Advancing paternal age and simplex autism / Connor M. PULEO in Autism, 16-4 (July 2012)  

Public ISBD [article]  inAutism > 16-4 (July 2012) . - p.367-380 Titre : Advancing paternal age and simplex autism Type de document : Texte imprimé et/ou numérique Auteurs : Connor M. PULEO, Auteur ; James SCHMEIDLER, Auteur ; Abraham REICHENBERG, Auteur ; Alexander KOLEVZON, Auteur ; Latha V. SOORYA, Auteur ; Joseph D. BUXBAUM, Auteur Année de publication : 2012 Article en page(s) : p.367-380 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  de novo  multiplex  paternal age  sex differences  simplex Index. décimale : PER Périodiques Résumé : De novo events appear more common in female and simplex autism spectrum disorder (ASD) cases and may underlie greater ASD risk in older fathers’ offspring. This study examined whether advancing paternal age predicts an increase in simplex (n = 90) versus multiplex ASD cases (n = 587) in 677 participants (340 families). Whether or not controlling for maternal age, results support a significant interaction of linear paternal age and sex of the child on simplex family type. Female ASD cases were significantly more likely to be simplex as paternal age increased, but the increase for males was not significant. Findings suggest that ASD arising from non-familial, de novo events may be far less prominent in males than in females, even if more prevalent in males, due to the substantially larger number of male cases attributable to other, more strongly male-biased risk factors. En ligne : http://dx.doi.org/10.1177/1362361311427154 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Advancing paternal age and simplex autism [Texte imprimé et/ou numérique] / Connor M. PULEO, Auteur ; James SCHMEIDLER, Auteur ; Abraham REICHENBERG, Auteur ; Alexander KOLEVZON, Auteur ; Latha V. SOORYA, Auteur ; Joseph D. BUXBAUM, Auteur . - 2012 . - p.367-380. Langues : Anglais (eng) in Autism > 16-4 (July 2012) . - p.367-380 Mots-clés : autism spectrum disorder  de novo  multiplex  paternal age  sex differences  simplex Index. décimale : PER Périodiques Résumé : De novo events appear more common in female and simplex autism spectrum disorder (ASD) cases and may underlie greater ASD risk in older fathers’ offspring. This study examined whether advancing paternal age predicts an increase in simplex (n = 90) versus multiplex ASD cases (n = 587) in 677 participants (340 families). Whether or not controlling for maternal age, results support a significant interaction of linear paternal age and sex of the child on simplex family type. Female ASD cases were significantly more likely to be simplex as paternal age increased, but the increase for males was not significant. Findings suggest that ASD arising from non-familial, de novo events may be far less prominent in males than in females, even if more prevalent in males, due to the substantially larger number of male cases attributable to other, more strongly male-biased risk factors. En ligne : http://dx.doi.org/10.1177/1362361311427154 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Behavioral and Psychosocial Interventions for Individuals with ASD / Latha V. SOORYA

Public ISBD in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM Titre : Behavioral and Psychosocial Interventions for Individuals with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Latha V. SOORYA, Auteur ; Laura A. CARPENTER, Auteur ; Zachary WARREN, Auteur Année de publication : 2013 Importance : p.69-84 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : This chapter provides a current overview of behavioral and psychosocial treatments for individuals with ASD. The approaches include empirically based methods as well as popular interventions designed to address core and associated symptoms. The chapter includes reviews of major comprehensive treatment programs and educational programs designed for young children with ASD, as well as targeted treatments to improve core deficits. Interventions designed to reduce problem behaviors, and alternative treatments commonly used in ASD are also addressed. Finally, trends and directions for future behavioral and psychosocial treatment research including a focus on implementation in community settings and designing treatments for older individuals with ASD are discussed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM Behavioral and Psychosocial Interventions for Individuals with ASD [Texte imprimé et/ou numérique] / Latha V. SOORYA, Auteur ; Laura A. CARPENTER, Auteur ; Zachary WARREN, Auteur . - 2013 . - p.69-84. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : This chapter provides a current overview of behavioral and psychosocial treatments for individuals with ASD. The approaches include empirically based methods as well as popular interventions designed to address core and associated symptoms. The chapter includes reviews of major comprehensive treatment programs and educational programs designed for young children with ASD, as well as targeted treatments to improve core deficits. Interventions designed to reduce problem behaviors, and alternative treatments commonly used in ASD are also addressed. Finally, trends and directions for future behavioral and psychosocial treatment research including a focus on implementation in community settings and designing treatments for older individuals with ASD are discussed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189

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Brief Report: The Autism Mental Status Examination: Development of a Brief Autism-Focused Exam / David GRODBERG in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.455-459 Titre : Brief Report: The Autism Mental Status Examination: Development of a Brief Autism-Focused Exam Type de document : Texte imprimé et/ou numérique Auteurs : David GRODBERG, Auteur ; Paige M. WEINGER, Auteur ; Alexander KOLEVZON, Auteur ; Latha V. SOORYA, Auteur ; Joseph D. BUXBAUM, Auteur Année de publication : 2012 Article en page(s) : p.455-459 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Mental status examination  Autism Diagnostic Observation Schedule  Autism Mental Status Examination Index. décimale : PER Périodiques Résumé : The Autism Mental Status Examination (AMSE) described here is an eight-item observational assessment that prompts the observation and recording of signs and symptoms of autism spectrum disorders (ASD). The AMSE is intended to take place seamlessly in the context of a clinical exam and produces a total score. Subjects were independently administered the AMSE and the Autism Diagnostic Observation Schedule (ADOS). The ADOS was used to estimate the most effective criterion cut-off on the AMSE. A score of five or greater produced excellent sensitivity and good specificity in a high-risk sample. Internal consistency was acceptable and inter-rater reliability was good to excellent. Preliminary findings indicate excellent classification accuracy and suggest that the AMSE provides a rapid and reliable observational assessment in a high-risk population. En ligne : http://dx.doi.org/10.1007/s10803-011-1255-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Brief Report: The Autism Mental Status Examination: Development of a Brief Autism-Focused Exam [Texte imprimé et/ou numérique] / David GRODBERG, Auteur ; Paige M. WEINGER, Auteur ; Alexander KOLEVZON, Auteur ; Latha V. SOORYA, Auteur ; Joseph D. BUXBAUM, Auteur . - 2012 . - p.455-459. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.455-459 Mots-clés : Autism spectrum disorder  Mental status examination  Autism Diagnostic Observation Schedule  Autism Mental Status Examination Index. décimale : PER Périodiques Résumé : The Autism Mental Status Examination (AMSE) described here is an eight-item observational assessment that prompts the observation and recording of signs and symptoms of autism spectrum disorders (ASD). The AMSE is intended to take place seamlessly in the context of a clinical exam and produces a total score. Subjects were independently administered the AMSE and the Autism Diagnostic Observation Schedule (ADOS). The ADOS was used to estimate the most effective criterion cut-off on the AMSE. A score of five or greater produced excellent sensitivity and good specificity in a high-risk sample. Internal consistency was acceptable and inter-rater reliability was good to excellent. Preliminary findings indicate excellent classification accuracy and suggest that the AMSE provides a rapid and reliable observational assessment in a high-risk population. En ligne : http://dx.doi.org/10.1007/s10803-011-1255-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Effects of age and symptomatology on cortical thickness in autism spectrum disorders / Krissy A. R. DOYLE-THOMAS in Research in Autism Spectrum Disorders, 7-1 (January 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50 Titre : Effects of age and symptomatology on cortical thickness in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Krissy A. R. DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur Année de publication : 2013 Article en page(s) : p.141-50 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Structural MRI  Cortical thickness  Social impairment  Developmental changes Index. décimale : PER Périodiques Résumé : Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Effects of age and symptomatology on cortical thickness in autism spectrum disorders [Texte imprimé et/ou numérique] / Krissy A. R. DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2013 . - p.141-50. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50 Mots-clés : Autism spectrum disorders  Structural MRI  Cortical thickness  Social impairment  Developmental changes Index. décimale : PER Périodiques Résumé : Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial / Evdokia ANAGNOSTOU in Molecular Autism, (December 2012)  

Public ISBD [article]  inMolecular Autism > (December 2012) . - 9 p. Titre : Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Evdokia ANAGNOSTOU, Auteur ; Latha V. SOORYA, Auteur ; William CHAPLIN, Auteur ; Jennifer BARTZ, Auteur ; Danielle B. HALPERN, Auteur ; Stacey WASSERMAN, Auteur ; A. Ting WANG, Auteur ; Lauren PEPA, Auteur ; Nadia TANEL, Auteur ; Azadeh KUSHKI, Auteur ; Eric HOLLANDER, Auteur Année de publication : 2012 Article en page(s) : 9 p. Langues : Anglais (eng) Mots-clés : Autism  Adults  Oxytocin  Clinical trial  Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND:There are no effective medications for the treatment of social cognition/function deficits in autism spectrum disorder (ASD), and adult intervention literature in this area is sparse. Emerging data from animal models and genetic association studies as well as early, single-dose intervention studies suggest that the oxytocin system may be a potential therapeutic target for social cognition/function deficits in ASD. The primary aim of this study was to examine the safety/therapeutic effects of intranasal oxytocin versus placebo in adults with ASD, with respect to the two core symptom domains of social cognition/functioning and repetitive behaviors.METHODS:This was a pilot, randomized, double-blind, placebo-controlled, parallel design trial of intranasal oxytocin versus placebo in 19 adults with ASD (16 males; 33.20 +/- 13.29 years). Subjects were randomized to 24 IU intranasal oxytocin or placebo in the morning and afternoon for 6 weeks. Measures of social function/cognition (the Diagnostic Analysis of Nonverbal Accuracy) and repetitive behaviors (Repetitive Behavior Scale Revised) were administered. Secondary measures included the Social Responsiveness Scale, Reading-the-Mind-in-the-Eyes Test and the Yale Brown Obsessive Compulsive Scale - compulsion subscale and quality of life (World Health Organization Quality of Life Questionnaire - emotional/social subscales). Full-information maximum-likelihood parameter estimates were obtained and tested using mixed-effects regression analyses.RESULTS:Although no significant changes were detected in the primary outcome measures after correcting for baseline differences, results suggested improvements after 6 weeks in measures of social cognition (Reading-the-Mind-in-the-Eyes Test, p = 0.002, d = 1.2), and quality of life (World Health Organization Quality of Life Questionnaire - emotion, p = 0.031, d = 0.84), both secondary measures. Oxytocin was well tolerated and no serious adverse effects were reported.CONCLUSIONS:This pilot study suggests that there is therapeutic potential to daily administration of intranasal oxytocin in adults with ASD and that larger and longer studies are warranted.TRIAL REGISTRATION:NCT00490802 En ligne : http://dx.doi.org/10.1186/2040-2392-3-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial [Texte imprimé et/ou numérique] / Evdokia ANAGNOSTOU, Auteur ; Latha V. SOORYA, Auteur ; William CHAPLIN, Auteur ; Jennifer BARTZ, Auteur ; Danielle B. HALPERN, Auteur ; Stacey WASSERMAN, Auteur ; A. Ting WANG, Auteur ; Lauren PEPA, Auteur ; Nadia TANEL, Auteur ; Azadeh KUSHKI, Auteur ; Eric HOLLANDER, Auteur . - 2012 . - 9 p. Langues : Anglais (eng) in Molecular Autism > (December 2012) . - 9 p. Mots-clés : Autism  Adults  Oxytocin  Clinical trial  Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND:There are no effective medications for the treatment of social cognition/function deficits in autism spectrum disorder (ASD), and adult intervention literature in this area is sparse. Emerging data from animal models and genetic association studies as well as early, single-dose intervention studies suggest that the oxytocin system may be a potential therapeutic target for social cognition/function deficits in ASD. The primary aim of this study was to examine the safety/therapeutic effects of intranasal oxytocin versus placebo in adults with ASD, with respect to the two core symptom domains of social cognition/functioning and repetitive behaviors.METHODS:This was a pilot, randomized, double-blind, placebo-controlled, parallel design trial of intranasal oxytocin versus placebo in 19 adults with ASD (16 males; 33.20 +/- 13.29 years). Subjects were randomized to 24 IU intranasal oxytocin or placebo in the morning and afternoon for 6 weeks. Measures of social function/cognition (the Diagnostic Analysis of Nonverbal Accuracy) and repetitive behaviors (Repetitive Behavior Scale Revised) were administered. Secondary measures included the Social Responsiveness Scale, Reading-the-Mind-in-the-Eyes Test and the Yale Brown Obsessive Compulsive Scale - compulsion subscale and quality of life (World Health Organization Quality of Life Questionnaire - emotional/social subscales). Full-information maximum-likelihood parameter estimates were obtained and tested using mixed-effects regression analyses.RESULTS:Although no significant changes were detected in the primary outcome measures after correcting for baseline differences, results suggested improvements after 6 weeks in measures of social cognition (Reading-the-Mind-in-the-Eyes Test, p = 0.002, d = 1.2), and quality of life (World Health Organization Quality of Life Questionnaire - emotion, p = 0.031, d = 0.84), both secondary measures. Oxytocin was well tolerated and no serious adverse effects were reported.CONCLUSIONS:This pilot study suggests that there is therapeutic potential to daily administration of intranasal oxytocin in adults with ASD and that larger and longer studies are warranted.TRIAL REGISTRATION:NCT00490802 En ligne : http://dx.doi.org/10.1186/2040-2392-3-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders / Krissy A. R. DOYLE-THOMAS in Research in Autism Spectrum Disorders, 8-1 (January 2014)  

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Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency / Latha V. SOORYA in Molecular Autism, (June 2013)  

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