Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé 'serum'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
How matrix metalloproteinase (MMP)-9 (rs3918242) polymorphism affects MMP-9 serum concentration and associates with autism spectrum disorders: A case-control study in Iranian population / Javid Rezaei LORD in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : How matrix metalloproteinase (MMP)-9 (rs3918242) polymorphism affects MMP-9 serum concentration and associates with autism spectrum disorders: A case-control study in Iranian population Type de document : Texte imprimé et/ou numérique Auteurs : Javid Rezaei LORD, Auteur ; Farhad MASHAYEKHI, Auteur ; Zivar SALEHI, Auteur Article en page(s) : p.882-888 Langues : Anglais (eng) Mots-clés : autism spectrum disorders gene polymorphism MMP-9 serum Index. décimale : PER Périodiques Résumé : The aim of this project was to evaluate the relationship of matrix metalloproteinase-9 (MMP-9) genetic variation and its serum concentration with autism spectrum disorder (ASD). One hundred ASD and 120 controls were enrolled in this study. Genomic DNA was extracted from blood and MMP-9 polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism and serum levels were measured by enzyme-linked immunosorbent assay. The frequencies of CC, CT, and TT genotypes were 72%, 26%, and 2% in controls and 31%, 57%, and 12% in ASD, respectively. The frequencies of C and T alleles in ASD were 59.5% and 40.5%, and controls were 86% and 14%, respectively. There is a significant increase in serum MMP-9 levels in ASD as compared to controls. We have also shown that TT genotype is significantly associated with increase serum MMP-9 levels in patients (TT, CT, and CC serum levels were 91.77 Â+ 10.53, 70.66 Â+ 7.21, and 38.66 Â+ 5.52 and in controls were 55.55 Â+ 11.39, 42.66 Â+ 7.85, and 30.55 Â+ 6.34 ng/ml, respectively). It is concluded that there is a significant association between rs3918242 MMP-9 polymorphism and its serum concentration with autism. We also suggest that TT genotype is associated with increased MMP9 expression and may be a risk factor for ASD. En ligne : http://dx.doi.org/10.1017/S0954579420002102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Development and Psychopathology > 34-3 (August 2022) . - p.882-888[article] How matrix metalloproteinase (MMP)-9 (rs3918242) polymorphism affects MMP-9 serum concentration and associates with autism spectrum disorders: A case-control study in Iranian population [Texte imprimé et/ou numérique] / Javid Rezaei LORD, Auteur ; Farhad MASHAYEKHI, Auteur ; Zivar SALEHI, Auteur . - p.882-888.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.882-888
Mots-clés : autism spectrum disorders gene polymorphism MMP-9 serum Index. décimale : PER Périodiques Résumé : The aim of this project was to evaluate the relationship of matrix metalloproteinase-9 (MMP-9) genetic variation and its serum concentration with autism spectrum disorder (ASD). One hundred ASD and 120 controls were enrolled in this study. Genomic DNA was extracted from blood and MMP-9 polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism and serum levels were measured by enzyme-linked immunosorbent assay. The frequencies of CC, CT, and TT genotypes were 72%, 26%, and 2% in controls and 31%, 57%, and 12% in ASD, respectively. The frequencies of C and T alleles in ASD were 59.5% and 40.5%, and controls were 86% and 14%, respectively. There is a significant increase in serum MMP-9 levels in ASD as compared to controls. We have also shown that TT genotype is significantly associated with increase serum MMP-9 levels in patients (TT, CT, and CC serum levels were 91.77 Â+ 10.53, 70.66 Â+ 7.21, and 38.66 Â+ 5.52 and in controls were 55.55 Â+ 11.39, 42.66 Â+ 7.85, and 30.55 Â+ 6.34 ng/ml, respectively). It is concluded that there is a significant association between rs3918242 MMP-9 polymorphism and its serum concentration with autism. We also suggest that TT genotype is associated with increased MMP9 expression and may be a risk factor for ASD. En ligne : http://dx.doi.org/10.1017/S0954579420002102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies / S. JOHN in Autism, 25-8 (November 2021)
[article]
Titre : Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies Type de document : Texte imprimé et/ou numérique Auteurs : S. JOHN, Auteur ; A. V. JAEGGI, Auteur Article en page(s) : p.2152-2161 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Humans Interpersonal Relations Oxytocin/blood autism blood meta-analysis oxytocin oxytocin levels plasma saliva serum Index. décimale : PER Périodiques Résumé : Oxytocin is a hormone that mediates interpersonal relationships through enhancing social recognition, social memory, and reducing stress. It is released centrally into the cerebrospinal fluid, as well as peripherally into the blood, where it can easily be measured. Some studies indicate that the oxytocin system with its social implications might be different in people with autism spectrum disorder. With summarizing evidence of 31 studies, this meta-analysis suggests that children with autism spectrum disorder have lower blood oxytocin levels compared to neurotypical individuals. This might not be the case for adults with autism spectrum disorder, where we could not find a difference. Our findings motivate further exploration of the oxytocin system in children with autism spectrum disorder. This could lead to therapeutic options in treating autism spectrum disorder in childhood. En ligne : http://dx.doi.org/10.1177/13623613211034375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 25-8 (November 2021) . - p.2152-2161[article] Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies [Texte imprimé et/ou numérique] / S. JOHN, Auteur ; A. V. JAEGGI, Auteur . - p.2152-2161.
Langues : Anglais (eng)
in Autism > 25-8 (November 2021) . - p.2152-2161
Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Humans Interpersonal Relations Oxytocin/blood autism blood meta-analysis oxytocin oxytocin levels plasma saliva serum Index. décimale : PER Périodiques Résumé : Oxytocin is a hormone that mediates interpersonal relationships through enhancing social recognition, social memory, and reducing stress. It is released centrally into the cerebrospinal fluid, as well as peripherally into the blood, where it can easily be measured. Some studies indicate that the oxytocin system with its social implications might be different in people with autism spectrum disorder. With summarizing evidence of 31 studies, this meta-analysis suggests that children with autism spectrum disorder have lower blood oxytocin levels compared to neurotypical individuals. This might not be the case for adults with autism spectrum disorder, where we could not find a difference. Our findings motivate further exploration of the oxytocin system in children with autism spectrum disorder. This could lead to therapeutic options in treating autism spectrum disorder in childhood. En ligne : http://dx.doi.org/10.1177/13623613211034375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451