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Auteur Tony CHARMAN |
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Sex differences in the association between infant markers and later autistic traits / Rachael BEDFORD in Molecular Autism, 7 (2016)
[article]
Titre : Sex differences in the association between infant markers and later autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Rachael BEDFORD, Auteur ; E. J. JONES, Auteur ; M. H. JOHNSON, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; T. GLIGA, Auteur Article en page(s) : 21p. Langues : Anglais (eng) Mots-clés : Attention/physiology Autism Spectrum Disorder/diagnosis/pathology Female Fixation, Ocular/physiology Humans Infant Male Phenotype Risk Factors Severity of Illness Index Sex Factors Siblings Surveys and Questionnaires Video Recording Autism Differential liability High risk Infants Sex difference Index. décimale : PER Périodiques Résumé : BACKGROUND: Although it is well established that the prevalence of autism spectrum disorder (ASD) is higher in males than females, there is relatively little understanding of the underlying mechanisms and their developmental time course. Sex-specific protective or risk factors have often been invoked to explain these differences, but such factors are yet to be identified. METHODS: We take a developmental approach, using a prospective sample of 104 infants at high and low familial risk for ASD, to characterise sex differences in infant markers known to predict emerging autism symptoms. We examine three markers previously shown to be associated with later autistic social-communication symptoms: the Autism Observation Scale for Infants (AOSI) total score, attention disengagement speed and gaze following behaviour. Our aim was to test whether sex differences were already present in these markers at 1 year of age, which would suggest sex-specific mechanisms of risk or protection. RESULTS: While no sex differences were found in any of the three markers investigated, we found sex differences in their relationship to 3-year autism traits; all three markers significantly predicted later autism traits only in the boys. CONCLUSIONS: Previously identified 'early autism markers' were associated with later autism symptoms only in boys. This suggests that there may be additional moderating risk or protective factors which remain to be identified. Our findings have important implications for prospective studies in terms of directly testing for the moderating effect of sex on emerging autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-016-0081-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 21p.[article] Sex differences in the association between infant markers and later autistic traits [Texte imprimé et/ou numérique] / Rachael BEDFORD, Auteur ; E. J. JONES, Auteur ; M. H. JOHNSON, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; T. GLIGA, Auteur . - 21p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 21p.
Mots-clés : Attention/physiology Autism Spectrum Disorder/diagnosis/pathology Female Fixation, Ocular/physiology Humans Infant Male Phenotype Risk Factors Severity of Illness Index Sex Factors Siblings Surveys and Questionnaires Video Recording Autism Differential liability High risk Infants Sex difference Index. décimale : PER Périodiques Résumé : BACKGROUND: Although it is well established that the prevalence of autism spectrum disorder (ASD) is higher in males than females, there is relatively little understanding of the underlying mechanisms and their developmental time course. Sex-specific protective or risk factors have often been invoked to explain these differences, but such factors are yet to be identified. METHODS: We take a developmental approach, using a prospective sample of 104 infants at high and low familial risk for ASD, to characterise sex differences in infant markers known to predict emerging autism symptoms. We examine three markers previously shown to be associated with later autistic social-communication symptoms: the Autism Observation Scale for Infants (AOSI) total score, attention disengagement speed and gaze following behaviour. Our aim was to test whether sex differences were already present in these markers at 1 year of age, which would suggest sex-specific mechanisms of risk or protection. RESULTS: While no sex differences were found in any of the three markers investigated, we found sex differences in their relationship to 3-year autism traits; all three markers significantly predicted later autism traits only in the boys. CONCLUSIONS: Previously identified 'early autism markers' were associated with later autism symptoms only in boys. This suggests that there may be additional moderating risk or protective factors which remain to be identified. Our findings have important implications for prospective studies in terms of directly testing for the moderating effect of sex on emerging autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-016-0081-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Social and Communication Development in Autism Spectrum Disorders / Tony CHARMAN
Titre : Social and Communication Development in Autism Spectrum Disorders : Early Identification, Diagnosis, and Intervention Type de document : Texte imprimé et/ou numérique Auteurs : Tony CHARMAN, Directeur de publication ; Wendy L. STONE, Directeur de publication Editeur : New-York [Etats-Unis] : Guilford Press Année de publication : 2006 Importance : 348 p. Format : 16,0cm x 23,5cm x 2,6cm ISBN/ISSN/EAN : 978-1-59385-284-9 Note générale : Bibliogr., Index Langues : Anglais (eng) Index. décimale : COM-A COM-A - Communication - Langage - Orthophonie Résumé : Early identification and intervention can lead to significantly better outcomes for children with autism spectrum disorders (ASD). Moreover, much has been learned in the past decade about early warning signs that previously might have gone unnoticed by professionals and parents. This volume brings together leading experts to present new advances in understanding and treating ASD in the first five years of life. Throughout, attention to both real-world practice and scientific research enhances the book's utiliry as a clinical reference and text. Grounded in cutting-edge frindings on the social-communication behavior of typically and atypically developing children, the volume first addresses assessment and diagnosis. Authors describe innovative measurement strategies and instruments that show promise in identifying ASD at a very young age. Mindful of the complexities of preschool diagnosis, the book also discusses the limitations of current diagnostic models. Following a review of screening approaches for community and clinical practice settings, evidence-based intervention models are examined in depth. Chapters focus on cote social-communication deficits, including problems with joint attention, communication and language, play, and imitation. Valuable advice is provided on matching treatment to individual children's needs, and salient directions for future research are identified. Concluding chapters explore some of the developmental and neurobiological processes that underlie social-communication impairments in ASD, further elucidating why and how early intervention can make a difference.
Tony Charman, PhD, is Readcr in Neurodevelopmental Disorders in the Behavioural and Brain Sciences Unit at the Institute of Child Health, University College London and Great Ormond Street Hospital for Children. He studies development in children with autism and the clinical application of this work via screening, diagnostic, outcome, early intervention, and epidemiological studies. He will be Editor-in-Chief of the " Journal of Child Psychology and Psychiatry " from 2007 to 2010, is currently Associate Editor of the " Journal of Autism and Developmental Disorders ", and is on the editorial boards of Autism : " The International journal of Research and Practice ", the " British Journal of Developmental Psychology " and the " Journal of Intellectual Disability Research ". Wendy Stone, PhD, is Professor of Pediatrics at Vanderbilt University, director of the Treatment and Research Institute for Autism Spectrum Disorders (TRIAD) at the Vanderbilt Kennedy Centre. And director of the Marino Autism Research Institue-Vanderbilt. Her primary research interests are early identification and intervention in autism, and the influence of early social-communicative development on later behavioral and diagnostic outcomes. She developed the Screening Tool for Autism in Two-Year-Olds (STAT), which is now being adapted for younger ages. She serves as chair of the Baby Siblings Research Consortium, is on the editorial boards of the " Journal of Autism and Developmental Disorders " and " Infants and Yowig Children ", and bas participated in several National Institutes of Health work groups focused on be, t practices in autism research.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373 Social and Communication Development in Autism Spectrum Disorders : Early Identification, Diagnosis, and Intervention [Texte imprimé et/ou numérique] / Tony CHARMAN, Directeur de publication ; Wendy L. STONE, Directeur de publication . - New-York [Etats-Unis] : Guilford Press, 2006 . - 348 p. ; 16,0cm x 23,5cm x 2,6cm.
ISBN : 978-1-59385-284-9
Bibliogr., Index
Langues : Anglais (eng)
Index. décimale : COM-A COM-A - Communication - Langage - Orthophonie Résumé : Early identification and intervention can lead to significantly better outcomes for children with autism spectrum disorders (ASD). Moreover, much has been learned in the past decade about early warning signs that previously might have gone unnoticed by professionals and parents. This volume brings together leading experts to present new advances in understanding and treating ASD in the first five years of life. Throughout, attention to both real-world practice and scientific research enhances the book's utiliry as a clinical reference and text. Grounded in cutting-edge frindings on the social-communication behavior of typically and atypically developing children, the volume first addresses assessment and diagnosis. Authors describe innovative measurement strategies and instruments that show promise in identifying ASD at a very young age. Mindful of the complexities of preschool diagnosis, the book also discusses the limitations of current diagnostic models. Following a review of screening approaches for community and clinical practice settings, evidence-based intervention models are examined in depth. Chapters focus on cote social-communication deficits, including problems with joint attention, communication and language, play, and imitation. Valuable advice is provided on matching treatment to individual children's needs, and salient directions for future research are identified. Concluding chapters explore some of the developmental and neurobiological processes that underlie social-communication impairments in ASD, further elucidating why and how early intervention can make a difference.
Tony Charman, PhD, is Readcr in Neurodevelopmental Disorders in the Behavioural and Brain Sciences Unit at the Institute of Child Health, University College London and Great Ormond Street Hospital for Children. He studies development in children with autism and the clinical application of this work via screening, diagnostic, outcome, early intervention, and epidemiological studies. He will be Editor-in-Chief of the " Journal of Child Psychology and Psychiatry " from 2007 to 2010, is currently Associate Editor of the " Journal of Autism and Developmental Disorders ", and is on the editorial boards of Autism : " The International journal of Research and Practice ", the " British Journal of Developmental Psychology " and the " Journal of Intellectual Disability Research ". Wendy Stone, PhD, is Professor of Pediatrics at Vanderbilt University, director of the Treatment and Research Institute for Autism Spectrum Disorders (TRIAD) at the Vanderbilt Kennedy Centre. And director of the Marino Autism Research Institue-Vanderbilt. Her primary research interests are early identification and intervention in autism, and the influence of early social-communicative development on later behavioral and diagnostic outcomes. She developed the Screening Tool for Autism in Two-Year-Olds (STAT), which is now being adapted for younger ages. She serves as chair of the Baby Siblings Research Consortium, is on the editorial boards of the " Journal of Autism and Developmental Disorders " and " Infants and Yowig Children ", and bas participated in several National Institutes of Health work groups focused on be, t practices in autism research.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373 Contenu
- Understanding and Measuring Social Communication in Children with Autism Spectrum Disorders / Amy M. WETHERBY
- Early Diagnosis of Children with Autism Spectrum Disorders / Catherine LORD
- Screening for Autism Spectrum Disorders in Populations: Progress, Challenges, and Questions for Future Research and Practice / Tony CHARMAN
- Early Screening for Autism Spectrum Disorders in Clinical Practice Settings / Lonnie ZWAIGENBAUM
- Treatment of Responding to and Initiating Joint Attention / Paul J. YODER
- Evidence-Based Interventions for Language Development in Young Children with Autism / Sally J ROGERS
- Promoting Social Reciprocity and Symbolic Representation in Children with Autism Spectrum Disorders: Designing Quality Peer Play Interventions / Pamela J. WOLFBERG
- Imitation: Some Cues for Intervention Approaches in Autism Spectrum Disorders / Jacqueline NADEL
- Augmentative and Alternative Communication Systems for Children with Autism / Patricia HOWLIN
- A Developmental Approach to Understanding Atypical Development / Tedra A. WALDEN
- The Neural Basis of Early Joint Attention Behavior / Peter C. MUNDY
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0000188 COM-A CHA Livre Centre d'Information et de Documentation du CRA Rhône-Alpes COM - Communication Disponible Les abonnés qui ont emprunté ce document ont également emprunté :
Treatment of Autism Spectrum Disorders PRELOCK, Patricia A. Autisme, comprendre et agir ROGE, Bernadette L'éternité dans une heure TAMMET, Daniel 100 idées pour accompagner un enfant avec autisme dans un cadre scolaire PRY, René Apprendre aux enfants autistes à comprendre la pensée des autres HOWLIN, Patricia Scolarisation accompagnée en maternelle d'un enfant avec autisme PHILIP, Christine Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project / Carolin MOESSNANG in Molecular Autism, 11 (2020)
[article]
Titre : Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project Type de document : Texte imprimé et/ou numérique Auteurs : Carolin MOESSNANG, Auteur ; Sarah BAUMEISTER, Auteur ; Julian TILLMANN, Auteur ; David GOYARD, Auteur ; Tony CHARMAN, Auteur ; Sara AMBROSINO, Auteur ; Simon BARON-COHEN, Auteur ; Christian F. BECKMANN, Auteur ; Sven BÖLTE, Auteur ; Carsten BOURS, Auteur ; Daisy CRAWLEY, Auteur ; Flavio DELL'ACQUA, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Vincent FROUIN, Auteur ; Hannah HAYWARD, Auteur ; Rosemary HOLT, Auteur ; Mark H. JOHNSON, Auteur ; Emily JONES, Auteur ; Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Luke MASON, Auteur ; Marianne OLDENHINKEL, Auteur ; Antonio PERSICO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Will SPOOREN, Auteur ; Eva LOTH, Auteur ; Declan G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur Article en page(s) : 17 p. Langues : Anglais (eng) Mots-clés : Animated shapes Autism Autism spectrum disorder Development Mentalizing Multi-site Social brain Theory of mind fMRI Science, Atheneum Partners, Blueprint Partnership, Boehringer Ingelheim, Daimler und Benz Stiftung, Elsevier, F. Hoffmann-La Roche, ICARE Schizophrenia, K. G. Jebsen Foundation, L.E.K Consulting, Lundbeck International Foundation (LINF), R. Adamczak, Roche Pharma, Science Foundation, Sumitomo Dainippon Pharma, Synapsis Foundation–Alzheimer Research Switzerland, and System Analytics, and has received lectures fees including travel fees from Boehringer Ingelheim, Fama Public Relations, Institut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Janssen-Cilag, Klinikum Christophsbad, Göppingen, Lilly Deutschland, Luzerner Psychiatrie, LVR Klinikum Düsseldorf, LWL Psychiatrie Verbund Westfalen-Lippe, Otsuka Pharmaceuticals, Reunions i Ciencia S. L., Spanish Society of Psychiatry, Südwestrundfunk Fernsehen, Stern TV, and Vitos Klinikum Kurhessen. WM has received lecture or travel fees from Pfizer, Grünenthal, University of Zürich, International Association for the Study on Pain (IASP), and European Federation of IASP Chapters (EFIC). SB discloses that he has in the last 5?years acted as an author, consultant or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Ability Partner, Kompetento, Expo Medica, Clarion Healthcare, and Prophase. He receives royalties for textbooks and diagnostic tools from Huber/Hogrefe, Kohlhammer, and UTB. The other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the "social brain," a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizing in ASD. METHODS: As part of the Longitudinal European Autism Project, we performed functional magnetic resonance imaging at six European sites in a large, well-powered, and deeply phenotyped sample of individuals with ASD (N = 205) and typically developing (TD) individuals (N = 189) aged 6 to 30?years. We presented an animated shapes task to assess and comprehensively characterize social brain activation during mentalizing. We tested for effects of age, diagnosis, and their association with symptom measures, including a continuous measure of autistic traits. RESULTS: We observed robust effects of task. Within the ASD sample, autistic traits were moderately associated with functional activation in one of the key regions of the social brain, the dorsomedial prefrontal cortex. However, there were no significant effects of diagnosis on task performance and no effects of age and diagnosis on social brain responses. Besides a lack of mean group differences, our data provide no evidence for meaningful differences in the distribution of brain response measures. Extensive control analyses suggest that the lack of case-control differences was not due to a variety of potential confounders. CONCLUSIONS: Contrary to prior reports, this large-scale study does not support the assumption that altered social brain activation during mentalizing forms a common neural marker of ASD, at least with the paradigm we employed. Yet, autistic individuals show socio-behavioral deficits. Our work therefore highlights the need to interrogate social brain function with other brain measures, such as connectivity and network-based approaches, using other paradigms, or applying complementary analysis approaches to assess individual differences in this heterogeneous condition. En ligne : http://dx.doi.org/10.1186/s13229-020-0317-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 17 p.[article] Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project [Texte imprimé et/ou numérique] / Carolin MOESSNANG, Auteur ; Sarah BAUMEISTER, Auteur ; Julian TILLMANN, Auteur ; David GOYARD, Auteur ; Tony CHARMAN, Auteur ; Sara AMBROSINO, Auteur ; Simon BARON-COHEN, Auteur ; Christian F. BECKMANN, Auteur ; Sven BÖLTE, Auteur ; Carsten BOURS, Auteur ; Daisy CRAWLEY, Auteur ; Flavio DELL'ACQUA, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Vincent FROUIN, Auteur ; Hannah HAYWARD, Auteur ; Rosemary HOLT, Auteur ; Mark H. JOHNSON, Auteur ; Emily JONES, Auteur ; Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Luke MASON, Auteur ; Marianne OLDENHINKEL, Auteur ; Antonio PERSICO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Will SPOOREN, Auteur ; Eva LOTH, Auteur ; Declan G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur . - 17 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 17 p.
Mots-clés : Animated shapes Autism Autism spectrum disorder Development Mentalizing Multi-site Social brain Theory of mind fMRI Science, Atheneum Partners, Blueprint Partnership, Boehringer Ingelheim, Daimler und Benz Stiftung, Elsevier, F. Hoffmann-La Roche, ICARE Schizophrenia, K. G. Jebsen Foundation, L.E.K Consulting, Lundbeck International Foundation (LINF), R. Adamczak, Roche Pharma, Science Foundation, Sumitomo Dainippon Pharma, Synapsis Foundation–Alzheimer Research Switzerland, and System Analytics, and has received lectures fees including travel fees from Boehringer Ingelheim, Fama Public Relations, Institut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Janssen-Cilag, Klinikum Christophsbad, Göppingen, Lilly Deutschland, Luzerner Psychiatrie, LVR Klinikum Düsseldorf, LWL Psychiatrie Verbund Westfalen-Lippe, Otsuka Pharmaceuticals, Reunions i Ciencia S. L., Spanish Society of Psychiatry, Südwestrundfunk Fernsehen, Stern TV, and Vitos Klinikum Kurhessen. WM has received lecture or travel fees from Pfizer, Grünenthal, University of Zürich, International Association for the Study on Pain (IASP), and European Federation of IASP Chapters (EFIC). SB discloses that he has in the last 5?years acted as an author, consultant or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Ability Partner, Kompetento, Expo Medica, Clarion Healthcare, and Prophase. He receives royalties for textbooks and diagnostic tools from Huber/Hogrefe, Kohlhammer, and UTB. The other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the "social brain," a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizing in ASD. METHODS: As part of the Longitudinal European Autism Project, we performed functional magnetic resonance imaging at six European sites in a large, well-powered, and deeply phenotyped sample of individuals with ASD (N = 205) and typically developing (TD) individuals (N = 189) aged 6 to 30?years. We presented an animated shapes task to assess and comprehensively characterize social brain activation during mentalizing. We tested for effects of age, diagnosis, and their association with symptom measures, including a continuous measure of autistic traits. RESULTS: We observed robust effects of task. Within the ASD sample, autistic traits were moderately associated with functional activation in one of the key regions of the social brain, the dorsomedial prefrontal cortex. However, there were no significant effects of diagnosis on task performance and no effects of age and diagnosis on social brain responses. Besides a lack of mean group differences, our data provide no evidence for meaningful differences in the distribution of brain response measures. Extensive control analyses suggest that the lack of case-control differences was not due to a variety of potential confounders. CONCLUSIONS: Contrary to prior reports, this large-scale study does not support the assumption that altered social brain activation during mentalizing forms a common neural marker of ASD, at least with the paradigm we employed. Yet, autistic individuals show socio-behavioral deficits. Our work therefore highlights the need to interrogate social brain function with other brain measures, such as connectivity and network-based approaches, using other paradigms, or applying complementary analysis approaches to assess individual differences in this heterogeneous condition. En ligne : http://dx.doi.org/10.1186/s13229-020-0317-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Specificity of executive function and theory of mind performance in relation to attention-deficit/hyperactivity symptoms in autism spectrum disorders / S. LUKITO in Molecular Autism, 8 (2017)
[article]
Titre : Specificity of executive function and theory of mind performance in relation to attention-deficit/hyperactivity symptoms in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : S. LUKITO, Auteur ; Catherine R. G. JONES, Auteur ; A. PICKLES, Auteur ; Gillian BAIRD, Auteur ; Francesca HAPPE, Auteur ; Tony CHARMAN, Auteur ; E. SIMONOFF, Auteur Article en page(s) : 60p. Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder Autism spectrum disorder Comorbidity Executive function Snap Theory of mind Index. décimale : PER Périodiques Résumé : Background: Individuals with autism spectrum disorder (ASD) frequently demonstrate symptoms of attention-deficit/hyperactivity disorder (ADHD). Previous findings in children with ASD have suggested that these symptoms are associated with an impairment in executive function (EF) abilities. However, studies rarely considered this association within a single framework that controls for other related factors such as Theory of Mind (ToM) abilities and ASD symptoms. Methods: We used structural equation modeling to explore the relations among EF, ToM, and symptoms of ASD and ADHD, using data from a population-based sample of 100 adolescents with ASD and full-scale IQ >/= 50 (the Special Needs and Autism Project (SNAP) cohort). The study used a multi-measure and multi-informant approach, where performance of inhibition, planning, switching, and working memory tasks indexed EF and performance on tasks involving mentalizing indexed ToM. Measures of ASD and ADHD symptoms included parent and teacher reports and direct observation of the children. Shared source of symptom reporting was accounted for with a parental rating latent factor indexed by symptom measures reported by parents. Results: Impairments in EF abilities were specifically associated with ADHD symptoms while impaired ToM was specifically associated with ASD symptoms, when accounting for the associations of each cognitive domain with the other factors. ASD and ADHD symptom latent factors were also correlated, but this association became nonsignificant once the shared source of reporting from parents was accounted for and within a model that also controlled for the correlated pathway between EF and ToM factors. The specific relations between the cognitive domains and behavioral symptoms remained even after controlling for IQ. Conclusions: In this ASD sample, symptoms of ADHD and ASD are underpinned by separate cognitive domains. The association between EF and ToM impairments is a likely partial explanation for the co-occurrence of ADHD symptoms in ASD, but the role of shared reporting effects is also important and supports the inclusion of independent informants and objective measures in future research. En ligne : http://dx.doi.org/10.1186/s13229-017-0177-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 60p.[article] Specificity of executive function and theory of mind performance in relation to attention-deficit/hyperactivity symptoms in autism spectrum disorders [Texte imprimé et/ou numérique] / S. LUKITO, Auteur ; Catherine R. G. JONES, Auteur ; A. PICKLES, Auteur ; Gillian BAIRD, Auteur ; Francesca HAPPE, Auteur ; Tony CHARMAN, Auteur ; E. SIMONOFF, Auteur . - 60p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 60p.
Mots-clés : Attention-deficit/hyperactivity disorder Autism spectrum disorder Comorbidity Executive function Snap Theory of mind Index. décimale : PER Périodiques Résumé : Background: Individuals with autism spectrum disorder (ASD) frequently demonstrate symptoms of attention-deficit/hyperactivity disorder (ADHD). Previous findings in children with ASD have suggested that these symptoms are associated with an impairment in executive function (EF) abilities. However, studies rarely considered this association within a single framework that controls for other related factors such as Theory of Mind (ToM) abilities and ASD symptoms. Methods: We used structural equation modeling to explore the relations among EF, ToM, and symptoms of ASD and ADHD, using data from a population-based sample of 100 adolescents with ASD and full-scale IQ >/= 50 (the Special Needs and Autism Project (SNAP) cohort). The study used a multi-measure and multi-informant approach, where performance of inhibition, planning, switching, and working memory tasks indexed EF and performance on tasks involving mentalizing indexed ToM. Measures of ASD and ADHD symptoms included parent and teacher reports and direct observation of the children. Shared source of symptom reporting was accounted for with a parental rating latent factor indexed by symptom measures reported by parents. Results: Impairments in EF abilities were specifically associated with ADHD symptoms while impaired ToM was specifically associated with ASD symptoms, when accounting for the associations of each cognitive domain with the other factors. ASD and ADHD symptom latent factors were also correlated, but this association became nonsignificant once the shared source of reporting from parents was accounted for and within a model that also controlled for the correlated pathway between EF and ToM factors. The specific relations between the cognitive domains and behavioral symptoms remained even after controlling for IQ. Conclusions: In this ASD sample, symptoms of ADHD and ASD are underpinned by separate cognitive domains. The association between EF and ToM impairments is a likely partial explanation for the co-occurrence of ADHD symptoms in ASD, but the role of shared reporting effects is also important and supports the inclusion of independent informants and objective measures in future research. En ligne : http://dx.doi.org/10.1186/s13229-017-0177-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 Specifying the Nature and Course of the Joint Attention Impairment in Autism in the Preschool Years: Implications for Diagnosis and Intervention / Tony CHARMAN in Autism, 2-1 (March 1998)
[article]
Titre : Specifying the Nature and Course of the Joint Attention Impairment in Autism in the Preschool Years: Implications for Diagnosis and Intervention Type de document : Texte imprimé et/ou numérique Auteurs : Tony CHARMAN, Auteur Article en page(s) : p.61-79 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The paper reviews recent experimental findings into the extent and specificity of the joint attention impairments shown by preschool children with autism. In contrast to the commonly held view that children with autism are impaired in declarative gestures but intact in requesting gestures, the pattern of intact and impaired joint attention abilities revealed by recent research is more complex. The research reviewed represents a significant advance on previous findings by dissociating form and function in gestural communicative acts, by adopting a developmental perspective and thus identifying changes in the precise nature of the joint attention impairments over time, and by taking advantage of recent advances in early detection and diagnosis that enable us to study very young preschoolers with autism. The lessons to be learnt from this research for clinical diagnosis, and early intervention and education programmes, are considered. En ligne : http://dx.doi.org/10.1177/1362361398021006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=207
in Autism > 2-1 (March 1998) . - p.61-79[article] Specifying the Nature and Course of the Joint Attention Impairment in Autism in the Preschool Years: Implications for Diagnosis and Intervention [Texte imprimé et/ou numérique] / Tony CHARMAN, Auteur . - p.61-79.
Langues : Anglais (eng)
in Autism > 2-1 (March 1998) . - p.61-79
Index. décimale : PER Périodiques Résumé : The paper reviews recent experimental findings into the extent and specificity of the joint attention impairments shown by preschool children with autism. In contrast to the commonly held view that children with autism are impaired in declarative gestures but intact in requesting gestures, the pattern of intact and impaired joint attention abilities revealed by recent research is more complex. The research reviewed represents a significant advance on previous findings by dissociating form and function in gestural communicative acts, by adopting a developmental perspective and thus identifying changes in the precise nature of the joint attention impairments over time, and by taking advantage of recent advances in early detection and diagnosis that enable us to study very young preschoolers with autism. The lessons to be learnt from this research for clinical diagnosis, and early intervention and education programmes, are considered. En ligne : http://dx.doi.org/10.1177/1362361398021006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=207 Stability of the Autism Diagnostic Interview—Revised from Pre-School to Elementary School Age in Children with Autism Spectrum Disorders / Jo MOSS in Journal of Autism and Developmental Disorders, 38-6 (July 2008)
PermalinkTackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways / Julian TILLMANN ; Freddy CLIQUET ; Frédérique AMSELLEM ; Anna MARUANI ; Claire LEBLOND ; Anita BEGGIATO ; David GERMANAUD ; Anouck AMESTOY ; Myriam LY-LE MOAL ; Daniel UMBRICHT ; Christopher CHATHAM ; Lorraine MURTAGH ; Manuel BOUVARD ; Marion LEBOYER ; Tony CHARMAN ; Thomas BOURGERON ; Richard DELORME ; Guillaume DUMAS ; EU-AIMS LEAP Group in Autism Research, 16-2 (February 2023)
PermalinkTemperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants / M. K. J. PIJL in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
PermalinkTemperament in the First 2 Years of Life in Infants at High-Risk for Autism Spectrum Disorders / Sally M. CLIFFORD in Journal of Autism and Developmental Disorders, 43-3 (March 2013)
PermalinkThe Association Between Child and Family Characteristics and the Mental Health and Wellbeing of Caregivers of Children with Autism in Mid-Childhood / E. SALOMONE in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
PermalinkThe Association Between Emotional and Behavioral Problems in Children with Autism Spectrum Disorder and Psychological Distress in Their Parents: A Systematic Review and Meta-analysis / I. YORKE in Journal of Autism and Developmental Disorders, 48-10 (October 2018)
PermalinkThe Association Between Social Cognition and Executive Functioning and Symptoms of Anxiety and Depression in Adolescents With Autism Spectrum Disorders / Matthew J. HOLLOCKS in Autism Research, 7-2 (April 2014)
PermalinkThe association between theory of mind, executive function, and the symptoms of autism spectrum disorder / Catherine R. G. JONES in Autism Research, 11-1 (January 2018)
PermalinkThe association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder / M. J. HOLLOCKS in Autism Research, 14-8 (August 2021)
PermalinkThe Autism Family Experience Questionnaire (AFEQ): An Ecologically-Valid, Parent-Nominated Measure of Family Experience, Quality of Life and Prioritised Outcomes for Early Intervention / K. LEADBITTER in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
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