Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior / Vanessa B. PUETZ in Development and Psychopathology, 33-4 (October 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1300-1307 Titre : Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa B. PUETZ, Auteur ; Essi VIDING, Auteur ; Ferdinand HOFFMANN, Auteur ; Mattia I. GERIN, Auteur ; Molly SHARP, Auteur ; Georgia RANKIN, Auteur ; Eleanor A. MAGUIRE, Auteur ; Andrea MECHELLI, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : p.1300-1307 Langues : Anglais (eng) Mots-clés : autobiographical memory  conduct problems  depression  maltreatment  prosocial behavior Index. décimale : PER Périodiques Résumé : Objectives Childhood maltreatment is associated with altered neural reactivity during autobiographical memory (ABM) recall and a pattern of overgeneral memory (OGM). Altered ABM and OGM have been linked with psychopathology and poorer social functioning. The present study investigated the association between altered ABM and subsequent socio-emotional functioning (measured two years later) in a sample of adolescents with (N = 20; maltreatment group, MT) and without (N = 17; non-MT group) documented childhood maltreatment histories. Method At baseline, adolescents (aged 12.6 ± 1.45 years) were administered the Autobiographical Memory Test to measure OGM. Participants also recalled specific ABMs in response to emotionally valenced cue words during functional MRI. Adolescents in both groups underwent assessments measuring depressive symptoms and prosocial behavior at both timepoints. Regression analyses were carried out to predict outcome measures at follow-up controlling for baseline levels. Results In the MT group, greater OGM at baseline significantly predicted reduced prosocial behavior at follow-up and showed a trend level association with elevated depressive symptoms. Patterns of altered ABM-related brain activity did not significantly predict future psycho-social functioning. Conclusions The current findings highlight the potential value of OGM as a cognitive mechanism that could be targeted to reduce risk of depression in adolescents with prior histories of maltreatment. En ligne : http://dx.doi.org/10.1017/S0954579420000504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior [Texte imprimé et/ou numérique] / Vanessa B. PUETZ, Auteur ; Essi VIDING, Auteur ; Ferdinand HOFFMANN, Auteur ; Mattia I. GERIN, Auteur ; Molly SHARP, Auteur ; Georgia RANKIN, Auteur ; Eleanor A. MAGUIRE, Auteur ; Andrea MECHELLI, Auteur ; Eamon J. MCCRORY, Auteur . - p.1300-1307. Langues : Anglais (eng) in Development and Psychopathology > 33-4 (October 2021) . - p.1300-1307 Mots-clés : autobiographical memory  conduct problems  depression  maltreatment  prosocial behavior Index. décimale : PER Périodiques Résumé : Objectives Childhood maltreatment is associated with altered neural reactivity during autobiographical memory (ABM) recall and a pattern of overgeneral memory (OGM). Altered ABM and OGM have been linked with psychopathology and poorer social functioning. The present study investigated the association between altered ABM and subsequent socio-emotional functioning (measured two years later) in a sample of adolescents with (N = 20; maltreatment group, MT) and without (N = 17; non-MT group) documented childhood maltreatment histories. Method At baseline, adolescents (aged 12.6 ± 1.45 years) were administered the Autobiographical Memory Test to measure OGM. Participants also recalled specific ABMs in response to emotionally valenced cue words during functional MRI. Adolescents in both groups underwent assessments measuring depressive symptoms and prosocial behavior at both timepoints. Regression analyses were carried out to predict outcome measures at follow-up controlling for baseline levels. Results In the MT group, greater OGM at baseline significantly predicted reduced prosocial behavior at follow-up and showed a trend level association with elevated depressive symptoms. Patterns of altered ABM-related brain activity did not significantly predict future psycho-social functioning. Conclusions The current findings highlight the potential value of OGM as a cognitive mechanism that could be targeted to reduce risk of depression in adolescents with prior histories of maltreatment. En ligne : http://dx.doi.org/10.1017/S0954579420000504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Effects of DTNBP1 genotype on brain development in children / Stefania TOGNIN in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1287-1294 Titre : Effects of DTNBP1 genotype on brain development in children Type de document : Texte imprimé et/ou numérique Auteurs : Stefania TOGNIN, Auteur ; Essi VIDING, Auteur ; Eamon J. MCCRORY, Auteur ; Lauren J. TAYLOR, Auteur ; Michael C. O'DONOVAN, Auteur ; Philip MCGUIRE, Auteur ; Andrea MECHELLI, Auteur Année de publication : 2011 Article en page(s) : p.1287-1294 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background:  Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin-binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain development is poorly understood. The present investigation examined for the first time the effects of DTNBP1 on brain structure in children. Our hypothesis was that a genetic variation in DTNBP1 (i.e., the single nucleotide polymorphism rs2619538) would be associated with differences in both gray and white matter brain regions previously implicated in schizophrenia. Methods:  Magnetic resonance imaging and voxel-based morphometry were used to examine brain structure in 52 male children aged between 10 and 12 years. Statistical inferences on the effects of DTNBP1 genotype on gray and white matter volume (GMV and WMV) were made at p < .05 after family-wise error correction for multiple comparisons across the whole brain. Results:  Individuals homozygous for the schizophrenia high-risk allele (AA) compared with those homozygous for the low-risk allele (TT) expressed reduced GMV in the left anterior cingulate gyrus and reduced WMV in the left medial frontal area. Conclusions:  Our results suggest that genetic variation in DTNBP1 is associated with differences in gray and white matter; and that these effects are already evident in children as young as 10–12 years. These findings are consistent with the notion that the DTNBP1 genotype influences brain development and may thereby modulate vulnerability to schizophrenia. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02427.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 [article] Effects of DTNBP1 genotype on brain development in children [Texte imprimé et/ou numérique] / Stefania TOGNIN, Auteur ; Essi VIDING, Auteur ; Eamon J. MCCRORY, Auteur ; Lauren J. TAYLOR, Auteur ; Michael C. O'DONOVAN, Auteur ; Philip MCGUIRE, Auteur ; Andrea MECHELLI, Auteur . - 2011 . - p.1287-1294. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1287-1294 Index. décimale : PER Périodiques Résumé : Background:  Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin-binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain development is poorly understood. The present investigation examined for the first time the effects of DTNBP1 on brain structure in children. Our hypothesis was that a genetic variation in DTNBP1 (i.e., the single nucleotide polymorphism rs2619538) would be associated with differences in both gray and white matter brain regions previously implicated in schizophrenia. Methods:  Magnetic resonance imaging and voxel-based morphometry were used to examine brain structure in 52 male children aged between 10 and 12 years. Statistical inferences on the effects of DTNBP1 genotype on gray and white matter volume (GMV and WMV) were made at p < .05 after family-wise error correction for multiple comparisons across the whole brain. Results:  Individuals homozygous for the schizophrenia high-risk allele (AA) compared with those homozygous for the low-risk allele (TT) expressed reduced GMV in the left anterior cingulate gyrus and reduced WMV in the left medial frontal area. Conclusions:  Our results suggest that genetic variation in DTNBP1 is associated with differences in gray and white matter; and that these effects are already evident in children as young as 10–12 years. These findings are consistent with the notion that the DTNBP1 genotype influences brain development and may thereby modulate vulnerability to schizophrenia. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02427.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147

Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children / Stephane A. DE BRITO in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112 Titre : Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children Type de document : Texte imprimé et/ou numérique Auteurs : Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : 105-112 Langues : Anglais (eng) Mots-clés : maltreatment  child abuse  orbitofrontal cortex  middle temporal gyrus  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children [Texte imprimé et/ou numérique] / Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur . - 105-112. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112 Mots-clés : maltreatment  child abuse  orbitofrontal cortex  middle temporal gyrus  voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation / Philip A. KELLY in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1591-1609 Titre : Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation Type de document : Texte imprimé et/ou numérique Auteurs : Philip A. KELLY, Auteur ; Essi VIDING, Auteur ; Vanessa B. PUETZ, Auteur ; Amy L. PALMER, Auteur ; Andrea MECHELLI, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Sophie SAMUEL, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : p.1591-1609 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While maltreatment is known to impact social and emotional functioning, threat processing, and neural structure, the potentially dimorphic influence of sex on these outcomes remains relatively understudied. We investigated sex differences across these domains in a large community sample of children aged 10 to 14 years (n = 122) comprising 62 children with verified maltreatment experience and 60 well-matched nonmaltreated peers. The maltreated group relative to the nonmaltreated comparison group exhibited poorer social and emotional functioning (more peer problems and heightened emotional reactivity). Cognitively, they displayed a pattern of attentional avoidance of threat in a visual dot-probe task. Similar patterns were observed in males and females in these domains. Reduced gray matter volume was found to characterize the maltreated group in the medial orbitofrontal cortex, bilateral middle temporal lobes, and bilateral supramarginal gyrus; sex differences were observed only in the supramarginal gyrus. In addition, a disordinal interaction between maltreatment exposure and sex was found in the postcentral gyrus. Finally, attentional avoidance to threat mediated the relationship between maltreatment and emotional reactivity, and medial orbitofrontal cortex gray matter volume mediated the relationship between maltreatment and peer functioning. Similar mediation patterns were observed across sexes. This study highlights the utility of combining multiple levels of analysis when studying the “latent vulnerability” engendered by childhood maltreatment and yields tentative findings regarding a neural basis of sex differences in long-term outcomes for maltreated children. En ligne : http://dx.doi.org/10.1017/S0954579415000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation [Texte imprimé et/ou numérique] / Philip A. KELLY, Auteur ; Essi VIDING, Auteur ; Vanessa B. PUETZ, Auteur ; Amy L. PALMER, Auteur ; Andrea MECHELLI, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Sophie SAMUEL, Auteur ; Eamon J. MCCRORY, Auteur . - p.1591-1609. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1591-1609 Index. décimale : PER Périodiques Résumé : While maltreatment is known to impact social and emotional functioning, threat processing, and neural structure, the potentially dimorphic influence of sex on these outcomes remains relatively understudied. We investigated sex differences across these domains in a large community sample of children aged 10 to 14 years (n = 122) comprising 62 children with verified maltreatment experience and 60 well-matched nonmaltreated peers. The maltreated group relative to the nonmaltreated comparison group exhibited poorer social and emotional functioning (more peer problems and heightened emotional reactivity). Cognitively, they displayed a pattern of attentional avoidance of threat in a visual dot-probe task. Similar patterns were observed in males and females in these domains. Reduced gray matter volume was found to characterize the maltreated group in the medial orbitofrontal cortex, bilateral middle temporal lobes, and bilateral supramarginal gyrus; sex differences were observed only in the supramarginal gyrus. In addition, a disordinal interaction between maltreatment exposure and sex was found in the postcentral gyrus. Finally, attentional avoidance to threat mediated the relationship between maltreatment and emotional reactivity, and medial orbitofrontal cortex gray matter volume mediated the relationship between maltreatment and peer functioning. Similar mediation patterns were observed across sexes. This study highlights the utility of combining multiple levels of analysis when studying the “latent vulnerability” engendered by childhood maltreatment and yields tentative findings regarding a neural basis of sex differences in long-term outcomes for maltreated children. En ligne : http://dx.doi.org/10.1017/S0954579415000966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

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