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Incidental brain MRI findings in an autism twin study / Julio C. MONTERREY in Autism Research, 10-1 (January 2017)
[article]
Titre : Incidental brain MRI findings in an autism twin study Type de document : Texte imprimé et/ou numérique Auteurs : Julio C. MONTERREY, Auteur ; Jennifer PHILIPS, Auteur ; Sue CLEVELAND, Auteur ; Serena TANAKA, Auteur ; Patrick BARNES, Auteur ; Joachim F. HALLMAYER, Auteur ; Alan L. REISS, Auteur ; Laura C. LAZZERONI, Auteur ; Antonio Y. HARDAN, Auteur Article en page(s) : p.113-120 Langues : Anglais (eng) Mots-clés : autism incidental findings neuroimaging MRI twins Index. décimale : PER Périodiques Résumé : Brain magnetic resonance imaging (MRI) studies suggest the prevalence of asymptomatic “incidental” findings (IF) in autism spectrum disorder (ASD) is similar to that of neurotypically developing (NT) controls. However, given the causes of IF may include both genetic and environmental factors, a twin study would facilitate comparing brain IF between ASD and NT subjects. MRI scans were examined to assess the prevalence of brain IF in twin “case pairs” (at least one twin with diagnosis of ASD) and twin “control pairs” (NT). Fifty case pairs and thirty-two control pairs were analyzed. IF were found in 68% of subjects with ASD, 71% of unaffected ASD siblings, and in 58% of control subjects (P?=?0.4). IF requiring clinical follow-up occurred more frequently in subjects with ASD compared to NT controls (17% vs. 5%, respectively; P?=?0.02). The concordance rate of IF in twins was 83%. A mixed effects model found younger age, male sex, and “family environment” to be significantly associated with IF. There was no difference in the prevalence rate of IF between ASD subjects and NT controls. More IF required clinical follow-up in ASD subjects compared to NT controls. The prevalence rate of IF observed in this twin study was higher than rates previously reported in singleton studies. Our results suggest the shared environment of twins – perhaps in utero – increases the risk of brain IF. Brain MRI in the initial work-up of ASD may be indicated in twins, especially in males. En ligne : http://dx.doi.org/10.1002/aur.1720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.113-120[article] Incidental brain MRI findings in an autism twin study [Texte imprimé et/ou numérique] / Julio C. MONTERREY, Auteur ; Jennifer PHILIPS, Auteur ; Sue CLEVELAND, Auteur ; Serena TANAKA, Auteur ; Patrick BARNES, Auteur ; Joachim F. HALLMAYER, Auteur ; Alan L. REISS, Auteur ; Laura C. LAZZERONI, Auteur ; Antonio Y. HARDAN, Auteur . - p.113-120.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.113-120
Mots-clés : autism incidental findings neuroimaging MRI twins Index. décimale : PER Périodiques Résumé : Brain magnetic resonance imaging (MRI) studies suggest the prevalence of asymptomatic “incidental” findings (IF) in autism spectrum disorder (ASD) is similar to that of neurotypically developing (NT) controls. However, given the causes of IF may include both genetic and environmental factors, a twin study would facilitate comparing brain IF between ASD and NT subjects. MRI scans were examined to assess the prevalence of brain IF in twin “case pairs” (at least one twin with diagnosis of ASD) and twin “control pairs” (NT). Fifty case pairs and thirty-two control pairs were analyzed. IF were found in 68% of subjects with ASD, 71% of unaffected ASD siblings, and in 58% of control subjects (P?=?0.4). IF requiring clinical follow-up occurred more frequently in subjects with ASD compared to NT controls (17% vs. 5%, respectively; P?=?0.02). The concordance rate of IF in twins was 83%. A mixed effects model found younger age, male sex, and “family environment” to be significantly associated with IF. There was no difference in the prevalence rate of IF between ASD subjects and NT controls. More IF required clinical follow-up in ASD subjects compared to NT controls. The prevalence rate of IF observed in this twin study was higher than rates previously reported in singleton studies. Our results suggest the shared environment of twins – perhaps in utero – increases the risk of brain IF. Brain MRI in the initial work-up of ASD may be indicated in twins, especially in males. En ligne : http://dx.doi.org/10.1002/aur.1720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Is there concordance in attitudes and beliefs between parents and scientists about autism spectrum disorder? / Ruth L FISCHBACH in Autism, 20-3 (April 2016)
[article]
Titre : Is there concordance in attitudes and beliefs between parents and scientists about autism spectrum disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Ruth L FISCHBACH, Auteur ; Mark J HARRIS, Auteur ; Michelle S. BALLAN, Auteur ; Gerald D FISCHBACH, Auteur ; Bruce G LINK, Auteur Article en page(s) : p.353-363 Langues : Anglais (eng) Mots-clés : autism spectrum disorder concordance communication genetic testing incidental findings stigma vaccines Index. décimale : PER Périodiques Résumé : There is no reported investigation comparing concordance in attitudes and beliefs about autism spectrum disorder between parents of children with autism spectrum disorder and scientists who research autism spectrum disorder. To investigate the level of concordance between these groups on causes of autism, priorities of research, perceived stigma, and disclosure of genetic test results, telephone interviews were conducted. Parents (n?=?502) were recruited from the Simons Simplex Collection, and research scientists (n?=?60) were recruited from investigators funded by the Simons Foundation. Response rates were notable (parents 91%, scientists 80%). Parents and scientists differed significantly regarding beliefs of the likely major cause of autism (p?=?0.007) and priorities for further research (p?0.001). Scientists believed in genetic causes while many parents believed in vaccines as the cause of autism. Parents (37%) were more likely to hesitate vaccinating their child (p?0.001). In contrast, there was strong concordance regarding extent of perceived stigma (95% vs 92%) and preferences for disclosure of genetic test results, including incidental findings. While scientists believed communication important, paradoxically fewer than half reported it important for scientists to communicate directly with parents. Better communication between parents and scientists should improve mutual understanding and ultimately the health and well-being of children with autism spectrum disorder and their families. En ligne : http://dx.doi.org/10.1177/1362361315585310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Autism > 20-3 (April 2016) . - p.353-363[article] Is there concordance in attitudes and beliefs between parents and scientists about autism spectrum disorder? [Texte imprimé et/ou numérique] / Ruth L FISCHBACH, Auteur ; Mark J HARRIS, Auteur ; Michelle S. BALLAN, Auteur ; Gerald D FISCHBACH, Auteur ; Bruce G LINK, Auteur . - p.353-363.
Langues : Anglais (eng)
in Autism > 20-3 (April 2016) . - p.353-363
Mots-clés : autism spectrum disorder concordance communication genetic testing incidental findings stigma vaccines Index. décimale : PER Périodiques Résumé : There is no reported investigation comparing concordance in attitudes and beliefs about autism spectrum disorder between parents of children with autism spectrum disorder and scientists who research autism spectrum disorder. To investigate the level of concordance between these groups on causes of autism, priorities of research, perceived stigma, and disclosure of genetic test results, telephone interviews were conducted. Parents (n?=?502) were recruited from the Simons Simplex Collection, and research scientists (n?=?60) were recruited from investigators funded by the Simons Foundation. Response rates were notable (parents 91%, scientists 80%). Parents and scientists differed significantly regarding beliefs of the likely major cause of autism (p?=?0.007) and priorities for further research (p?0.001). Scientists believed in genetic causes while many parents believed in vaccines as the cause of autism. Parents (37%) were more likely to hesitate vaccinating their child (p?0.001). In contrast, there was strong concordance regarding extent of perceived stigma (95% vs 92%) and preferences for disclosure of genetic test results, including incidental findings. While scientists believed communication important, paradoxically fewer than half reported it important for scientists to communicate directly with parents. Better communication between parents and scientists should improve mutual understanding and ultimately the health and well-being of children with autism spectrum disorder and their families. En ligne : http://dx.doi.org/10.1177/1362361315585310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285