A Bayesian approach for exploring person?*?environment interaction within the environmental sensitivity meta-framework / Francesca LIONETTI in Journal of Child Psychology and Psychiatry, 65-11 (November 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1486-1500 Titre : A Bayesian approach for exploring person?*?environment interaction within the environmental sensitivity meta-framework Type de document : Texte imprimé et/ou numérique Auteurs : Francesca LIONETTI, Auteur ; Antonio CALCAGNÌ, Auteur ; Giulio D'URSO, Auteur ; Maria SPINELLI, Auteur ; Mirco FASOLO, Auteur ; Michael PLUESS, Auteur ; Massimiliano PASTORE, Auteur Article en page(s) : p.1486-1500 Langues : Anglais (eng) Mots-clés : Differential susceptibility  diathesis-stress  vantage sensitivity  Bayesian approach  MCMC estimates Index. décimale : PER Périodiques Résumé : Background For investigating the individual?environment interplay and individual differences in response to environmental exposures as captured by models of environmental sensitivity including Diathesis-stress, Differential Susceptibility, and Vantage Sensitivity, over the last few years, a series of statistical guidelines have been proposed. However, available solutions suffer of computational problems especially relevant when sample size is not sufficiently large, a common condition in observational and clinical studies. Method In the current contribution, we propose a Bayesian solution for estimating interaction parameters via Monte Carlo Markov Chains (MCMC), adapting Widaman et al. (Psychological Methods, 17, 2012, 615) Nonlinear Least Squares (NLS) approach. Results Findings from an applied exemplification and a simulation study showed that with relatively big samples both MCMC and NLS estimates converged on the same results. Conversely, MCMC clearly outperformed NLS, resolving estimation problems and providing more accurate estimates, particularly with small samples and greater residual variance. Conclusions As the body of research exploring the interplay between individual and environmental variables grows, enabling predictions regarding the form of interaction and the extent of effects, the Bayesian approach could emerge as a feasible and readily applicable solution to numerous computational challenges inherent in existing frequentist methods. This approach holds promise for enhancing the trustworthiness of research outcomes, thereby impacting clinical and applied understanding. En ligne : https://doi.org/10.1111/jcpp.14000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] A Bayesian approach for exploring person?*?environment interaction within the environmental sensitivity meta-framework [Texte imprimé et/ou numérique] / Francesca LIONETTI, Auteur ; Antonio CALCAGNÌ, Auteur ; Giulio D'URSO, Auteur ; Maria SPINELLI, Auteur ; Mirco FASOLO, Auteur ; Michael PLUESS, Auteur ; Massimiliano PASTORE, Auteur . - p.1486-1500. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1486-1500 Mots-clés : Differential susceptibility  diathesis-stress  vantage sensitivity  Bayesian approach  MCMC estimates Index. décimale : PER Périodiques Résumé : Background For investigating the individual?environment interplay and individual differences in response to environmental exposures as captured by models of environmental sensitivity including Diathesis-stress, Differential Susceptibility, and Vantage Sensitivity, over the last few years, a series of statistical guidelines have been proposed. However, available solutions suffer of computational problems especially relevant when sample size is not sufficiently large, a common condition in observational and clinical studies. Method In the current contribution, we propose a Bayesian solution for estimating interaction parameters via Monte Carlo Markov Chains (MCMC), adapting Widaman et al. (Psychological Methods, 17, 2012, 615) Nonlinear Least Squares (NLS) approach. Results Findings from an applied exemplification and a simulation study showed that with relatively big samples both MCMC and NLS estimates converged on the same results. Conversely, MCMC clearly outperformed NLS, resolving estimation problems and providing more accurate estimates, particularly with small samples and greater residual variance. Conclusions As the body of research exploring the interplay between individual and environmental variables grows, enabling predictions regarding the form of interaction and the extent of effects, the Bayesian approach could emerge as a feasible and readily applicable solution to numerous computational challenges inherent in existing frequentist methods. This approach holds promise for enhancing the trustworthiness of research outcomes, thereby impacting clinical and applied understanding. En ligne : https://doi.org/10.1111/jcpp.14000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study / Robert KEERS in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1921-1933 Titre : Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study Type de document : Texte imprimé et/ou numérique Auteurs : Robert KEERS, Auteur ; Michael PLUESS, Auteur Article en page(s) : p.1921-1933 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study [Texte imprimé et/ou numérique] / Robert KEERS, Auteur ; Michael PLUESS, Auteur . - p.1921-1933. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1921-1933 Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses / Jay BELSKY in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143 Titre : Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur Article en page(s) : p.1135-1143 Langues : Anglais (eng) Mots-clés : Gene-environment interaction  diathesis-stress  differential susceptibility  child care  DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur . - p.1135-1143. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143 Mots-clés : Gene-environment interaction  diathesis-stress  differential susceptibility  child care  DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression / Patricia P. SILVEIRA in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1601-1617 Titre : Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression Type de document : Texte imprimé et/ou numérique Auteurs : Patricia P. SILVEIRA, Auteur ; Irina POKHVISNEVA, Auteur ; Carine PARENT, Auteur ; Shirong CAI, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.1601-1617 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene. Prenatal adversities were computed in two community birth cohorts using information on health during pregnancy, birth weight, gestational age, income, domestic violence/sexual abuse, marital strain, as well as maternal smoking, anxiety, and depression. A genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. Prenatal adversities predicted a wide range of developmental and behavioral alterations in children as young as 2 years of age in both cohorts. There were interactions between the genetic score and adversities for several domains of the Child Behavior Checklist (CBCL), with pervasive developmental problems remaining significant adjustment for multiple comparisons. Scores combining different prenatal adverse exposures predict childhood behavior and interact with the genetic background to influence the risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression [Texte imprimé et/ou numérique] / Patricia P. SILVEIRA, Auteur ; Irina POKHVISNEVA, Auteur ; Carine PARENT, Auteur ; Shirong CAI, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur . - p.1601-1617. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1601-1617 Index. décimale : PER Périodiques Résumé : While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene. Prenatal adversities were computed in two community birth cohorts using information on health during pregnancy, birth weight, gestational age, income, domestic violence/sexual abuse, marital strain, as well as maternal smoking, anxiety, and depression. A genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. Prenatal adversities predicted a wide range of developmental and behavioral alterations in children as young as 2 years of age in both cohorts. There were interactions between the genetic score and adversities for several domains of the Child Behavior Checklist (CBCL), with pervasive developmental problems remaining significant adjustment for multiple comparisons. Scores combining different prenatal adverse exposures predict childhood behavior and interact with the genetic background to influence the risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes / Jay BELSKY in Development and Psychopathology, 27-3 (August 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-3 (August 2015) . - p.725-746 Titre : Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur Article en page(s) : p.725-746 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Here we tested whether there was genetic moderation of effects of early maternal sensitivity on social-emotional and cognitive-linguistic development from early childhood onward and whether any detected Gene × Environment interaction effects proved consistent with differential-susceptibility or diathesis-stress models of Person × Environment interaction (N = 695). Two new approaches for evaluating models were employed with 12 candidate genes. Whereas maternal sensitivity proved to be a consistent predictor of child functioning across the primary-school years, candidate genes did not show many main effects, nor did they tend to interact with maternal sensitivity/insensitivity. These findings suggest that the developmental benefits of early sensitive mothering and the costs of insensitive mothering look more similar than different across genetically different children in the current sample. Although acknowledgement of this result is important, it is equally important that the generally null Gene × Environment results reported here not be overgeneralized to other samples, other predictors, other outcomes, and other candidate genes. En ligne : http://dx.doi.org/10.1017/S0954579414000844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur . - p.725-746. Langues : Anglais (eng) in Development and Psychopathology > 27-3 (August 2015) . - p.725-746 Index. décimale : PER Périodiques Résumé : Here we tested whether there was genetic moderation of effects of early maternal sensitivity on social-emotional and cognitive-linguistic development from early childhood onward and whether any detected Gene × Environment interaction effects proved consistent with differential-susceptibility or diathesis-stress models of Person × Environment interaction (N = 695). Two new approaches for evaluating models were employed with 12 candidate genes. Whereas maternal sensitivity proved to be a consistent predictor of child functioning across the primary-school years, candidate genes did not show many main effects, nor did they tend to interact with maternal sensitivity/insensitivity. These findings suggest that the developmental benefits of early sensitive mothering and the costs of insensitive mothering look more similar than different across genetically different children in the current sample. Although acknowledgement of this result is important, it is equally important that the generally null Gene × Environment results reported here not be overgeneralized to other samples, other predictors, other outcomes, and other candidate genes. En ligne : http://dx.doi.org/10.1017/S0954579414000844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes—CORRIGENDUM / Jay BELSKY in Development and Psychopathology, 28-4 pt2 (November 2016)  

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Differential susceptibility to rearing experience: the case of childcare / Michael PLUESS in Journal of Child Psychology and Psychiatry, 50-4 (April 2009)  

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Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model / Alexia JOLICOEUR-MARTINEAU in Development and Psychopathology, 32-1 (February 2020)  

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Effects of maternal sensitivity on low birth weight children's academic achievement: a test of differential susceptibility versus diathesis stress / Julia JAEKEL in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

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Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys / Michael PLUESS in Development and Psychopathology, 34-3 (August 2022)  

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Investigating sensitivity through the lens of parents: validation of the parent-report version of the Highly Sensitive Child scale / Alessandra SPERATI in Development and Psychopathology, 36-1 (February 2024)  

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Polygenic differential susceptibility to prenatal adversity / Jay BELSKY in Development and Psychopathology, 31-2 (May 2019)  

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Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation / Sandra MACHLITT-NORTHEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

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Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study / Desiree Y. PHUA in Development and Psychopathology, 29-5 (December 2017)  

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Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study—CORRIGENDUM / Desiree Y. PHUA in Development and Psychopathology, 30-4 (October 2018)  

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