Atypical sensory processing in adolescents with an autism spectrum disorder and their non-affected siblings / Wouter DE LA MARCHE in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.639-645 Titre : Atypical sensory processing in adolescents with an autism spectrum disorder and their non-affected siblings Type de document : Texte imprimé et/ou numérique Auteurs : Wouter DE LA MARCHE, Auteur ; Jean STEYAERT, Auteur ; Ilse L.J. NOENS, Auteur Année de publication : 2012 Article en page(s) : p.639-645 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Adolescents  Siblings  Sensory profile  Intermediate phenotype Index. décimale : PER Périodiques Résumé : Atypical sensory processing is common in autism spectrum disorders (ASD). Specific profiles have been proposed in different age groups, but no study has focused specifically on adolescents. Identifying traits of ASD that are shared by individuals with ASD and their non-affected family members can shed light on the genetic underpinnings of ASD. Eighty adolescents with ASD (64 boys, 16 girls), 56 non-affected adolescent siblings (21 boys, 35 girls) and 33 adolescent controls (18 boys, 15 girls) filled out the Adolescent/Adult Sensory Profile, a self-report questionnaire resulting in four sensory quadrants according to Dunn's model of sensory processing. Adolescents with ASD differed significantly from controls on the quadrants Sensation Seeking and Sensation Avoidance. On quadrant 2 (Sensation Seeking) siblings scored significantly lower than controls and significantly higher than ASD. These results confirm the presence of atypical sensory processing in adolescents with ASD. We argue that reduced Sensation Seeking might be a candidate for an intermediate phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.09.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] Atypical sensory processing in adolescents with an autism spectrum disorder and their non-affected siblings [Texte imprimé et/ou numérique] / Wouter DE LA MARCHE, Auteur ; Jean STEYAERT, Auteur ; Ilse L.J. NOENS, Auteur . - 2012 . - p.639-645. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.639-645 Mots-clés : Autism spectrum disorder  Adolescents  Siblings  Sensory profile  Intermediate phenotype Index. décimale : PER Périodiques Résumé : Atypical sensory processing is common in autism spectrum disorders (ASD). Specific profiles have been proposed in different age groups, but no study has focused specifically on adolescents. Identifying traits of ASD that are shared by individuals with ASD and their non-affected family members can shed light on the genetic underpinnings of ASD. Eighty adolescents with ASD (64 boys, 16 girls), 56 non-affected adolescent siblings (21 boys, 35 girls) and 33 adolescent controls (18 boys, 15 girls) filled out the Adolescent/Adult Sensory Profile, a self-report questionnaire resulting in four sensory quadrants according to Dunn's model of sensory processing. Adolescents with ASD differed significantly from controls on the quadrants Sensation Seeking and Sensation Avoidance. On quadrant 2 (Sensation Seeking) siblings scored significantly lower than controls and significantly higher than ASD. These results confirm the presence of atypical sensory processing in adolescents with ASD. We argue that reduced Sensation Seeking might be a candidate for an intermediate phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.09.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

Platelet studies in autism spectrum disorder patients and first-degree relatives / Nora BIJL in Molecular Autism, (October 2015)  

Public ISBD [article]  inMolecular Autism > (October 2015) . - p.1-10 Titre : Platelet studies in autism spectrum disorder patients and first-degree relatives Type de document : Texte imprimé et/ou numérique Auteurs : Nora BIJL, Auteur ; Chantal THYS, Auteur ; Christine WITTEVRONGEL, Auteur ; Wouter DE LA MARCHE, Auteur ; Koenraad DEVRIENDT, Auteur ; Hilde PEETERS, Auteur ; Chris VAN GEET, Auteur ; Kathleen FRESON, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Platelets have been proven to be a useful cellular model to study some neuropathologies, due to the overlapping biological features between neurons and platelets as granule secreting cells. Altered platelet dense granule morphology was previously reported in three autism spectrum disorder (ASD) patients with chromosomal translocations that disrupted ASD candidate genes NBEA, SCAMP5, and AMYSIN, but a systematic analysis of platelet function in ASD is lacking in contrast to numerous reports of elevated serotonin levels in platelets and blood as potential biomarker for ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0051-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Platelet studies in autism spectrum disorder patients and first-degree relatives [Texte imprimé et/ou numérique] / Nora BIJL, Auteur ; Chantal THYS, Auteur ; Christine WITTEVRONGEL, Auteur ; Wouter DE LA MARCHE, Auteur ; Koenraad DEVRIENDT, Auteur ; Hilde PEETERS, Auteur ; Chris VAN GEET, Auteur ; Kathleen FRESON, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (October 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : Platelets have been proven to be a useful cellular model to study some neuropathologies, due to the overlapping biological features between neurons and platelets as granule secreting cells. Altered platelet dense granule morphology was previously reported in three autism spectrum disorder (ASD) patients with chromosomal translocations that disrupted ASD candidate genes NBEA, SCAMP5, and AMYSIN, but a systematic analysis of platelet function in ASD is lacking in contrast to numerous reports of elevated serotonin levels in platelets and blood as potential biomarker for ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0051-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Quantitative autism traits in first degree relatives: evidence for the broader autism phenotype in fathers, but not in mothers and siblings / Wouter DE LA MARCHE in Autism, 16-3 (May 2012)  

Public ISBD [article]  inAutism > 16-3 (May 2012) . - p.247-260 Titre : Quantitative autism traits in first degree relatives: evidence for the broader autism phenotype in fathers, but not in mothers and siblings Type de document : Texte imprimé et/ou numérique Auteurs : Wouter DE LA MARCHE, Auteur ; Ilse L.J. NOENS, Auteur ; Jan LUTS, Auteur ; Evert M. SCHOLTE, Auteur ; Sabine VAN HUFFEL, Auteur ; Jean STEYAERT, Auteur Année de publication : 2012 Article en page(s) : p.247-260 Langues : Anglais (eng) Mots-clés : Quantitative autism traits  broader autism phenotype  autism spectrum disorders  siblings  parents Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) symptoms are present in unaffected relatives and individuals from the general population. Results are inconclusive, however, on whether unaffected relatives have higher levels of quantitative autism traits (QAT) or not. This might be due to differences in research populations, because behavioral data and molecular genetic research suggest that the genetic etiology of ASD is different in multiplex and simplex families. We compared 117 unaffected siblings and 276 parents of at least one child with ASD with 280 children and 595 adults from the general population on the presence of QAT using the Social Responsiveness Scale (SRS). Mean SRS scores for siblings, control children, parents and control adults were 25.4, 26.6, 33.7 and 32.9. Fathers of children with ASD showed significantly higher levels of QAT than controls, but siblings and mothers did not. We could not detect a statistically significant difference in SRS scores between relatives from simplex and multiplex families. These results do not support the theory of differential (genetic) etiology in multiplex and simplex families and suggest that a carried genetic risk is generally not expressed phenotypically in most relatives, except in fathers. En ligne : http://dx.doi.org/10.1177/1362361311421776 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Quantitative autism traits in first degree relatives: evidence for the broader autism phenotype in fathers, but not in mothers and siblings [Texte imprimé et/ou numérique] / Wouter DE LA MARCHE, Auteur ; Ilse L.J. NOENS, Auteur ; Jan LUTS, Auteur ; Evert M. SCHOLTE, Auteur ; Sabine VAN HUFFEL, Auteur ; Jean STEYAERT, Auteur . - 2012 . - p.247-260. Langues : Anglais (eng) in Autism > 16-3 (May 2012) . - p.247-260 Mots-clés : Quantitative autism traits  broader autism phenotype  autism spectrum disorders  siblings  parents Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) symptoms are present in unaffected relatives and individuals from the general population. Results are inconclusive, however, on whether unaffected relatives have higher levels of quantitative autism traits (QAT) or not. This might be due to differences in research populations, because behavioral data and molecular genetic research suggest that the genetic etiology of ASD is different in multiplex and simplex families. We compared 117 unaffected siblings and 276 parents of at least one child with ASD with 280 children and 595 adults from the general population on the presence of QAT using the Social Responsiveness Scale (SRS). Mean SRS scores for siblings, control children, parents and control adults were 25.4, 26.6, 33.7 and 32.9. Fathers of children with ASD showed significantly higher levels of QAT than controls, but siblings and mothers did not. We could not detect a statistically significant difference in SRS scores between relatives from simplex and multiplex families. These results do not support the theory of differential (genetic) etiology in multiplex and simplex families and suggest that a carried genetic risk is generally not expressed phenotypically in most relatives, except in fathers. En ligne : http://dx.doi.org/10.1177/1362361311421776 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview / Wouter DE LA MARCHE in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.40-51 Titre : The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview Type de document : Texte imprimé et/ou numérique Auteurs : Wouter DE LA MARCHE, Auteur ; Ilse NOENS, Auteur ; Bart BOETS, Auteur ; Sofie KUPPENS, Auteur ; Jean STEYAERT, Auteur Article en page(s) : p.40-51 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  DSM-5  Factor analysis  3di Index. décimale : PER Périodiques Résumé : Abstract Several studies have focused on the underlying symptom structure of Autism Spectrum Disorders (ASD), but results have been equivocal. We performed a confirmatory factor analysis on data of the Developmental, Dimensional and Diagnostic Interview of 275 participants with ASD between 3 and 23 years of age, aimed at strengthening the empirical evidence of previously published factor structure solutions using the same instrument. As none of these hypothesised models fitted our data, an exploratory factor analysis was undertaken. Results pointed towards a five factor model. A ‘Restricted and Repetitive Behaviour and Interest’ factor could be separated from ‘Shaking and Nodding’, ‘Emotional Reciprocity’ and two other factors that both represented deficits in social interaction and communication. Although not completely confirming, our results are generally in favour of the present DSM-5 criteria. By showing that the items did not fully segregate according to theoretically postulated subdomains, we offer a possible explanation for the heterogeneity in proposed factor structures for ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview [Texte imprimé et/ou numérique] / Wouter DE LA MARCHE, Auteur ; Ilse NOENS, Auteur ; Bart BOETS, Auteur ; Sofie KUPPENS, Auteur ; Jean STEYAERT, Auteur . - p.40-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.40-51 Mots-clés : Autism spectrum disorders  DSM-5  Factor analysis  3di Index. décimale : PER Périodiques Résumé : Abstract Several studies have focused on the underlying symptom structure of Autism Spectrum Disorders (ASD), but results have been equivocal. We performed a confirmatory factor analysis on data of the Developmental, Dimensional and Diagnostic Interview of 275 participants with ASD between 3 and 23 years of age, aimed at strengthening the empirical evidence of previously published factor structure solutions using the same instrument. As none of these hypothesised models fitted our data, an exploratory factor analysis was undertaken. Results pointed towards a five factor model. A ‘Restricted and Repetitive Behaviour and Interest’ factor could be separated from ‘Shaking and Nodding’, ‘Emotional Reciprocity’ and two other factors that both represented deficits in social interaction and communication. Although not completely confirming, our results are generally in favour of the present DSM-5 criteria. By showing that the items did not fully segregate according to theoretically postulated subdomains, we offer a possible explanation for the heterogeneity in proposed factor structures for ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

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