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Auteur Andrew PICKLES |
Documents disponibles écrits par cet auteur (66)
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Precursors to Social and Communication Difficulties in Infants At-Risk for Autism: Gaze Following and Attentional Engagement / Rachael BEDFORD in Journal of Autism and Developmental Disorders, 42-10 (October 2012)
[article]
Titre : Precursors to Social and Communication Difficulties in Infants At-Risk for Autism: Gaze Following and Attentional Engagement Type de document : Texte imprimé et/ou numérique Auteurs : Rachael BEDFORD, Auteur ; Mayada ELSABBAGH, Auteur ; Teodora GLIGA, Auteur ; Andrew PICKLES, Auteur ; Atsushi SENJU, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; THE BASIS TEAM, Auteur Année de publication : 2012 Article en page(s) : p.2208-2218 Langues : Anglais (eng) Mots-clés : Autism At-risk siblings Broader autism phenotype Joint attention Gaze following Index. décimale : PER Périodiques Résumé : Whilst joint attention (JA) impairments in autism have been widely studied, little is known about the early development of gaze following, a precursor to establishing JA. We employed eye-tracking to record gaze following longitudinally in infants with and without a family history of autism spectrum disorder (ASD) at 7 and 13 months. No group difference was found between at-risk and low-risk infants in gaze following behaviour at either age. However, despite following gaze successfully at 13 months, at-risk infants with later emerging socio-communication difficulties (both those with ASD and atypical development at 36 months of age) allocated less attention to the congruent object compared to typically developing at-risk siblings and low-risk controls. The findings suggest that the subtle emergence of difficulties in JA in infancy may be related to ASD and other atypical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-012-1450-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180
in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2208-2218[article] Precursors to Social and Communication Difficulties in Infants At-Risk for Autism: Gaze Following and Attentional Engagement [Texte imprimé et/ou numérique] / Rachael BEDFORD, Auteur ; Mayada ELSABBAGH, Auteur ; Teodora GLIGA, Auteur ; Andrew PICKLES, Auteur ; Atsushi SENJU, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; THE BASIS TEAM, Auteur . - 2012 . - p.2208-2218.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2208-2218
Mots-clés : Autism At-risk siblings Broader autism phenotype Joint attention Gaze following Index. décimale : PER Périodiques Résumé : Whilst joint attention (JA) impairments in autism have been widely studied, little is known about the early development of gaze following, a precursor to establishing JA. We employed eye-tracking to record gaze following longitudinally in infants with and without a family history of autism spectrum disorder (ASD) at 7 and 13 months. No group difference was found between at-risk and low-risk infants in gaze following behaviour at either age. However, despite following gaze successfully at 13 months, at-risk infants with later emerging socio-communication difficulties (both those with ASD and atypical development at 36 months of age) allocated less attention to the congruent object compared to typically developing at-risk siblings and low-risk controls. The findings suggest that the subtle emergence of difficulties in JA in infancy may be related to ASD and other atypical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-012-1450-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 Predicting the rate of language development from early motor skills in at-risk infants who develop autism spectrum disorder / Hayley C. LEONARD in Research in Autism Spectrum Disorders, 13-14 (May 2015)
[article]
Titre : Predicting the rate of language development from early motor skills in at-risk infants who develop autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hayley C. LEONARD, Auteur ; Rachael BEDFORD, Auteur ; Andrew PICKLES, Auteur ; Elisabeth L. HILL, Auteur Article en page(s) : p.15-24 Langues : Anglais (eng) Mots-clés : Motor development Autism spectrum disorder Infancy Language development Prospective Index. décimale : PER Périodiques Résumé : Abstract The aim of the current paper was to use data from a prospective study to assess the impact of early motor skills on the rate of language development in infants with an older sibling with autism spectrum disorder (ASD), who are at increased risk of developing ASD themselves. Infants were tested prospectively at four points (7, 14, 24 and 36 months), and were assessed for ASD at the last visit. Latent growth curve analysis was used to model rate of language development using the Vineland Adaptive Behavior Scales between 7–36 months in infants at high and low familial risk for ASD. Motor scores from the Mullen Scales of Early Learning at 7 months were used as predictors of language growth. Gross Motor scores predicted the subsequent rate of expressive, but not receptive, language development in at-risk siblings who were later diagnosed with ASD. Although the pattern was similar for fine motor skills, the relationship did not reach significance. It seems that early motor delay impacts the rate of development of expressive language, and this may be of particular importance to infants at increased risk of developing ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 13-14 (May 2015) . - p.15-24[article] Predicting the rate of language development from early motor skills in at-risk infants who develop autism spectrum disorder [Texte imprimé et/ou numérique] / Hayley C. LEONARD, Auteur ; Rachael BEDFORD, Auteur ; Andrew PICKLES, Auteur ; Elisabeth L. HILL, Auteur . - p.15-24.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 13-14 (May 2015) . - p.15-24
Mots-clés : Motor development Autism spectrum disorder Infancy Language development Prospective Index. décimale : PER Périodiques Résumé : Abstract The aim of the current paper was to use data from a prospective study to assess the impact of early motor skills on the rate of language development in infants with an older sibling with autism spectrum disorder (ASD), who are at increased risk of developing ASD themselves. Infants were tested prospectively at four points (7, 14, 24 and 36 months), and were assessed for ASD at the last visit. Latent growth curve analysis was used to model rate of language development using the Vineland Adaptive Behavior Scales between 7–36 months in infants at high and low familial risk for ASD. Motor scores from the Mullen Scales of Early Learning at 7 months were used as predictors of language growth. Gross Motor scores predicted the subsequent rate of expressive, but not receptive, language development in at-risk siblings who were later diagnosed with ASD. Although the pattern was similar for fine motor skills, the relationship did not reach significance. It seems that early motor delay impacts the rate of development of expressive language, and this may be of particular importance to infants at increased risk of developing ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Predictors of language regression and its association with subsequent communication development in children with autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
[article]
Titre : Predictors of language regression and its association with subsequent communication development in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Andrew PICKLES, Auteur ; Nicola WRIGHT, Auteur ; Rachael BEDFORD, Auteur ; Mandy STEIMAN, Auteur ; Eric DUKU, Auteur ; Teresa BENNETT, Auteur ; Stelios GEORGIADES, Auteur ; Connor M. KERNS, Auteur ; Pat MIRENDA, Auteur ; Isabel M. SMITH, Auteur ; Wendy J. UNGAR, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; Mayada ELSABBAGH, Auteur Article en page(s) : p.1243-1251 Langues : Anglais (eng) Mots-clés : Child Child, Preschool Humans Autism Spectrum Disorder/diagnosis Autistic Disorder/complications Longitudinal Studies Prospective Studies Language Development Disorders/complications Speech Language Development Language autism development Index. décimale : PER Périodiques Résumé : BACKGROUND: Language regression, broadly defined as the loss of acquired language skills in early childhood, is a distinctive feature of autism. Little is known about the factors underlying regression or the prognosis of children who exhibit regression. We examine potential predictors of language regression and test its association with language development in a prospective longitudinal sample of children with autism spectrum disorder (ASD) from diagnosis to age 10 years. METHODS: We analysed data from Pathways in ASD, a prospective longitudinal study of 421 children enrolled around the time of an autism diagnosis between 2 and 5 years. Autism Diagnostic Interview-Revised data were available for 408 children, of whom 90 (22%) were classified as having language regression. RESULTS: Demographic and other health factors including caregiver education, family income, child sex, reported seizures, and age of enrolment did not differ between children with and without language regression. Children with language regression walked earlier and attained first words sooner than those without regression. However, both groups attained phrase speech at comparable ages. Those with regression exhibited greater delays in expressive and receptive communication over the follow-up period, although this effect was attenuated when accounting for baseline differences in motor and cognitive ability. Overall, those with language regression continued to exhibit expressive but not receptive communication delay compared to those without regression. Communication trajectories were heterogeneous to age 10 years, irrespective of regression status. CONCLUSIONS: Although language regression can be alarming, our findings confirm that its occurrence does not necessarily foreshadow worse developmental outcomes relative to those without regression. Although a discrepancy in age-equivalent communication skills may persist, this can be expected to be of less practical importance with rising average levels of skills. Future studies need to account for the significant variability in language trajectories by considering factors beyond developmental regression. En ligne : http://dx.doi.org/10.1111/jcpp.13565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1243-1251[article] Predictors of language regression and its association with subsequent communication development in children with autism [Texte imprimé et/ou numérique] / Andrew PICKLES, Auteur ; Nicola WRIGHT, Auteur ; Rachael BEDFORD, Auteur ; Mandy STEIMAN, Auteur ; Eric DUKU, Auteur ; Teresa BENNETT, Auteur ; Stelios GEORGIADES, Auteur ; Connor M. KERNS, Auteur ; Pat MIRENDA, Auteur ; Isabel M. SMITH, Auteur ; Wendy J. UNGAR, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; Mayada ELSABBAGH, Auteur . - p.1243-1251.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1243-1251
Mots-clés : Child Child, Preschool Humans Autism Spectrum Disorder/diagnosis Autistic Disorder/complications Longitudinal Studies Prospective Studies Language Development Disorders/complications Speech Language Development Language autism development Index. décimale : PER Périodiques Résumé : BACKGROUND: Language regression, broadly defined as the loss of acquired language skills in early childhood, is a distinctive feature of autism. Little is known about the factors underlying regression or the prognosis of children who exhibit regression. We examine potential predictors of language regression and test its association with language development in a prospective longitudinal sample of children with autism spectrum disorder (ASD) from diagnosis to age 10 years. METHODS: We analysed data from Pathways in ASD, a prospective longitudinal study of 421 children enrolled around the time of an autism diagnosis between 2 and 5 years. Autism Diagnostic Interview-Revised data were available for 408 children, of whom 90 (22%) were classified as having language regression. RESULTS: Demographic and other health factors including caregiver education, family income, child sex, reported seizures, and age of enrolment did not differ between children with and without language regression. Children with language regression walked earlier and attained first words sooner than those without regression. However, both groups attained phrase speech at comparable ages. Those with regression exhibited greater delays in expressive and receptive communication over the follow-up period, although this effect was attenuated when accounting for baseline differences in motor and cognitive ability. Overall, those with language regression continued to exhibit expressive but not receptive communication delay compared to those without regression. Communication trajectories were heterogeneous to age 10 years, irrespective of regression status. CONCLUSIONS: Although language regression can be alarming, our findings confirm that its occurrence does not necessarily foreshadow worse developmental outcomes relative to those without regression. Although a discrepancy in age-equivalent communication skills may persist, this can be expected to be of less practical importance with rising average levels of skills. Future studies need to account for the significant variability in language trajectories by considering factors beyond developmental regression. En ligne : http://dx.doi.org/10.1111/jcpp.13565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years / Jonathan GREEN in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)
[article]
Titre : Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years Type de document : Texte imprimé et/ou numérique Auteurs : Jonathan GREEN, Auteur ; Andrew PICKLES, Auteur ; Greg PASCO, Auteur ; Rachael BEDFORD, Auteur ; Ming Wai WAN, Auteur ; Mayada ELSABBAGH, Auteur ; Vicky SLONIMS, Auteur ; Teea GLIGA, Auteur ; Emily JONES, Auteur ; Celeste H.M. CHEUNG, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Team THE BRITISH AUTISM STUDY OF INFANT SIBLINGS, Auteur Article en page(s) : p.1330-1340 Langues : Anglais (eng) Mots-clés : Pre-emptive intervention prevention trials autism autism spectrum disorder high-risk siblings parent-mediated intervention Index. décimale : PER Périodiques Résumé : Background There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. Methods A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. Primary outcome: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. Secondary outcomes: blind-rated parent–child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. Results Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. Conclusions Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent–child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials. En ligne : http://dx.doi.org/10.1111/jcpp.12728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1330-1340[article] Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years [Texte imprimé et/ou numérique] / Jonathan GREEN, Auteur ; Andrew PICKLES, Auteur ; Greg PASCO, Auteur ; Rachael BEDFORD, Auteur ; Ming Wai WAN, Auteur ; Mayada ELSABBAGH, Auteur ; Vicky SLONIMS, Auteur ; Teea GLIGA, Auteur ; Emily JONES, Auteur ; Celeste H.M. CHEUNG, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Team THE BRITISH AUTISM STUDY OF INFANT SIBLINGS, Auteur . - p.1330-1340.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1330-1340
Mots-clés : Pre-emptive intervention prevention trials autism autism spectrum disorder high-risk siblings parent-mediated intervention Index. décimale : PER Périodiques Résumé : Background There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. Methods A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. Primary outcome: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. Secondary outcomes: blind-rated parent–child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. Results Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. Conclusions Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent–child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials. En ligne : http://dx.doi.org/10.1111/jcpp.12728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 Regression, Developmental Trajectory and Associated Problems in Disorders in the Autism Spectrum: The SNAP Study / Gillian BAIRD in Journal of Autism and Developmental Disorders, 38-10 (November 2008)
[article]
Titre : Regression, Developmental Trajectory and Associated Problems in Disorders in the Autism Spectrum: The SNAP Study Type de document : Texte imprimé et/ou numérique Auteurs : Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; Iris CARCANI-RATHWELL, Auteur ; Emily SIMONOFF, Auteur ; Andrew PICKLES, Auteur ; Tom LOUCAS, Auteur ; Susie CHANDLER, Auteur ; David MELDRUM, Auteur ; Devanitha SERKANA, Auteur Année de publication : 2008 Article en page(s) : p.1827-1836 Langues : Anglais (eng) Mots-clés : SNAP Autism Regression Outcome Epilepsy Gastro-intestinal-problems Index. décimale : PER Périodiques Résumé : We report rates of regression and associated findings in a population derived group of 255 children aged 9–14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems. En ligne : http://dx.doi.org/10.1007/s10803-008-0571-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=640
in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1827-1836[article] Regression, Developmental Trajectory and Associated Problems in Disorders in the Autism Spectrum: The SNAP Study [Texte imprimé et/ou numérique] / Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; Iris CARCANI-RATHWELL, Auteur ; Emily SIMONOFF, Auteur ; Andrew PICKLES, Auteur ; Tom LOUCAS, Auteur ; Susie CHANDLER, Auteur ; David MELDRUM, Auteur ; Devanitha SERKANA, Auteur . - 2008 . - p.1827-1836.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1827-1836
Mots-clés : SNAP Autism Regression Outcome Epilepsy Gastro-intestinal-problems Index. décimale : PER Périodiques Résumé : We report rates of regression and associated findings in a population derived group of 255 children aged 9–14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems. En ligne : http://dx.doi.org/10.1007/s10803-008-0571-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=640 School Achievement and Adult Qualifications among Adoptees: A Longitudinal Study / Barbara MAUGHAN in Journal of Child Psychology and Psychiatry, 39-5 (July 1998)
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