Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study / Kun QIN ; Luis R. PATINO ; Maxwell J. TALLMAN ; Du LEI ; Lu LU ; Wenbin LI ; Thomas J. BLOM ; Kaitlyn M. BRUNS ; Jeffrey A. WELGE ; Jeffrey R. STRAWN ; Qiyong GONG ; John A. SWEENEY ; Manpreet K. SINGH ; Melissa P. DELBELLO in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1072-1086 Titre : Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study Type de document : Texte imprimé et/ou numérique Auteurs : Kun QIN, Auteur ; Luis R. PATINO, Auteur ; Maxwell J. TALLMAN, Auteur ; Du LEI, Auteur ; Lu LU, Auteur ; Wenbin LI, Auteur ; Thomas J. BLOM, Auteur ; Kaitlyn M. BRUNS, Auteur ; Jeffrey A. WELGE, Auteur ; Jeffrey R. STRAWN, Auteur ; Qiyong GONG, Auteur ; John A. SWEENEY, Auteur ; Manpreet K. SINGH, Auteur ; Melissa P. DELBELLO, Auteur Article en page(s) : p.1072-1086 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD. Methods Depressed and/or anxious youth (n = 119, age = 14.9?+?1.6?years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8?+?1.7?years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare their brain connectome patterns, followed by machine learning of topological metrics. Results High-risk youth showed weaker connectivity patterns that were mainly located in the default mode network (DMN) (network weight = 50.1%) relative to controls, and connectivity patterns derived from the visual network (VN) constituted the largest proportion of aberrant stronger pairs (network weight = 54.9%). Global local efficiency (Elocal, p = .022) and clustering coefficient (Cp, p = .029) and nodal metrics of the right superior frontal gyrus (SFG) (Elocal: p < .001; Cp: p = .001) in the high-risk group were significantly higher than those in healthy subjects, and similar patterns were also found in the left insula (degree: p = .004; betweenness: p = .005; age-by-group interaction, p = .038) and right hippocampus (degree: p = .003; betweenness: p = .003). The case-control classifier achieved a cross-validation accuracy of 78.4%. Conclusions Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth. En ligne : https://doi.org/10.1111/jcpp.13946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study [Texte imprimé et/ou numérique] / Kun QIN, Auteur ; Luis R. PATINO, Auteur ; Maxwell J. TALLMAN, Auteur ; Du LEI, Auteur ; Lu LU, Auteur ; Wenbin LI, Auteur ; Thomas J. BLOM, Auteur ; Kaitlyn M. BRUNS, Auteur ; Jeffrey A. WELGE, Auteur ; Jeffrey R. STRAWN, Auteur ; Qiyong GONG, Auteur ; John A. SWEENEY, Auteur ; Manpreet K. SINGH, Auteur ; Melissa P. DELBELLO, Auteur . - p.1072-1086. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1072-1086 Index. décimale : PER Périodiques Résumé : Background Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD. Methods Depressed and/or anxious youth (n = 119, age = 14.9?+?1.6?years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8?+?1.7?years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare their brain connectome patterns, followed by machine learning of topological metrics. Results High-risk youth showed weaker connectivity patterns that were mainly located in the default mode network (DMN) (network weight = 50.1%) relative to controls, and connectivity patterns derived from the visual network (VN) constituted the largest proportion of aberrant stronger pairs (network weight = 54.9%). Global local efficiency (Elocal, p = .022) and clustering coefficient (Cp, p = .029) and nodal metrics of the right superior frontal gyrus (SFG) (Elocal: p < .001; Cp: p = .001) in the high-risk group were significantly higher than those in healthy subjects, and similar patterns were also found in the left insula (degree: p = .004; betweenness: p = .005; age-by-group interaction, p = .038) and right hippocampus (degree: p = .003; betweenness: p = .003). The case-control classifier achieved a cross-validation accuracy of 78.4%. Conclusions Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth. En ligne : https://doi.org/10.1111/jcpp.13946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder / Elizabeth BLANK in Journal of Autism and Developmental Disorders, 55-3 (March 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.940-954 Titre : Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth BLANK, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Travis LARSH, Auteur ; Rana ELMAGHRABY, Auteur ; Rui LIU, Auteur ; Elizabeth SMITH, Auteur ; Grace WESTERKAMP, Auteur ; Yanchen LIU, Auteur ; Paul S. HORN, Auteur ; Ethan GREENSTEIN, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur Article en page(s) : p.940-954 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Major depressive disorder (MDD) disproportionately affects those living with autism spectrum disorder (ASD) and is associated with significant impairment and treatment recidivism. En ligne : https://doi.org/10.1007/s10803-024-06244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Elizabeth BLANK, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Travis LARSH, Auteur ; Rana ELMAGHRABY, Auteur ; Rui LIU, Auteur ; Elizabeth SMITH, Auteur ; Grace WESTERKAMP, Auteur ; Yanchen LIU, Auteur ; Paul S. HORN, Auteur ; Ethan GREENSTEIN, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur . - p.940-954. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.940-954 Index. décimale : PER Périodiques Résumé : Major depressive disorder (MDD) disproportionately affects those living with autism spectrum disorder (ASD) and is associated with significant impairment and treatment recidivism. En ligne : https://doi.org/10.1007/s10803-024-06244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome / Lauren M. SCHMITT in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 47 p. Titre : Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. SCHMITT, Auteur ; Joy LI, Auteur ; Rui LIU, Auteur ; Paul S. HORN, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur Article en page(s) : 47 p. Langues : Anglais (eng) Mots-clés : Child  Male  Humans  Female  Fragile X Syndrome  Executive Function  Autism Spectrum Disorder  Electroencephalography/methods  Brain  Connectivity  Eeg  Electroencephalography  Fxs  Fragile X syndrome  commercial or financial relationships that could be construed as a potential  conflict of interest for the current manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and autism spectrum disorder. Executive function (EF), necessary for adaptive goal-oriented behavior and dependent on frontal lobe function, is impaired in individuals with FXS. Yet, little is known how alterations in frontal lobe neural activity is related to EF deficits in FXS. METHODS: Sixty-one participants with FXS (54% males) and 71 age- and sex-matched typically-developing controls (TDC; 58% males) completed a five-minute resting state electroencephalography (EEG) protocol and a computerized battery of tests of EF, the Test of Attentional Performance for Children (KiTAP). Following source localization (minimum-norm estimate), we computed debiased weighted phase lag index (dWPLI), a phase connectivity value, for pairings between 18 nodes in frontal regions for gamma (30-55 Hz) and alpha (10.5-12.5 Hz) bands. Linear models were generated with fixed factors of group, sex, frequency, and connection. Relationships between frontal connectivity and EF variables also were examined. RESULTS: Individuals with FXS demonstrated increased gamma band and reduced alpha band connectivity across all frontal regions and across hemispheres compared to TDC. After controlling for nonverbal IQ, increased error rates on EF tasks were associated with increased gamma band and reduced alpha band connectivity. LIMITATIONS: Frontal connectivity findings are limited to intrinsic brain activity during rest and may not generalize to frontal connectivity during EF tasks or everyday function. CONCLUSIONS: We report gamma hyper-connectivity and alpha hypo-connectivity within source-localized frontal brain regions in FXS compared to TDC during resting-state EEG. For the first time in FXS, we report significant associations between EF and altered frontal connectivity, with increased error rate relating to increased gamma band connectivity and reduced alpha band connectivity. These findings suggest increased phase connectivity within gamma band may impair EF performance, whereas greater alpha band connectivity may provide compensatory support for EF. Together, these findings provide important insight into neurophysiological mechanisms of EF deficits in FXS and provide novel targets for treatment development. En ligne : http://dx.doi.org/10.1186/s13229-022-00527-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome [Texte imprimé et/ou numérique] / Lauren M. SCHMITT, Auteur ; Joy LI, Auteur ; Rui LIU, Auteur ; Paul S. HORN, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur . - 47 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 47 p. Mots-clés : Child  Male  Humans  Female  Fragile X Syndrome  Executive Function  Autism Spectrum Disorder  Electroencephalography/methods  Brain  Connectivity  Eeg  Electroencephalography  Fxs  Fragile X syndrome  commercial or financial relationships that could be construed as a potential  conflict of interest for the current manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and autism spectrum disorder. Executive function (EF), necessary for adaptive goal-oriented behavior and dependent on frontal lobe function, is impaired in individuals with FXS. Yet, little is known how alterations in frontal lobe neural activity is related to EF deficits in FXS. METHODS: Sixty-one participants with FXS (54% males) and 71 age- and sex-matched typically-developing controls (TDC; 58% males) completed a five-minute resting state electroencephalography (EEG) protocol and a computerized battery of tests of EF, the Test of Attentional Performance for Children (KiTAP). Following source localization (minimum-norm estimate), we computed debiased weighted phase lag index (dWPLI), a phase connectivity value, for pairings between 18 nodes in frontal regions for gamma (30-55 Hz) and alpha (10.5-12.5 Hz) bands. Linear models were generated with fixed factors of group, sex, frequency, and connection. Relationships between frontal connectivity and EF variables also were examined. RESULTS: Individuals with FXS demonstrated increased gamma band and reduced alpha band connectivity across all frontal regions and across hemispheres compared to TDC. After controlling for nonverbal IQ, increased error rates on EF tasks were associated with increased gamma band and reduced alpha band connectivity. LIMITATIONS: Frontal connectivity findings are limited to intrinsic brain activity during rest and may not generalize to frontal connectivity during EF tasks or everyday function. CONCLUSIONS: We report gamma hyper-connectivity and alpha hypo-connectivity within source-localized frontal brain regions in FXS compared to TDC during resting-state EEG. For the first time in FXS, we report significant associations between EF and altered frontal connectivity, with increased error rate relating to increased gamma band connectivity and reduced alpha band connectivity. These findings suggest increased phase connectivity within gamma band may impair EF performance, whereas greater alpha band connectivity may provide compensatory support for EF. Together, these findings provide important insight into neurophysiological mechanisms of EF deficits in FXS and provide novel targets for treatment development. En ligne : http://dx.doi.org/10.1186/s13229-022-00527-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Brief Report: Feasibility of the Probabilistic Reversal Learning Task as an Outcome Measure in an Intervention Trial for Individuals with Autism Spectrum Disorder / Lauren M. SCHMITT in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.4191-4199 Titre : Brief Report: Feasibility of the Probabilistic Reversal Learning Task as an Outcome Measure in an Intervention Trial for Individuals with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. SCHMITT, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Rebecca SHAFFER, Auteur Article en page(s) : p.4191-4199 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/psychology/therapy  Feasibility Studies  Humans  Outcome Assessment, Health Care  Reproducibility of Results  Reversal Learning/physiology  Autism spectrum disorder  Cognitive flexibility  Outcome measurement  Reversal learning  training (RS, LS). Index. décimale : PER Périodiques Résumé : Cognitive flexibility deficits are a hallmark feature of autism spectrum disorder (ASD), but few evidence-based behavioral interventions have successfully addressed this treatment target. Outcome measurement selection may help account for previous findings. The probabilistic reversal learning task (PRL) is a measure of cognitive flexibility previously validated for use in ASD, but its use as an outcome measure has not yet been assessed. The current study examined the feasibility, reproducibility, and sensitivity of PRL in a within-subjects trial of Regulating Together, a group-based intervention targeting emotion regulation. We demonstrated the PRL is highly feasible, showed test-retest reproducibility, and is sensitive to detect change following the intervention. Our findings demonstrate the PRL task may be a useful outcome measure of cognitive flexibility in future intervention trials in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05288-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Brief Report: Feasibility of the Probabilistic Reversal Learning Task as an Outcome Measure in an Intervention Trial for Individuals with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lauren M. SCHMITT, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Rebecca SHAFFER, Auteur . - p.4191-4199. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.4191-4199 Mots-clés : Autism Spectrum Disorder/psychology/therapy  Feasibility Studies  Humans  Outcome Assessment, Health Care  Reproducibility of Results  Reversal Learning/physiology  Autism spectrum disorder  Cognitive flexibility  Outcome measurement  Reversal learning  training (RS, LS). Index. décimale : PER Périodiques Résumé : Cognitive flexibility deficits are a hallmark feature of autism spectrum disorder (ASD), but few evidence-based behavioral interventions have successfully addressed this treatment target. Outcome measurement selection may help account for previous findings. The probabilistic reversal learning task (PRL) is a measure of cognitive flexibility previously validated for use in ASD, but its use as an outcome measure has not yet been assessed. The current study examined the feasibility, reproducibility, and sensitivity of PRL in a within-subjects trial of Regulating Together, a group-based intervention targeting emotion regulation. We demonstrated the PRL is highly feasible, showed test-retest reproducibility, and is sensitive to detect change following the intervention. Our findings demonstrate the PRL task may be a useful outcome measure of cognitive flexibility in future intervention trials in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05288-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II / Lindsay S. SCHENKEL in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.775-781 Titre : Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay S. SCHENKEL, Auteur ; Amy E. WEST, Auteur ; Rachel H. JACOBS, Auteur ; John A. SWEENEY, Auteur ; Mani N. PAVULURI, Auteur Année de publication : 2012 Article en page(s) : p.775-781 Langues : Anglais (eng) Mots-clés : Pediatric bipolar disorder  neurocognitive function  bipolar I disorder  bipolar II disorder  clinical subtypes Index. décimale : PER Périodiques Résumé : Background:  Impaired profiles of neurocognitive function have been consistently demonstrated among pediatric patients with bipolar disorder (BD), and may aid in the identification of endophenotypes across subtypes of the disorder. This study aims to determine phenotypic cognitive profiles of patients with BD Type I and II. Methods:  Subjects (N = 79) consisted of BD I (n = 27) and BD II (n = 19) patients and demographic and intellectually matched healthy controls (HC; n = 33) that completed a battery of neurocognitive tasks. Results:  Bipolar disorder Type I patients performed significantly more poorly compared to HC on all domains of cognitive function including attention, executive function, working memory, visual memory, and verbal learning and memory. BD I patients also performed more poorly compared to BD II patients on all domains of cognitive functioning with the exception of working memory, whereas BD II patients did poorly relative to HC only on verbal learning and memory. Conclusions:  Findings from the current study indicate that BD I patients are characterized by more severe cognitive impairment relative to BD II patients who show an intermediate pattern of performance between BD I patients and HC. Verbal learning and memory may effectively differentiate pediatric BD patients and controls, regardless of the subtype of BD, and may serve as a cognitive endophenotype for the disorder. Additionally, these findings move us closer to developing effective cognitive interventions tailored to specific subtypes of pediatric BD patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02519.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II [Texte imprimé et/ou numérique] / Lindsay S. SCHENKEL, Auteur ; Amy E. WEST, Auteur ; Rachel H. JACOBS, Auteur ; John A. SWEENEY, Auteur ; Mani N. PAVULURI, Auteur . - 2012 . - p.775-781. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.775-781 Mots-clés : Pediatric bipolar disorder  neurocognitive function  bipolar I disorder  bipolar II disorder  clinical subtypes Index. décimale : PER Périodiques Résumé : Background:  Impaired profiles of neurocognitive function have been consistently demonstrated among pediatric patients with bipolar disorder (BD), and may aid in the identification of endophenotypes across subtypes of the disorder. This study aims to determine phenotypic cognitive profiles of patients with BD Type I and II. Methods:  Subjects (N = 79) consisted of BD I (n = 27) and BD II (n = 19) patients and demographic and intellectually matched healthy controls (HC; n = 33) that completed a battery of neurocognitive tasks. Results:  Bipolar disorder Type I patients performed significantly more poorly compared to HC on all domains of cognitive function including attention, executive function, working memory, visual memory, and verbal learning and memory. BD I patients also performed more poorly compared to BD II patients on all domains of cognitive functioning with the exception of working memory, whereas BD II patients did poorly relative to HC only on verbal learning and memory. Conclusions:  Findings from the current study indicate that BD I patients are characterized by more severe cognitive impairment relative to BD II patients who show an intermediate pattern of performance between BD I patients and HC. Verbal learning and memory may effectively differentiate pediatric BD patients and controls, regardless of the subtype of BD, and may serve as a cognitive endophenotype for the disorder. Additionally, these findings move us closer to developing effective cognitive interventions tailored to specific subtypes of pediatric BD patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02519.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder / Haylie L. MILLER in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

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Motor Functioning and Dyspraxia in Autism Spectrum Disorders / Matthew W. MOSCONI

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Neurologic Aspects of Autism / Nancy J. MINSHEW

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Risperidone and the 5-HT2A Receptor Antagonist M100907 Improve Probabilistic Reversal Learning in BTBR T?+?tf/J Mice / Dionisio A. AMODEO in Autism Research, 7-5 (October 2014)  

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Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem / Lauren M. SCHMITT in Molecular Autism, (September 2014)  

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Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents / Erin K. BOJANEK in Autism Research, 18-3 (March 2025)  

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Spatial Working Memory Deficits in Autism / Shelly D. STEELE in Journal of Autism and Developmental Disorders, 37-4 (April 2007)  

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The adenosine A2A receptor agonist, CGS 21680, attenuates a probabilistic reversal learning deficit and elevated grooming behavior in BTBR mice / Dionisio A. AMODEO in Autism Research, 11-2 (February 2018)  

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