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Auteur Amy MARGOLIS |
Documents disponibles écrits par cet auteur (2)



Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial / Yun WANG in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
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[article]
Titre : Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Yun WANG, Auteur ; Ellen KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur Article en page(s) : p.1381-1391 Langues : Anglais (eng) Mots-clés : Adolescent Humans Child Young Adult Adult Lisdexamfetamine Dimesylate/pharmacology/therapeutic use Central Nervous System Stimulants/pharmacology Attention Deficit Disorder with Hyperactivity Brain Mapping Brain/diagnostic imaging Magnetic Resonance Imaging Adhd Dynamic Functional MRI (fMRI) Lisdexamfetamine Striatum Structural Equation Modeling Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391[article] Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial [Texte imprimé et/ou numérique] / Yun WANG, Auteur ; Ellen KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur . - p.1381-1391.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391
Mots-clés : Adolescent Humans Child Young Adult Adult Lisdexamfetamine Dimesylate/pharmacology/therapeutic use Central Nervous System Stimulants/pharmacology Attention Deficit Disorder with Hyperactivity Brain Mapping Brain/diagnostic imaging Magnetic Resonance Imaging Adhd Dynamic Functional MRI (fMRI) Lisdexamfetamine Striatum Structural Equation Modeling Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
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[article]
Titre : Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia RAUH, Auteur Article en page(s) : p.1316-1331 Langues : Anglais (eng) Mots-clés : Male Adolescent Pregnancy Female Humans Child Prenatal Exposure Delayed Effects/metabolism Prospective Studies Air Pollution/adverse effects Brain Particulate Matter/adverse effects/analysis/metabolism Polycyclic Aromatic Hydrocarbons Air Pollutants Air pollution arterial spin labeling diffusion tensor imaging magnetic resonance imaging magnetic resonance spectroscopy particulate matter polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331[article] Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood [Texte imprimé et/ou numérique] / Bradley S. PETERSON, Auteur ; Ravi BANSAL, Auteur ; Siddhant SAWARDEKAR, Auteur ; Carlo NATI, Auteur ; Eman R. ELGABALAWY, Auteur ; Lori A. HOEPNER, Auteur ; Wanda GARCIA, Auteur ; Xuejun HAO, Auteur ; Amy MARGOLIS, Auteur ; Frederica PERERA, Auteur ; Virginia RAUH, Auteur . - p.1316-1331.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1316-1331
Mots-clés : Male Adolescent Pregnancy Female Humans Child Prenatal Exposure Delayed Effects/metabolism Prospective Studies Air Pollution/adverse effects Brain Particulate Matter/adverse effects/analysis/metabolism Polycyclic Aromatic Hydrocarbons Air Pollutants Air pollution arterial spin labeling diffusion tensor imaging magnetic resonance imaging magnetic resonance spectroscopy particulate matter polycyclic aromatic hydrocarbons Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. METHODS: In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM(2.5) ) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6-14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization. RESULTS: Both exposures were associated with thinning of dorsal parietal cortices and thickening of postero-inferior and mesial wall cortices. They were associated with smaller white matter volumes, reduced organization in white matter of the internal capsule and frontal lobe, higher metabolite concentrations in frontal cortex, reduced cortical blood flow, and greater microstructural organization in subcortical gray matter nuclei. Associations were stronger for PM(2.5) in boys and PAH in girls. Youth with low exposure accounted for most significant associations of ADHD, anxiety, socialization, and intelligence measures with cortical thickness and white matter volumes, whereas it appears that high exposures generally disrupted these neurotypical brain-behavior associations, likely because strong exposure-related effects increased the variances of these brain measures. CONCLUSIONS: The commonality of effects across exposures suggests PM(2.5) and PAH disrupt brain development through one or more common molecular pathways, such as inflammation or oxidative stress. Progressively higher exposures were associated with greater disruptions in local volumes, tissue organization, metabolite concentrations, and blood flow throughout cortical and subcortical brain regions and the white matter pathways interconnecting them. Together these affected regions comprise cortico-striato-thalamo-cortical circuits, which support the regulation of thought, emotion, and behavior. En ligne : http://dx.doi.org/10.1111/jcpp.13578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490