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The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder / Chang-Jiang YANG in Research in Autism Spectrum Disorders, 9 (January 2015)
[article]
Titre : The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; Chun-Ling LIU, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur Année de publication : 2015 Article en page(s) : p.174-181 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Stress Cortisol IL-6 TNF-? Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of ASD is currently phenotype based with no reliable laboratory test available to assist clinicians. The desire for clinically useful and reliable biomarkers is strong. Researches have shown that individuals with autism often exhibit dysfunction of hypothalamic–pituitary–adrenal (HPA) axis and cytokines. The purpose of this study was to evaluate diurnal variation of cortisol (cortisol VAR), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?) as potential biomarkers for ASD. The present results demonstrated that in comparison to the healthy controls, the individuals with autism showed a lower level of cortisol VAR, higher level of IL-6 and TNF-?. The levels of cortisol VAR, IL-6 and TNF-? have significantly correlations with the severity of ASD measured by CARS scores. The results of ROC analysis indicated the cortisol VAR, IL-6 and TNF-? were potential biomarkers in diagnosis of ASD. The combination of three factors performed the best sensitivity and specificity for diagnosis of ASD. Therefore, the present study may reveal a simple clinical approach with great potential for assisting the diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.174-181[article] The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder [Texte imprimé et/ou numérique] / Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; Chun-Ling LIU, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur . - 2015 . - p.174-181.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.174-181
Mots-clés : Autism spectrum disorders Stress Cortisol IL-6 TNF-? Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of ASD is currently phenotype based with no reliable laboratory test available to assist clinicians. The desire for clinically useful and reliable biomarkers is strong. Researches have shown that individuals with autism often exhibit dysfunction of hypothalamic–pituitary–adrenal (HPA) axis and cytokines. The purpose of this study was to evaluate diurnal variation of cortisol (cortisol VAR), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?) as potential biomarkers for ASD. The present results demonstrated that in comparison to the healthy controls, the individuals with autism showed a lower level of cortisol VAR, higher level of IL-6 and TNF-?. The levels of cortisol VAR, IL-6 and TNF-? have significantly correlations with the severity of ASD measured by CARS scores. The results of ROC analysis indicated the cortisol VAR, IL-6 and TNF-? were potential biomarkers in diagnosis of ASD. The combination of three factors performed the best sensitivity and specificity for diagnosis of ASD. Therefore, the present study may reveal a simple clinical approach with great potential for assisting the diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder / T. YAMAUCHI in Autism Research, 14-11 (November 2021)
[article]
Titre : Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. YAMAUCHI, Auteur ; M. MAKINODAN, Auteur ; M. TORITSUKA, Auteur ; K. OKUMURA, Auteur ; Y. KAYASHIMA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; M. TAKAHASHI, Auteur ; T. KOMORI, Auteur ; Y. YAMAGUCHI, Auteur ; R. TAKADA, Auteur ; K. YAMAMURO, Auteur ; S. KIMOTO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.2330-2341 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Cytokines Humans Macrophages Monocytes Tumor Necrosis Factor-alpha Tnf-? diagnosis inflammation macrophage monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-? (TNF-?), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-? expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-? expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-? expression in M1 macrophages and the TNF-? expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-? expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-? expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-? expression in differentiated M1 macrophages and TNF-? expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-? expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2330-2341[article] Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / T. YAMAUCHI, Auteur ; M. MAKINODAN, Auteur ; M. TORITSUKA, Auteur ; K. OKUMURA, Auteur ; Y. KAYASHIMA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; M. TAKAHASHI, Auteur ; T. KOMORI, Auteur ; Y. YAMAGUCHI, Auteur ; R. TAKADA, Auteur ; K. YAMAMURO, Auteur ; S. KIMOTO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. KISHIMOTO, Auteur . - p.2330-2341.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2330-2341
Mots-clés : Adult Autism Spectrum Disorder Cytokines Humans Macrophages Monocytes Tumor Necrosis Factor-alpha Tnf-? diagnosis inflammation macrophage monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-? (TNF-?), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-? expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-? expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-? expression in M1 macrophages and the TNF-? expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-? expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-? expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-? expression in differentiated M1 macrophages and TNF-? expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-? expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450