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Three phases of Gene * Environment interaction research: Theoretical assumptions underlying gene selection / Xiaoya ZHANG in Development and Psychopathology, 34-1 (February 2022)
[article]
Titre : Three phases of Gene * Environment interaction research: Theoretical assumptions underlying gene selection Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoya ZHANG, Auteur ; Jay BELSKY, Auteur Article en page(s) : p.295-306 Langues : Anglais (eng) Mots-clés : diathesis stress differential susceptibility G*E interaction gene selection Index. décimale : PER Périodiques Résumé : Some Gene * Environment interaction (G*E) research has focused upon single candidate genes, whereas other related work has targeted multiple genes (e.g., polygenic scores). Each approach has informed efforts to identify individuals who are either especially vulnerable to the negative effects of contextual adversity (diathesis stress) or especially susceptible to both positive and negative contextual conditions (differential susceptibility). A critical step in all such molecular G*E research is the selection of genetic variants thought to moderate environmental influences, a subject that has not received a great deal of attention in critiques of G*E research (beyond the observation of small effects of individual genes). Here we conceptually distinguish three phases of G*E work based on the selection of genes presumed to moderate environmental effects and the theoretical basis of such decisions: (a) single candidate genes, (b) composited (multiple) candidate genes, and (c) GWAS-derived polygenic scores. This illustrative, not exhaustive, review makes it clear that implicit or explicit theoretical assumptions inform gene selection in ways that have not been clearly articulated or fully appreciated. En ligne : http://dx.doi.org/10.1017/s0954579420000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-1 (February 2022) . - p.295-306[article] Three phases of Gene * Environment interaction research: Theoretical assumptions underlying gene selection [Texte imprimé et/ou numérique] / Xiaoya ZHANG, Auteur ; Jay BELSKY, Auteur . - p.295-306.
Langues : Anglais (eng)
in Development and Psychopathology > 34-1 (February 2022) . - p.295-306
Mots-clés : diathesis stress differential susceptibility G*E interaction gene selection Index. décimale : PER Périodiques Résumé : Some Gene * Environment interaction (G*E) research has focused upon single candidate genes, whereas other related work has targeted multiple genes (e.g., polygenic scores). Each approach has informed efforts to identify individuals who are either especially vulnerable to the negative effects of contextual adversity (diathesis stress) or especially susceptible to both positive and negative contextual conditions (differential susceptibility). A critical step in all such molecular G*E research is the selection of genetic variants thought to moderate environmental influences, a subject that has not received a great deal of attention in critiques of G*E research (beyond the observation of small effects of individual genes). Here we conceptually distinguish three phases of G*E work based on the selection of genes presumed to moderate environmental effects and the theoretical basis of such decisions: (a) single candidate genes, (b) composited (multiple) candidate genes, and (c) GWAS-derived polygenic scores. This illustrative, not exhaustive, review makes it clear that implicit or explicit theoretical assumptions inform gene selection in ways that have not been clearly articulated or fully appreciated. En ligne : http://dx.doi.org/10.1017/s0954579420000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes / Keith F. WIDAMAN in Development and Psychopathology, 35-3 (August 2023)
[article]
Titre : Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Keith F. WIDAMAN, Auteur Article en page(s) : p.1171-1187 Langues : Anglais (eng) Mots-clés : environmental risk G*E interaction genetic risk regression analysis risk indices Index. décimale : PER Périodiques Résumé : Indices of cumulative risk (CR) have long been used in developmental research to encode the number of risk factors a child or adolescent experiences that may impede optimal developmental outcomes. Initial contributions concentrated on indices of cumulative environmental risk; more recently, indices of cumulative genetic risk have been employed. In this article, regression analytic methods are proposed for interrogating strongly the validity of risk indices by testing optimality of compositing weights, enabling more informative modeling of effects of CR indices. Reanalyses of data from two studies are reported. One study involved 10 environmental risk factors predicting Verbal IQ in 215 four-year-old children. The second study included an index of genetic CR in a G*E interaction investigation of 281 target participants assessed at age 15 years and then again at age 31 years for observed hostility during videotaped interactions with close family relations. Principles to guide evaluation of results of statistical modeling are presented, and implications of results for research and theory are discussed. The ultimate goals of this paper are to develop stronger tests of conjectures involving CR indices and to promote methods for improving replicability of results across studies. En ligne : http://dx.doi.org/10.1017/S0954579421001097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Development and Psychopathology > 35-3 (August 2023) . - p.1171-1187[article] Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes [Texte imprimé et/ou numérique] / Keith F. WIDAMAN, Auteur . - p.1171-1187.
Langues : Anglais (eng)
in Development and Psychopathology > 35-3 (August 2023) . - p.1171-1187
Mots-clés : environmental risk G*E interaction genetic risk regression analysis risk indices Index. décimale : PER Périodiques Résumé : Indices of cumulative risk (CR) have long been used in developmental research to encode the number of risk factors a child or adolescent experiences that may impede optimal developmental outcomes. Initial contributions concentrated on indices of cumulative environmental risk; more recently, indices of cumulative genetic risk have been employed. In this article, regression analytic methods are proposed for interrogating strongly the validity of risk indices by testing optimality of compositing weights, enabling more informative modeling of effects of CR indices. Reanalyses of data from two studies are reported. One study involved 10 environmental risk factors predicting Verbal IQ in 215 four-year-old children. The second study included an index of genetic CR in a G*E interaction investigation of 281 target participants assessed at age 15 years and then again at age 31 years for observed hostility during videotaped interactions with close family relations. Principles to guide evaluation of results of statistical modeling are presented, and implications of results for research and theory are discussed. The ultimate goals of this paper are to develop stronger tests of conjectures involving CR indices and to promote methods for improving replicability of results across studies. En ligne : http://dx.doi.org/10.1017/S0954579421001097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510