Annual Research Review: Progress in using brain morphometry as a clinical tool for diagnosing psychiatric disorders / Alexander HAUBOLD in Journal of Child Psychology and Psychiatry, 53-5 (May 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-5 (May 2012) . - p.519-535 Titre : Annual Research Review: Progress in using brain morphometry as a clinical tool for diagnosing psychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : Alexander HAUBOLD, Auteur ; Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur Année de publication : 2012 Article en page(s) : p.519-535 Langues : Anglais (eng) Mots-clés : Machine learning  brain morphometry  automated diagnosis  cortical thickness  psychiatric disorders  cross validationsupport vector machines Index. décimale : PER Périodiques Résumé : Brain morphometry in recent decades has increased our understanding of the neural bases of psychiatric disorders by localizing anatomical disturbances to specific nuclei and subnuclei of the brain. At least some of these disturbances precede the overt expression of clinical symptoms and possibly are endophenotypes that could be used to diagnose an individual accurately as having a specific psychiatric disorder. More accurate diagnoses could significantly reduce the emotional and financial burden of disease by aiding clinicians in implementing appropriate treatments earlier and in tailoring treatment to the individual needs. Several methods, especially those based on machine learning, have been proposed that use anatomical brain measures and gold-standard diagnoses of participants to learn decision rules that classify a person automatically as having one disorder rather than another. We review the general principles and procedures for machine learning, particularly as applied to diagnostic classification, and then review the procedures that have thus far attempted to diagnose psychiatric illnesses automatically using anatomical measures of the brain. We discuss the strengths and limitations of extant procedures and note that the sensitivity and specificity of these procedures in their most successful implementations have approximated 90%. Although these methods have not yet been applied within clinical settings, they provide strong evidence that individual patients can be diagnosed accurately using the spatial pattern of disturbances across the brain. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02539.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 [article] Annual Research Review: Progress in using brain morphometry as a clinical tool for diagnosing psychiatric disorders [Texte imprimé et/ou numérique] / Alexander HAUBOLD, Auteur ; Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur . - 2012 . - p.519-535. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-5 (May 2012) . - p.519-535 Mots-clés : Machine learning  brain morphometry  automated diagnosis  cortical thickness  psychiatric disorders  cross validationsupport vector machines Index. décimale : PER Périodiques Résumé : Brain morphometry in recent decades has increased our understanding of the neural bases of psychiatric disorders by localizing anatomical disturbances to specific nuclei and subnuclei of the brain. At least some of these disturbances precede the overt expression of clinical symptoms and possibly are endophenotypes that could be used to diagnose an individual accurately as having a specific psychiatric disorder. More accurate diagnoses could significantly reduce the emotional and financial burden of disease by aiding clinicians in implementing appropriate treatments earlier and in tailoring treatment to the individual needs. Several methods, especially those based on machine learning, have been proposed that use anatomical brain measures and gold-standard diagnoses of participants to learn decision rules that classify a person automatically as having one disorder rather than another. We review the general principles and procedures for machine learning, particularly as applied to diagnostic classification, and then review the procedures that have thus far attempted to diagnose psychiatric illnesses automatically using anatomical measures of the brain. We discuss the strengths and limitations of extant procedures and note that the sensitivity and specificity of these procedures in their most successful implementations have approximated 90%. Although these methods have not yet been applied within clinical settings, they provide strong evidence that individual patients can be diagnosed accurately using the spatial pattern of disturbances across the brain. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02539.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154

Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis / Petya D. RADOEVA in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Titre : Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur Article en page(s) : p.305-314 Langues : Anglais (eng) Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis [Texte imprimé et/ou numérique] / Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur . - p.305-314. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331 Titre : Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia RAUH, Auteur Article en page(s) : p.1316-1331 Langues : Anglais (eng) Mots-clés : Male  Adolescent  Pregnancy  Female  Humans  Child  Prenatal Exposure Delayed Effects/metabolism  Prospective Studies  Air Pollution/adverse effects  Brain  Particulate Matter/adverse effects/analysis/metabolism  Polycyclic Aromatic Hydrocarbons  Air Pollutants  Air pollution  arterial spin labeling  diffusion tensor imaging  magnetic resonance imaging  magnetic resonance spectroscopy  particulate matter  polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood [Texte imprimé et/ou numérique] / Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia RAUH, Auteur . - p.1316-1331. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331 Mots-clés : Male  Adolescent  Pregnancy  Female  Humans  Child  Prenatal Exposure Delayed Effects/metabolism  Prospective Studies  Air Pollution/adverse effects  Brain  Particulate Matter/adverse effects/analysis/metabolism  Polycyclic Aromatic Hydrocarbons  Air Pollutants  Air pollution  arterial spin labeling  diffusion tensor imaging  magnetic resonance imaging  magnetic resonance spectroscopy  particulate matter  polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome / Kerstin J. PLESSEN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1013–1022 Titre : Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Kerstin J. PLESSEN, Auteur ; Astri J. LUNDERVOLD, Auteur ; Bradley S. PETERSON, Auteur ; Achim GASS, Auteur ; Stein Atle LIE, Auteur ; Tore WENTZEL-LARSEN, Auteur ; Åsa HAMMAR, Auteur ; Ravi BANSAL, Auteur ; Dongrong XU, Auteur ; Jochen G. HIRSCH, Auteur ; Arvid LUNDERVOLD, Auteur ; Renate GRUNER, Auteur ; Kenneth HUGDAHL, Auteur Année de publication : 2007 Article en page(s) : p.1013–1022 Langues : Anglais (eng) Mots-clés : Tourette-syndrome brain-development brain-imaging Index. décimale : PER Périodiques Résumé : Background: Brain imaging studies have revealed anatomical anomalies in the brains of individuals with Tourette syndrome (TS). Prefrontal regions have been found to be larger and the corpus callosum (CC) area smaller in children and young adults with TS compared with healthy control subjects, and these anatomical features have been understood to reflect neural plasticity that helps to attenuate the severity of tics. Method: CC white matter connectivity, as measured by the Fractional Anisotropy (FA) index from diffusion tensor images, was assessed in 20 clinically well-defined boys with Tourette syndrome and 20 age- and gender-matched controls. Results: The hypothesis that children with TS would show reduced measures of connectivity in CC fibers was confirmed for all subregions of the CC. There was no significant interaction of TS and region. Reductions in FA in CC regions may reflect either fewer interhemispheric fibers or reduced axonal myelination. FA values did not correlate significantly with the severity of tic symptoms. Group differences in measures of connectivity did not seem to be attributable to the presence of comorbid ADHD or OCD, to medication exposure, or group differences in IQ. Conclusion: Our findings of a reduced interhemispheral white matter connectivity add to the understanding of neural connectivity and plasticity in the brains of children who have TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01639.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791 [article] Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome [Texte imprimé et/ou numérique] / Kerstin J. PLESSEN, Auteur ; Astri J. LUNDERVOLD, Auteur ; Bradley S. PETERSON, Auteur ; Achim GASS, Auteur ; Stein Atle LIE, Auteur ; Tore WENTZEL-LARSEN, Auteur ; Åsa HAMMAR, Auteur ; Ravi BANSAL, Auteur ; Dongrong XU, Auteur ; Jochen G. HIRSCH, Auteur ; Arvid LUNDERVOLD, Auteur ; Renate GRUNER, Auteur ; Kenneth HUGDAHL, Auteur . - 2007 . - p.1013–1022. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1013–1022 Mots-clés : Tourette-syndrome brain-development brain-imaging Index. décimale : PER Périodiques Résumé : Background: Brain imaging studies have revealed anatomical anomalies in the brains of individuals with Tourette syndrome (TS). Prefrontal regions have been found to be larger and the corpus callosum (CC) area smaller in children and young adults with TS compared with healthy control subjects, and these anatomical features have been understood to reflect neural plasticity that helps to attenuate the severity of tics. Method: CC white matter connectivity, as measured by the Fractional Anisotropy (FA) index from diffusion tensor images, was assessed in 20 clinically well-defined boys with Tourette syndrome and 20 age- and gender-matched controls. Results: The hypothesis that children with TS would show reduced measures of connectivity in CC fibers was confirmed for all subregions of the CC. There was no significant interaction of TS and region. Reductions in FA in CC regions may reflect either fewer interhemispheric fibers or reduced axonal myelination. FA values did not correlate significantly with the severity of tic symptoms. Group differences in measures of connectivity did not seem to be attributable to the presence of comorbid ADHD or OCD, to medication exposure, or group differences in IQ. Conclusion: Our findings of a reduced interhemispheral white matter connectivity add to the understanding of neural connectivity and plasticity in the brains of children who have TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01639.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791

Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders / Angela TSENG in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1332-1346 Titre : Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Angela TSENG, Auteur ; Ravi BANSAL, Auteur ; Jun LIU, Auteur ; Andrew J. GERBER, Auteur ; Suzanne GOH, Auteur ; Jonathan POSNER, Auteur ; Tiziano COLIBAZZI, Auteur ; Molly ALGERMISSEN, Auteur ; I. Chin CHIANG, Auteur ; James A. RUSSELL, Auteur ; Bradley S. PETERSON, Auteur Article en page(s) : p.1332-1346 Langues : Anglais (eng) Mots-clés : Circumplex model of affect  Valence  Arousal  Autism spectrum disorders  Facial emotion Index. décimale : PER Périodiques Résumé : The Affective Circumplex Model holds that emotions can be described as linear combinations of two underlying, independent neurophysiological systems (arousal, valence). Given research suggesting individuals with autism spectrum disorders (ASD) have difficulty processing emotions, we used the circumplex model to compare how individuals with ASD and typically-developing (TD) individuals respond to facial emotions. Participants (51 ASD, 80 TD) rated facial expressions along arousal and valence dimensions; we fitted closed, smooth, 2-dimensional curves to their ratings to examine overall circumplex contours. We modeled individual and group influences on parameters describing curve contours to identify differences in dimensional effects across groups. Significant main effects of diagnosis indicated the ASD-group’s ratings were constricted for the entire circumplex, suggesting range constriction across all emotions. Findings did not change when covarying for overall intelligence. En ligne : http://dx.doi.org/10.1007/s10803-013-1993-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Angela TSENG, Auteur ; Ravi BANSAL, Auteur ; Jun LIU, Auteur ; Andrew J. GERBER, Auteur ; Suzanne GOH, Auteur ; Jonathan POSNER, Auteur ; Tiziano COLIBAZZI, Auteur ; Molly ALGERMISSEN, Auteur ; I. Chin CHIANG, Auteur ; James A. RUSSELL, Auteur ; Bradley S. PETERSON, Auteur . - p.1332-1346. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1332-1346 Mots-clés : Circumplex model of affect  Valence  Arousal  Autism spectrum disorders  Facial emotion Index. décimale : PER Périodiques Résumé : The Affective Circumplex Model holds that emotions can be described as linear combinations of two underlying, independent neurophysiological systems (arousal, valence). Given research suggesting individuals with autism spectrum disorders (ASD) have difficulty processing emotions, we used the circumplex model to compare how individuals with ASD and typically-developing (TD) individuals respond to facial emotions. Participants (51 ASD, 80 TD) rated facial expressions along arousal and valence dimensions; we fitted closed, smooth, 2-dimensional curves to their ratings to examine overall circumplex contours. We modeled individual and group influences on parameters describing curve contours to identify differences in dimensional effects across groups. Significant main effects of diagnosis indicated the ASD-group’s ratings were constricted for the entire circumplex, suggesting range constriction across all emotions. Findings did not change when covarying for overall intelligence. En ligne : http://dx.doi.org/10.1007/s10803-013-1993-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

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