Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders / Mikle SOUTH in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.412-421 Titre : Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders Type de document : texte imprimé Auteurs : Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur Année de publication : 2012 Article en page(s) : p.412-421 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  amygdala  anxiety  fear conditioning  dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders [texte imprimé] / Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur . - 2012 . - p.412-421. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.412-421 Mots-clés : autism spectrum disorders  amygdala  anxiety  fear conditioning  dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders / Anja S. EUSER in Development and Psychopathology, 25-4 (November 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-4 (November 2013) . - p.1119-1136 Titre : Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders Type de document : texte imprimé Auteurs : Anja S. EUSER, Auteur ; Kirstin GREAVES-LORD, Auteur ; Michael J. CROWLEY, Auteur ; Brittany E. EVANS, Auteur ; Anja C. HUIZINK, Auteur ; Ingmar H.A. FRANKEN, Auteur Article en page(s) : p.1119-1136 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Risky decision making, a hallmark phenotype of substance use disorders (SUD), is thought to be associated with deficient feedback processing. Whether these aberrations are present prior to SUD onset or reflect merely a consequence of chronic substance use on the brain remains unclear. The present study investigated whether blunted feedback processing during risky decision making reflects a biological predisposition to SUD. We assessed event-related potentials elicited by positive and negative feedback during performance of a modified version of the Balloon Analogue Risk Task (BART) among high-risk adolescents with a parental history of SUD (HR; n = 61) and normal-risk controls (NR; n = 91). HR males made significantly more risky and faster decisions during the BART than did NR controls. Moreover, HR adolescents showed significantly reduced P300 amplitudes in response to both positive and negative feedback as compared to NR controls. These differences were not secondary to prolonged substance use exposure. Results are discussed in terms of feedback-specific processes. Reduced P300 amplitudes in the BART may reflect poor processing of feedback at the level of overall salience, which may keep people from effectively predicting the probability of future gains and losses. Though conclusions are tentative, blunted feedback processing during risky decision making may represent a promising endophenotypic vulnerability marker for SUD. En ligne : http://dx.doi.org/10.1017/S0954579413000412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders [texte imprimé] / Anja S. EUSER, Auteur ; Kirstin GREAVES-LORD, Auteur ; Michael J. CROWLEY, Auteur ; Brittany E. EVANS, Auteur ; Anja C. HUIZINK, Auteur ; Ingmar H.A. FRANKEN, Auteur . - p.1119-1136. Langues : Anglais (eng) in Development and Psychopathology > 25-4 (November 2013) . - p.1119-1136 Index. décimale : PER Périodiques Résumé : Risky decision making, a hallmark phenotype of substance use disorders (SUD), is thought to be associated with deficient feedback processing. Whether these aberrations are present prior to SUD onset or reflect merely a consequence of chronic substance use on the brain remains unclear. The present study investigated whether blunted feedback processing during risky decision making reflects a biological predisposition to SUD. We assessed event-related potentials elicited by positive and negative feedback during performance of a modified version of the Balloon Analogue Risk Task (BART) among high-risk adolescents with a parental history of SUD (HR; n = 61) and normal-risk controls (NR; n = 91). HR males made significantly more risky and faster decisions during the BART than did NR controls. Moreover, HR adolescents showed significantly reduced P300 amplitudes in response to both positive and negative feedback as compared to NR controls. These differences were not secondary to prolonged substance use exposure. Results are discussed in terms of feedback-specific processes. Reduced P300 amplitudes in the BART may reflect poor processing of feedback at the level of overall salience, which may keep people from effectively predicting the probability of future gains and losses. Though conclusions are tentative, blunted feedback processing during risky decision making may represent a promising endophenotypic vulnerability marker for SUD. En ligne : http://dx.doi.org/10.1017/S0954579413000412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) / Lars O. WHITE in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.1011-1013 Titre : Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) Type de document : texte imprimé Auteurs : Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Bertram MÃœLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur Article en page(s) : p.1011-1013 Langues : Anglais (eng) Mots-clés : Maltreatment  psychopathology Index. décimale : PER Périodiques Résumé : We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view. En ligne : http://dx.doi.org/10.1111/jcpp.12770 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) [texte imprimé] / Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Bertram MÃœLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur . - p.1011-1013. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.1011-1013 Mots-clés : Maltreatment  psychopathology Index. décimale : PER Périodiques Résumé : We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view. En ligne : http://dx.doi.org/10.1111/jcpp.12770 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Early processing (N170) of infant faces in mothers of children with autism spectrum disorder and its association with maternal sensitivity / C. MARQUEZ in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.744-758 Titre : Early processing (N170) of infant faces in mothers of children with autism spectrum disorder and its association with maternal sensitivity Type de document : texte imprimé Auteurs : C. MARQUEZ, Auteur ; Humberto NICOLINI, Auteur ; Michael J. CROWLEY, Auteur ; R. SOLIS-VIVANCO, Auteur Article en page(s) : p.744-758 Langues : Anglais (eng) Mots-clés : N170  autism spectrum disorder  event-related potential  infant face processing  maternal sensitivity  mothers Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit impaired adult facial processing, as shown by the N170 event-related potential. However, few studies explore such processing in mothers of children with ASD, and none has assessed the early processing of infant faces in these women. Moreover, whether processing of infant facial expressions in mothers of children with ASD is related to their response to their child's needs (maternal sensitivity [MS]) remains unknown. This study explored the N170 related to infant faces in a group of mothers of children with ASD (MA) and a reference group of mothers of children without ASD. For both emotional (crying, smiling) and neutral expressions, the MA group exhibited larger amplitudes of N170 in the right hemisphere, while the reference group showed similar interhemispheric amplitudes. This lateralization effect within the MA group was not present for nonfaces and was stronger in the mothers with higher MS. We propose that mothers of ASD children use specialized perceptual resources to process infant faces, and this specialization is mediated by MS. Our findings suggest that having an ASD child modulates mothers' early neurophysiological responsiveness to infant cues. Whether this modulation represents a biological marker or a response given by experience remains to be explored. Autism Research 2019, 12: 744-758. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: When mothers of children with autism spectrum disorder (ASD) see baby faces expressing emotions, they show a right-sided electrical response in the brain. This lateralization was stronger in mothers who were more sensitive to their children's needs. We conclude that having a child with ASD and being more attuned to their behavior generates a specialized pattern of brain activity when processing infant faces. Whether this pattern is biological or given by experience remains to be explored. En ligne : http://dx.doi.org/10.1002/aur.2102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Early processing (N170) of infant faces in mothers of children with autism spectrum disorder and its association with maternal sensitivity [texte imprimé] / C. MARQUEZ, Auteur ; Humberto NICOLINI, Auteur ; Michael J. CROWLEY, Auteur ; R. SOLIS-VIVANCO, Auteur . - p.744-758. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.744-758 Mots-clés : N170  autism spectrum disorder  event-related potential  infant face processing  maternal sensitivity  mothers Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit impaired adult facial processing, as shown by the N170 event-related potential. However, few studies explore such processing in mothers of children with ASD, and none has assessed the early processing of infant faces in these women. Moreover, whether processing of infant facial expressions in mothers of children with ASD is related to their response to their child's needs (maternal sensitivity [MS]) remains unknown. This study explored the N170 related to infant faces in a group of mothers of children with ASD (MA) and a reference group of mothers of children without ASD. For both emotional (crying, smiling) and neutral expressions, the MA group exhibited larger amplitudes of N170 in the right hemisphere, while the reference group showed similar interhemispheric amplitudes. This lateralization effect within the MA group was not present for nonfaces and was stronger in the mothers with higher MS. We propose that mothers of ASD children use specialized perceptual resources to process infant faces, and this specialization is mediated by MS. Our findings suggest that having an ASD child modulates mothers' early neurophysiological responsiveness to infant cues. Whether this modulation represents a biological marker or a response given by experience remains to be explored. Autism Research 2019, 12: 744-758. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: When mothers of children with autism spectrum disorder (ASD) see baby faces expressing emotions, they show a right-sided electrical response in the brain. This lateralization was stronger in mothers who were more sensitive to their children's needs. We conclude that having a child with ASD and being more attuned to their behavior generates a specialized pattern of brain activity when processing infant faces. Whether this pattern is biological or given by experience remains to be explored. En ligne : http://dx.doi.org/10.1002/aur.2102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study / Charlotte C. SCHULZ in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 573-585 Titre : Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study Type de document : texte imprimé Auteurs : Charlotte C. SCHULZ, Auteur ; Kai VON KLITZING, Auteur ; Lorenz DESERNO, Auteur ; Margaret A. SHERIDAN, Auteur ; Michael J. CROWLEY, Auteur ; Margerete J.S. SCHOETT, Auteur ; Ferdinand HOFFMANN, Auteur ; Arno VILLRINGER, Auteur ; Pascal VRTIÄŒKA, Auteur ; Lars O. WHITE, Auteur Article en page(s) : 573-585 Langues : Anglais (eng) Mots-clés : adolescence  emotional maltreatment  neglect  fMRI  social exclusion Index. décimale : PER Périodiques Résumé : Child maltreatment gives rise to atypical patterns of social functioning with peers which might be particularly pronounced in early adolescence when peer influence typically peaks. Yet, few neuroimaging studies in adolescents use peer interaction paradigms to parse neural correlates of distinct maltreatment exposures. This fMRI study examines effects of abuse, neglect, and emotional maltreatment (EM) among 98 youth (n = 58 maltreated; n = 40 matched controls) using an event-related Cyberball paradigm affording assessment of both social exclusion and inclusion across early and mid-adolescence ( 13.5 years, n = 50; >13.5 years, n = 48). Younger adolescents showed increased activation to social exclusion versus inclusion in regions implicated in mentalizing (e.g., superior temporal gyrus). Individual exposure-specific analyses suggested that neglect and EM coincided with less reduction of activation to social exclusion relative to inclusion in the dorsal anterior cingulate cortex/pre-supplementary motor area (dACC/pre-SMA) among younger versus older adolescents. Integrative follow-up analyses showed that EM accounted for this dACC/pre-SMA activation pattern over and above other exposures. Moreover, age-independent results within respective exposure groups revealed that greater magnitude of neglect predicted blunted exclusion-related activity in the parahippocampal gyrus, while EM predicted increased activation to social exclusion in the precuneus/posterior cingulate cortex. En ligne : http://dx.doi.org/10.1017/s0954579421001681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study [texte imprimé] / Charlotte C. SCHULZ, Auteur ; Kai VON KLITZING, Auteur ; Lorenz DESERNO, Auteur ; Margaret A. SHERIDAN, Auteur ; Michael J. CROWLEY, Auteur ; Margerete J.S. SCHOETT, Auteur ; Ferdinand HOFFMANN, Auteur ; Arno VILLRINGER, Auteur ; Pascal VRTIÄŒKA, Auteur ; Lars O. WHITE, Auteur . - 573-585. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 573-585 Mots-clés : adolescence  emotional maltreatment  neglect  fMRI  social exclusion Index. décimale : PER Périodiques Résumé : Child maltreatment gives rise to atypical patterns of social functioning with peers which might be particularly pronounced in early adolescence when peer influence typically peaks. Yet, few neuroimaging studies in adolescents use peer interaction paradigms to parse neural correlates of distinct maltreatment exposures. This fMRI study examines effects of abuse, neglect, and emotional maltreatment (EM) among 98 youth (n = 58 maltreated; n = 40 matched controls) using an event-related Cyberball paradigm affording assessment of both social exclusion and inclusion across early and mid-adolescence ( 13.5 years, n = 50; >13.5 years, n = 48). Younger adolescents showed increased activation to social exclusion versus inclusion in regions implicated in mentalizing (e.g., superior temporal gyrus). Individual exposure-specific analyses suggested that neglect and EM coincided with less reduction of activation to social exclusion relative to inclusion in the dorsal anterior cingulate cortex/pre-supplementary motor area (dACC/pre-SMA) among younger versus older adolescents. Integrative follow-up analyses showed that EM accounted for this dACC/pre-SMA activation pattern over and above other exposures. Moreover, age-independent results within respective exposure groups revealed that greater magnitude of neglect predicted blunted exclusion-related activity in the parahippocampal gyrus, while EM predicted increased activation to social exclusion in the precuneus/posterior cingulate cortex. En ligne : http://dx.doi.org/10.1017/s0954579421001681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Failure is Not an Option: Risk-Taking is Moderated by Anxiety and Also by Cognitive Ability in Children and Adolescents Diagnosed with an Autism Spectrum Disorder / Mikle SOUTH in Journal of Autism and Developmental Disorders, 41-1 (January 2011)  

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Frontal EEG asymmetry moderates the relation between borderline personality disorder features and feelings of social rejection in adolescents / Victoria E. STEAD in Development and Psychopathology, 35-2 (May 2023)  

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Inter-trial coherence of medial frontal theta oscillations linked to differential feedback processing in youth and young adults with autism / Stefon VAN NOORDT in Research in Autism Spectrum Disorders, 37 (May 2017)  

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Mood Symptoms and Emotional Responsiveness to Threat in School-Aged Children / Jessica L. BORELLI in Journal of Clinical Child & Adolescent Psychology, 40-2 (March-April 2011)  

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A potentiated startle study of uncertainty and contextual anxiety in adolescents diagnosed with autism spectrum disorder / Paul D. CHAMBERLAIN in Molecular Autism, (September 2013)  

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Preserved reward outcome processing in ASD as revealed by event-related potentials / James C. MCPARTLAND in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

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Psychophysiological and Behavioral Responses to a Novel Intruder Threat Task for Children on the Autism Spectrum / Mikle SOUTH in Journal of Autism and Developmental Disorders, 47-12 (December 2017)  

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Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence / Lars O. WHITE in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

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The N170 event-related potential reflects delayed neural response to faces when visual attention is directed to the eyes in youths with ASD / Termara PARKER in Autism Research, 14-7 (July 2021)  

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