncrasy  inter-subject  naturalistic  pupil  pupillometry Index. décimale : PER Périodiques Résumé : Abstract Recent neuroimaging and eye-tracking studies have suggested that children with autism exhibit more variable and idiosyncratic brain responses and eye movements than typically developing (TD) children. Here, we extended this research to pupillometry recordings. We successfully acquired pupillometry recordings from 111 children (74 with autism), 4.5-years-old on average, who viewed three 90 s movies, twice. We extracted their pupillary time-course for each movie, capturing their stimulus evoked pupillary responses. We then computed the correlation between the time-course of each child and those of all others in their group as well as between each autistic child and all children in the TD group. This yielded an average inter-subject correlation value per child, representing how similar their pupillary responses were to all others in their group or the comparison group. Children with autism exhibited significantly weaker inter-subject correlations than TD children in all comparisons. These differences were independent of previously reported differences in gaze inter-subject correlations and were largest in responses to a naturalistic movie containing footage of a social interaction between two TD children. The results demonstrate the utility of measuring the idiosyncrasy of pupil regulation, which can be performed with passive viewing of movies even by young children with co-occurring intellectual disability. These findings reveal that a considerable number of children with autism have significantly less stable, idiosyncratic pupil regulation than TD children, indicative of more variable, weakly regulated, underlying neural activity. En ligne : https://dx.doi.org/10.1002/aur.3234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

The pupil: a window on social automatic processing in autism spectrum disorder children / Nadia AGUILLON-HERNANDEZ in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.768-778 Titre : The pupil: a window on social automatic processing in autism spectrum disorder children Type de document : texte imprimé Auteurs : Nadia AGUILLON-HERNANDEZ, Auteur ; Yassine MOFID, Auteur ; Marianne LATINUS, Auteur ; Laetitia ROCHE, Auteur ; Maria Rosa BUFO, Auteur ; Mathieu LEMAIRE, Auteur ; Joëlle MALVY, Auteur ; Joëlle MARTINEAU, Auteur ; Claire WARDAK, Auteur ; Frédérique BONNET-BRILHAULT, Auteur Article en page(s) : p.768-778 Langues : Anglais (eng) Mots-clés : Pupil  autism spectrum disorder  development  dynamism  emotion  faces  neutral Index. décimale : PER Périodiques Résumé : BACKGROUND: Faces are crucial social stimuli, eliciting automatic processing associated with increased physiological arousal in observers. The level of arousal can be indexed by pupil diameter (the 'Event-Related Pupil Dilation', ERPD). However, many parameters could influence the arousal evoked by a face and its social saliency (e.g. virtual vs. real, neutral vs. emotional, static vs. dynamic). A few studies have shown an atypical ERPD in autism spectrum disorder (ASD) patients using several kinds of faces but no study has focused on identifying which parameter of the stimulus is the most interfering with face processing in ASD. METHODS: In order to disentangle the influence of these parameters, we propose an original paradigm including stimuli along an ecological social saliency gradient: from static objects to virtual faces to dynamic emotional faces. This strategy was applied to 186 children (78 ASD and 108 typically developing (TD) children) in two pupillometric studies (22 ASD and 47 TD children in the study 1 and 56 ASD and 61 TD children in the study 2). RESULTS: Strikingly, the ERPD in ASD children is insensitive to any of the parameters tested: the ERPD was similar for objects, static faces or dynamic faces. On the opposite, the ERPD in TD children is sensitive to all the parameters tested: the humanoid, biological, dynamic and emotional quality of the stimuli. Moreover, ERPD had a good discriminative power between ASD and TD children: ASD had a larger ERPD than TD in response to virtual faces, while TD had a larger ERPD than ASD for dynamic faces. CONCLUSIONS: This novel approach evidences an abnormal physiological adjustment to socially relevant stimuli in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] The pupil: a window on social automatic processing in autism spectrum disorder children [texte imprimé] / Nadia AGUILLON-HERNANDEZ, Auteur ; Yassine MOFID, Auteur ; Marianne LATINUS, Auteur ; Laetitia ROCHE, Auteur ; Maria Rosa BUFO, Auteur ; Mathieu LEMAIRE, Auteur ; Joëlle MALVY, Auteur ; Joëlle MARTINEAU, Auteur ; Claire WARDAK, Auteur ; Frédérique BONNET-BRILHAULT, Auteur . - p.768-778. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.768-778 Mots-clés : Pupil  autism spectrum disorder  development  dynamism  emotion  faces  neutral Index. décimale : PER Périodiques Résumé : BACKGROUND: Faces are crucial social stimuli, eliciting automatic processing associated with increased physiological arousal in observers. The level of arousal can be indexed by pupil diameter (the 'Event-Related Pupil Dilation', ERPD). However, many parameters could influence the arousal evoked by a face and its social saliency (e.g. virtual vs. real, neutral vs. emotional, static vs. dynamic). A few studies have shown an atypical ERPD in autism spectrum disorder (ASD) patients using several kinds of faces but no study has focused on identifying which parameter of the stimulus is the most interfering with face processing in ASD. METHODS: In order to disentangle the influence of these parameters, we propose an original paradigm including stimuli along an ecological social saliency gradient: from static objects to virtual faces to dynamic emotional faces. This strategy was applied to 186 children (78 ASD and 108 typically developing (TD) children) in two pupillometric studies (22 ASD and 47 TD children in the study 1 and 56 ASD and 61 TD children in the study 2). RESULTS: Strikingly, the ERPD in ASD children is insensitive to any of the parameters tested: the ERPD was similar for objects, static faces or dynamic faces. On the opposite, the ERPD in TD children is sensitive to all the parameters tested: the humanoid, biological, dynamic and emotional quality of the stimuli. Moreover, ERPD had a good discriminative power between ASD and TD children: ASD had a larger ERPD than TD in response to virtual faces, while TD had a larger ERPD than ASD for dynamic faces. CONCLUSIONS: This novel approach evidences an abnormal physiological adjustment to socially relevant stimuli in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Pupillary responses during a joint attention task are associated with nonverbal cognitive abilities and sub-clinical symptoms of autism / Valentyna ERSTENYUK in Research in Autism Spectrum Disorders, 8-6 (June 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-6 (June 2014) . - p.644-653 Titre : Pupillary responses during a joint attention task are associated with nonverbal cognitive abilities and sub-clinical symptoms of autism Type de document : texte imprimé Auteurs : Valentyna ERSTENYUK, Auteur ; Meghan R. SWANSON, Auteur ; Michael SILLER, Auteur Article en page(s) : p.644-653 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Pupil  Joint attention  Gaze following  Intelligence  Broad autism phenotype Index. décimale : PER Périodiques Résumé : Measures of pupillary dilation provide a temporally sensitive, quantitative indicator of cognitive resource allocation. The current study included 39 typically developing children between 3 and 9 years of age. Children completed a free-viewing task designed to elicit gaze following, a core deficit of Autism Spectrum Disorders (ASD). Results revealed a negative association between children's pupil dilation and a standardized measure of nonverbal intelligence, suggesting that children with lower intelligence allocated more cognitive resources than children with higher intelligence. In addition, the results revealed a negative association between pupil dilation and a parent-report measure of sub-clinical symptoms of ASD, suggesting that children with fewer ASD-related symptoms allocated more cognitive resources than children who showed more sub-clinical symptoms of ASD. Both associations were independent of each other and could not be explained by variation in chronological age. These findings extend previous research demonstrating associations between basic aspects of visual processing and intelligence. In addition, these findings comport with recent theories of ASD that emphasize reduced sensitivity to the reward value of social situations. When confronted with social ambiguity, children with more ASD-related symptoms allocated fewer cognitive resources to resolving this ambiguity than children who showed fewer sub-clinical symptoms of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Pupillary responses during a joint attention task are associated with nonverbal cognitive abilities and sub-clinical symptoms of autism [texte imprimé] / Valentyna ERSTENYUK, Auteur ; Meghan R. SWANSON, Auteur ; Michael SILLER, Auteur . - p.644-653. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-6 (June 2014) . - p.644-653 Mots-clés : Autism Spectrum Disorder  Pupil  Joint attention  Gaze following  Intelligence  Broad autism phenotype Index. décimale : PER Périodiques Résumé : Measures of pupillary dilation provide a temporally sensitive, quantitative indicator of cognitive resource allocation. The current study included 39 typically developing children between 3 and 9 years of age. Children completed a free-viewing task designed to elicit gaze following, a core deficit of Autism Spectrum Disorders (ASD). Results revealed a negative association between children's pupil dilation and a standardized measure of nonverbal intelligence, suggesting that children with lower intelligence allocated more cognitive resources than children with higher intelligence. In addition, the results revealed a negative association between pupil dilation and a parent-report measure of sub-clinical symptoms of ASD, suggesting that children with fewer ASD-related symptoms allocated more cognitive resources than children who showed more sub-clinical symptoms of ASD. Both associations were independent of each other and could not be explained by variation in chronological age. These findings extend previous research demonstrating associations between basic aspects of visual processing and intelligence. In addition, these findings comport with recent theories of ASD that emphasize reduced sensitivity to the reward value of social situations. When confronted with social ambiguity, children with more ASD-related symptoms allocated fewer cognitive resources to resolving this ambiguity than children who showed fewer sub-clinical symptoms of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder / Leonie POLZER in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2167-2180 Titre : Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder Type de document : texte imprimé Auteurs : Leonie POLZER, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur Article en page(s) : p.2167-2180 Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis  Locus Coeruleus  Norepinephrine  Attention/physiology  Pupil/physiology  attention  eye-tracking technology  preschool  pupil Index. décimale : PER Périodiques Résumé : Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus-norpinephrine (LC-NE) system modulates sensory reactivity and is a promising underlying mechanism. LC-NE activity is indexed by a stimulus-evoked pupillary response (SEPR) and partially by a luminance-adaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video-based eye tracking in young children (18-65 months) with ASD (n = 57) and typically developing (TD) children (n = 39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non-social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC-NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed. En ligne : http://dx.doi.org/10.1002/aur.2818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder [texte imprimé] / Leonie POLZER, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur . - p.2167-2180. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2167-2180 Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis  Locus Coeruleus  Norepinephrine  Attention/physiology  Pupil/physiology  attention  eye-tracking technology  preschool  pupil Index. décimale : PER Périodiques Résumé : Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus-norpinephrine (LC-NE) system modulates sensory reactivity and is a promising underlying mechanism. LC-NE activity is indexed by a stimulus-evoked pupillary response (SEPR) and partially by a luminance-adaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video-based eye tracking in young children (18-65 months) with ASD (n = 57) and typically developing (TD) children (n = 39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non-social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC-NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed. En ligne : http://dx.doi.org/10.1002/aur.2818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488