Longitudinal study of neurological soft signs in first-episode early-onset psychosis / María MAYORAL in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.323-331 Titre : Longitudinal study of neurological soft signs in first-episode early-onset psychosis Type de document : Texte imprimé et/ou numérique Auteurs : María MAYORAL, Auteur ; I. BOMBIN, Auteur ; Josefina CASTRO-FORNIELES, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Soraya OTERO, Auteur ; Mara PARELLADA, Auteur ; Dolores MORENO, Auteur ; I. BAEZA, Auteur ; Montserrat GRAELL, Auteur ; Marta RAPADO, Auteur ; Celso ARANGO, Auteur Année de publication : 2012 Article en page(s) : p.323-331 Langues : Anglais (eng) Mots-clés : Neurological soft signs  children and adolescents  psychosis  neurodevelopment Index. décimale : PER Périodiques Résumé : Background:  In recent decades, the assessment of neurological soft signs (NSS) in patients with psychosis has become a subject of special interest. The study of the progression of NSS during adolescence will provide valuable information about the role of NSS as endophenotypes or biomarkers and about brain development at a stage in which brain maturation has not yet been completed. Methods:  Neurological soft signs were assessed in a sample of 110 first episodes of early-onset psychosis (EOP) and 98 healthy children and adolescents at two different times in a 2-year follow-up period. Results:  Patients with EOP showed more NSS than controls both at baseline (p < .001) and the 2-year follow-up (p < .001). No differences were found in the number of signs among the different diagnostic subgroups (schizophrenia, bipolar disorder, and other psychoses). When we examined the changes in NSS over the follow-up, the reduction of NSS in the patients was greater than the controls for ‘Motor coordination’ (p = .032), ‘Others’ (p < .001), and ‘Total score’ (p < .001) of the NES. Conclusion:  Despite the greater reduction of NSS in patients than in controls along the follow-up, patients still have more neurological signs than healthy controls; therefore, these signs may be considered a trait marker. NSS do not seem to be specific to schizophrenia as they are present in different EOPs. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02475.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Longitudinal study of neurological soft signs in first-episode early-onset psychosis [Texte imprimé et/ou numérique] / María MAYORAL, Auteur ; I. BOMBIN, Auteur ; Josefina CASTRO-FORNIELES, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Soraya OTERO, Auteur ; Mara PARELLADA, Auteur ; Dolores MORENO, Auteur ; I. BAEZA, Auteur ; Montserrat GRAELL, Auteur ; Marta RAPADO, Auteur ; Celso ARANGO, Auteur . - 2012 . - p.323-331. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.323-331 Mots-clés : Neurological soft signs  children and adolescents  psychosis  neurodevelopment Index. décimale : PER Périodiques Résumé : Background:  In recent decades, the assessment of neurological soft signs (NSS) in patients with psychosis has become a subject of special interest. The study of the progression of NSS during adolescence will provide valuable information about the role of NSS as endophenotypes or biomarkers and about brain development at a stage in which brain maturation has not yet been completed. Methods:  Neurological soft signs were assessed in a sample of 110 first episodes of early-onset psychosis (EOP) and 98 healthy children and adolescents at two different times in a 2-year follow-up period. Results:  Patients with EOP showed more NSS than controls both at baseline (p < .001) and the 2-year follow-up (p < .001). No differences were found in the number of signs among the different diagnostic subgroups (schizophrenia, bipolar disorder, and other psychoses). When we examined the changes in NSS over the follow-up, the reduction of NSS in the patients was greater than the controls for ‘Motor coordination’ (p = .032), ‘Others’ (p < .001), and ‘Total score’ (p < .001) of the NES. Conclusion:  Despite the greater reduction of NSS in patients than in controls along the follow-up, patients still have more neurological signs than healthy controls; therefore, these signs may be considered a trait marker. NSS do not seem to be specific to schizophrenia as they are present in different EOPs. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02475.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

The affective dimension of early-onset psychosis and its relationship with suicide / Vanessa SANCHEZ-GISTAU in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.747-755 Titre : The affective dimension of early-onset psychosis and its relationship with suicide Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa SANCHEZ-GISTAU, Auteur ; Inmaculada BAEZA, Auteur ; Celso ARANGO, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Elena DE LA SERNA, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Beatriz PAYA, Auteur ; Cloe LLORENTE, Auteur ; Josefina CASTRO-FORNIELES, Auteur Article en page(s) : p.747-755 Langues : Anglais (eng) Mots-clés : Psychosis  suicidality  depression Index. décimale : PER Périodiques Résumé : Background The affective dimension has scarcely been studied in early-onset psychosis. Our aims were to investigate the prevalence and type of affective symptoms in the prodromal and acute phases of early-onset psychosis and to examine their relationship with suicide. We also sought to establish whether the presence of premorbid antecedents or the presence of affective symptoms during the prodromal and acute phase might predict a later diagnosis of bipolar disorder (BP) or schizophrenia (SZ). Method Participants were 95 youths, aged 9–17 years, experiencing a first episode of a psychotic disorder (FEP) according to DSM-IV criteria. Prodromal affective symptoms in the year prior to the onset of full-blown psychosis were assessed by means of the K-SADS. Affective symptoms during the acute episode were evaluated using the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Suicidality was assessed during the acute episode and at 6 and 12 months. Results Half of the patients experienced affective symptoms during the prodrome, with depressive symptoms being the most frequently reported. During the acute episode, 23.2% presented depressive, 41.4% mixed and 18.9% manic symptoms. After logistic regression analysis, only the presence of depressive symptoms was significantly associated with suicidality during the 12 months following the FEP. Neither early premorbid antecedents nor the prevalence or type of affective symptoms during the FEP predicted a diagnosis of BP or SZ at 12 months. However, both depressive and manic prodromal symptoms were associated with a later diagnosis of BP. Conclusions The FEP of both SZ and BP is preceded by an identifiable prodromal phase. Early detection programs should target young people at clinical risk for the extended psychosis phenotype. The high prevalence of affective symptoms during the early phases of psychosis may encourage clinicians to identify and treat them in order to prevent suicide behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] The affective dimension of early-onset psychosis and its relationship with suicide [Texte imprimé et/ou numérique] / Vanessa SANCHEZ-GISTAU, Auteur ; Inmaculada BAEZA, Auteur ; Celso ARANGO, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Elena DE LA SERNA, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Beatriz PAYA, Auteur ; Cloe LLORENTE, Auteur ; Josefina CASTRO-FORNIELES, Auteur . - p.747-755. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.747-755 Mots-clés : Psychosis  suicidality  depression Index. décimale : PER Périodiques Résumé : Background The affective dimension has scarcely been studied in early-onset psychosis. Our aims were to investigate the prevalence and type of affective symptoms in the prodromal and acute phases of early-onset psychosis and to examine their relationship with suicide. We also sought to establish whether the presence of premorbid antecedents or the presence of affective symptoms during the prodromal and acute phase might predict a later diagnosis of bipolar disorder (BP) or schizophrenia (SZ). Method Participants were 95 youths, aged 9–17 years, experiencing a first episode of a psychotic disorder (FEP) according to DSM-IV criteria. Prodromal affective symptoms in the year prior to the onset of full-blown psychosis were assessed by means of the K-SADS. Affective symptoms during the acute episode were evaluated using the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Suicidality was assessed during the acute episode and at 6 and 12 months. Results Half of the patients experienced affective symptoms during the prodrome, with depressive symptoms being the most frequently reported. During the acute episode, 23.2% presented depressive, 41.4% mixed and 18.9% manic symptoms. After logistic regression analysis, only the presence of depressive symptoms was significantly associated with suicidality during the 12 months following the FEP. Neither early premorbid antecedents nor the prevalence or type of affective symptoms during the FEP predicted a diagnosis of BP or SZ at 12 months. However, both depressive and manic prodromal symptoms were associated with a later diagnosis of BP. Conclusions The FEP of both SZ and BP is preceded by an identifiable prodromal phase. Early detection programs should target young people at clinical risk for the extended psychosis phenotype. The high prevalence of affective symptoms during the early phases of psychosis may encourage clinicians to identify and treat them in order to prevent suicide behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Two-year diagnostic stability in early-onset first-episode psychosis / Josefina CASTRO-FORNIELES in Journal of Child Psychology and Psychiatry, 52-10 (October 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1089-1098 Titre : Two-year diagnostic stability in early-onset first-episode psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Josefina CASTRO-FORNIELES, Auteur ; Elena DE LA SERNA, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Dolores MORENO, Auteur ; Soraya OTERO, Auteur ; Celso ARANGO, Auteur Année de publication : 2011 Article en page(s) : p.1089-1098 Langues : Anglais (eng) Mots-clés : psychosis  diagnosis  schizophrenia  bipolar disorder Index. décimale : PER Périodiques Résumé : Background:  Only one study has used a prospective method to analyze the diagnostic stability of first psychotic episodes in children and adolescents. The Child and Adolescent First-Episode Psychosis Study (CAFEPS) is a 2-year, prospective longitudinal study of early-onset first episodes of psychosis (EO-FEP). Aim:  To describe diagnostic stability and the variables related to diagnostic changes. Methods:  Participants were 83 patients (aged 9–17 years) with an EO-FEP consecutively attended. They were assessed with a structured interview (Kiddie-Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version) and clinical scales at baseline and after 2 years. Results:  The global consistency for all diagnoses was 63.9%. The small group of bipolar disorder had high stability (92.31%) as did the group with schizophrenia spectrum disorders (90.00%). Depressive disorder had lower stability (37.50%) and the lowest values were for psychotic disorder not otherwise specified (11.76%) and brief psychotic disorder (0%).The most frequent diagnostic shift was to schizophrenia spectrum and bipolar disorders. One group of patients did not meet the criteria for any diagnosis at follow-up. Independent predictors of change to schizophrenia spectrum disorders were lower scores on the Children’s Global Assessment Scale (CGAS) and the Hamilton Depression Rating Scale. Predictors of not having a diagnosis at follow-up were the CGAS and the Strauss–Carpenter Outcome Scale. Conclusions:  Global diagnostic stability was 63.9%. Bipolar and schizophrenia spectrum disorders were the most stable diagnoses, while depressive disorder and other psychosis the least stable. Psychosocial functioning at baseline was a good predictor of diagnosis at follow-up. These data show the need for longitudinal follow-up in EO-FEP before a stable diagnosis is reached. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02443.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 [article] Two-year diagnostic stability in early-onset first-episode psychosis [Texte imprimé et/ou numérique] / Josefina CASTRO-FORNIELES, Auteur ; Elena DE LA SERNA, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Mara PARELLADA, Auteur ; Montserrat GRAELL, Auteur ; Dolores MORENO, Auteur ; Soraya OTERO, Auteur ; Celso ARANGO, Auteur . - 2011 . - p.1089-1098. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1089-1098 Mots-clés : psychosis  diagnosis  schizophrenia  bipolar disorder Index. décimale : PER Périodiques Résumé : Background:  Only one study has used a prospective method to analyze the diagnostic stability of first psychotic episodes in children and adolescents. The Child and Adolescent First-Episode Psychosis Study (CAFEPS) is a 2-year, prospective longitudinal study of early-onset first episodes of psychosis (EO-FEP). Aim:  To describe diagnostic stability and the variables related to diagnostic changes. Methods:  Participants were 83 patients (aged 9–17 years) with an EO-FEP consecutively attended. They were assessed with a structured interview (Kiddie-Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version) and clinical scales at baseline and after 2 years. Results:  The global consistency for all diagnoses was 63.9%. The small group of bipolar disorder had high stability (92.31%) as did the group with schizophrenia spectrum disorders (90.00%). Depressive disorder had lower stability (37.50%) and the lowest values were for psychotic disorder not otherwise specified (11.76%) and brief psychotic disorder (0%).The most frequent diagnostic shift was to schizophrenia spectrum and bipolar disorders. One group of patients did not meet the criteria for any diagnosis at follow-up. Independent predictors of change to schizophrenia spectrum disorders were lower scores on the Children’s Global Assessment Scale (CGAS) and the Hamilton Depression Rating Scale. Predictors of not having a diagnosis at follow-up were the CGAS and the Strauss–Carpenter Outcome Scale. Conclusions:  Global diagnostic stability was 63.9%. Bipolar and schizophrenia spectrum disorders were the most stable diagnoses, while depressive disorder and other psychosis the least stable. Psychosocial functioning at baseline was a good predictor of diagnosis at follow-up. These data show the need for longitudinal follow-up in EO-FEP before a stable diagnosis is reached. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02443.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142

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