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Auteur R. ISHIDA |
Documents disponibles écrits par cet auteur (4)
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Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder / S. KITAMURA in Autism Research, 14-9 (September 2021)
[article]
Titre : Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.1886-1895 Langues : Anglais (eng) Mots-clés : Adult Adverse Childhood Experiences Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Child Gray Matter/diagnostic imaging Humans Magnetic Resonance Imaging Parietal Lobe/diagnostic imaging autism spectrum disorder gray matter parietal lobe post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1886-1895[article] Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder [Texte imprimé et/ou numérique] / S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur . - p.1886-1895.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1886-1895
Mots-clés : Adult Adverse Childhood Experiences Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Child Gray Matter/diagnostic imaging Humans Magnetic Resonance Imaging Parietal Lobe/diagnostic imaging autism spectrum disorder gray matter parietal lobe post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Correction to: Review of Cognitive Characteristics of Autism Spectrum Disorder Using Performance on Six Subtests on Four Versions of the Wechsler Intelligence Scale for Children / M. TAKAYANAGI in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
[article]
Titre : Correction to: Review of Cognitive Characteristics of Autism Spectrum Disorder Using Performance on Six Subtests on Four Versions of the Wechsler Intelligence Scale for Children Type de document : Texte imprimé et/ou numérique Auteurs : M. TAKAYANAGI, Auteur ; Y. KAWASAKI, Auteur ; M. SHINOMIYA, Auteur ; H. HIROSHI, Auteur ; S. OKADA, Auteur ; T. INO, Auteur ; K. SAKAI, Auteur ; K. MURAKAMI, Auteur ; R. ISHIDA, Auteur ; K. MIZUNO, Auteur ; S. I. NIWA, Auteur Article en page(s) : p.254 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-021-05020-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.254[article] Correction to: Review of Cognitive Characteristics of Autism Spectrum Disorder Using Performance on Six Subtests on Four Versions of the Wechsler Intelligence Scale for Children [Texte imprimé et/ou numérique] / M. TAKAYANAGI, Auteur ; Y. KAWASAKI, Auteur ; M. SHINOMIYA, Auteur ; H. HIROSHI, Auteur ; S. OKADA, Auteur ; T. INO, Auteur ; K. SAKAI, Auteur ; K. MURAKAMI, Auteur ; R. ISHIDA, Auteur ; K. MIZUNO, Auteur ; S. I. NIWA, Auteur . - p.254.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.254
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-021-05020-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 Review of Cognitive Characteristics of Autism Spectrum Disorder Using Performance on Six Subtests on Four Versions of the Wechsler Intelligence Scale for Children / M. TAKAYANAGI in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
[article]
Titre : Review of Cognitive Characteristics of Autism Spectrum Disorder Using Performance on Six Subtests on Four Versions of the Wechsler Intelligence Scale for Children Type de document : Texte imprimé et/ou numérique Auteurs : M. TAKAYANAGI, Auteur ; Y. KAWASAKI, Auteur ; M. SHINOMIYA, Auteur ; H. HIROSHI, Auteur ; S. OKADA, Auteur ; T. INO, Auteur ; K. SAKAI, Auteur ; K. MURAKAMI, Auteur ; R. ISHIDA, Auteur ; K. MIZUNO, Auteur ; S. I. NIWA, Auteur Article en page(s) : p.240-253 Langues : Anglais (eng) Mots-clés : Aptitude Autism Spectrum Disorder/diagnosis Child Cognition Humans Prevalence Wechsler Scales Autism spectrum disorder (ASD) Cognitive function Intelligence ability Systematic review Index. décimale : PER Périodiques Résumé : This study was a systematic review of research using the Wechsler Intelligence Scale for Children (WISC) with Autism Spectrum Disorder (ASD) to examine cognitive characteristics of children with ASD beyond the impact of revisions based on WISC and diagnostic criteria changes. The classic "islets of ability" was found in individuals with full-scale IQs?100. The "right-descending profiles" were observed among high IQ score individuals. High levels on the Block Design and low Coding levels were consistently found regardless of the variation in intellectual functioning or diagnosis. This review identified patterns of cognitive characteristics in ASD individuals using empirical data that researchers may have previously been aware of, based on their experiences, owing to the increased prevalence of ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04932-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.240-253[article] Review of Cognitive Characteristics of Autism Spectrum Disorder Using Performance on Six Subtests on Four Versions of the Wechsler Intelligence Scale for Children [Texte imprimé et/ou numérique] / M. TAKAYANAGI, Auteur ; Y. KAWASAKI, Auteur ; M. SHINOMIYA, Auteur ; H. HIROSHI, Auteur ; S. OKADA, Auteur ; T. INO, Auteur ; K. SAKAI, Auteur ; K. MURAKAMI, Auteur ; R. ISHIDA, Auteur ; K. MIZUNO, Auteur ; S. I. NIWA, Auteur . - p.240-253.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.240-253
Mots-clés : Aptitude Autism Spectrum Disorder/diagnosis Child Cognition Humans Prevalence Wechsler Scales Autism spectrum disorder (ASD) Cognitive function Intelligence ability Systematic review Index. décimale : PER Périodiques Résumé : This study was a systematic review of research using the Wechsler Intelligence Scale for Children (WISC) with Autism Spectrum Disorder (ASD) to examine cognitive characteristics of children with ASD beyond the impact of revisions based on WISC and diagnostic criteria changes. The classic "islets of ability" was found in individuals with full-scale IQs?100. The "right-descending profiles" were observed among high IQ score individuals. High levels on the Block Design and low Coding levels were consistently found regardless of the variation in intellectual functioning or diagnosis. This review identified patterns of cognitive characteristics in ASD individuals using empirical data that researchers may have previously been aware of, based on their experiences, owing to the increased prevalence of ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04932-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder / T. YAMAUCHI in Autism Research, 14-11 (November 2021)
[article]
Titre : Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. YAMAUCHI, Auteur ; M. MAKINODAN, Auteur ; M. TORITSUKA, Auteur ; K. OKUMURA, Auteur ; Y. KAYASHIMA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; M. TAKAHASHI, Auteur ; T. KOMORI, Auteur ; Y. YAMAGUCHI, Auteur ; R. TAKADA, Auteur ; K. YAMAMURO, Auteur ; S. KIMOTO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.2330-2341 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Cytokines Humans Macrophages Monocytes Tumor Necrosis Factor-alpha Tnf-? diagnosis inflammation macrophage monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-? (TNF-?), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-? expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-? expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-? expression in M1 macrophages and the TNF-? expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-? expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-? expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-? expression in differentiated M1 macrophages and TNF-? expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-? expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2330-2341[article] Tumor necrosis factor-? expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / T. YAMAUCHI, Auteur ; M. MAKINODAN, Auteur ; M. TORITSUKA, Auteur ; K. OKUMURA, Auteur ; Y. KAYASHIMA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; M. TAKAHASHI, Auteur ; T. KOMORI, Auteur ; Y. YAMAGUCHI, Auteur ; R. TAKADA, Auteur ; K. YAMAMURO, Auteur ; S. KIMOTO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. KISHIMOTO, Auteur . - p.2330-2341.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2330-2341
Mots-clés : Adult Autism Spectrum Disorder Cytokines Humans Macrophages Monocytes Tumor Necrosis Factor-alpha Tnf-? diagnosis inflammation macrophage monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-? (TNF-?), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-? expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-? expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-? expression in M1 macrophages and the TNF-? expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-? expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-? expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-? expression in differentiated M1 macrophages and TNF-? expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-? expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450