Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? / Kerrie SHANDLEY in Autism Research, 7-5 (October 2014)  

Public ISBD [article]  inAutism Research > 7-5 (October 2014) . - p.535-542 Titre : Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur Article en page(s) : p.535-542 Langues : Anglais (eng) Mots-clés : porphyrins  biomarker  ASD diagnosis  ASD severity  heavy metals  mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n?=?70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n?=?36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n?=?54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? [Texte imprimé et/ou numérique] / Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur . - p.535-542. Langues : Anglais (eng) in Autism Research > 7-5 (October 2014) . - p.535-542 Mots-clés : porphyrins  biomarker  ASD diagnosis  ASD severity  heavy metals  mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n?=?70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n?=?36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n?=?54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder / Aleesha WHITELY in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.5072-5078 Titre : Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Aleesha WHITELY, Auteur ; Kerrie SHANDLEY, Auteur ; Minh HUYNH, Auteur ; Christine M. BROWN, Auteur ; David W. AUSTIN, Auteur ; Jahar BHOWMIK, Auteur Article en page(s) : p.5072-5078 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/etiology  Child  Female  Humans  Infant  Male  Meperidine  Mothers  Pregnancy  Risk Factors  Surveys and Questionnaires  Analgesia  Autism spectrum disorder  Breastfeeding  Labour interventions  Pregnancy complications Index. décimale : PER Périodiques Résumé : A succession of interconnected environmental factors is believed to contribute substantially to the development of autism spectrum disorder (ASD). This exploratory study therefore aims to identify potential risk factors for ASD that are associated with pregnancy, birth and infant feeding. Demographic and health-related data on children aged 3-13 years (N=4306) was collected through an online survey completed by biological mothers. A fitted logistic regression model identified advanced maternal age, prenatal bleeding, pre-eclampsia, perinatal pethidine usage, foetal distress before birth and male sex of child as associated with an increased risk of ASD, whereas longer gestational duration demonstrated a protective effect. These findings highlight potential risk factors and predictor interrelationships which may contribute to overall ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-021-05348-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Aleesha WHITELY, Auteur ; Kerrie SHANDLEY, Auteur ; Minh HUYNH, Auteur ; Christine M. BROWN, Auteur ; David W. AUSTIN, Auteur ; Jahar BHOWMIK, Auteur . - p.5072-5078. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.5072-5078 Mots-clés : Autism Spectrum Disorder/complications/etiology  Child  Female  Humans  Infant  Male  Meperidine  Mothers  Pregnancy  Risk Factors  Surveys and Questionnaires  Analgesia  Autism spectrum disorder  Breastfeeding  Labour interventions  Pregnancy complications Index. décimale : PER Périodiques Résumé : A succession of interconnected environmental factors is believed to contribute substantially to the development of autism spectrum disorder (ASD). This exploratory study therefore aims to identify potential risk factors for ASD that are associated with pregnancy, birth and infant feeding. Demographic and health-related data on children aged 3-13 years (N=4306) was collected through an online survey completed by biological mothers. A fitted logistic regression model identified advanced maternal age, prenatal bleeding, pre-eclampsia, perinatal pethidine usage, foetal distress before birth and male sex of child as associated with an increased risk of ASD, whereas longer gestational duration demonstrated a protective effect. These findings highlight potential risk factors and predictor interrelationships which may contribute to overall ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-021-05348-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Challenging child behaviours positively predict symptoms of posttraumatic stress disorder in parents of children with Autism Spectrum Disorder and Rare Diseases / Michelle STEWART in Research in Autism Spectrum Disorders, 69 (January 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 69 (January 2020) . - p.101467 Titre : Challenging child behaviours positively predict symptoms of posttraumatic stress disorder in parents of children with Autism Spectrum Disorder and Rare Diseases Type de document : Texte imprimé et/ou numérique Auteurs : Michelle STEWART, Auteur ; Alexandra SCHNABEL, Auteur ; David J. HALLFORD, Auteur ; Jane A. MCGILLIVRAY, Auteur ; David FORBES, Auteur ; Madeline FOSTER, Auteur ; Kerrie SHANDLEY, Auteur ; Madeleine GARDAM, Auteur ; David W. AUSTIN, Auteur Article en page(s) : p.101467 Langues : Anglais (eng) Mots-clés : Autism  ASD  Rare diseases  Traumatic stress  Trauma  PTSD Index. décimale : PER Périodiques Résumé : Background This study investigated the validity of conceptualising elevated stress in parents of children who exhibit challenging behaviour within the framework of posttraumatic stress disorder (PTSD). It was hypothesised that parents of children with autism spectrum disorder (ASD), and parents of children with a rare disease would endorse greater PTSD symptomatology than parents of typically developing (TD) children, and that challenging child behaviours would positively predict PTSD symptomatology. Method The Life Events Checklist for DSM-5, Developmental Behaviour Checklist (Parent) and PTSD Checklist for DSM-5 were administered to 395 parents. Results Significantly more PTSD symptomatology was reported by parents of children with ASD and parents of children with a rare disease than parents of TD children, and challenging child behaviours positively predicted PTSD symptomatology in both groups. Conclusion A PTSD framework may validly explain elevated stress among some parents of children with ASD and parents of children with a rare disease, and has important implications for support delivered to parents by healthcare providers. En ligne : https://doi.org/10.1016/j.rasd.2019.101467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Challenging child behaviours positively predict symptoms of posttraumatic stress disorder in parents of children with Autism Spectrum Disorder and Rare Diseases [Texte imprimé et/ou numérique] / Michelle STEWART, Auteur ; Alexandra SCHNABEL, Auteur ; David J. HALLFORD, Auteur ; Jane A. MCGILLIVRAY, Auteur ; David FORBES, Auteur ; Madeline FOSTER, Auteur ; Kerrie SHANDLEY, Auteur ; Madeleine GARDAM, Auteur ; David W. AUSTIN, Auteur . - p.101467. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 69 (January 2020) . - p.101467 Mots-clés : Autism  ASD  Rare diseases  Traumatic stress  Trauma  PTSD Index. décimale : PER Périodiques Résumé : Background This study investigated the validity of conceptualising elevated stress in parents of children who exhibit challenging behaviour within the framework of posttraumatic stress disorder (PTSD). It was hypothesised that parents of children with autism spectrum disorder (ASD), and parents of children with a rare disease would endorse greater PTSD symptomatology than parents of typically developing (TD) children, and that challenging child behaviours would positively predict PTSD symptomatology. Method The Life Events Checklist for DSM-5, Developmental Behaviour Checklist (Parent) and PTSD Checklist for DSM-5 were administered to 395 parents. Results Significantly more PTSD symptomatology was reported by parents of children with ASD and parents of children with a rare disease than parents of TD children, and challenging child behaviours positively predicted PTSD symptomatology in both groups. Conclusion A PTSD framework may validly explain elevated stress among some parents of children with ASD and parents of children with a rare disease, and has important implications for support delivered to parents by healthcare providers. En ligne : https://doi.org/10.1016/j.rasd.2019.101467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Reconceptualizing Autism: Moving Beyond the Behavioral to Address Cause, Cure and Prevention / Kerrie SHANDLEY in Autism Insights, 2 ([01/01/2010])  

Public ISBD [article]  inAutism Insights > 2 [01/01/2010] . - p.25-30 Titre : Reconceptualizing Autism: Moving Beyond the Behavioral to Address Cause, Cure and Prevention Type de document : Application, site Internet Auteurs : Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur Année de publication : 2010 Article en page(s) : p.25-30 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Since the publication of Leo Kanner’s seminal paper in 1943, there has been essentially no definitive light shed on the cause, prevention or cure of autism. It is our contention that the reason lies, at least in part, with the original psychiatric conceptualization of the condition and the subsequent acceptance of this framework by health professionals ever since. We suggest an urgent revision of autism as a disease state such that its operationalization in major diagnostic systems such as the Diagnostic and Statistical Manual of Mental Disorders and International Classification of Diseases recognizes the biological variables known to be associated with autism. En ligne : http://dx.doi.org/10.4137/AUI.S4592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Reconceptualizing Autism: Moving Beyond the Behavioral to Address Cause, Cure and Prevention [Application, site Internet] / Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur . - 2010 . - p.25-30. Langues : Anglais (eng) in Autism Insights > 2 [01/01/2010] . - p.25-30 Index. décimale : PER Périodiques Résumé : Since the publication of Leo Kanner’s seminal paper in 1943, there has been essentially no definitive light shed on the cause, prevention or cure of autism. It is our contention that the reason lies, at least in part, with the original psychiatric conceptualization of the condition and the subsequent acceptance of this framework by health professionals ever since. We suggest an urgent revision of autism as a disease state such that its operationalization in major diagnostic systems such as the Diagnostic and Statistical Manual of Mental Disorders and International Classification of Diseases recognizes the biological variables known to be associated with autism. En ligne : http://dx.doi.org/10.4137/AUI.S4592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

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