Atypical autonomic nervous system complexity accompanies social cognition task performance in ASD / Hamidreza SAGHIR in Research in Autism Spectrum Disorders, 39 (July 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 39 (July 2017) . - p.54-62 Titre : Atypical autonomic nervous system complexity accompanies social cognition task performance in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Hamidreza SAGHIR, Auteur ; Annie DUPUIS, Auteur ; Tom CHAU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : p.54-62 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Autonomic nervous system  Complexity analysis  Social cognition  RMET  Theory of mind  ASD in children Index. décimale : PER Périodiques Résumé : AbstractBackground Emerging evidence suggests that autonomic nervous system (ANS) function is affected in ASD. Existing literature has focused on quantifying the activity of ANS components (i.e. sympathetic/parasympathetic systems) individually. To this end, measures such as respiratory sinus arrhythmia (RSA) and high- and low-frequency spectral components of heart rate variability have been employed. Recent findings indicate that these methods employ assumptions that do not fully consider the complexity of the ANS system and the interaction of its components. To this end, we propose a new method for examining ANS function in ASD. Methods A sample of typically developing (TD) children (n = 34) and children with ASD (n = 45) performed the Reading the Mind in the Eyes Task (RMET), preceded and followed by periods of baseline movie-watching. Multiscale Entropy (MSE) was employed as a new tool to examine the complexity of the cardiac signal. Results Significant group differences in MSE emerged to suggest atypicality in the regularity of the autonomic signal at short and long time scales in the ASD group during the RMET task. Conclusions For the RMET task, our results may suggest atypical activation of parasympathetic influences on the heart, which contributes to short-term patterns in the heartbeat signal, as well as atypicalities in the slower acting processes. Results also suggest that the coupling between the fast-acting and slow-acting influences may be atypical in ASD during the examined social cognition task. En ligne : https://doi.org/10.1016/j.rasd.2017.04.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Atypical autonomic nervous system complexity accompanies social cognition task performance in ASD [Texte imprimé et/ou numérique] / Hamidreza SAGHIR, Auteur ; Annie DUPUIS, Auteur ; Tom CHAU, Auteur ; Azadeh KUSHKI, Auteur . - p.54-62. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 39 (July 2017) . - p.54-62 Mots-clés : Autism spectrum disorder  Autonomic nervous system  Complexity analysis  Social cognition  RMET  Theory of mind  ASD in children Index. décimale : PER Périodiques Résumé : AbstractBackground Emerging evidence suggests that autonomic nervous system (ANS) function is affected in ASD. Existing literature has focused on quantifying the activity of ANS components (i.e. sympathetic/parasympathetic systems) individually. To this end, measures such as respiratory sinus arrhythmia (RSA) and high- and low-frequency spectral components of heart rate variability have been employed. Recent findings indicate that these methods employ assumptions that do not fully consider the complexity of the ANS system and the interaction of its components. To this end, we propose a new method for examining ANS function in ASD. Methods A sample of typically developing (TD) children (n = 34) and children with ASD (n = 45) performed the Reading the Mind in the Eyes Task (RMET), preceded and followed by periods of baseline movie-watching. Multiscale Entropy (MSE) was employed as a new tool to examine the complexity of the cardiac signal. Results Significant group differences in MSE emerged to suggest atypicality in the regularity of the autonomic signal at short and long time scales in the ASD group during the RMET task. Conclusions For the RMET task, our results may suggest atypical activation of parasympathetic influences on the heart, which contributes to short-term patterns in the heartbeat signal, as well as atypicalities in the slower acting processes. Results also suggest that the coupling between the fast-acting and slow-acting influences may be atypical in ASD during the examined social cognition task. En ligne : https://doi.org/10.1016/j.rasd.2017.04.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology / Sakeena PANJU in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-10 Titre : Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology Type de document : Texte imprimé et/ou numérique Auteurs : Sakeena PANJU, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has been associated with autonomic atypicalities, although the nature of these differences remains largely unknown. Moreover, existing literature suggests large variability in autonomic function in ASD, motivating the need to examine the existence of subgroups that exhibit more homogeneous autonomic features. En ligne : http://dx.doi.org/10.1186/s13229-015-0057-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology [Texte imprimé et/ou numérique] / Sakeena PANJU, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has been associated with autonomic atypicalities, although the nature of these differences remains largely unknown. Moreover, existing literature suggests large variability in autonomic function in ASD, motivating the need to examine the existence of subgroups that exhibit more homogeneous autonomic features. En ligne : http://dx.doi.org/10.1186/s13229-015-0057-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study / Alana IABONI ; Brett TROST ; Miriam REUTER ; Zsuzsa LINDENMAIER ; Azadeh KUSHKI ; Elizabeth KELLEY ; Jessica JONES ; Muhammed AYUB ; Stelios GEORGIADES ; Robert NICOLSON ; Elim CHAN ; Andrada CRETU ; Jessica BRIAN ; Evdokia ANAGNOSTOU in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1290-1300 Titre : Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study Type de document : Texte imprimé et/ou numérique Auteurs : Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammed AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1290-1300 Langues : Anglais (eng) Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected?=?0.015) and adaptive function (ABAS-2) scores (p corrected?=?0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p?=?0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study [Texte imprimé et/ou numérique] / Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammed AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1290-1300. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1290-1300 Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected?=?0.015) and adaptive function (ABAS-2) scores (p corrected?=?0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p?=?0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Erratum to: Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review / Azadeh KUSHKI in Journal of Autism and Developmental Disorders, 41-12 (December 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1717 Titre : Erratum to: Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review Type de document : Texte imprimé et/ou numérique Auteurs : Azadeh KUSHKI, Auteur ; Tom CHAU, Auteur ; Evdokia ANAGNOSTOU, Auteur Année de publication : 2011 Article en page(s) : p.1717 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-011-1335-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 [article] Erratum to: Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review [Texte imprimé et/ou numérique] / Azadeh KUSHKI, Auteur ; Tom CHAU, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2011 . - p.1717. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1717 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-011-1335-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148

Functional autonomic nervous system profile in children with autism spectrum disorder / Azadeh KUSHKI in Molecular Autism, (July 2014)  

Public ISBD [article]  inMolecular Autism > (July 2014) . - p.1-10 Titre : Functional autonomic nervous system profile in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Azadeh KUSHKI, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autonomic dysregulation has been recently reported as a feature of autism spectrum disorder (ASD). However, the nature of autonomic atypicalities in ASD remain largely unknown. The goal of this study was to characterize the cardiac autonomic profile of children with ASD across four domains affected in ASD (anxiety, attention, response inhibition, and social cognition), and suggested to be affected by autonomic dysregulation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-39 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Functional autonomic nervous system profile in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Azadeh KUSHKI, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (July 2014) . - p.1-10 Index. décimale : PER Périodiques Résumé : Autonomic dysregulation has been recently reported as a feature of autism spectrum disorder (ASD). However, the nature of autonomic atypicalities in ASD remain largely unknown. The goal of this study was to characterize the cardiac autonomic profile of children with ASD across four domains affected in ASD (anxiety, attention, response inhibition, and social cognition), and suggested to be affected by autonomic dysregulation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-39 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Handwriting Difficulties in Children with Autism Spectrum Disorders: A Scoping Review / Azadeh KUSHKI in Journal of Autism and Developmental Disorders, 41-12 (December 2011)  

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Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores / Alexandra LAUTARESCU ; Tony CHARMAN ; Jennifer CROSBIE ; Russell J SCHACHAR ; Alana IABONI ; Stelios GEORGIADES ; Robert NICOLSON ; Elizabeth KELLEY ; Muhammad AYUB ; Jessica JONES ; Paul D ARNOLD ; Jason P LERCH ; Evdokia ANAGNOSTOU ; Azadeh KUSHKI in Molecular Autism, 15 (2024)  

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Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial / Evdokia ANAGNOSTOU in Molecular Autism, (December 2012)  

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Novel Therapeutics in Autism Spectrum Disorders / Evdokia ANAGNOSTOU

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Patterns and impact of technology use in autistic children / Robyn CARDY in Research in Autism Spectrum Disorders, 108 (October 2023)  

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Short report: Evaluating the safety and usability of head-mounted virtual reality compared to monitor-displayed video for children with autism spectrum disorder / Mahan MALIHI in Autism, 24-7 (October 2020)  

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Specificity of autonomic arousal to anxiety in children with autism spectrum disorder / Tabitha A. CHIU in Autism Research, 9-4 (April 2016)  

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