Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults / Jinni SU in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Titre : Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults Type de document : texte imprimé Auteurs : Jinni SU, Auteur ; Sally I.Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1763-1775 Langues : Anglais (eng) Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults [texte imprimé] / Jinni SU, Auteur ; Sally I.Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur . - p.1763-1775. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples / Kit K. ELAM in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.82-91 Titre : Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples Type de document : texte imprimé Auteurs : Kit K. ELAM, Auteur ; Kaitlin BOUNTRESS, Auteur ; Thao HA, Auteur ; Daniel S. SHAW, Auteur ; Melvin N. WILSON, Auteur ; Fazil ALIEV, Auteur ; Danielle M. DICK, Auteur ; Kathryn LEMERY-CHALFANT, Auteur Article en page(s) : p.82-91 Langues : Anglais (eng) Mots-clés : adolescence  alcohol use  externalizing  longitudinal  polygenic Index. décimale : PER Périodiques Résumé : Externalizing behavior in early adolescence is associated with alcohol use in adolescence and early adulthood and these behaviors often emerge as part of a developmental sequence. This pattern can be the result of heterotypic continuity, in which different behaviors emerge over time based on an underlying shared etiology. In particular, there is largely a shared genetic etiology underlying externalizing and substance use behaviors. We examined whether polygenic risk for alcohol use disorder predicted (1) externalizing behavior in early adolescence and alcohol use in adolescence in the Early Steps Multisite sample and (2) externalizing behavior in adolescence and alcohol use in early adulthood in the Project Alliance 1 (PAL1) sample. We examined associations separately for African Americans and European Americans. When examining European Americans in the Early Steps sample, greater polygenic risk was associated with externalizing behavior in early adolescence. In European Americans in PAL1, we found greater polygenic risk was associated with alcohol use in early adulthood. Effects were largely absent in African Americans in both samples. Results imply that genetic predisposition for alcohol use disorder may increase risk for externalizing and alcohol use as these behaviors emerge developmentally. En ligne : https://dx.doi.org/10.1017/S0954579422000980 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples [texte imprimé] / Kit K. ELAM, Auteur ; Kaitlin BOUNTRESS, Auteur ; Thao HA, Auteur ; Daniel S. SHAW, Auteur ; Melvin N. WILSON, Auteur ; Fazil ALIEV, Auteur ; Danielle M. DICK, Auteur ; Kathryn LEMERY-CHALFANT, Auteur . - p.82-91. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.82-91 Mots-clés : adolescence  alcohol use  externalizing  longitudinal  polygenic Index. décimale : PER Périodiques Résumé : Externalizing behavior in early adolescence is associated with alcohol use in adolescence and early adulthood and these behaviors often emerge as part of a developmental sequence. This pattern can be the result of heterotypic continuity, in which different behaviors emerge over time based on an underlying shared etiology. In particular, there is largely a shared genetic etiology underlying externalizing and substance use behaviors. We examined whether polygenic risk for alcohol use disorder predicted (1) externalizing behavior in early adolescence and alcohol use in adolescence in the Early Steps Multisite sample and (2) externalizing behavior in adolescence and alcohol use in early adulthood in the Project Alliance 1 (PAL1) sample. We examined associations separately for African Americans and European Americans. When examining European Americans in the Early Steps sample, greater polygenic risk was associated with externalizing behavior in early adolescence. In European Americans in PAL1, we found greater polygenic risk was associated with alcohol use in early adulthood. Effects were largely absent in African Americans in both samples. Results imply that genetic predisposition for alcohol use disorder may increase risk for externalizing and alcohol use as these behaviors emerge developmentally. En ligne : https://dx.doi.org/10.1017/S0954579422000980 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Developmental mediation of genetic variation in response to the Fast Track prevention program / Dustin ALBERT in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.81-95 Titre : Developmental mediation of genetic variation in response to the Fast Track prevention program Type de document : texte imprimé Auteurs : Dustin ALBERT, Auteur ; Daniel W. BELSKY, Auteur ; D. Max CROWLEY, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; Jennifer E. LANSFORD, Auteur ; Danielle M. DICK, Auteur ; Kenneth A. DODGE, Auteur Article en page(s) : p.81-95 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We conducted a developmental analysis of genetic moderation of the effect of the Fast Track intervention on adult externalizing psychopathology. The Fast Track intervention enrolled 891 children at high risk to develop externalizing behavior problems when they were in kindergarten. Half of the enrolled children were randomly assigned to receive 10 years of treatment, with a range of services and resources provided to the children and their families, and the other half to usual care (controls). We previously showed that the effect of the Fast Track intervention on participants' risk of externalizing psychopathology at age 25 years was moderated by a variant in the glucocorticoid receptor gene. Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm. In this study, we test a developmental hypothesis about the origins of this for better and for worse Gene × Intervention interaction (G × I): that the observed G × I effect on adult psychopathology is mediated by the proximal impact of intervention on childhood externalizing problems and adolescent substance use and delinquency. We analyzed longitudinal data tracking the 270 European American children in the Fast Track randomized control trial with available genetic information (129 intervention children, 141 control group peers, 69% male) from kindergarten through age 25 years. Results show that the same pattern of for better and for worse susceptibility to intervention observed at the age 25 follow-up was evident already during childhood. At the elementary school follow-ups and at the middle/high school follow-ups, rs10482672 predicted better adjustment among children receiving the Fast Track intervention and worse adjustment among children in the control condition. In turn, these proximal G × I effects early in development mediated the ultimate G × I effect on externalizing psychopathology at age 25 years. We discuss the contribution of these findings to the growing literature on genetic susceptibility to environmental intervention. En ligne : http://dx.doi.org/10.1017/S095457941400131X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Developmental mediation of genetic variation in response to the Fast Track prevention program [texte imprimé] / Dustin ALBERT, Auteur ; Daniel W. BELSKY, Auteur ; D. Max CROWLEY, Auteur ; John E. BATES, Auteur ; Gregory S. PETTIT, Auteur ; Jennifer E. LANSFORD, Auteur ; Danielle M. DICK, Auteur ; Kenneth A. DODGE, Auteur . - p.81-95. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.81-95 Index. décimale : PER Périodiques Résumé : We conducted a developmental analysis of genetic moderation of the effect of the Fast Track intervention on adult externalizing psychopathology. The Fast Track intervention enrolled 891 children at high risk to develop externalizing behavior problems when they were in kindergarten. Half of the enrolled children were randomly assigned to receive 10 years of treatment, with a range of services and resources provided to the children and their families, and the other half to usual care (controls). We previously showed that the effect of the Fast Track intervention on participants' risk of externalizing psychopathology at age 25 years was moderated by a variant in the glucocorticoid receptor gene. Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm. In this study, we test a developmental hypothesis about the origins of this for better and for worse Gene × Intervention interaction (G × I): that the observed G × I effect on adult psychopathology is mediated by the proximal impact of intervention on childhood externalizing problems and adolescent substance use and delinquency. We analyzed longitudinal data tracking the 270 European American children in the Fast Track randomized control trial with available genetic information (129 intervention children, 141 control group peers, 69% male) from kindergarten through age 25 years. Results show that the same pattern of for better and for worse susceptibility to intervention observed at the age 25 follow-up was evident already during childhood. At the elementary school follow-ups and at the middle/high school follow-ups, rs10482672 predicted better adjustment among children receiving the Fast Track intervention and worse adjustment among children in the control condition. In turn, these proximal G × I effects early in development mediated the ultimate G × I effect on externalizing psychopathology at age 25 years. We discuss the contribution of these findings to the growing literature on genetic susceptibility to environmental intervention. En ligne : http://dx.doi.org/10.1017/S095457941400131X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins / Jeanne E. SAVAGE in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.79-92 Titre : Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins Type de document : texte imprimé Auteurs : Jeanne E. SAVAGE, Auteur ; Richard J. ROSE, Auteur ; Lea PULKKINEN, Auteur ; Karri SILVENTOINEN, Auteur ; Tellervo KORHONEN, Auteur ; Jaakko KAPRIO, Auteur ; Nathan GILLESPIE, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.79-92 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early maturation, indexed by pubertal development (PD), has been associated with earlier initiation and greater frequency of adolescent substance use, but this relationship may be biased by confounding factors and effects that change across development. Using a population-based Finnish twin sample (N = 3,632 individuals), we conducted twin modeling and multilevel structural equation modeling of the relationship between PD and substance use at ages 12–22. Shared environmental factors contributed to early PD and heavier substance use for females. Biological father absence was associated with early PD for boys but not girls, and did not account for the relationship between PD and substance use. The association between early PD and heavier substance use was partially due to between-family confounds, although early PD appeared to qualitatively alter long-term trajectories for some substances (nicotine), but not others (alcohol). Mediation by peer and parental factors did not explain this relationship within families. However, higher peer substance use and lower parental monitoring were themselves associated with heavier substance use, strengthening the existing evidence for these factors as targets for prevention/intervention efforts. Early maturation was not supported as a robust determinant of alcohol use trajectories in adolescence and young adulthood, but may require longer term follow-up. Subtle effects of early PD on nicotine and illicit drug use trajectories throughout adolescence and adulthood merit further investigation. En ligne : https://doi.org/10.1017/S0954579417000487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335 [article] Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins [texte imprimé] / Jeanne E. SAVAGE, Auteur ; Richard J. ROSE, Auteur ; Lea PULKKINEN, Auteur ; Karri SILVENTOINEN, Auteur ; Tellervo KORHONEN, Auteur ; Jaakko KAPRIO, Auteur ; Nathan GILLESPIE, Auteur ; Danielle M. DICK, Auteur . - p.79-92. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.79-92 Index. décimale : PER Périodiques Résumé : Early maturation, indexed by pubertal development (PD), has been associated with earlier initiation and greater frequency of adolescent substance use, but this relationship may be biased by confounding factors and effects that change across development. Using a population-based Finnish twin sample (N = 3,632 individuals), we conducted twin modeling and multilevel structural equation modeling of the relationship between PD and substance use at ages 12–22. Shared environmental factors contributed to early PD and heavier substance use for females. Biological father absence was associated with early PD for boys but not girls, and did not account for the relationship between PD and substance use. The association between early PD and heavier substance use was partially due to between-family confounds, although early PD appeared to qualitatively alter long-term trajectories for some substances (nicotine), but not others (alcohol). Mediation by peer and parental factors did not explain this relationship within families. However, higher peer substance use and lower parental monitoring were themselves associated with heavier substance use, strengthening the existing evidence for these factors as targets for prevention/intervention efforts. Early maturation was not supported as a robust determinant of alcohol use trajectories in adolescence and young adulthood, but may require longer term follow-up. Subtle effects of early PD on nicotine and illicit drug use trajectories throughout adolescence and adulthood merit further investigation. En ligne : https://doi.org/10.1017/S0954579417000487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335

Effect of housing relocation and neighborhood environment on adolescent mental and behavioral health / Gayle R. BYCK in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1185-1193 Titre : Effect of housing relocation and neighborhood environment on adolescent mental and behavioral health Type de document : texte imprimé Auteurs : Gayle R. BYCK, Auteur ; John BOLLAND, Auteur ; Danielle M. DICK, Auteur ; Gregory SWANN, Auteur ; David B. HENRY, Auteur ; Brian MUSTANSKI, Auteur Article en page(s) : p.1185-1193 Langues : Anglais (eng) Mots-clés : Adolescent  housing relocation  sexual risk-taking  mental health  substance abuse Index. décimale : PER Périodiques Résumé : Background This study examined whether relocating from a high-poverty neighborhood to a lower poverty neighborhood as part of a federal housing relocation program (HOPE VI; Housing Opportunities for People Everywhere) had effects on adolescent mental and behavioral health compared to adolescents consistently living in lower poverty neighborhoods. Methods Sociodemographic, risk behavior, and neighborhood data were collected from 592 low-income, primarily African-American adolescents and their primary caregivers. Structured psychiatric interviews were conducted with adolescents. Prerelocation neighborhood, demographic, and risk behavior data were also included. Hierarchical Linear Modeling (HLM) was used to test associations between neighborhood variables and risk outcomes. HLM was used to test whether the effect of neighborhood relocation and neighborhood characteristics might explain differences in sexual risk taking, substance use, and mental health outcomes. Results Adolescents who relocated of HOPE VI neighborhoods (n = 158) fared worse than control group participants (n = 429) on most self-reported mental health outcomes. The addition of subjective neighborhood measures generally did not substantively change these results. Conclusions Our findings suggest that moving from a high-poverty neighborhood to a somewhat lower poverty neighborhood is not associated with better mental health and risk behavior outcomes in adolescents. The continued effects of having grown up in a high-poverty neighborhood, the small improvements in their new neighborhoods, the comparatively short length of time they lived in their new neighborhood, and/or the stress of moving appears to worsen most of the mental health outcomes of HOPE VI compared to control group participants who consistently lived in the lower poverty neighborhoods. En ligne : http://dx.doi.org/10.1111/jcpp.12386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Effect of housing relocation and neighborhood environment on adolescent mental and behavioral health [texte imprimé] / Gayle R. BYCK, Auteur ; John BOLLAND, Auteur ; Danielle M. DICK, Auteur ; Gregory SWANN, Auteur ; David B. HENRY, Auteur ; Brian MUSTANSKI, Auteur . - p.1185-1193. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1185-1193 Mots-clés : Adolescent  housing relocation  sexual risk-taking  mental health  substance abuse Index. décimale : PER Périodiques Résumé : Background This study examined whether relocating from a high-poverty neighborhood to a lower poverty neighborhood as part of a federal housing relocation program (HOPE VI; Housing Opportunities for People Everywhere) had effects on adolescent mental and behavioral health compared to adolescents consistently living in lower poverty neighborhoods. Methods Sociodemographic, risk behavior, and neighborhood data were collected from 592 low-income, primarily African-American adolescents and their primary caregivers. Structured psychiatric interviews were conducted with adolescents. Prerelocation neighborhood, demographic, and risk behavior data were also included. Hierarchical Linear Modeling (HLM) was used to test associations between neighborhood variables and risk outcomes. HLM was used to test whether the effect of neighborhood relocation and neighborhood characteristics might explain differences in sexual risk taking, substance use, and mental health outcomes. Results Adolescents who relocated of HOPE VI neighborhoods (n = 158) fared worse than control group participants (n = 429) on most self-reported mental health outcomes. The addition of subjective neighborhood measures generally did not substantively change these results. Conclusions Our findings suggest that moving from a high-poverty neighborhood to a somewhat lower poverty neighborhood is not associated with better mental health and risk behavior outcomes in adolescents. The continued effects of having grown up in a high-poverty neighborhood, the small improvements in their new neighborhoods, the comparatively short length of time they lived in their new neighborhood, and/or the stress of moving appears to worsen most of the mental health outcomes of HOPE VI compared to control group participants who consistently lived in the lower poverty neighborhoods. En ligne : http://dx.doi.org/10.1111/jcpp.12386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students / Jinni SU in Development and Psychopathology, 30-5 (December 2018)  

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A longitudinal study examining the associations between interpersonal trauma and romantic relationships among college students / Rebecca L. SMITH in Development and Psychopathology, 35-3 (August 2023)  

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MAOA-uVNTR and early physical discipline interact to influence delinquent behavior / Michael C. EDWARDS in Journal of Child Psychology and Psychiatry, 51-6 (June 2010)  

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Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence / E. Leighton DURHAM ; Sarah J. BRISLIN ; Peter B. BARR ; Danielle M. DICK ; Tyler M. MOORE ; Brandon L. PIERCE ; Lin TONG ; Gabrielle REIMANN ; Hee Jung JEONG ; Randolph M. DUPONT ; Antonia N. KACZKURKIN in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

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Parental Socialization and Adolescents'Alcohol Use Behaviors: Predictive Disparities in Parents'Versus Adolescents'Perceptions of the Parenting Environment / Shawn J. LATENDRESSE in Journal of Clinical Child & Adolescent Psychology, 38-2 (March-April 2009)  

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Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife / Mallory STEPHENSON in Development and Psychopathology, 37-2 (May 2025)  

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Risk and protective factors for comorbid internalizing and externalizing problems among economically disadvantaged African American youth / Jingwen LIU in Development and Psychopathology, 29-3 (August 2017)  

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Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk / Frances L. WANG in Development and Psychopathology, 30-1 (February 2018)  

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A systematic review of gene-by-intervention studies of alcohol and other substance use / Zoe E. NEALE in Development and Psychopathology, 33-4 (October 2021)  

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The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse / Mallory STEPHENSON in Development and Psychopathology, 34-5 (December 2022)  

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