Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study / Timothy C. NIELSEN in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2371-2380 Titre : Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Timothy C. NIELSEN, Auteur ; Natasha NASSAR, Auteur ; Antonia W. SHAND, Auteur ; Hannah F. JONES, Auteur ; Velda X. HAN, Auteur ; Shrujna PATEL, Auteur ; Adam J. GUASTELLA, Auteur ; Russell C DALE, Auteur ; Samantha J. LAIN, Auteur Article en page(s) : p.2371-2380 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  Humans  Autism Spectrum Disorder/epidemiology/etiology  Cohort Studies  Odds Ratio  Logistic Models  Autoimmune Diseases/epidemiology/complications  Australia  autism Spectrum disorder  autoimmune diseases  infections  pregnancy Index. décimale : PER Périodiques Résumé : The aim of this study was to examine potential synergistic effects between maternal autoimmune disease and early childhood infections and their association with autism spectrum disorder (ASD) in offspring. Both exposures have been associated with increased risk of ASD in previous studies, but potential synergistic effects remain underexplored. We conducted a population-based cohort study of singleton children born at term gestation (37-41 weeks) in New South Wales, Australia from January 2002 to December 2008. Maternal autoimmune diagnoses and childhood infections before age 2 years were identified from linked maternal and child hospital admissions, and ASD diagnoses by age 9 years were identified from linked disability services data. Multivariable logistic regression assessed the association between each exposure and ASD and additive interaction between exposures, controlling for potential confounders. A total of 18,451 children exposed to maternal autoimmune disease were propensity score matched (1:2) to 36,902 unexposed children. Any maternal autoimmune disease (adjusted odds ratio (aOR) 1.25, 95% confidence interval (CI) 1.07-1.47) and any childhood infection before age 2 years (aOR 1.38, 95% CI 1.15-1.67) were each associated with ASD. However, there was no evidence of additive interaction between the two exposures (relative excess risk due to interaction [RERI] 0.128, 95% CI -0.418-0.675) resulting in increased odds of ASD in offspring. Future studies could examine potential interactions between other sources of maternal immune activation and childhood infection and impact on ASD and other neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study [Texte imprimé et/ou numérique] / Timothy C. NIELSEN, Auteur ; Natasha NASSAR, Auteur ; Antonia W. SHAND, Auteur ; Hannah F. JONES, Auteur ; Velda X. HAN, Auteur ; Shrujna PATEL, Auteur ; Adam J. GUASTELLA, Auteur ; Russell C DALE, Auteur ; Samantha J. LAIN, Auteur . - p.2371-2380. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2371-2380 Mots-clés : Child  Child, Preschool  Humans  Autism Spectrum Disorder/epidemiology/etiology  Cohort Studies  Odds Ratio  Logistic Models  Autoimmune Diseases/epidemiology/complications  Australia  autism Spectrum disorder  autoimmune diseases  infections  pregnancy Index. décimale : PER Périodiques Résumé : The aim of this study was to examine potential synergistic effects between maternal autoimmune disease and early childhood infections and their association with autism spectrum disorder (ASD) in offspring. Both exposures have been associated with increased risk of ASD in previous studies, but potential synergistic effects remain underexplored. We conducted a population-based cohort study of singleton children born at term gestation (37-41 weeks) in New South Wales, Australia from January 2002 to December 2008. Maternal autoimmune diagnoses and childhood infections before age 2 years were identified from linked maternal and child hospital admissions, and ASD diagnoses by age 9 years were identified from linked disability services data. Multivariable logistic regression assessed the association between each exposure and ASD and additive interaction between exposures, controlling for potential confounders. A total of 18,451 children exposed to maternal autoimmune disease were propensity score matched (1:2) to 36,902 unexposed children. Any maternal autoimmune disease (adjusted odds ratio (aOR) 1.25, 95% confidence interval (CI) 1.07-1.47) and any childhood infection before age 2 years (aOR 1.38, 95% CI 1.15-1.67) were each associated with ASD. However, there was no evidence of additive interaction between the two exposures (relative excess risk due to interaction [RERI] 0.128, 95% CI -0.418-0.675) resulting in increased odds of ASD in offspring. Future studies could examine potential interactions between other sources of maternal immune activation and childhood infection and impact on ASD and other neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

A Comparison of Autism Prevalence Trends in Denmark and Western Australia / Erik T. PARNER in Journal of Autism and Developmental Disorders, 41-12 (December 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1601-1608 Titre : A Comparison of Autism Prevalence Trends in Denmark and Western Australia Type de document : Texte imprimé et/ou numérique Auteurs : Erik T. PARNER, Auteur ; Poul THORSEN, Auteur ; Glenys DIXON, Auteur ; Nicholas H. DE KLERK, Auteur ; Helen LEONARD, Auteur ; Natasha NASSAR, Auteur ; Jenny BOURKE, Auteur ; Carol BOWER, Auteur ; Emma J. GLASSON, Auteur Année de publication : 2011 Article en page(s) : p.1601-1608 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorders  Prevalence  Diagnosis  Denmark  Western Australia Index. décimale : PER Périodiques Résumé : Prevalence statistics for autism spectrum disorders (ASD) vary widely across geographical boundaries. Some variation can be explained by diagnostic methods, case ascertainment and age at diagnosis. This study compared prevalence statistics for two distinct geographical regions, Denmark and Western Australia, both of which have had population-based registers and consistent classification systems operating over the past decade. Overall ASD prevalence rates were higher in Denmark (68.5 per 10,000 children) compared with Western Australia (51.0 per 10,000 children), while the diagnosis of childhood autism was more prevalent in Western Australia (39.3 per 10,000 children) compared with Denmark (21.8 per 10,000 children). These differences are probably caused by local phenomena affecting case ascertainment but influence from biological or geographical factors may exist. En ligne : http://dx.doi.org/10.1007/s10803-011-1186-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 [article] A Comparison of Autism Prevalence Trends in Denmark and Western Australia [Texte imprimé et/ou numérique] / Erik T. PARNER, Auteur ; Poul THORSEN, Auteur ; Glenys DIXON, Auteur ; Nicholas H. DE KLERK, Auteur ; Helen LEONARD, Auteur ; Natasha NASSAR, Auteur ; Jenny BOURKE, Auteur ; Carol BOWER, Auteur ; Emma J. GLASSON, Auteur . - 2011 . - p.1601-1608. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1601-1608 Mots-clés : Autism  Autism spectrum disorders  Prevalence  Diagnosis  Denmark  Western Australia Index. décimale : PER Périodiques Résumé : Prevalence statistics for autism spectrum disorders (ASD) vary widely across geographical boundaries. Some variation can be explained by diagnostic methods, case ascertainment and age at diagnosis. This study compared prevalence statistics for two distinct geographical regions, Denmark and Western Australia, both of which have had population-based registers and consistent classification systems operating over the past decade. Overall ASD prevalence rates were higher in Denmark (68.5 per 10,000 children) compared with Western Australia (51.0 per 10,000 children), while the diagnosis of childhood autism was more prevalent in Western Australia (39.3 per 10,000 children) compared with Denmark (21.8 per 10,000 children). These differences are probably caused by local phenomena affecting case ascertainment but influence from biological or geographical factors may exist. En ligne : http://dx.doi.org/10.1007/s10803-011-1186-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148

Estimating the Prevalence of Autism Spectrum Disorder in New South Wales, Australia: A Data Linkage Study of Three Routinely Collected Datasets / Timothy C. NIELSEN in Journal of Autism and Developmental Disorders, 54-4 (April 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1558-1566 Titre : Estimating the Prevalence of Autism Spectrum Disorder in New South Wales, Australia: A Data Linkage Study of Three Routinely Collected Datasets Type de document : Texte imprimé et/ou numérique Auteurs : Timothy C. NIELSEN, Auteur ; Natasha NASSAR, Auteur ; Kelsie A. BOULTON, Auteur ; Adam J. GUASTELLA, Auteur ; Samantha J. LAIN, Auteur Article en page(s) : p.1558-1566 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Routinely collected data help estimate the prevalence of autism spectrum disorder (ASD) in jurisdictions without active autism surveillance. We created a population-based cohort of 1,211,834 children born in 2002-2015 in New South Wales, Australia using data linkage. Children with ASD were identified in three datasets - disability services, hospital admissions, and ambulatory mental health data. The prevalence of ASD in the cohort was 1.3% by age 12 and prevalence at age 6 increased an average of 4.1% per year (95% Confidence Interval, 3.3%, 4.8%). Most children with ASD were identified in disability services data (87%), although data linkage identified 1,711 additional cases that were more likely female, older at first contact, and living in major cities and less disadvantaged areas. En ligne : https://doi.org/10.1007/s10803-022-05887-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Estimating the Prevalence of Autism Spectrum Disorder in New South Wales, Australia: A Data Linkage Study of Three Routinely Collected Datasets [Texte imprimé et/ou numérique] / Timothy C. NIELSEN, Auteur ; Natasha NASSAR, Auteur ; Kelsie A. BOULTON, Auteur ; Adam J. GUASTELLA, Auteur ; Samantha J. LAIN, Auteur . - p.1558-1566. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1558-1566 Index. décimale : PER Périodiques Résumé : Routinely collected data help estimate the prevalence of autism spectrum disorder (ASD) in jurisdictions without active autism surveillance. We created a population-based cohort of 1,211,834 children born in 2002-2015 in New South Wales, Australia using data linkage. Children with ASD were identified in three datasets - disability services, hospital admissions, and ambulatory mental health data. The prevalence of ASD in the cohort was 1.3% by age 12 and prevalence at age 6 increased an average of 4.1% per year (95% Confidence Interval, 3.3%, 4.8%). Most children with ASD were identified in disability services data (87%), although data linkage identified 1,711 additional cases that were more likely female, older at first contact, and living in major cities and less disadvantaged areas. En ligne : https://doi.org/10.1007/s10803-022-05887-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Unpacking the complex nature of the autism epidemic / Helen LEONARD in Research in Autism Spectrum Disorders, 4-4 (October-December 2010)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.548-554 Titre : Unpacking the complex nature of the autism epidemic Type de document : Texte imprimé et/ou numérique Auteurs : Helen LEONARD, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Glenys DIXON, Auteur ; Jenny BOURKE, Auteur ; Karina AIBERTI, Auteur ; Natasha NASSAR, Auteur ; Carol BOWER, Auteur ; Emma J. GLASSON, Auteur Année de publication : 2010 Article en page(s) : p.548-554 Langues : Anglais (eng) Mots-clés : Autistic-disorder Autism Autism-spectrum-disorder Diagnosis Intellectual-disability Autism-epidemic Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders is unknown but there are claims of increasing prevalence in many countries. Despite more than a decade of epidemiological investigation, it is still unclear whether the rising trend in prevalence reflects a true increase or changes in diagnostic trends and improvements in case ascertainment. This paper discusses changes in diagnostic criteria, decreasing age at diagnosis, improved case ascertainment, diagnostic substitution, and social and cultural influences on the overall effects on prevalence, including the role of an ASD diagnosis as a gateway to funding. The evidence suggests that the increased prevalence of autism spectrum disorder can be partly supported by each of these factors, but remains largely unquantified due to a variety of other global and local factors. The question of how much of a real increase in prevalence has occurred remains crucially important to understand the classification, epidemiology and etiology of autism spectrum disorders but can only be answered if controlling these other factors. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.01.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Unpacking the complex nature of the autism epidemic [Texte imprimé et/ou numérique] / Helen LEONARD, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Glenys DIXON, Auteur ; Jenny BOURKE, Auteur ; Karina AIBERTI, Auteur ; Natasha NASSAR, Auteur ; Carol BOWER, Auteur ; Emma J. GLASSON, Auteur . - 2010 . - p.548-554. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.548-554 Mots-clés : Autistic-disorder Autism Autism-spectrum-disorder Diagnosis Intellectual-disability Autism-epidemic Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders is unknown but there are claims of increasing prevalence in many countries. Despite more than a decade of epidemiological investigation, it is still unclear whether the rising trend in prevalence reflects a true increase or changes in diagnostic trends and improvements in case ascertainment. This paper discusses changes in diagnostic criteria, decreasing age at diagnosis, improved case ascertainment, diagnostic substitution, and social and cultural influences on the overall effects on prevalence, including the role of an ASD diagnosis as a gateway to funding. The evidence suggests that the increased prevalence of autism spectrum disorder can be partly supported by each of these factors, but remains largely unquantified due to a variety of other global and local factors. The question of how much of a real increase in prevalence has occurred remains crucially important to understand the classification, epidemiology and etiology of autism spectrum disorders but can only be answered if controlling these other factors. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.01.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

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