Developmental functioning and medical Co-morbidity profile of children with complex and essential autism / Jaimie FLOR in Autism Research, 10-8 (August 2017)  

Public ISBD [article]  inAutism Research > 10-8 (August 2017) . - p.1344-1352 Titre : Developmental functioning and medical Co-morbidity profile of children with complex and essential autism Type de document : Texte imprimé et/ou numérique Auteurs : Jaimie FLOR, Auteur ; Jayne BELLANDO, Auteur ; Maya LOPEZ, Auteur ; Amy SHUI, Auteur Article en page(s) : p.1344-1352 Langues : Anglais (eng) Mots-clés : autism  developmental  children  microcephaly  dysmorphology  essential autism complex autism Index. décimale : PER Périodiques Résumé : Children with Autism Spectrum Disorders (ASD) may be characterized as “complex” (those with microcephaly and/or dysmorphology) or “essential” (those with neither of these two). Previous studies found subjects in the complex group exhibited lower IQ scores, poorer response to behavioral intervention, more seizures and more abnormal EEGs and brain MRIs compared to the essential group. The objective of this study was to determine if there are differences in complex versus essential subjects based on several developmental/psychological measures as well as certain medical comorbidities. This study utilized data from 1,347 individuals (2–17 years old) well-characterized subjects enrolled in Autism Treatment Network (ATN) Registry. Head circumference measurement and the Autism Dysmorphology Measure (ADM) were used by trained physicians to classify subjects as complex or essential. Significantly lower scores were seen for complex subjects in cognitive level, adaptive behavior and quality of life. Complex subjects showed significantly increased physician-documented GI symptoms and were on a higher number of medications. No significant differences in autism severity scores, behavioral ratings and parent-reported sleep problems were found. After adjusting for multiple comparisons made, adaptive scores remained significantly lower for the complex group, and the complex group used a significantly higher number of medications and had increased GI symptoms. Complex and essential autism subtypes may have distinct developmental and medical correlates and thus underlines the importance of looking for microcephaly and dysmorphology, when evaluating a child with autism. Determining this distinction in autism may have implications in prognosis, identifying medical co-morbidities, directing diagnostic evaluations and treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.1779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Developmental functioning and medical Co-morbidity profile of children with complex and essential autism [Texte imprimé et/ou numérique] / Jaimie FLOR, Auteur ; Jayne BELLANDO, Auteur ; Maya LOPEZ, Auteur ; Amy SHUI, Auteur . - p.1344-1352. Langues : Anglais (eng) in Autism Research > 10-8 (August 2017) . - p.1344-1352 Mots-clés : autism  developmental  children  microcephaly  dysmorphology  essential autism complex autism Index. décimale : PER Périodiques Résumé : Children with Autism Spectrum Disorders (ASD) may be characterized as “complex” (those with microcephaly and/or dysmorphology) or “essential” (those with neither of these two). Previous studies found subjects in the complex group exhibited lower IQ scores, poorer response to behavioral intervention, more seizures and more abnormal EEGs and brain MRIs compared to the essential group. The objective of this study was to determine if there are differences in complex versus essential subjects based on several developmental/psychological measures as well as certain medical comorbidities. This study utilized data from 1,347 individuals (2–17 years old) well-characterized subjects enrolled in Autism Treatment Network (ATN) Registry. Head circumference measurement and the Autism Dysmorphology Measure (ADM) were used by trained physicians to classify subjects as complex or essential. Significantly lower scores were seen for complex subjects in cognitive level, adaptive behavior and quality of life. Complex subjects showed significantly increased physician-documented GI symptoms and were on a higher number of medications. No significant differences in autism severity scores, behavioral ratings and parent-reported sleep problems were found. After adjusting for multiple comparisons made, adaptive scores remained significantly lower for the complex group, and the complex group used a significantly higher number of medications and had increased GI symptoms. Complex and essential autism subtypes may have distinct developmental and medical correlates and thus underlines the importance of looking for microcephaly and dysmorphology, when evaluating a child with autism. Determining this distinction in autism may have implications in prognosis, identifying medical co-morbidities, directing diagnostic evaluations and treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.1779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

Dyslexie développementale : exemple d'évaluation en milieu neuropédiatrique. A propos de 62 observations / B. ECHENNE in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 62-63 (Mai 2001)

Public ISBD [article]  inApproche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 62-63 (Mai 2001) . - p.129-134 Titre : Dyslexie développementale : exemple d'évaluation en milieu neuropédiatrique. A propos de 62 observations Type de document : Texte imprimé et/ou numérique Auteurs : B. ECHENNE, Auteur ; Renée CHEMINAL, Auteur ; Philippe COMPAGNON, Auteur ; F. RIVIER, Auteur ; D. DELPORT, Auteur ; Maya LOPEZ, Auteur ; P. KLEMM, Auteur ; E. ECHENNE, Auteur ; C. GRAS, Auteur ; J.-M. PERRET, Auteur ; M.J. PARAYRE-CHANEZ, Auteur Année de publication : 2001 Article en page(s) : p.129-134 Langues : Français (fre) Mots-clés : Dyslexies  Dysphasies  Troubles du langage  Difficultés scolaires Index. décimale : PER Périodiques Résumé : Soixante-deux enfants dyslexiques ont été pris en charge pendant une période de trois ans dans le service de Neuropédiatrie du CHR de Montpellier. Une évaluation détaillée, comportant l’analyse des potentialités globales, des capacités langagières, orales et écrites, du niveau scolaire réel, des difficultés psychologiques éventuelles, ainsi que de certaines fonctions cognitives (perceptions phonétiques, gnosies auditivo-verbales, perception visuelle, attention, mémoire immédiate...) y est pratiquée. L’analyse de ces observations fait ressortir l’hétérogénéité des dyslexies, la fréquence des troubles du langage oral préexistants, et le caractère le plus souvent inadapté des modes d’analyse et de prise en charge de ces enfants. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=197 [article] Dyslexie développementale : exemple d'évaluation en milieu neuropédiatrique. A propos de 62 observations [Texte imprimé et/ou numérique] / B. ECHENNE, Auteur ; Renée CHEMINAL, Auteur ; Philippe COMPAGNON, Auteur ; F. RIVIER, Auteur ; D. DELPORT, Auteur ; Maya LOPEZ, Auteur ; P. KLEMM, Auteur ; E. ECHENNE, Auteur ; C. GRAS, Auteur ; J.-M. PERRET, Auteur ; M.J. PARAYRE-CHANEZ, Auteur . - 2001 . - p.129-134. Langues : Français (fre) in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 62-63 (Mai 2001) . - p.129-134 Mots-clés : Dyslexies  Dysphasies  Troubles du langage  Difficultés scolaires Index. décimale : PER Périodiques Résumé : Soixante-deux enfants dyslexiques ont été pris en charge pendant une période de trois ans dans le service de Neuropédiatrie du CHR de Montpellier. Une évaluation détaillée, comportant l’analyse des potentialités globales, des capacités langagières, orales et écrites, du niveau scolaire réel, des difficultés psychologiques éventuelles, ainsi que de certaines fonctions cognitives (perceptions phonétiques, gnosies auditivo-verbales, perception visuelle, attention, mémoire immédiate...) y est pratiquée. L’analyse de ces observations fait ressortir l’hétérogénéité des dyslexies, la fréquence des troubles du langage oral préexistants, et le caractère le plus souvent inadapté des modes d’analyse et de prise en charge de ces enfants. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=197

Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism / Stepan MELNYK in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377 Titre : Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur Année de publication : 2012 Article en page(s) : p.367-377 Langues : Anglais (eng) Mots-clés : Autism  Oxidative stress  Metabolic  Epigenetics  Glutathione  DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism [Texte imprimé et/ou numérique] / Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur . - 2012 . - p.367-377. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377 Mots-clés : Autism  Oxidative stress  Metabolic  Epigenetics  Glutathione  DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

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