Autism and social robotics: A systematic review / Paola PENNISI in Autism Research, 9-2 (February 2016)  

Public ISBD [article]  inAutism Research > 9-2 (February 2016) . - p.165-183 Titre : Autism and social robotics: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Paola PENNISI, Auteur ; Alessandro TONACCI, Auteur ; Gennaro TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; Liliana RUTA, Auteur ; Sebastiano GANGEMI, Auteur ; Giovanni PIOGGIA, Auteur Article en page(s) : p.165-183 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  social robotics  autism therapy  humanoid robots  autism diagnosis Index. décimale : PER Périodiques Résumé : Social robotics could be a promising method for Autism Spectrum Disorders (ASD) treatment. The aim of this article is to carry out a systematic literature review of the studies on this topic that were published in the last 10 years. We tried to address the following questions: can social robots be a useful tool in autism therapy? We followed the PRISMA guidelines, and the protocol was registered within PROSPERO database (CRD42015016158). We found many positive implications in the use of social robots in therapy as for example: ASD subjects often performed better with a robot partner rather than a human partner; sometimes, ASD patients had, toward robots, behaviors that TD patients had toward human agents; ASDs had a lot of social behaviors toward robots; during robotic sessions, ASDs showed reduced repetitive and stereotyped behaviors and, social robots manage to improve spontaneous language during therapy sessions. Therefore, robots provide therapists and researchers a means to connect with autistic subjects in an easier way, but studies in this area are still insufficient. It is necessary to clarify whether sex, intelligence quotient, and age of participants affect the outcome of therapy and whether any beneficial effects only occur during the robotic session or if they are still observable outside the clinical/experimental context. En ligne : http://dx.doi.org/10.1002/aur.1527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Autism and social robotics: A systematic review [Texte imprimé et/ou numérique] / Paola PENNISI, Auteur ; Alessandro TONACCI, Auteur ; Gennaro TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; Liliana RUTA, Auteur ; Sebastiano GANGEMI, Auteur ; Giovanni PIOGGIA, Auteur . - p.165-183. Langues : Anglais (eng) in Autism Research > 9-2 (February 2016) . - p.165-183 Mots-clés : autism spectrum disorder  social robotics  autism therapy  humanoid robots  autism diagnosis Index. décimale : PER Périodiques Résumé : Social robotics could be a promising method for Autism Spectrum Disorders (ASD) treatment. The aim of this article is to carry out a systematic literature review of the studies on this topic that were published in the last 10 years. We tried to address the following questions: can social robots be a useful tool in autism therapy? We followed the PRISMA guidelines, and the protocol was registered within PROSPERO database (CRD42015016158). We found many positive implications in the use of social robots in therapy as for example: ASD subjects often performed better with a robot partner rather than a human partner; sometimes, ASD patients had, toward robots, behaviors that TD patients had toward human agents; ASDs had a lot of social behaviors toward robots; during robotic sessions, ASDs showed reduced repetitive and stereotyped behaviors and, social robots manage to improve spontaneous language during therapy sessions. Therefore, robots provide therapists and researchers a means to connect with autistic subjects in an easier way, but studies in this area are still insufficient. It is necessary to clarify whether sex, intelligence quotient, and age of participants affect the outcome of therapy and whether any beneficial effects only occur during the robotic session or if they are still observable outside the clinical/experimental context. En ligne : http://dx.doi.org/10.1002/aur.1527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Brief Report: Peculiar Evolution of Autistic Behaviors in Two Unrelated Children with Brachidactyly-Mental Retardation Syndrome / Luigi MAZZONE in Journal of Autism and Developmental Disorders, 42-10 (October 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2202-2207 Titre : Brief Report: Peculiar Evolution of Autistic Behaviors in Two Unrelated Children with Brachidactyly-Mental Retardation Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Luigi MAZZONE, Auteur ; Lia VASSENA, Auteur ; Liliana RUTA, Auteur ; Diego MUGNO, Auteur ; Ornella GALESI, Auteur ; Marco FICHERA, Auteur Année de publication : 2012 Article en page(s) : p.2202-2207 Langues : Anglais (eng) Mots-clés : Autism  2q37 region  BDMR  Evolutionary course Index. décimale : PER Périodiques Résumé : Brachidactyly-Mental Retardation (BDMR) Syndrome (MIM 600430) is associated with terminal deletions at chromosome 2q37 and a limited number of studies also reported an association between 2q37 → qter deletion and autism. Herein we describe two cases of autism in unrelated children with BDMR Syndrome, showing physical, cognitive, behavioral, and disease natural history homologies, with a very prominent social impairment in the first 4 years of life. At follow-up evaluations, spanning a 5-years period, both children experienced a progressive reduction of the autistic symptoms, besides retaining compromised cognitive ability. This report supports the hypothesis that genes in the 2q37 region may contribute to the etiology of autism, leading, however, to a peculiar evolution of the disease, with symptoms severity decreasing over time. En ligne : http://dx.doi.org/10.1007/s10803-011-1432-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Brief Report: Peculiar Evolution of Autistic Behaviors in Two Unrelated Children with Brachidactyly-Mental Retardation Syndrome [Texte imprimé et/ou numérique] / Luigi MAZZONE, Auteur ; Lia VASSENA, Auteur ; Liliana RUTA, Auteur ; Diego MUGNO, Auteur ; Ornella GALESI, Auteur ; Marco FICHERA, Auteur . - 2012 . - p.2202-2207. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2202-2207 Mots-clés : Autism  2q37 region  BDMR  Evolutionary course Index. décimale : PER Périodiques Résumé : Brachidactyly-Mental Retardation (BDMR) Syndrome (MIM 600430) is associated with terminal deletions at chromosome 2q37 and a limited number of studies also reported an association between 2q37 → qter deletion and autism. Herein we describe two cases of autism in unrelated children with BDMR Syndrome, showing physical, cognitive, behavioral, and disease natural history homologies, with a very prominent social impairment in the first 4 years of life. At follow-up evaluations, spanning a 5-years period, both children experienced a progressive reduction of the autistic symptoms, besides retaining compromised cognitive ability. This report supports the hypothesis that genes in the 2q37 region may contribute to the etiology of autism, leading, however, to a peculiar evolution of the disease, with symptoms severity decreasing over time. En ligne : http://dx.doi.org/10.1007/s10803-011-1432-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

Implementation of the Early Start Denver Model in an Italian community / Costanza COLOMBI in Autism, 22-2 (February 2018)  

Public ISBD [article]  inAutism > 22-2 (February 2018) . - p.126-133 Titre : Implementation of the Early Start Denver Model in an Italian community Type de document : Texte imprimé et/ou numérique Auteurs : Costanza COLOMBI, Auteur ; Antonio NARZISI, Auteur ; Liliana RUTA, Auteur ; Virginia CIGALA, Auteur ; Antonella GAGLIANO, Auteur ; Giovanni PIOGGIA, Auteur ; Rosamaria SIRACUSANO, Auteur ; Sally J ROGERS, Auteur ; Filippo MURATORI, Auteur ; Prima Pietra TEAM, Auteur Année de publication : 2018 Article en page(s) : p.126-133 Langues : Anglais (eng) Mots-clés : autism,autism spectrum disorder,early intervention,Early Start Denver Model,preschoolers Index. décimale : PER Périodiques Résumé : Identifying effective, community-based specialized interventions for young children with autism spectrum disorder is an international clinical and research priority. We evaluated the effectiveness of the Early Start Denver Model intervention in a group of young children with autism spectrum disorder living in an Italian community compared to a group of Italian children who received treatment as usual. A total of 22 young children diagnosed with autism spectrum disorder received the Early Start Denver Model in a center-based context for 6?h per week over 6?months. The Early Start Denver Model group was compared to a group of 70 young children diagnosed with autism spectrum disorder who received treatment as usual for an average of 5.2?h over 6?months. Children in both groups improved in cognitive, adaptive, and social skills after 3?months and 6?months of treatment. Children in the Early Start Denver Model group made larger gains in cognitive and social skills after 3 and 6?months of treatment. The Early Start Denver Model group made larger gains in adaptive skills after 3?months of treatment. Our results are discussed in terms of implications for intervention research and clinical practice. Our study supports the positive impact of the Early Start Denver Model in a non-English-speaking community. En ligne : https://doi.org/10.1177/1362361316665792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335 [article] Implementation of the Early Start Denver Model in an Italian community [Texte imprimé et/ou numérique] / Costanza COLOMBI, Auteur ; Antonio NARZISI, Auteur ; Liliana RUTA, Auteur ; Virginia CIGALA, Auteur ; Antonella GAGLIANO, Auteur ; Giovanni PIOGGIA, Auteur ; Rosamaria SIRACUSANO, Auteur ; Sally J ROGERS, Auteur ; Filippo MURATORI, Auteur ; Prima Pietra TEAM, Auteur . - 2018 . - p.126-133. Langues : Anglais (eng) in Autism > 22-2 (February 2018) . - p.126-133 Mots-clés : autism,autism spectrum disorder,early intervention,Early Start Denver Model,preschoolers Index. décimale : PER Périodiques Résumé : Identifying effective, community-based specialized interventions for young children with autism spectrum disorder is an international clinical and research priority. We evaluated the effectiveness of the Early Start Denver Model intervention in a group of young children with autism spectrum disorder living in an Italian community compared to a group of Italian children who received treatment as usual. A total of 22 young children diagnosed with autism spectrum disorder received the Early Start Denver Model in a center-based context for 6?h per week over 6?months. The Early Start Denver Model group was compared to a group of 70 young children diagnosed with autism spectrum disorder who received treatment as usual for an average of 5.2?h over 6?months. Children in both groups improved in cognitive, adaptive, and social skills after 3?months and 6?months of treatment. Children in the Early Start Denver Model group made larger gains in cognitive and social skills after 3 and 6?months of treatment. The Early Start Denver Model group made larger gains in adaptive skills after 3?months of treatment. Our results are discussed in terms of implications for intervention research and clinical practice. Our study supports the positive impact of the Early Start Denver Model in a non-English-speaking community. En ligne : https://doi.org/10.1177/1362361316665792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335

Outcomes of a Robot-Assisted Social-Emotional Understanding Intervention for Young Children with Autism Spectrum Disorders / Flavia MARINO in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.1973-1987 Titre : Outcomes of a Robot-Assisted Social-Emotional Understanding Intervention for Young Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Flavia MARINO, Auteur ; Paola CHILA, Auteur ; Stefania TRUSSO SFRAZZETTO, Auteur ; Cristina CARROZZA, Auteur ; Ilaria CRIMI, Auteur ; Chiara FAILLA, Auteur ; Mario BUSA, Auteur ; Giuseppe BERNAVA, Auteur ; Gennaro TARTARISCO, Auteur ; David VAGNI, Auteur ; Liliana RUTA, Auteur ; Giovanni PIOGGIA, Auteur Article en page(s) : p.1973-1987 Langues : Anglais (eng) Mots-clés : Asd  Cbt  Emotion  Rct  Robot  Social Index. décimale : PER Périodiques Résumé : This study is a randomized control trial aimed at testing the role of a human-assisted social robot as an intervention mediator in a socio-emotional understanding protocol for children with autism spectrum disorders (ASD). Fourteen children (4-8 years old) were randomly assigned to 10 sessions of a cognitive behavioural therapy (CBT) intervention implemented in a group setting either with or without the assistance of a social robot. The CBT protocol was based on Rational Emotive Behaviour Therapy (REBT) principles. Pre- and post-intervention assessments were conducted using the Test of Emotional Comprehension (TEC) and the Emotional Lexicon Test (ELT). Substantial improvements in contextualized emotion recognition, comprehension and emotional perspective-taking through the use of human-assisted social robots were attained. En ligne : http://dx.doi.org/10.1007/s10803-019-03953-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 [article] Outcomes of a Robot-Assisted Social-Emotional Understanding Intervention for Young Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Flavia MARINO, Auteur ; Paola CHILA, Auteur ; Stefania TRUSSO SFRAZZETTO, Auteur ; Cristina CARROZZA, Auteur ; Ilaria CRIMI, Auteur ; Chiara FAILLA, Auteur ; Mario BUSA, Auteur ; Giuseppe BERNAVA, Auteur ; Gennaro TARTARISCO, Auteur ; David VAGNI, Auteur ; Liliana RUTA, Auteur ; Giovanni PIOGGIA, Auteur . - p.1973-1987. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.1973-1987 Mots-clés : Asd  Cbt  Emotion  Rct  Robot  Social Index. décimale : PER Périodiques Résumé : This study is a randomized control trial aimed at testing the role of a human-assisted social robot as an intervention mediator in a socio-emotional understanding protocol for children with autism spectrum disorders (ASD). Fourteen children (4-8 years old) were randomly assigned to 10 sessions of a cognitive behavioural therapy (CBT) intervention implemented in a group setting either with or without the assistance of a social robot. The CBT protocol was based on Rational Emotive Behaviour Therapy (REBT) principles. Pre- and post-intervention assessments were conducted using the Test of Emotional Comprehension (TEC) and the Emotional Lexicon Test (ELT). Substantial improvements in contextualized emotion recognition, comprehension and emotional perspective-taking through the use of human-assisted social robots were attained. En ligne : http://dx.doi.org/10.1007/s10803-019-03953-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425

Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome / Hannah STEEB in Molecular Autism, (January 2014)  

Public ISBD [article]  inMolecular Autism > (January 2014) Titre : Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Hannah STEEB, Auteur ; Jordan RAMSEY, Auteur ; Paul GUEST, Auteur ; Pawel STOCKI, Auteur ; Jason COOPER, Auteur ; Hassan RAHMOUNE, Auteur ; Erin INGUDOMNUKUL, Auteur ; Bonnie AUYEUNG, Auteur ; Liliana RUTA, Auteur ; Simon BARON-COHEN, Auteur ; Sabine BAHN, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The higher prevalence of Asperger Syndrome (AS) and other autism spectrum conditions in males has been known for many years. However, recent multiplex immunoassay profiling studies have shown that males and females with AS have distinct proteomic changes in serum. Here, we analysed sera from adults diagnosed with AS (males=14, females=16) and controls (males=13, females=16) not on medication at the time of sample collection, using a combination of multiplex immunoassay and shotgun label-free liquid chromatography mass spectrometry (LC-MSE). The main objective was to identify sex-specific serum protein changes associated with AS. Multiplex immunoassay profiling led to identification of 16 proteins that were significantly altered in AS individuals in a sex-specific manner. Three of these proteins were altered in females (ADIPO, IgA, APOA1), seven were changed in males (BMP6, CTGF, ICAM1, IL-12p70, IL-16, TF, TNF-alpha) and six were changed in both sexes but in opposite directions (CHGA, EPO, IL-3, TENA, PAP, SHBG). Shotgun LC-MSE profiling led to identification of 13 serum proteins which had significant sex-specific changes in the AS group and, of these, 12 were altered in females (APOC2, APOE, ARMC3, CLC4K, FETUB, GLCE, MRRP1, PTPA, RN149, TLE1, TRIPB, ZC3HE) and one protein was altered in males (RGPD4). The free androgen index in females with AS showed an increased ratio of 1.63 compared to controls.CONCLUSION:Taken together, the serum multiplex immunoassay and shotgun LC-MSE profiling results indicate that adult females with AS had alterations in proteins involved mostly in lipid transport and metabolism pathways, while adult males with AS showed changes predominantly in inflammation signalling. These results provide further evidence that the search for biomarkers or novel drug targets in AS may require stratification into male and female subgroups, and could lead to the development of novel targeted treatment approaches. En ligne : http://dx.doi.org/10.1186/2040-2392-5-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome [Texte imprimé et/ou numérique] / Hannah STEEB, Auteur ; Jordan RAMSEY, Auteur ; Paul GUEST, Auteur ; Pawel STOCKI, Auteur ; Jason COOPER, Auteur ; Hassan RAHMOUNE, Auteur ; Erin INGUDOMNUKUL, Auteur ; Bonnie AUYEUNG, Auteur ; Liliana RUTA, Auteur ; Simon BARON-COHEN, Auteur ; Sabine BAHN, Auteur. Langues : Anglais (eng) in Molecular Autism > (January 2014) Index. décimale : PER Périodiques Résumé : The higher prevalence of Asperger Syndrome (AS) and other autism spectrum conditions in males has been known for many years. However, recent multiplex immunoassay profiling studies have shown that males and females with AS have distinct proteomic changes in serum. Here, we analysed sera from adults diagnosed with AS (males=14, females=16) and controls (males=13, females=16) not on medication at the time of sample collection, using a combination of multiplex immunoassay and shotgun label-free liquid chromatography mass spectrometry (LC-MSE). The main objective was to identify sex-specific serum protein changes associated with AS. Multiplex immunoassay profiling led to identification of 16 proteins that were significantly altered in AS individuals in a sex-specific manner. Three of these proteins were altered in females (ADIPO, IgA, APOA1), seven were changed in males (BMP6, CTGF, ICAM1, IL-12p70, IL-16, TF, TNF-alpha) and six were changed in both sexes but in opposite directions (CHGA, EPO, IL-3, TENA, PAP, SHBG). Shotgun LC-MSE profiling led to identification of 13 serum proteins which had significant sex-specific changes in the AS group and, of these, 12 were altered in females (APOC2, APOE, ARMC3, CLC4K, FETUB, GLCE, MRRP1, PTPA, RN149, TLE1, TRIPB, ZC3HE) and one protein was altered in males (RGPD4). The free androgen index in females with AS showed an increased ratio of 1.63 compared to controls.CONCLUSION:Taken together, the serum multiplex immunoassay and shotgun LC-MSE profiling results indicate that adult females with AS had alterations in proteins involved mostly in lipid transport and metabolism pathways, while adult males with AS showed changes predominantly in inflammation signalling. These results provide further evidence that the search for biomarkers or novel drug targets in AS may require stratification into male and female subgroups, and could lead to the development of novel targeted treatment approaches. En ligne : http://dx.doi.org/10.1186/2040-2392-5-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

The Autism-Spectrum Quotient—Italian Version: A Cross-Cultural Confirmation of the Broader Autism Phenotype / Liliana RUTA in Journal of Autism and Developmental Disorders, 42-4 (April 2012)  

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The Male Prevalence in Autism Spectrum Disorders : Hypotheses on its Neurobiological Basis / Flavio KELLER

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