Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates / Elyse L. MORIN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1579-1596 Titre : Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates Type de document : Texte imprimé et/ou numérique Auteurs : Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1579-1596 Langues : Anglais (eng) Mots-clés : Adolescent  *Amygdala/diagnostic imaging  Animals  Brain  Child  Female  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  *Prefrontal Cortex/diagnostic imaging  Pregnancy  Primates  *amygdala functional connectivity  *childhood maltreatment  *early life stress  *prefrontal cortex  *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates [Texte imprimé et/ou numérique] / Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur . - p.1579-1596. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1579-1596 Mots-clés : Adolescent  *Amygdala/diagnostic imaging  Animals  Brain  Child  Female  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  *Prefrontal Cortex/diagnostic imaging  Pregnancy  Primates  *amygdala functional connectivity  *childhood maltreatment  *early life stress  *prefrontal cortex  *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Effects of sex and early maternal abuse on adrenocorticotropin hormone and cortisol responses to the corticotropin-releasing hormone challenge during the first 3 years of life in group-living rhesus monkeys / Mar M. SANCHEZ in Development and Psychopathology, 22-1 (January 2010)  

Public ISBD [article]  inDevelopment and Psychopathology > 22-1 (January 2010) . - p.45-53 Titre : Effects of sex and early maternal abuse on adrenocorticotropin hormone and cortisol responses to the corticotropin-releasing hormone challenge during the first 3 years of life in group-living rhesus monkeys Type de document : Texte imprimé et/ou numérique Auteurs : Mar M. SANCHEZ, Auteur ; Kai MCCORMACK, Auteur ; Alison P. GRAND, Auteur ; Richelle FULKS, Auteur ; Anne GRAFF, Auteur ; Dario MAESTRIPIERI, Auteur Année de publication : 2010 Article en page(s) : p.45-53 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In this study we investigated the development of the hypothalamic–pituitary–adrenal (HPA) axis in 21 group-living rhesus monkeys infants that were physically abused by their mothers in the first few months of life and in 21 nonabused controls. Cortisol and adrenocorticotropin hormone (ACTH) responses to a corticotropin-releasing hormone (CRH) challenge were assessed at 6-month intervals during the subjects' first 3 years of life. Abused infants exhibited greater cortisol responses to CRH than controls across the 3 years. Abused infants also exhibited blunted ACTH secretion in response to CRH, especially at 6 months of age. Although there were no significant sex differences in abuse experienced early in life, females showed a greater cortisol response to CRH than males at all ages. There were no significant sex differences in the ACTH response to CRH, or significant interactions between sex and abuse in the ACTH or cortisol response. Our findings suggest that early parental maltreatment results in greater adrenocortical, and possibly also pituitary, responsiveness to challenges later in life. These long-term alterations in neuroendocrine function may be one the mechanisms through which infant abuse results in later psychopathologies. Our study also suggests that there are developmental sex differences in adrenal function that occur irrespective of early stressful experience. The results of this study can enhance our understanding of the long-term effects of child maltreatment as well as our knowledge of the development of the HPA axis in human and nonhuman primates. En ligne : http://dx.doi.org/10.1017/s0954579409990253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969 [article] Effects of sex and early maternal abuse on adrenocorticotropin hormone and cortisol responses to the corticotropin-releasing hormone challenge during the first 3 years of life in group-living rhesus monkeys [Texte imprimé et/ou numérique] / Mar M. SANCHEZ, Auteur ; Kai MCCORMACK, Auteur ; Alison P. GRAND, Auteur ; Richelle FULKS, Auteur ; Anne GRAFF, Auteur ; Dario MAESTRIPIERI, Auteur . - 2010 . - p.45-53. Langues : Anglais (eng) in Development and Psychopathology > 22-1 (January 2010) . - p.45-53 Index. décimale : PER Périodiques Résumé : In this study we investigated the development of the hypothalamic–pituitary–adrenal (HPA) axis in 21 group-living rhesus monkeys infants that were physically abused by their mothers in the first few months of life and in 21 nonabused controls. Cortisol and adrenocorticotropin hormone (ACTH) responses to a corticotropin-releasing hormone (CRH) challenge were assessed at 6-month intervals during the subjects' first 3 years of life. Abused infants exhibited greater cortisol responses to CRH than controls across the 3 years. Abused infants also exhibited blunted ACTH secretion in response to CRH, especially at 6 months of age. Although there were no significant sex differences in abuse experienced early in life, females showed a greater cortisol response to CRH than males at all ages. There were no significant sex differences in the ACTH response to CRH, or significant interactions between sex and abuse in the ACTH or cortisol response. Our findings suggest that early parental maltreatment results in greater adrenocortical, and possibly also pituitary, responsiveness to challenges later in life. These long-term alterations in neuroendocrine function may be one the mechanisms through which infant abuse results in later psychopathologies. Our study also suggests that there are developmental sex differences in adrenal function that occur irrespective of early stressful experience. The results of this study can enhance our understanding of the long-term effects of child maltreatment as well as our knowledge of the development of the HPA axis in human and nonhuman primates. En ligne : http://dx.doi.org/10.1017/s0954579409990253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969

Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study / Chris GUNTER in Autism Research, 15-3 (March 2022)  

Public ISBD [article]  inAutism Research > 15-3 (March 2022) . - p.447-463 Titre : Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study Type de document : Texte imprimé et/ou numérique Auteurs : Chris GUNTER, Auteur ; R. Alan HARRIS, Auteur ; Zsofia KOVACS-BALINT, Auteur ; Muthuswamy RAVEENDRAN, Auteur ; Vasiliki MICHOPOULOS, Auteur ; Jocelyne BACHEVALIER, Auteur ; Jessica RAPER, Auteur ; Mar M. SANCHEZ, Auteur ; Jeffrey ROGERS, Auteur Article en page(s) : p.447-463 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our understanding of influences on atypical human social behavior, such as that observed in autism spectrum disorders (ASD), many significant questions remain. Improved understanding of the relationships among variation in specific genes and variation in expressed social behavior in a nonhuman primate would benefit efforts to investigate risk factors, developmental mechanisms, and potential therapies for behavioral disorders including ASD. To study genetic influences on key aspects of social behavior and interactions?individual competence and/or motivation for specific aspects of social behavior?we quantified individual variation in social interactions among juvenile rhesus macaques using both a standard macaque ethogram and a macaque-relevant modification of the human Social Responsiveness Scale. Our analyses demonstrate that various aspects of juvenile social behavior exhibit significant genetic heritability, with estimated quantitative genetic effects similar to that described for ASD in human children. We also performed exome sequencing and analyzed variants in 143 genes previously suggested to influence risk for human ASD. We find preliminary evidence for genetic association between specific variants and both individual behaviors and multi-behavioral factor scores. To our knowledge, this is the first demonstration that spontaneous social behaviors performed by free-ranging juvenile rhesus macaques display significant genetic heritability and then to use exome sequencing data to examine potential macaque genetic associations in genes associated with human ASD. En ligne : https://doi.org/10.1002/aur.2675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study [Texte imprimé et/ou numérique] / Chris GUNTER, Auteur ; R. Alan HARRIS, Auteur ; Zsofia KOVACS-BALINT, Auteur ; Muthuswamy RAVEENDRAN, Auteur ; Vasiliki MICHOPOULOS, Auteur ; Jocelyne BACHEVALIER, Auteur ; Jessica RAPER, Auteur ; Mar M. SANCHEZ, Auteur ; Jeffrey ROGERS, Auteur . - p.447-463. Langues : Anglais (eng) in Autism Research > 15-3 (March 2022) . - p.447-463 Index. décimale : PER Périodiques Résumé : Abstract Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our understanding of influences on atypical human social behavior, such as that observed in autism spectrum disorders (ASD), many significant questions remain. Improved understanding of the relationships among variation in specific genes and variation in expressed social behavior in a nonhuman primate would benefit efforts to investigate risk factors, developmental mechanisms, and potential therapies for behavioral disorders including ASD. To study genetic influences on key aspects of social behavior and interactions?individual competence and/or motivation for specific aspects of social behavior?we quantified individual variation in social interactions among juvenile rhesus macaques using both a standard macaque ethogram and a macaque-relevant modification of the human Social Responsiveness Scale. Our analyses demonstrate that various aspects of juvenile social behavior exhibit significant genetic heritability, with estimated quantitative genetic effects similar to that described for ASD in human children. We also performed exome sequencing and analyzed variants in 143 genes previously suggested to influence risk for human ASD. We find preliminary evidence for genetic association between specific variants and both individual behaviors and multi-behavioral factor scores. To our knowledge, this is the first demonstration that spontaneous social behaviors performed by free-ranging juvenile rhesus macaques display significant genetic heritability and then to use exome sequencing data to examine potential macaque genetic associations in genes associated with human ASD. En ligne : https://doi.org/10.1002/aur.2675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation / Stacy S. DRURY in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Titre : Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation Type de document : Texte imprimé et/ou numérique Auteurs : Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1539-1551 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation [Texte imprimé et/ou numérique] / Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur . - p.1539-1551. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Understanding behavioral effects of early life stress using the reactive scope and allostatic load models / Brittany R. HOWELL in Development and Psychopathology, 23-4 (November 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-4 (November 2011) . - p.1001-1016 Titre : Understanding behavioral effects of early life stress using the reactive scope and allostatic load models Type de document : Texte imprimé et/ou numérique Auteurs : Brittany R. HOWELL, Auteur ; Mar M. SANCHEZ, Auteur Année de publication : 2011 Article en page(s) : p.1001-1016 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The mechanisms through which early life stress leads to psychopathology are thought to involve allostatic load, the “wear and tear” an organism is subjected to as a consequence of sustained elevated levels of glucocorticoids caused by repeated/prolonged stress activations. The allostatic load model described this phenomenon, but has been criticized as inadequate to explain alterations associated with early adverse experience in some systems, including behavior, which cannot be entirely explained from an energy balance perspective. The reactive scope model has been more recently proposed and focuses less on energy balance and more on dynamic ranges of physiological and behavioral mediators. In this review we examine the mechanisms underlying the behavioral consequences of early life stress in the context of both these models. We focus on adverse experiences that involve mother–infant relationship disruption, and dissect those mechanisms involving maternal care as a regulator of development of neural circuits that control emotional and social behaviors in the offspring. We also discuss the evolutionary purpose of the plasticity in behavioral development, which has a clear adaptive value in a changing environment. En ligne : http://dx.doi.org/10.1017/S0954579411000460 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Understanding behavioral effects of early life stress using the reactive scope and allostatic load models [Texte imprimé et/ou numérique] / Brittany R. HOWELL, Auteur ; Mar M. SANCHEZ, Auteur . - 2011 . - p.1001-1016. Langues : Anglais (eng) in Development and Psychopathology > 23-4 (November 2011) . - p.1001-1016 Index. décimale : PER Périodiques Résumé : The mechanisms through which early life stress leads to psychopathology are thought to involve allostatic load, the “wear and tear” an organism is subjected to as a consequence of sustained elevated levels of glucocorticoids caused by repeated/prolonged stress activations. The allostatic load model described this phenomenon, but has been criticized as inadequate to explain alterations associated with early adverse experience in some systems, including behavior, which cannot be entirely explained from an energy balance perspective. The reactive scope model has been more recently proposed and focuses less on energy balance and more on dynamic ranges of physiological and behavioral mediators. In this review we examine the mechanisms underlying the behavioral consequences of early life stress in the context of both these models. We focus on adverse experiences that involve mother–infant relationship disruption, and dissect those mechanisms involving maternal care as a regulator of development of neural circuits that control emotional and social behaviors in the offspring. We also discuss the evolutionary purpose of the plasticity in behavioral development, which has a clear adaptive value in a changing environment. En ligne : http://dx.doi.org/10.1017/S0954579411000460 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

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