Appropriateness, Acceptability, and Feasibility of a Neurodiversity-Based Self-determination Program for Autistic Adults / T.A. Meridian MCDONALD in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2933-2953 Titre : Appropriateness, Acceptability, and Feasibility of a Neurodiversity-Based Self-determination Program for Autistic Adults Type de document : texte imprimé Auteurs : T.A. Meridian MCDONALD, Auteur ; Salima LALANI, Auteur ; Ivy CHEN, Auteur ; Claire M. COTTON, Auteur ; Lydia L. MACDONALD, Auteur ; Lana J. BOURSOULIAN, Auteur ; Jiahao WANG, Auteur ; Beth A. MALOW, Auteur Article en page(s) : p.2933-2953 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Published self-determination programs do not adequately address the needs of autistic adults. We designed a multi-component self-determination program, grounded in the neurodiversity paradigm, to help autistic adults achieve goals to improve their quality of life. The first phase involved 5 days of psychoeducation, practice, and social events; the second phase included 3 months of telecoaching; and the third phase included follow-up. Thirty-four university students coached 31 autistic adults on three evolving goals. On average, participants completed one goal per week. Most participants were satisfied with the program. We found that the program was appropriate, acceptable, and feasible. This program is a promising approach to helping autistic adults gain self-determination skills and improve their quality of life. En ligne : https://doi.org/10.1007/s10803-022-05598-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Appropriateness, Acceptability, and Feasibility of a Neurodiversity-Based Self-determination Program for Autistic Adults [texte imprimé] / T.A. Meridian MCDONALD, Auteur ; Salima LALANI, Auteur ; Ivy CHEN, Auteur ; Claire M. COTTON, Auteur ; Lydia L. MACDONALD, Auteur ; Lana J. BOURSOULIAN, Auteur ; Jiahao WANG, Auteur ; Beth A. MALOW, Auteur . - p.2933-2953. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2933-2953 Index. décimale : PER Périodiques Résumé : Published self-determination programs do not adequately address the needs of autistic adults. We designed a multi-component self-determination program, grounded in the neurodiversity paradigm, to help autistic adults achieve goals to improve their quality of life. The first phase involved 5 days of psychoeducation, practice, and social events; the second phase included 3 months of telecoaching; and the third phase included follow-up. Thirty-four university students coached 31 autistic adults on three evolving goals. On average, participants completed one goal per week. Most participants were satisfied with the program. We found that the program was appropriate, acceptable, and feasible. This program is a promising approach to helping autistic adults gain self-determination skills and improve their quality of life. En ligne : https://doi.org/10.1007/s10803-022-05598-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Autism and physical health across the lifespan / Emily S. KUSCHNER in Autism, 25-3 (April 2021)  

Public ISBD [article]  inAutism > 25-3 (April 2021) . - p.599-602 Titre : Autism and physical health across the lifespan Type de document : texte imprimé Auteurs : Emily S. KUSCHNER, Auteur ; Beth A. MALOW, Auteur Article en page(s) : p.599-602 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/13623613211006524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 [article] Autism and physical health across the lifespan [texte imprimé] / Emily S. KUSCHNER, Auteur ; Beth A. MALOW, Auteur . - p.599-602. Langues : Anglais (eng) in Autism > 25-3 (April 2021) . - p.599-602 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/13623613211006524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444

Behaviour, cognition, and autism symptoms and their relationship with sleep problem severity in young children with autism spectrum disorder / Stephanie ROUSSIS in Research in Autism Spectrum Disorders, 83 (May 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 83 (May 2021) . - 101743 Titre : Behaviour, cognition, and autism symptoms and their relationship with sleep problem severity in young children with autism spectrum disorder Type de document : texte imprimé Auteurs : Stephanie ROUSSIS, Auteur ; Amanda L. RICHDALE, Auteur ; Terry KATZ, Auteur ; Beth A. MALOW, Auteur ; Josephine BARBARO, Auteur ; Nancy SADKA, Auteur Article en page(s) : 101743 Langues : Anglais (eng) Mots-clés : Sleep problem  Behaviour  Autism  Young children Index. décimale : PER Périodiques Résumé : Background In autism, poor sleep begins in early childhood, varies in severity and is associated with behavioural difficulties. We examined relationships between sleep and behaviour in young children with autism and no, mild/typical or severe/atypical sleep problems to determine behavioural profiles that may differentiate sleep problem severity. Method Parents of children with autism aged 2- to 5-years reported on their child’s sleep behaviour (CSHQ), including additional written descriptions of sleep behaviours. Children were then classified as good sleepers or as having mild/typical or severe/atypical sleep problems using National Sleep Foundation guidelines and current sleep literature. The three sleep groups were compared on autistic severity (ADOS), cognition (Mullen Scales of Early Leaning) and behaviour (BASC-3). Results Parents of 46 children aged 24- to 71-months participated. The severe/atypical sleep group were more likely to have multiple severe sleep difficulties. The sleep groups did not differ on autism severity or cognition. The BASC-3 withdrawal subscale differentiated severe problem sleepers from the other groups, while BASC-3 inattention differentiated problem sleepers from good sleepers. The severe/atypical sleep problem group also had more overall behaviour problems than good sleepers Conclusions Social withdrawal and multiple, severe sleep difficulties may underlie difficulties in treating poor sleep in some autistic children, suggesting that an individualised approach to treatment is needed to address severe sleep concerns. Early detection and intervention for poor sleep may reduce or prevent significant sleep and behavioural concerns continuing into later childhood. Sleep interventions that include targeting attention and withdrawal behaviours may assist in in this regard. En ligne : https://doi.org/10.1016/j.rasd.2021.101743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446 [article] Behaviour, cognition, and autism symptoms and their relationship with sleep problem severity in young children with autism spectrum disorder [texte imprimé] / Stephanie ROUSSIS, Auteur ; Amanda L. RICHDALE, Auteur ; Terry KATZ, Auteur ; Beth A. MALOW, Auteur ; Josephine BARBARO, Auteur ; Nancy SADKA, Auteur . - 101743. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 83 (May 2021) . - 101743 Mots-clés : Sleep problem  Behaviour  Autism  Young children Index. décimale : PER Périodiques Résumé : Background In autism, poor sleep begins in early childhood, varies in severity and is associated with behavioural difficulties. We examined relationships between sleep and behaviour in young children with autism and no, mild/typical or severe/atypical sleep problems to determine behavioural profiles that may differentiate sleep problem severity. Method Parents of children with autism aged 2- to 5-years reported on their child’s sleep behaviour (CSHQ), including additional written descriptions of sleep behaviours. Children were then classified as good sleepers or as having mild/typical or severe/atypical sleep problems using National Sleep Foundation guidelines and current sleep literature. The three sleep groups were compared on autistic severity (ADOS), cognition (Mullen Scales of Early Leaning) and behaviour (BASC-3). Results Parents of 46 children aged 24- to 71-months participated. The severe/atypical sleep group were more likely to have multiple severe sleep difficulties. The sleep groups did not differ on autism severity or cognition. The BASC-3 withdrawal subscale differentiated severe problem sleepers from the other groups, while BASC-3 inattention differentiated problem sleepers from good sleepers. The severe/atypical sleep problem group also had more overall behaviour problems than good sleepers Conclusions Social withdrawal and multiple, severe sleep difficulties may underlie difficulties in treating poor sleep in some autistic children, suggesting that an individualised approach to treatment is needed to address severe sleep concerns. Early detection and intervention for poor sleep may reduce or prevent significant sleep and behavioural concerns continuing into later childhood. Sleep interventions that include targeting attention and withdrawal behaviours may assist in in this regard. En ligne : https://doi.org/10.1016/j.rasd.2021.101743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446

Brief report: Measures of effectiveness for single-question sleep problem screeners in children with autism spectrum disorder / Alison R. MARVIN in Research in Autism Spectrum Disorders, 80 (February 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 80 (February 2021) . - p.101699 Titre : Brief report: Measures of effectiveness for single-question sleep problem screeners in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Alison R. MARVIN, Auteur ; Daniel L. COURY, Auteur ; Beth A. MALOW, Auteur ; J. Kiely LAW, Auteur ; Amanda E. BENNETT, Auteur Article en page(s) : p.101699 Langues : Anglais (eng) Mots-clés : Autism  Sleep  Composite Sleep Disturbance Index  Screening  Primary care  Psychometrics Index. décimale : PER Périodiques Résumé : Background Although screening for sleep problems in children with ASD is recommended, primary care providers generally ask parents a single, high-level screening question about their child’s sleep. Can this capture whether a child has severe sleep problems? Method Parents of children with ASD ages 3–17 years recruited from a validated and verified US-based autism research registry completed an online survey on co-occurring conditions, including “degree of sleep problems”. The Composite Sleep Disturbance Index (CSDI) and its question on “parent satisfaction with current sleep pattern” were also incorporated. Results 610 parent/child dyads were analyzed. 377 (62%) children had severe sleep problems per CSDI; 215 (57%) were parent-rated with Moderate/Severe sleep problems. 219 (93%) of 233 children without a severe sleep problem on CSDI were parent-rated as having None/Mild sleep problems. 94% with Moderate/Severe sleep problems per parents had severe sleep problems per CSDI. However, 15% of those whose parents rated as None had a severe sleep problem. 200 (33%) children had a Mild sleep problem rating; of these, 134 (67%) had CSDI severe sleep problem and 66 (33%) did not. Conclusions A single question about sleep was good at classifying severe vs. non-severe sleep problems in children with ASD, especially with extreme responses. However, a single question was poor at classifying intermediate/non-extreme responses, and a significant number of children with severe sleep problems were missed. Screening with a short, validated questionnaire or asking more probing questions would assist in diagnosing most children with sleep problems. Parents may benefit from sleep education. En ligne : https://doi.org/10.1016/j.rasd.2020.101699 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Brief report: Measures of effectiveness for single-question sleep problem screeners in children with autism spectrum disorder [texte imprimé] / Alison R. MARVIN, Auteur ; Daniel L. COURY, Auteur ; Beth A. MALOW, Auteur ; J. Kiely LAW, Auteur ; Amanda E. BENNETT, Auteur . - p.101699. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 80 (February 2021) . - p.101699 Mots-clés : Autism  Sleep  Composite Sleep Disturbance Index  Screening  Primary care  Psychometrics Index. décimale : PER Périodiques Résumé : Background Although screening for sleep problems in children with ASD is recommended, primary care providers generally ask parents a single, high-level screening question about their child’s sleep. Can this capture whether a child has severe sleep problems? Method Parents of children with ASD ages 3–17 years recruited from a validated and verified US-based autism research registry completed an online survey on co-occurring conditions, including “degree of sleep problems”. The Composite Sleep Disturbance Index (CSDI) and its question on “parent satisfaction with current sleep pattern” were also incorporated. Results 610 parent/child dyads were analyzed. 377 (62%) children had severe sleep problems per CSDI; 215 (57%) were parent-rated with Moderate/Severe sleep problems. 219 (93%) of 233 children without a severe sleep problem on CSDI were parent-rated as having None/Mild sleep problems. 94% with Moderate/Severe sleep problems per parents had severe sleep problems per CSDI. However, 15% of those whose parents rated as None had a severe sleep problem. 200 (33%) children had a Mild sleep problem rating; of these, 134 (67%) had CSDI severe sleep problem and 66 (33%) did not. Conclusions A single question about sleep was good at classifying severe vs. non-severe sleep problems in children with ASD, especially with extreme responses. However, a single question was poor at classifying intermediate/non-extreme responses, and a significant number of children with severe sleep problems were missed. Screening with a short, validated questionnaire or asking more probing questions would assist in diagnosing most children with sleep problems. Parents may benefit from sleep education. En ligne : https://doi.org/10.1016/j.rasd.2020.101699 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data / Olivia J. VEATCH in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data Type de document : texte imprimé Auteurs : Olivia J. VEATCH, Auteur ; Diego R. MAZZOTTI, Auteur ; Robert T. SCHULTZ, Auteur ; Ted ABEL, Auteur ; Jacob J. MICHAELSON, Auteur ; Edward S. BRODKIN, Auteur ; Birkan TUNC, Auteur ; Susan G. ASSOULINE, Auteur ; Thomas NICKL-JOCKSCHAT, Auteur ; Beth A. MALOW, Auteur ; James S. SUTCLIFFE, Auteur ; Allan I. PACK, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications/genetics  Biological Phenomena  Child  Exome/genetics  Humans  Sleep Wake Disorders/complications/genetics  Exome Sequencing  Autism spectrum disorders  Genetic risk scores  Pleiotropy  Sleep duration  Systems biology Index. décimale : PER Périodiques Résumé : BACKGROUND: Numerous genes are implicated in autism spectrum disorder (ASD). ASD encompasses a wide-range and severity of symptoms and co-occurring conditions; however, the details of how genetic variation contributes to phenotypic differences are unclear. This creates a challenge for translating genetic evidence into clinically useful knowledge. Sleep disturbances are particularly prevalent co-occurring conditions in ASD, and genetics may inform treatment. Identifying convergent mechanisms with evidence for dysfunction that connect ASD and sleep biology could help identify better treatments for sleep disturbances in these individuals. METHODS: To identify mechanisms that influence risk for ASD and co-occurring sleep disturbances, we analyzed whole exome sequence data from individuals in the Simons Simplex Collection (n = 2380). We predicted protein damaging variants (PDVs) in genes currently implicated in either ASD or sleep duration in typically developing children. We predicted a network of ASD-related proteins with direct evidence for interaction with sleep duration-related proteins encoded by genes with PDVs. Overrepresentation analyses of Gene Ontology-defined biological processes were conducted on the resulting gene set. We calculated the likelihood of dysfunction in the top overrepresented biological process. We then tested if scores reflecting genetic dysfunction in the process were associated with parent-reported sleep duration. RESULTS: There were 29 genes with PDVs in the ASD dataset where variation was reported in the literature to be associated with both ASD and sleep duration. A network of 108 proteins encoded by ASD and sleep duration candidate genes with PDVs was identified. The mechanism overrepresented in PDV-containing genes that encode proteins in the interaction network with the most evidence for dysfunction was cerebral cortex development (GO:0,021,987). Scores reflecting dysfunction in this process were associated with sleep durations; the largest effects were observed in adolescents (p = 4.65 × 10(-3)). CONCLUSIONS: Our bioinformatic-driven approach detected a biological process enriched for genes encoding a protein-protein interaction network linking ASD gene products with sleep duration gene products where accumulation of potentially damaging variants in individuals with ASD was associated with sleep duration as reported by the parents. Specifically, genetic dysfunction impacting development of the cerebral cortex may affect sleep by disrupting sleep homeostasis which is evidenced to be regulated by this brain region. Future functional assessments and objective measurements of sleep in adolescents with ASD could provide the basis for more informed treatment of sleep problems in these individuals. En ligne : https://dx.doi.org/10.1186/s11689-022-09448-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data [texte imprimé] / Olivia J. VEATCH, Auteur ; Diego R. MAZZOTTI, Auteur ; Robert T. SCHULTZ, Auteur ; Ted ABEL, Auteur ; Jacob J. MICHAELSON, Auteur ; Edward S. BRODKIN, Auteur ; Birkan TUNC, Auteur ; Susan G. ASSOULINE, Auteur ; Thomas NICKL-JOCKSCHAT, Auteur ; Beth A. MALOW, Auteur ; James S. SUTCLIFFE, Auteur ; Allan I. PACK, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Adolescent  Autism Spectrum Disorder/complications/genetics  Biological Phenomena  Child  Exome/genetics  Humans  Sleep Wake Disorders/complications/genetics  Exome Sequencing  Autism spectrum disorders  Genetic risk scores  Pleiotropy  Sleep duration  Systems biology Index. décimale : PER Périodiques Résumé : BACKGROUND: Numerous genes are implicated in autism spectrum disorder (ASD). ASD encompasses a wide-range and severity of symptoms and co-occurring conditions; however, the details of how genetic variation contributes to phenotypic differences are unclear. This creates a challenge for translating genetic evidence into clinically useful knowledge. Sleep disturbances are particularly prevalent co-occurring conditions in ASD, and genetics may inform treatment. Identifying convergent mechanisms with evidence for dysfunction that connect ASD and sleep biology could help identify better treatments for sleep disturbances in these individuals. METHODS: To identify mechanisms that influence risk for ASD and co-occurring sleep disturbances, we analyzed whole exome sequence data from individuals in the Simons Simplex Collection (n = 2380). We predicted protein damaging variants (PDVs) in genes currently implicated in either ASD or sleep duration in typically developing children. We predicted a network of ASD-related proteins with direct evidence for interaction with sleep duration-related proteins encoded by genes with PDVs. Overrepresentation analyses of Gene Ontology-defined biological processes were conducted on the resulting gene set. We calculated the likelihood of dysfunction in the top overrepresented biological process. We then tested if scores reflecting genetic dysfunction in the process were associated with parent-reported sleep duration. RESULTS: There were 29 genes with PDVs in the ASD dataset where variation was reported in the literature to be associated with both ASD and sleep duration. A network of 108 proteins encoded by ASD and sleep duration candidate genes with PDVs was identified. The mechanism overrepresented in PDV-containing genes that encode proteins in the interaction network with the most evidence for dysfunction was cerebral cortex development (GO:0,021,987). Scores reflecting dysfunction in this process were associated with sleep durations; the largest effects were observed in adolescents (p = 4.65 × 10(-3)). CONCLUSIONS: Our bioinformatic-driven approach detected a biological process enriched for genes encoding a protein-protein interaction network linking ASD gene products with sleep duration gene products where accumulation of potentially damaging variants in individuals with ASD was associated with sleep duration as reported by the parents. Specifically, genetic dysfunction impacting development of the cerebral cortex may affect sleep by disrupting sleep homeostasis which is evidenced to be regulated by this brain region. Future functional assessments and objective measurements of sleep in adolescents with ASD could provide the basis for more informed treatment of sleep problems in these individuals. En ligne : https://dx.doi.org/10.1186/s11689-022-09448-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Characterizing Sleep in Adolescents and Adults with Autism Spectrum Disorders / Samantha E. GOLDMAN in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

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A clinical-translational review of sleep problems in neurodevelopmental disabilities / Sarika U. PETERS in Journal of Neurodevelopmental Disorders, 16 (2024)  

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A community-based sleep educational intervention for children with autism spectrum disorder / Lydia L. MACDONALD in Research in Autism Spectrum Disorders, 81 (March 2021)  

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Course and Predictors of Sleep and Co-occurring Problems in Children with Autism Spectrum Disorder / Micah O. MAZUREK in Journal of Autism and Developmental Disorders, 49-5 (May 2019)  

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ECHO autism adult healthcare: Training community clinicians to provide quality care for autistic adults / Beth A. MALOW in Autism Research, 16-8 (August 2023)  

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ECHO Autism Transition: Enhancing healthcare for adolescents and young adults with autism spectrum disorder / Micah O. MAZUREK in Autism, 24-3 (April 2020)  

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Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes / Beth A. MALOW in Journal of Autism and Developmental Disorders, 42-8 (August 2012)  

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Feasibility of Actigraphy for Evaluating Sleep and Daytime Physical Activity in Children with Autism Spectrum Disorder / M.L. ALDER in Journal of Autism and Developmental Disorders, 53-9 (September 2023)  

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Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay / Olivia J. VEATCH in Journal of Autism and Developmental Disorders, 45-1 (January 2015)  

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Health conditions in autism: Defining the trajectory from adolescence to early adulthood / Beth A. MALOW in Autism Research, 16-7 (July 2023)  

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