45 recherche sur le mot-clé 'epilepsy'

Epilepsy and Autism Severity: A Study of 6,975 Children / J. B. EWEN in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1251-1259 Titre : Epilepsy and Autism Severity: A Study of 6,975 Children Type de document : Texte imprimé et/ou numérique Auteurs : J. B. EWEN, Auteur ; A. R. MARVIN, Auteur ; K. LAW, Auteur ; P. H. LIPKIN, Auteur Article en page(s) : p.1251-1259 Langues : Anglais (eng) Mots-clés : effect size  epilepsy  regression  risk factor  severity Index. décimale : PER Périodiques Résumé : Epilepsy is known to occur in a higher-than-expected proportion of individuals with autism spectrum disorders (ASDs). Prior studies of this heterogeneous disorder have suggested that intelligence quotient (IQ) may drive this relationship. Because intellectual disability (ID) is, independently of ASD, a risk factor for epilepsy, current literature calls into question the long-understood unique relationship between ASD and epilepsy. Second, data have been unclear about whether developmental regression in ASD is associated with epilepsy. Using two cohorts from an online research registry, totaling 6,975 children with ASD, we examined the independent role of four ASD severity measures in driving the relationship with epilepsy: ID, language impairment, core ASD symptom severity, and motor dysfunction, controlling for two known relevant factors: age and sex. We also examined whether developmental regression and epilepsy have an independent statistical link. All four ASD severity factors showed independent statistical associations with epilepsy in one cohort, and three in the other. ID showed the largest relative risk (RR) in both cohorts. Effect sizes were modest. Regression similarly showed an independent statistical association with epilepsy, but with small effect size. Similar to previous work, ID showed the greatest contribution to RR for epilepsy among children with ASD. However, other ASD severity markers showed statistical associations, demonstrating that the ASD-epilepsy association is not reducible to the effect of ID. Inconsistencies in the literature may be due to underpowered studies, yet moving forward with larger-n studies, clinical significance and scientific relevance may be dictated by effect size and not merely statistical significance. Autism Res 2019, 12: 1251-1259. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Epilepsy is known to occur more often in individuals with autism spectrum disorders (ASDs) than is the case in the general population. The association between ASD and epilepsy is of interest because studying the two disorders in combination may help advance our understanding of genetic, molecular, and cellular mechanisms-as well as therapies-for both. Recent studies have suggested that intelligence quotient (IQ) alone in individuals with ASD may account for the increased prevalence of epilepsy. However, our approach was to look at a range of severity factors relevant to ASD and to look for correlations between each severity factor and epilepsy, within two large samples of children with ASD. In summary, we found that each severity factor-presence of intellectual disability, presence of language atypicalities, ASD-specific symptoms severity, and presence of motor issues-independently predicted a small increased risk for epilepsy, countering the argument that IQ alone is a risk factor. We also examined whether epilepsy is associated with developmental regression. Although severe epilepsy syndromes such as Landau-Kleffner syndrome are known to cause autistic-like symptoms following developmental regression, there is controversy about whether other forms of epilepsy are associated with the more common developmental regression seen in many young children with epilepsy. Indeed, we found a small association between epilepsy and developmental regression. En ligne : http://dx.doi.org/10.1002/aur.2132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Epilepsy and Autism Severity: A Study of 6,975 Children [Texte imprimé et/ou numérique] / J. B. EWEN, Auteur ; A. R. MARVIN, Auteur ; K. LAW, Auteur ; P. H. LIPKIN, Auteur . - p.1251-1259. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1251-1259 Mots-clés : effect size  epilepsy  regression  risk factor  severity Index. décimale : PER Périodiques Résumé : Epilepsy is known to occur in a higher-than-expected proportion of individuals with autism spectrum disorders (ASDs). Prior studies of this heterogeneous disorder have suggested that intelligence quotient (IQ) may drive this relationship. Because intellectual disability (ID) is, independently of ASD, a risk factor for epilepsy, current literature calls into question the long-understood unique relationship between ASD and epilepsy. Second, data have been unclear about whether developmental regression in ASD is associated with epilepsy. Using two cohorts from an online research registry, totaling 6,975 children with ASD, we examined the independent role of four ASD severity measures in driving the relationship with epilepsy: ID, language impairment, core ASD symptom severity, and motor dysfunction, controlling for two known relevant factors: age and sex. We also examined whether developmental regression and epilepsy have an independent statistical link. All four ASD severity factors showed independent statistical associations with epilepsy in one cohort, and three in the other. ID showed the largest relative risk (RR) in both cohorts. Effect sizes were modest. Regression similarly showed an independent statistical association with epilepsy, but with small effect size. Similar to previous work, ID showed the greatest contribution to RR for epilepsy among children with ASD. However, other ASD severity markers showed statistical associations, demonstrating that the ASD-epilepsy association is not reducible to the effect of ID. Inconsistencies in the literature may be due to underpowered studies, yet moving forward with larger-n studies, clinical significance and scientific relevance may be dictated by effect size and not merely statistical significance. Autism Res 2019, 12: 1251-1259. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Epilepsy is known to occur more often in individuals with autism spectrum disorders (ASDs) than is the case in the general population. The association between ASD and epilepsy is of interest because studying the two disorders in combination may help advance our understanding of genetic, molecular, and cellular mechanisms-as well as therapies-for both. Recent studies have suggested that intelligence quotient (IQ) alone in individuals with ASD may account for the increased prevalence of epilepsy. However, our approach was to look at a range of severity factors relevant to ASD and to look for correlations between each severity factor and epilepsy, within two large samples of children with ASD. In summary, we found that each severity factor-presence of intellectual disability, presence of language atypicalities, ASD-specific symptoms severity, and presence of motor issues-independently predicted a small increased risk for epilepsy, countering the argument that IQ alone is a risk factor. We also examined whether epilepsy is associated with developmental regression. Although severe epilepsy syndromes such as Landau-Kleffner syndrome are known to cause autistic-like symptoms following developmental regression, there is controversy about whether other forms of epilepsy are associated with the more common developmental regression seen in many young children with epilepsy. Indeed, we found a small association between epilepsy and developmental regression. En ligne : http://dx.doi.org/10.1002/aur.2132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Epilepsy in adulthood: Prevalence, incidence, and associated antiepileptic drug use in autistic adults in a state Medicaid system / Lauren BISHOP in Autism, 25-3 (April 2021)  

Public ISBD [article]  inAutism > 25-3 (April 2021) . - p.831-839 Titre : Epilepsy in adulthood: Prevalence, incidence, and associated antiepileptic drug use in autistic adults in a state Medicaid system Type de document : Texte imprimé et/ou numérique Auteurs : Lauren BISHOP, Auteur ; Kiley J. MCLEAN, Auteur ; Eric RUBENSTEIN, Auteur Article en page(s) : p.831-839 Langues : Anglais (eng) Mots-clés : Medicaid  autism spectrum disorders  epilepsy  gender  intellectual disability  medical comorbidity  sex differences  stroke Index. décimale : PER Périodiques Résumé : Epilepsy is more common in autistic children compared to children without autism, but we do not have good estimates of how many autistic adults have epilepsy. We used data from a full population of 7513 autistic adults who received Medicaid in Wisconsin to figure out the proportion of autistic adults who have epilepsy, as compared to 18,429 adults with intellectual disability. We also wanted to assess how often epilepsy is first diagnosed in adulthood. Finally, we wanted to see whether antiepileptic drugs are being used to treat epilepsy in autistic adults. We found that 34.6% of autistic adults with intellectual disability and 11.1% of autistic adults without intellectual disability had epilepsy, compared to 27.0% of adults with intellectual disability alone. Autistic women and autistic adults with intellectual disability were more likely than autistic men and autistic adults without intellectual disability to have both previous and new diagnoses of epilepsy. Finally, we found that antiepileptic medications are commonly prescribed to autistic people who do not have epilepsy potentially to treat mental health conditions or behavior problems, and that antiepileptic medications are not always prescribed to autistic people with epilepsy even though they are indicated as a first-line epilepsy treatment. The findings of this study highlight the need to effectively treat and prevent epilepsy in autistic adults. En ligne : http://dx.doi.org/10.1177/1362361320942982 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 [article] Epilepsy in adulthood: Prevalence, incidence, and associated antiepileptic drug use in autistic adults in a state Medicaid system [Texte imprimé et/ou numérique] / Lauren BISHOP, Auteur ; Kiley J. MCLEAN, Auteur ; Eric RUBENSTEIN, Auteur . - p.831-839. Langues : Anglais (eng) in Autism > 25-3 (April 2021) . - p.831-839 Mots-clés : Medicaid  autism spectrum disorders  epilepsy  gender  intellectual disability  medical comorbidity  sex differences  stroke Index. décimale : PER Périodiques Résumé : Epilepsy is more common in autistic children compared to children without autism, but we do not have good estimates of how many autistic adults have epilepsy. We used data from a full population of 7513 autistic adults who received Medicaid in Wisconsin to figure out the proportion of autistic adults who have epilepsy, as compared to 18,429 adults with intellectual disability. We also wanted to assess how often epilepsy is first diagnosed in adulthood. Finally, we wanted to see whether antiepileptic drugs are being used to treat epilepsy in autistic adults. We found that 34.6% of autistic adults with intellectual disability and 11.1% of autistic adults without intellectual disability had epilepsy, compared to 27.0% of adults with intellectual disability alone. Autistic women and autistic adults with intellectual disability were more likely than autistic men and autistic adults without intellectual disability to have both previous and new diagnoses of epilepsy. Finally, we found that antiepileptic medications are commonly prescribed to autistic people who do not have epilepsy potentially to treat mental health conditions or behavior problems, and that antiepileptic medications are not always prescribed to autistic people with epilepsy even though they are indicated as a first-line epilepsy treatment. The findings of this study highlight the need to effectively treat and prevent epilepsy in autistic adults. En ligne : http://dx.doi.org/10.1177/1362361320942982 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444

Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study / Elina JOKIRANTA in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557 Titre : Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study Type de document : Texte imprimé et/ou numérique Auteurs : Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur Article en page(s) : p.2547-2557 Langues : Anglais (eng) Mots-clés : Epilepsy  Autism spectrum disorders  Intellectual disability  Gender  Age at onset  Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 [article] Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study [Texte imprimé et/ou numérique] / Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur . - p.2547-2557. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557 Mots-clés : Epilepsy  Autism spectrum disorders  Intellectual disability  Gender  Age at onset  Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240

Epilepsy and EEG Findings in Children with Autism Spectrum Disorders / Nashwa M. SAMRA in Autism - Open Access, 7-3 ([01/06/2017])  

Public ISBD [article]  inAutism - Open Access > 7-3 [01/06/2017] . - 6 p. Titre : Epilepsy and EEG Findings in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Nashwa M. SAMRA, Auteur ; Hadeer M. ABDEL GHAFFAR, Auteur ; Heba A. EL-AWADY, Auteur ; Mohamed R. SOLTAN, Auteur ; Rabab M. ABDEL MOKTADER, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Epilepsy  EEG  Autism spectrum disorders Index. décimale : PER Périodiques Résumé : Background: Epilepsy is strongly associated with Autism Spectrum Disorders (ASD). This high rate of epilepsy suggests that ASD and epilepsy might share a common pathophysiological basis. Objective: To study the characteristics of EEG findings and epilepsy in autistic spectrum disorders (ASD) and the associated neuropsychological symptoms. Methods: Sixty children with ASD, aged from 3 to 11 years old, were included in the study. EEG recordings were obtained for each child. All patients were evaluated with respect to clinical and familial characteristics and with the Childhood Autism Rating Scale (CARS).Results: The frequency of epileptiform EEG abnormalities in children with ASD was 40%, and the frequency of epilepsy was 30%. EEG abnormalities were associated with a diagnosis of epilepsy in 13.3%. Seizures and EEG changes were frequent among children with severe autism. Aggressive behaviours, hyperactivity and delayed developmental history were more frequent among patients with seizures. Sleep disturbance and hyperactivity were more common among participants with sever autism. On the other hand, aggressive behaviour and developmental delay were more common among patients with mild to moderate autism. Conclusion: Autism is one of the risk factors for epilepsy. Epilepsy occurs in one-third of patients with ASD. EEG abnormalities occur in 40% of patients with ASD. Epilepsy may be considered as one of the aggravating factors for behavioural/emotional outcomes for individuals with autism. Treatment of EEG changes might have a positive effect on the symptomatic improvement of children with ASD and EEGs changes. En ligne : https://dx.doi.org/10.4172/2165-7890.1000211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Epilepsy and EEG Findings in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Nashwa M. SAMRA, Auteur ; Hadeer M. ABDEL GHAFFAR, Auteur ; Heba A. EL-AWADY, Auteur ; Mohamed R. SOLTAN, Auteur ; Rabab M. ABDEL MOKTADER, Auteur . - 6 p. Langues : Anglais (eng) in Autism - Open Access > 7-3 [01/06/2017] . - 6 p. Mots-clés : Epilepsy  EEG  Autism spectrum disorders Index. décimale : PER Périodiques Résumé : Background: Epilepsy is strongly associated with Autism Spectrum Disorders (ASD). This high rate of epilepsy suggests that ASD and epilepsy might share a common pathophysiological basis. Objective: To study the characteristics of EEG findings and epilepsy in autistic spectrum disorders (ASD) and the associated neuropsychological symptoms. Methods: Sixty children with ASD, aged from 3 to 11 years old, were included in the study. EEG recordings were obtained for each child. All patients were evaluated with respect to clinical and familial characteristics and with the Childhood Autism Rating Scale (CARS).Results: The frequency of epileptiform EEG abnormalities in children with ASD was 40%, and the frequency of epilepsy was 30%. EEG abnormalities were associated with a diagnosis of epilepsy in 13.3%. Seizures and EEG changes were frequent among children with severe autism. Aggressive behaviours, hyperactivity and delayed developmental history were more frequent among patients with seizures. Sleep disturbance and hyperactivity were more common among participants with sever autism. On the other hand, aggressive behaviour and developmental delay were more common among patients with mild to moderate autism. Conclusion: Autism is one of the risk factors for epilepsy. Epilepsy occurs in one-third of patients with ASD. EEG abnormalities occur in 40% of patients with ASD. Epilepsy may be considered as one of the aggravating factors for behavioural/emotional outcomes for individuals with autism. Treatment of EEG changes might have a positive effect on the symptomatic improvement of children with ASD and EEGs changes. En ligne : https://dx.doi.org/10.4172/2165-7890.1000211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Epilepsy Associated with ASD and Intellectual Disability / Carla MARINI  

Public ISBD in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA Titre : Epilepsy Associated with ASD and Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Carla MARINI, Auteur Année de publication : 2016 Importance : p.365-373 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Chromosomal rearrangements  Epilepsy  Genetic  Seizures Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The co-occurrence of autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy is well established among clinicians and researchers. Epilepsy is reported to occur in ASD, with a prevalence ranging from 5% to 46%. Among patients with epilepsy, ASD symptoms may occur in 15–35% of children and about a quarter will also have ID. Epilepsy onset shows a bimodal curve with a first peak before 5 years of age and a second during adolescence. Seizures may be either focal or generalized including infantile spasms. Epileptic encephalopathies in addition to intractable seizures often manifest ID and ASD. The frequent association among epileptic, ID, and autistic phenotypes suggests that these disorders may share common predisposing genes. Molecular genetic studies and, more recently, whole-exome sequencing have indeed shown that mutations of specific genes may cause ASD, seizures, and ID, which confirms the common underlying pathophysiological mechanism at least in some patients. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00022-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA Epilepsy Associated with ASD and Intellectual Disability [Texte imprimé et/ou numérique] / Carla MARINI, Auteur . - 2016 . - p.365-373. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Chromosomal rearrangements  Epilepsy  Genetic  Seizures Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The co-occurrence of autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy is well established among clinicians and researchers. Epilepsy is reported to occur in ASD, with a prevalence ranging from 5% to 46%. Among patients with epilepsy, ASD symptoms may occur in 15–35% of children and about a quarter will also have ID. Epilepsy onset shows a bimodal curve with a first peak before 5 years of age and a second during adolescence. Seizures may be either focal or generalized including infantile spasms. Epileptic encephalopathies in addition to intractable seizures often manifest ID and ASD. The frequent association among epileptic, ID, and autistic phenotypes suggests that these disorders may share common predisposing genes. Molecular genetic studies and, more recently, whole-exome sequencing have indeed shown that mutations of specific genes may cause ASD, seizures, and ID, which confirms the common underlying pathophysiological mechanism at least in some patients. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00022-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301

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Epilepsy in autism spectrum disorder / Arlene MANNION in Research in Autism Spectrum Disorders, 8-4 (April 2014)  

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Epilepsy in Individuals with a History of Asperger’s Syndrome: A Danish Nationwide Register-Based Cohort Study / Svend Erik MOURIDSEN in Journal of Autism and Developmental Disorders, 43-6 (June 2013)  

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Brief Report: Prevalence of Co-occurring Epilepsy and Autism Spectrum Disorder: The U.S. National Survey of Children’s Health 2011–2012 / Shiny THOMAS in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

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Exploring the Relationship Between Autism Spectrum Disorder and Epilepsy Using Latent Class Cluster Analysis / Michael L. CUCCARO in Journal of Autism and Developmental Disorders, 42-8 (August 2012)  

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Maternal Expressed Emotion and Adjustment in Children with Epilepsy / Matthew HODES in Journal of Child Psychology and Psychiatry, 40-7 (October 1999)

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