[article]
| Titre : |
Effects of age and symptomatology on cortical thickness in autism spectrum disorders |
| Type de document : |
texte imprimé |
| Auteurs : |
Krissy DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason P. LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p.141-50 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorders Structural MRI Cortical thickness Social impairment Developmental changes |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. |
| En ligne : |
http://dx.doi.org/10.1016/j.rasd.2012.08.004 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 |
in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50
[article] Effects of age and symptomatology on cortical thickness in autism spectrum disorders [texte imprimé] / Krissy DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason P. LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2013 . - p.141-50. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50
| Mots-clés : |
Autism spectrum disorders Structural MRI Cortical thickness Social impairment Developmental changes |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. |
| En ligne : |
http://dx.doi.org/10.1016/j.rasd.2012.08.004 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 |
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Faire une suggestion Affiner la rechercheAdvancing paternal age and simplex autism in Autism, 16-4 (July 2012)
Behavioral and Psychosocial Interventions for Individuals with ASD
