Annual Research Review: Progress in using brain morphometry as a clinical tool for diagnosing psychiatric disorders / Alexander HAUBOLD in Journal of Child Psychology and Psychiatry, 53-5 (May 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-5 (May 2012) . - p.519-535 Titre : Annual Research Review: Progress in using brain morphometry as a clinical tool for diagnosing psychiatric disorders Type de document : texte imprimé Auteurs : Alexander HAUBOLD, Auteur ; Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur Année de publication : 2012 Article en page(s) : p.519-535 Langues : Anglais (eng) Mots-clés : Machine learning  brain morphometry  automated diagnosis  cortical thickness  psychiatric disorders  cross validationsupport vector machines Index. décimale : PER Périodiques Résumé : Brain morphometry in recent decades has increased our understanding of the neural bases of psychiatric disorders by localizing anatomical disturbances to specific nuclei and subnuclei of the brain. At least some of these disturbances precede the overt expression of clinical symptoms and possibly are endophenotypes that could be used to diagnose an individual accurately as having a specific psychiatric disorder. More accurate diagnoses could significantly reduce the emotional and financial burden of disease by aiding clinicians in implementing appropriate treatments earlier and in tailoring treatment to the individual needs. Several methods, especially those based on machine learning, have been proposed that use anatomical brain measures and gold-standard diagnoses of participants to learn decision rules that classify a person automatically as having one disorder rather than another. We review the general principles and procedures for machine learning, particularly as applied to diagnostic classification, and then review the procedures that have thus far attempted to diagnose psychiatric illnesses automatically using anatomical measures of the brain. We discuss the strengths and limitations of extant procedures and note that the sensitivity and specificity of these procedures in their most successful implementations have approximated 90%. Although these methods have not yet been applied within clinical settings, they provide strong evidence that individual patients can be diagnosed accurately using the spatial pattern of disturbances across the brain. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02539.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 [article] Annual Research Review: Progress in using brain morphometry as a clinical tool for diagnosing psychiatric disorders [texte imprimé] / Alexander HAUBOLD, Auteur ; Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur . - 2012 . - p.519-535. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-5 (May 2012) . - p.519-535 Mots-clés : Machine learning  brain morphometry  automated diagnosis  cortical thickness  psychiatric disorders  cross validationsupport vector machines Index. décimale : PER Périodiques Résumé : Brain morphometry in recent decades has increased our understanding of the neural bases of psychiatric disorders by localizing anatomical disturbances to specific nuclei and subnuclei of the brain. At least some of these disturbances precede the overt expression of clinical symptoms and possibly are endophenotypes that could be used to diagnose an individual accurately as having a specific psychiatric disorder. More accurate diagnoses could significantly reduce the emotional and financial burden of disease by aiding clinicians in implementing appropriate treatments earlier and in tailoring treatment to the individual needs. Several methods, especially those based on machine learning, have been proposed that use anatomical brain measures and gold-standard diagnoses of participants to learn decision rules that classify a person automatically as having one disorder rather than another. We review the general principles and procedures for machine learning, particularly as applied to diagnostic classification, and then review the procedures that have thus far attempted to diagnose psychiatric illnesses automatically using anatomical measures of the brain. We discuss the strengths and limitations of extant procedures and note that the sensitivity and specificity of these procedures in their most successful implementations have approximated 90%. Although these methods have not yet been applied within clinical settings, they provide strong evidence that individual patients can be diagnosed accurately using the spatial pattern of disturbances across the brain. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02539.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154

Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults / Sahar DELAVARI ; Jonathan SADIK ; Lars ERSLAND ; Irene ELGEN ; Siddhant SAWARDEKAR ; Ravi BANSAL ; Stein Magnus AUKLAND in Journal of Child Psychology and Psychiatry, 66-5 (May 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.635-649 Titre : Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults Type de document : texte imprimé Auteurs : Sahar DELAVARI, Auteur ; Jonathan SADIK, Auteur ; Lars ERSLAND, Auteur ; Irene ELGEN, Auteur ; Siddhant SAWARDEKAR, Auteur ; Ravi BANSAL, Auteur ; Stein Magnus AUKLAND, Auteur Article en page(s) : p.635-649 Langues : Anglais (eng) Mots-clés : Premature birth  preterm birth  magnetic resonance imaging  diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Background Fifteen million infants annually are born prematurely, placing them at high risk for life-long adverse neurodevelopmental outcomes. Whether brain tissue abnormalities that accompany preterm birth persist into young adulthood and are associated with long-term cognitive or psychiatric outcomes is not known. Methods From infancy into young adulthood, we followed a population-based sample of consecutively identified preterm infants and their matched term controls. The preterm group was born at an average gestational age of 31.5+2.6 weeks. We obtained Diffusion Tensor Imaging scans and assessed cognitive and psychiatric outcomes in young adulthood, at a mean age of 19 (range 17.6 20.8) years. Usable data were acquired from 180 participants (89 preterm, 91 term). Results Preterm birth was associated with lower fractional anisotropy (FA) and higher average diffusion coefficient (ADC) values in deep white matter tracts of the internal capsule, cerebral peduncles, inferior frontal-occipital fasciculus, sagittal stratum and splenium of the corpus callosum, as well as in grey matter of the caudate, putamen and thalamus. A younger gestational age at birth accentuated these tissue abnormalities. Perinatal characteristics, including lower 5-min APGAR score, history of bronchopulmonary dysplasia, more days of oxygen supplementation and multiple births all increased ADC values in deep white matter tracts and grey matter throughout the brain. Preterm individuals had significantly lower full-scale IQ and more frequent lifetime psychiatric disorders. Those with psychiatric illnesses had significantly higher ADC and lower FA values throughout the deep posterior white matter. Conclusions Abnormalities in brain tissue microstructure associated with preterm birth persist into young adulthood and likely represent disordered myelination and accompanying axonal pathology. These disturbances are associated with a higher likelihood of developing a psychiatric disorder by young adulthood. Brain tissue disturbances were accentuated in those born at younger gestational ages and in those with a history of perinatal complications associated with infection and inflammation. En ligne : https://doi.org/10.1111/jcpp.14069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults [texte imprimé] / Sahar DELAVARI, Auteur ; Jonathan SADIK, Auteur ; Lars ERSLAND, Auteur ; Irene ELGEN, Auteur ; Siddhant SAWARDEKAR, Auteur ; Ravi BANSAL, Auteur ; Stein Magnus AUKLAND, Auteur . - p.635-649. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.635-649 Mots-clés : Premature birth  preterm birth  magnetic resonance imaging  diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Background Fifteen million infants annually are born prematurely, placing them at high risk for life-long adverse neurodevelopmental outcomes. Whether brain tissue abnormalities that accompany preterm birth persist into young adulthood and are associated with long-term cognitive or psychiatric outcomes is not known. Methods From infancy into young adulthood, we followed a population-based sample of consecutively identified preterm infants and their matched term controls. The preterm group was born at an average gestational age of 31.5+2.6 weeks. We obtained Diffusion Tensor Imaging scans and assessed cognitive and psychiatric outcomes in young adulthood, at a mean age of 19 (range 17.6 20.8) years. Usable data were acquired from 180 participants (89 preterm, 91 term). Results Preterm birth was associated with lower fractional anisotropy (FA) and higher average diffusion coefficient (ADC) values in deep white matter tracts of the internal capsule, cerebral peduncles, inferior frontal-occipital fasciculus, sagittal stratum and splenium of the corpus callosum, as well as in grey matter of the caudate, putamen and thalamus. A younger gestational age at birth accentuated these tissue abnormalities. Perinatal characteristics, including lower 5-min APGAR score, history of bronchopulmonary dysplasia, more days of oxygen supplementation and multiple births all increased ADC values in deep white matter tracts and grey matter throughout the brain. Preterm individuals had significantly lower full-scale IQ and more frequent lifetime psychiatric disorders. Those with psychiatric illnesses had significantly higher ADC and lower FA values throughout the deep posterior white matter. Conclusions Abnormalities in brain tissue microstructure associated with preterm birth persist into young adulthood and likely represent disordered myelination and accompanying axonal pathology. These disturbances are associated with a higher likelihood of developing a psychiatric disorder by young adulthood. Brain tissue disturbances were accentuated in those born at younger gestational ages and in those with a history of perinatal complications associated with infection and inflammation. En ligne : https://doi.org/10.1111/jcpp.14069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis / Petya D. RADOEVA in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Titre : Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis Type de document : texte imprimé Auteurs : Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur Article en page(s) : p.305-314 Langues : Anglais (eng) Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis [texte imprimé] / Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur . - p.305-314. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood / Erik DE WATER in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.1010-1020 Titre : A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood Type de document : texte imprimé Auteurs : Erik DE WATER, Auteur ; Paul CURTIN, Auteur ; Anna ZILVERSTAND, Auteur ; A. SJODIN, Auteur ; Anny BONILLA, Auteur ; Julie B. HERBSTMAN, Auteur ; Judyth RAMIREZ, Auteur ; Amy E. MARGOLIS, Auteur ; Ravi BANSAL, Auteur ; Robin M. WHYATT, Auteur ; Bradley S. PETERSON, Auteur ; Pam FACTOR-LITVAK, Auteur ; Megan K. HORTON, Auteur Article en page(s) : p.1010-1020 Langues : Anglais (eng) Mots-clés : Children  executive functioning  flame retardants  pregnancy  resting state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. METHODS: In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE concentrations measured in maternal serum and intrinsic functional network organization (i.e., global and local efficiency; estimated using a graph-theoretical approach) in 5-year-old children (n = 34). We explored whether PBDE serum concentrations were associated with executive functioning (EF) assessed using a parent-report questionnaire (BRIEF-P) (n = 106) and whether changes in intrinsic functional network organization linked the association between prenatal PBDE serum concentrations and EF problems. RESULTS: Children with higher prenatal PBDE serum concentrations showed: (a) increased global efficiency of brain areas involved in visual attention (e.g., inferior occipital gyrus) (beta's = .01, FDR-corrected p's En ligne : http://dx.doi.org/10.1111/jcpp.13040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood [texte imprimé] / Erik DE WATER, Auteur ; Paul CURTIN, Auteur ; Anna ZILVERSTAND, Auteur ; A. SJODIN, Auteur ; Anny BONILLA, Auteur ; Julie B. HERBSTMAN, Auteur ; Judyth RAMIREZ, Auteur ; Amy E. MARGOLIS, Auteur ; Ravi BANSAL, Auteur ; Robin M. WHYATT, Auteur ; Bradley S. PETERSON, Auteur ; Pam FACTOR-LITVAK, Auteur ; Megan K. HORTON, Auteur . - p.1010-1020. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.1010-1020 Mots-clés : Children  executive functioning  flame retardants  pregnancy  resting state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. METHODS: In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE concentrations measured in maternal serum and intrinsic functional network organization (i.e., global and local efficiency; estimated using a graph-theoretical approach) in 5-year-old children (n = 34). We explored whether PBDE serum concentrations were associated with executive functioning (EF) assessed using a parent-report questionnaire (BRIEF-P) (n = 106) and whether changes in intrinsic functional network organization linked the association between prenatal PBDE serum concentrations and EF problems. RESULTS: Children with higher prenatal PBDE serum concentrations showed: (a) increased global efficiency of brain areas involved in visual attention (e.g., inferior occipital gyrus) (beta's = .01, FDR-corrected p's En ligne : http://dx.doi.org/10.1111/jcpp.13040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331 Titre : Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood Type de document : texte imprimé Auteurs : Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy E. MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia A. RAUH, Auteur Article en page(s) : p.1316-1331 Langues : Anglais (eng) Mots-clés : Male  Adolescent  Pregnancy  Female  Humans  Child  Prenatal Exposure Delayed Effects/metabolism  Prospective Studies  Air Pollution/adverse effects  Brain  Particulate Matter/adverse effects/analysis/metabolism  Polycyclic Aromatic Hydrocarbons  Air Pollutants  Air pollution  arterial spin labeling  diffusion tensor imaging  magnetic resonance imaging  magnetic resonance spectroscopy  particulate matter  polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood [texte imprimé] / Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy E. MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia A. RAUH, Auteur . - p.1316-1331. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331 Mots-clés : Male  Adolescent  Pregnancy  Female  Humans  Child  Prenatal Exposure Delayed Effects/metabolism  Prospective Studies  Air Pollution/adverse effects  Brain  Particulate Matter/adverse effects/analysis/metabolism  Polycyclic Aromatic Hydrocarbons  Air Pollutants  Air pollution  arterial spin labeling  diffusion tensor imaging  magnetic resonance imaging  magnetic resonance spectroscopy  particulate matter  polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome / Kerstin J. PLESSEN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

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Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders / Angela TSENG in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

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Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

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