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Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder / R. GANZOLA in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)
[article]
Titre : Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : R. GANZOLA, Auteur ; A. M. MCINTOSH, Auteur ; T. NICKSON, Auteur ; E. SPROOTEN, Auteur ; M. E. BASTIN, Auteur ; S. GILES, Auteur ; A. MACDONALD, Auteur ; J. SUSSMANN, Auteur ; S. DUCHESNE, Auteur ; H. C. WHALLEY, Auteur Article en page(s) : p.917-927 Langues : Anglais (eng) Mots-clés : Bipolar disorder fractional anisotropy high-familial risk major depressive disorder white matter integrity Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood disorders are familial psychiatric diseases, in which patients show reduced white matter (WM) integrity. We sought to determine whether WM integrity was affected in young offspring at high-familial risk of mood disorder before they go on to develop major depressive disorder (MDD). METHODS: The Bipolar Family study is a prospective longitudinal study examining young individuals (age 16-25 years) at familial risk of mood disorder on three occasions 2 years apart. This study used baseline imaging data, categorizing groups according to clinical outcome at follow-up. Diffusion tensor MRI data were acquired for 61 controls and 106 high-risk individuals, the latter divided into 78 high-risk subjects who remained well throughout the study ('high-risk well') and 28 individuals who subsequently developed MDD ('high-risk MDD'). Voxel-wise between-group comparison of fractional anisotropy (FA) based on diagnostic status was performed using tract-based spatial statistics (TBSS). RESULTS: Compared to controls, both high-risk groups showed widespread decreases in FA (pcorr < .05) at baseline. Although FA in the high-risk MDD group negatively correlated with subthreshold depressive symptoms at the time of scanning (pcorr < .05), there were no statistically significant differences at p-corrected levels between the two high-risk groups. CONCLUSIONS: These results suggest that decreased FA is related to the presence of familial risk for mood disorder along with subdiagnostic symptoms at the time of scanning rather than predictive of subsequent diagnosis. Due to the difficulties performing such longitudinal prospective studies, we note, however, that this latter analysis may be underpowered due to sample size within the high-risk MDD group. Further clinical follow-up may clarify these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.917-927[article] Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder [Texte imprimé et/ou numérique] / R. GANZOLA, Auteur ; A. M. MCINTOSH, Auteur ; T. NICKSON, Auteur ; E. SPROOTEN, Auteur ; M. E. BASTIN, Auteur ; S. GILES, Auteur ; A. MACDONALD, Auteur ; J. SUSSMANN, Auteur ; S. DUCHESNE, Auteur ; H. C. WHALLEY, Auteur . - p.917-927.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.917-927
Mots-clés : Bipolar disorder fractional anisotropy high-familial risk major depressive disorder white matter integrity Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood disorders are familial psychiatric diseases, in which patients show reduced white matter (WM) integrity. We sought to determine whether WM integrity was affected in young offspring at high-familial risk of mood disorder before they go on to develop major depressive disorder (MDD). METHODS: The Bipolar Family study is a prospective longitudinal study examining young individuals (age 16-25 years) at familial risk of mood disorder on three occasions 2 years apart. This study used baseline imaging data, categorizing groups according to clinical outcome at follow-up. Diffusion tensor MRI data were acquired for 61 controls and 106 high-risk individuals, the latter divided into 78 high-risk subjects who remained well throughout the study ('high-risk well') and 28 individuals who subsequently developed MDD ('high-risk MDD'). Voxel-wise between-group comparison of fractional anisotropy (FA) based on diagnostic status was performed using tract-based spatial statistics (TBSS). RESULTS: Compared to controls, both high-risk groups showed widespread decreases in FA (pcorr < .05) at baseline. Although FA in the high-risk MDD group negatively correlated with subthreshold depressive symptoms at the time of scanning (pcorr < .05), there were no statistically significant differences at p-corrected levels between the two high-risk groups. CONCLUSIONS: These results suggest that decreased FA is related to the presence of familial risk for mood disorder along with subdiagnostic symptoms at the time of scanning rather than predictive of subsequent diagnosis. Due to the difficulties performing such longitudinal prospective studies, we note, however, that this latter analysis may be underpowered due to sample size within the high-risk MDD group. Further clinical follow-up may clarify these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder / Dinesh K. SHUKLA in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)
[article]
Titre : Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dinesh K. SHUKLA, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur Année de publication : 2011 Article en page(s) : p.286-295 Langues : Anglais (eng) Mots-clés : Diffusion tensor imaging autism spectrum disorder brain connectivity fractional anisotropy mean diffusion axial diffusion radial diffusion Index. décimale : PER Périodiques Résumé : Background: Previous diffusion tensor imaging (DTI) studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function of distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial statistics (TBSS) for an unbiased whole-brain quantitative estimation of the fractional anisotropy (FA), mean diffusion (MD) and axial and radial diffusion of the white matter tracts in children and adolescents with ASD.
Methods: DTI was performed in 26 ASD and 24 typically developing (TD) participants, aged 9–20 years. Groups were matched for age and IQ. Each participant’s aligned FA, MD and axial and radial diffusion data were projected onto the mean FA skeleton representing the centers of all tracts and the resulting data fed into voxelwise group statistics.
Results: TBSS revealed decreased FA and increased MD and radial diffusion in the ASD group compared to the TD group in the corpus callosum, anterior and posterior limbs of the internal capsule, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, cingulum, anterior thalamic radiation, and corticospinal tract. No single site with inverse effects (increased FA, reduced MD or radial diffusion in the ASD group) was detected. In clusters of significant group difference, age was positively correlated with FA and negatively correlated with MD and radial diffusion in the TD, but not the ASD group.
Conclusions: Our findings reveal white matter compromise affecting numerous tracts in children and adolescents with ASD. Slightly varying patterns of diffusion abnormalities detected for some tracts may suggest tract-specific patterns of white matter abnormalities associated with ASD. Age-dependent effects further show that maturational changes (increasing FA, decreasing MD and radial diffusion with age) are diminished in ASD from school-age childhood into young adulthood.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02342.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118
in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.286-295[article] Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder [Texte imprimé et/ou numérique] / Dinesh K. SHUKLA, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur . - 2011 . - p.286-295.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.286-295
Mots-clés : Diffusion tensor imaging autism spectrum disorder brain connectivity fractional anisotropy mean diffusion axial diffusion radial diffusion Index. décimale : PER Périodiques Résumé : Background: Previous diffusion tensor imaging (DTI) studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function of distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial statistics (TBSS) for an unbiased whole-brain quantitative estimation of the fractional anisotropy (FA), mean diffusion (MD) and axial and radial diffusion of the white matter tracts in children and adolescents with ASD.
Methods: DTI was performed in 26 ASD and 24 typically developing (TD) participants, aged 9–20 years. Groups were matched for age and IQ. Each participant’s aligned FA, MD and axial and radial diffusion data were projected onto the mean FA skeleton representing the centers of all tracts and the resulting data fed into voxelwise group statistics.
Results: TBSS revealed decreased FA and increased MD and radial diffusion in the ASD group compared to the TD group in the corpus callosum, anterior and posterior limbs of the internal capsule, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, cingulum, anterior thalamic radiation, and corticospinal tract. No single site with inverse effects (increased FA, reduced MD or radial diffusion in the ASD group) was detected. In clusters of significant group difference, age was positively correlated with FA and negatively correlated with MD and radial diffusion in the TD, but not the ASD group.
Conclusions: Our findings reveal white matter compromise affecting numerous tracts in children and adolescents with ASD. Slightly varying patterns of diffusion abnormalities detected for some tracts may suggest tract-specific patterns of white matter abnormalities associated with ASD. Age-dependent effects further show that maturational changes (increasing FA, decreasing MD and radial diffusion with age) are diminished in ASD from school-age childhood into young adulthood.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02342.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders / J. FITZGERALD in Journal of Autism and Developmental Disorders, 49-7 (July 2019)
[article]
Titre : Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : J. FITZGERALD, Auteur ; L. GALLAGHER, Auteur ; J. MCGRATH, Auteur Article en page(s) : p.2664-2674 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Dti Diffusion imaging Fractional anisotropy Structural connectivity Tbss Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2803-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2664-2674[article] Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / J. FITZGERALD, Auteur ; L. GALLAGHER, Auteur ; J. MCGRATH, Auteur . - p.2664-2674.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2664-2674
Mots-clés : Autism spectrum disorders Dti Diffusion imaging Fractional anisotropy Structural connectivity Tbss Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2803-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401