Beyond orchids and dandelions: Susceptibility to environmental influences is not bimodal / Xiaoya ZHANG in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.191-203 Titre : Beyond orchids and dandelions: Susceptibility to environmental influences is not bimodal Type de document : texte imprimé Auteurs : Xiaoya ZHANG, Auteur ; Keith WIDAMAN, Auteur ; Jay BELSKY, Auteur Article en page(s) : p.191-203 Langues : Anglais (eng) Mots-clés : differential susceptibility  domain general versus specific  polygenic scores  susceptibility continuum  temperament Index. décimale : PER Périodiques Résumé : This study focused on generality versus specificity of susceptibility of effects of eight family and child-care exposures measured between 3 and 54 months of age (e.g., sensitive parenting, child-care quality) on five child development outcomes assessed at age 4.5 years (e.g. behavior problems, preacademic skill), using data from The National Institute of Child Health and Human Development (NICHD) Study of Early Child Care and Youth Development (n = 1,364, boys = 705; White = 1,097, Black = 176, other = 91), while applying a novel influence-statistics method. Results indicated that susceptibility across the environment-predictor:child-outcome associations is normally rather than bimodally (i.e., orchid-dandelion) distributed. Analysis of susceptibility documents both domain generality and specificity of developmental plasticity, with effect sizes proving small in the former case. As predicted, children who as infants had difficult temperaments or who scored higher on a polygenic-plasticity score (serotonin-transporter-linked promoter region [5-HTTLPR], dopamine receptor D4 [DRD4], brain-derived neurotrophic factor [BDNF]) proved somewhat more susceptible to some of the environmental effects investigated. Results lead to the recommendation that two-types-of-individuals vis-a-vis susceptibility to environmental influences be questioned and general-trait conceptions of susceptibility be further investigated. En ligne : https://doi.org/10.1017/S0954579421000821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Beyond orchids and dandelions: Susceptibility to environmental influences is not bimodal [texte imprimé] / Xiaoya ZHANG, Auteur ; Keith WIDAMAN, Auteur ; Jay BELSKY, Auteur . - p.191-203. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.191-203 Mots-clés : differential susceptibility  domain general versus specific  polygenic scores  susceptibility continuum  temperament Index. décimale : PER Périodiques Résumé : This study focused on generality versus specificity of susceptibility of effects of eight family and child-care exposures measured between 3 and 54 months of age (e.g., sensitive parenting, child-care quality) on five child development outcomes assessed at age 4.5 years (e.g. behavior problems, preacademic skill), using data from The National Institute of Child Health and Human Development (NICHD) Study of Early Child Care and Youth Development (n = 1,364, boys = 705; White = 1,097, Black = 176, other = 91), while applying a novel influence-statistics method. Results indicated that susceptibility across the environment-predictor:child-outcome associations is normally rather than bimodally (i.e., orchid-dandelion) distributed. Analysis of susceptibility documents both domain generality and specificity of developmental plasticity, with effect sizes proving small in the former case. As predicted, children who as infants had difficult temperaments or who scored higher on a polygenic-plasticity score (serotonin-transporter-linked promoter region [5-HTTLPR], dopamine receptor D4 [DRD4], brain-derived neurotrophic factor [BDNF]) proved somewhat more susceptible to some of the environmental effects investigated. Results lead to the recommendation that two-types-of-individuals vis-a-vis susceptibility to environmental influences be questioned and general-trait conceptions of susceptibility be further investigated. En ligne : https://doi.org/10.1017/S0954579421000821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses / Jay BELSKY in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143 Titre : Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses Type de document : texte imprimé Auteurs : Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur Article en page(s) : p.1135-1143 Langues : Anglais (eng) Mots-clés : Gene-environment interaction  diathesis-stress  differential susceptibility  child care  DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses [texte imprimé] / Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur . - p.1135-1143. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143 Mots-clés : Gene-environment interaction  diathesis-stress  differential susceptibility  child care  DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes / Jay BELSKY in Development and Psychopathology, 27-3 (August 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-3 (August 2015) . - p.725-746 Titre : Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes Type de document : texte imprimé Auteurs : Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur Article en page(s) : p.725-746 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Here we tested whether there was genetic moderation of effects of early maternal sensitivity on social-emotional and cognitive-linguistic development from early childhood onward and whether any detected Gene × Environment interaction effects proved consistent with differential-susceptibility or diathesis-stress models of Person × Environment interaction (N = 695). Two new approaches for evaluating models were employed with 12 candidate genes. Whereas maternal sensitivity proved to be a consistent predictor of child functioning across the primary-school years, candidate genes did not show many main effects, nor did they tend to interact with maternal sensitivity/insensitivity. These findings suggest that the developmental benefits of early sensitive mothering and the costs of insensitive mothering look more similar than different across genetically different children in the current sample. Although acknowledgement of this result is important, it is equally important that the generally null Gene × Environment results reported here not be overgeneralized to other samples, other predictors, other outcomes, and other candidate genes. En ligne : http://dx.doi.org/10.1017/S0954579414000844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes [texte imprimé] / Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur . - p.725-746. Langues : Anglais (eng) in Development and Psychopathology > 27-3 (August 2015) . - p.725-746 Index. décimale : PER Périodiques Résumé : Here we tested whether there was genetic moderation of effects of early maternal sensitivity on social-emotional and cognitive-linguistic development from early childhood onward and whether any detected Gene × Environment interaction effects proved consistent with differential-susceptibility or diathesis-stress models of Person × Environment interaction (N = 695). Two new approaches for evaluating models were employed with 12 candidate genes. Whereas maternal sensitivity proved to be a consistent predictor of child functioning across the primary-school years, candidate genes did not show many main effects, nor did they tend to interact with maternal sensitivity/insensitivity. These findings suggest that the developmental benefits of early sensitive mothering and the costs of insensitive mothering look more similar than different across genetically different children in the current sample. Although acknowledgement of this result is important, it is equally important that the generally null Gene × Environment results reported here not be overgeneralized to other samples, other predictors, other outcomes, and other candidate genes. En ligne : http://dx.doi.org/10.1017/S0954579414000844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes—CORRIGENDUM / Jay BELSKY in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1569-1570 Titre : Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes—CORRIGENDUM Type de document : texte imprimé Auteurs : Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur Article en page(s) : p.1569-1570 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579414001497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes—CORRIGENDUM [texte imprimé] / Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur . - p.1569-1570. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1569-1570 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579414001497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model / Alexia JOLICOEUR-MARTINEAU in Development and Psychopathology, 32-1 (February 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-1 (February 2020) . - p.73-83 Titre : Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model Type de document : texte imprimé Auteurs : Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M.T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur Article en page(s) : p.73-83 Langues : Anglais (eng) Mots-clés : diathesis-stress  differential-susceptibility  gene-by-environment interaction  regions of significance  vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model [texte imprimé] / Alexia JOLICOEUR-MARTINEAU, Auteur ; Jay BELSKY, Auteur ; Eszter SZEKELY, Auteur ; Keith F. WIDAMAN, Auteur ; Michael PLUESS, Auteur ; Celia M.T. GREENWOOD, Auteur ; Ashley WAZANA, Auteur . - p.73-83. Langues : Anglais (eng) in Development and Psychopathology > 32-1 (February 2020) . - p.73-83 Mots-clés : diathesis-stress  differential-susceptibility  gene-by-environment interaction  regions of significance  vantage sensitivity Index. décimale : PER Périodiques Résumé : Currently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype x Environment interaction (G x E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G x E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G x E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N >/= 500 and (b) when effect size was large and N >/= 250, whereas RoS performed poorly. Computational tools to determine the type of G x E of multiple genes and environments are provided as extensions in our LEGIT R package. En ligne : http://dx.doi.org/10.1017/s0954579418001438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Editorial Perspective: Integrating exploratory and competitive–confirmatory approaches to testing person × environment interactions / Jay BELSKY in Journal of Child Psychology and Psychiatry, 59-3 (March 2018)  

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Evaluation of the interactionist model of socioeconomic status and problem behavior: A developmental cascade across generations / Monica J. MARTIN in Development and Psychopathology, 22-3 (August 2010)  

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Externalizing symptoms, effortful control, and intrusive parenting: A test of bidirectional longitudinal relations during early childhood / Nancy EISENBERG in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

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Genetic moderation of effects of maternal sensitivity on girl's age of menarche: Replication of the Manuck et al. study / Sarah HARTMAN in Development and Psychopathology, 27-3 (August 2015)  

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Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes / Keith F. WIDAMAN in Development and Psychopathology, 35-3 (August 2023)  

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Parenting and adolescents’ psychological adjustment: Longitudinal moderation by adolescents’ genetic sensitivity / Clare M. STOCKER in Development and Psychopathology, 29-4 (October 2017)  

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Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment / Stephanie M. SANSONE in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

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Social and economic antecedents and consequences of adolescent aggressive personality: Predictions from the interactionist model / Rand D. CONGER in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

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The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions / David HESSL in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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