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Auteur Cédric GALERA |
Documents disponibles écrits par cet auteur (10)



Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence / Massimiliano ORRI in Journal of Child Psychology and Psychiatry, 61-6 (June 2020)
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[article]
Titre : Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Massimiliano ORRI, Auteur ; Marie-Claude GEOFFROY, Auteur ; Gustavo TURECKI, Auteur ; Bei FENG, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Ginette DIONNE, Auteur ; Stéphane PAQUIN, Auteur ; Cédric GALERA, Auteur ; Johanne RENAUD, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.711-720 Langues : Anglais (eng) Mots-clés : Suicide attempt behavioral genetics impulsive-aggression longitudinal suicidal ideation twin study Index. décimale : PER Périodiques Résumé : BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood. METHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components. RESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027. CONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention. En ligne : http://dx.doi.org/10.1111/jcpp.13163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426
in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.711-720[article] Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence [Texte imprimé et/ou numérique] / Massimiliano ORRI, Auteur ; Marie-Claude GEOFFROY, Auteur ; Gustavo TURECKI, Auteur ; Bei FENG, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Ginette DIONNE, Auteur ; Stéphane PAQUIN, Auteur ; Cédric GALERA, Auteur ; Johanne RENAUD, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Michel BOIVIN, Auteur . - p.711-720.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.711-720
Mots-clés : Suicide attempt behavioral genetics impulsive-aggression longitudinal suicidal ideation twin study Index. décimale : PER Périodiques Résumé : BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood. METHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components. RESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027. CONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention. En ligne : http://dx.doi.org/10.1111/jcpp.13163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 Developmental profiles of childhood attention-deficit/hyperactivity disorder and irritability: association with adolescent mental health, functional impairment, and suicidal outcomes / Cédric GALERA in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)
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Titre : Developmental profiles of childhood attention-deficit/hyperactivity disorder and irritability: association with adolescent mental health, functional impairment, and suicidal outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Cédric GALERA, Auteur ; Massimiliano ORRI, Auteur ; Francis VERGUNST, Auteur ; Maria MELCHIOR, Auteur ; Judith VAN DER WAERDEN, Auteur ; Manuel P. BOUVARD, Auteur ; Ophélie COLLET, Auteur ; Michel BOIVIN, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur Année de publication : 2021 Article en page(s) : p.232-243 Langues : Anglais (eng) Mots-clés : Adhd functional impairment irritability mental health problems suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Irritability is frequently comorbid with ADHD. Although irritability alone has been linked to deleterious mental health and adaptive issues, the joint developmental course of ADHD and irritability symptoms during childhood as well as its association with later mental health and suicidal outcomes is not fully understood. We aimed to describe the developmental trajectories of childhood ADHD and irritability symptoms and to quantify their association with adolescent mental health and suicidal outcomes. METHODS: The Quebec Longitudinal Study of Child Development (QLSCD) included 1407 participants from the general population followed up from age 5 months to 17 years. We used a multitrajectory approach to identify developmental trajectories of childhood (6-12 years) ADHD and irritability symptoms. Outcome measures were adolescent (13-17 years) mental health (psychiatric symptoms/functional impairment) and suicidal outcomes. RESULTS: We identified distinct developmental profiles: combined absent or very low ADHD and absent or very low irritability (940 [66.8%]; reference group), moderately high irritability and low ADHD (158 [11.2%]), moderately high ADHD and low irritability (198 [14.1%]), and combined high ADHD and high irritability (111 [7.9%]). Multivariate modeling showed that, compared to children in the reference group, those in the combined high ADHD and high irritability profile showed higher levels of ADHD continuity (d ranges = 0.40-0.50), externalizing (d ranges = 0.25-0.59), internalizing (d ranges = 0.20-0.29), and functional impairments (d ranges = 0.17-0.48) and suicidal behaviors (odds ratio (OR) = 2.12, confidence interval (CI) = 1.47-3.06) in adolescence. CONCLUSIONS: The presence of persistently high levels of irritability along with ADHD symptoms during childhood significantly predicts adolescent ADHD continuity, externalizing, internalizing, and suicidal outcomes. Systematic consideration of irritability when assessing and treating ADHD may improve long-term mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.13270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440
in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.232-243[article] Developmental profiles of childhood attention-deficit/hyperactivity disorder and irritability: association with adolescent mental health, functional impairment, and suicidal outcomes [Texte imprimé et/ou numérique] / Cédric GALERA, Auteur ; Massimiliano ORRI, Auteur ; Francis VERGUNST, Auteur ; Maria MELCHIOR, Auteur ; Judith VAN DER WAERDEN, Auteur ; Manuel P. BOUVARD, Auteur ; Ophélie COLLET, Auteur ; Michel BOIVIN, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur . - 2021 . - p.232-243.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.232-243
Mots-clés : Adhd functional impairment irritability mental health problems suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Irritability is frequently comorbid with ADHD. Although irritability alone has been linked to deleterious mental health and adaptive issues, the joint developmental course of ADHD and irritability symptoms during childhood as well as its association with later mental health and suicidal outcomes is not fully understood. We aimed to describe the developmental trajectories of childhood ADHD and irritability symptoms and to quantify their association with adolescent mental health and suicidal outcomes. METHODS: The Quebec Longitudinal Study of Child Development (QLSCD) included 1407 participants from the general population followed up from age 5 months to 17 years. We used a multitrajectory approach to identify developmental trajectories of childhood (6-12 years) ADHD and irritability symptoms. Outcome measures were adolescent (13-17 years) mental health (psychiatric symptoms/functional impairment) and suicidal outcomes. RESULTS: We identified distinct developmental profiles: combined absent or very low ADHD and absent or very low irritability (940 [66.8%]; reference group), moderately high irritability and low ADHD (158 [11.2%]), moderately high ADHD and low irritability (198 [14.1%]), and combined high ADHD and high irritability (111 [7.9%]). Multivariate modeling showed that, compared to children in the reference group, those in the combined high ADHD and high irritability profile showed higher levels of ADHD continuity (d ranges = 0.40-0.50), externalizing (d ranges = 0.25-0.59), internalizing (d ranges = 0.20-0.29), and functional impairments (d ranges = 0.17-0.48) and suicidal behaviors (odds ratio (OR) = 2.12, confidence interval (CI) = 1.47-3.06) in adolescence. CONCLUSIONS: The presence of persistently high levels of irritability along with ADHD symptoms during childhood significantly predicts adolescent ADHD continuity, externalizing, internalizing, and suicidal outcomes. Systematic consideration of irritability when assessing and treating ADHD may improve long-term mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.13270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440
Titre : Epidémiologie psychiatrique Type de document : Texte imprimé et/ou numérique Auteurs : Cédric GALERA, Auteur Année de publication : 2021 Importance : p.67-73 Index. décimale : SCI-E SCI-E - Psychiatrie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=497 Epidémiologie psychiatrique [Texte imprimé et/ou numérique] / Cédric GALERA, Auteur . - 2021 . - p.67-73.
Index. décimale : SCI-E SCI-E - Psychiatrie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=497 Exemplaires
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in Trouble déficit de l'attention avec ou sans hyperactivité de l'enfant à l'adulte / Manuel P. BOUVARD
Titre : Epidémiologie du TDAH Type de document : Texte imprimé et/ou numérique Auteurs : Cédric GALERA, Auteur ; Flore MOULIN, Auteur ; Manuel P. BOUVARD, Auteur Année de publication : 2016 Importance : p.192-208 Langues : Français (fre) Index. décimale : TRO-E TRO-E - TDA-H Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299 Epidémiologie du TDAH [Texte imprimé et/ou numérique] / Cédric GALERA, Auteur ; Flore MOULIN, Auteur ; Manuel P. BOUVARD, Auteur . - 2016 . - p.192-208.
in Trouble déficit de l'attention avec ou sans hyperactivité de l'enfant à l'adulte / Manuel P. BOUVARD
Langues : Français (fre)
Index. décimale : TRO-E TRO-E - TDA-H Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299 Exemplaires
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Titre : ETP à destination des patients avec un TDAH et de leur entourage Type de document : Texte imprimé et/ou numérique Auteurs : Cédric GALERA, Auteur Année de publication : 2020 Importance : p.252-266 Langues : Français (fre) Index. décimale : SCI-G SCI-G - Autres Domaines Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543 ETP à destination des patients avec un TDAH et de leur entourage [Texte imprimé et/ou numérique] / Cédric GALERA, Auteur . - 2020 . - p.252-266.
Langues : Français (fre)
Index. décimale : SCI-G SCI-G - Autres Domaines Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire PermalinkSocio-Behavioral Characteristics of Children with Rubinstein-Taybi Syndrome / Cédric GALERA in Journal of Autism and Developmental Disorders, 39-9 (September 2009)
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PermalinkPermalinkPermalinkTroubles de la pragmatique du langage chez des enfants avec autisme de haut niveau / Katallin ETCHEGOYHEN in Bulletin Scientifique de l'arapi (Le), 21 (Printemps 2008)
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