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Three phases of Gene * Environment interaction research: Theoretical assumptions underlying gene selection / Xiaoya ZHANG in Development and Psychopathology, 34-1 (February 2022)
[article]
Titre : Three phases of Gene * Environment interaction research: Theoretical assumptions underlying gene selection Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoya ZHANG, Auteur ; Jay BELSKY, Auteur Article en page(s) : p.295-306 Langues : Anglais (eng) Mots-clés : diathesis stress differential susceptibility G*E interaction gene selection Index. décimale : PER Périodiques Résumé : Some Gene * Environment interaction (G*E) research has focused upon single candidate genes, whereas other related work has targeted multiple genes (e.g., polygenic scores). Each approach has informed efforts to identify individuals who are either especially vulnerable to the negative effects of contextual adversity (diathesis stress) or especially susceptible to both positive and negative contextual conditions (differential susceptibility). A critical step in all such molecular G*E research is the selection of genetic variants thought to moderate environmental influences, a subject that has not received a great deal of attention in critiques of G*E research (beyond the observation of small effects of individual genes). Here we conceptually distinguish three phases of G*E work based on the selection of genes presumed to moderate environmental effects and the theoretical basis of such decisions: (a) single candidate genes, (b) composited (multiple) candidate genes, and (c) GWAS-derived polygenic scores. This illustrative, not exhaustive, review makes it clear that implicit or explicit theoretical assumptions inform gene selection in ways that have not been clearly articulated or fully appreciated. En ligne : http://dx.doi.org/10.1017/s0954579420000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-1 (February 2022) . - p.295-306[article] Three phases of Gene * Environment interaction research: Theoretical assumptions underlying gene selection [Texte imprimé et/ou numérique] / Xiaoya ZHANG, Auteur ; Jay BELSKY, Auteur . - p.295-306.
Langues : Anglais (eng)
in Development and Psychopathology > 34-1 (February 2022) . - p.295-306
Mots-clés : diathesis stress differential susceptibility G*E interaction gene selection Index. décimale : PER Périodiques Résumé : Some Gene * Environment interaction (G*E) research has focused upon single candidate genes, whereas other related work has targeted multiple genes (e.g., polygenic scores). Each approach has informed efforts to identify individuals who are either especially vulnerable to the negative effects of contextual adversity (diathesis stress) or especially susceptible to both positive and negative contextual conditions (differential susceptibility). A critical step in all such molecular G*E research is the selection of genetic variants thought to moderate environmental influences, a subject that has not received a great deal of attention in critiques of G*E research (beyond the observation of small effects of individual genes). Here we conceptually distinguish three phases of G*E work based on the selection of genes presumed to moderate environmental effects and the theoretical basis of such decisions: (a) single candidate genes, (b) composited (multiple) candidate genes, and (c) GWAS-derived polygenic scores. This illustrative, not exhaustive, review makes it clear that implicit or explicit theoretical assumptions inform gene selection in ways that have not been clearly articulated or fully appreciated. En ligne : http://dx.doi.org/10.1017/s0954579420000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474