Adaptation of the “ten questions” to screen for autism and other neurodevelopmental disorders in Uganda / Angelina KAKOOZA-MWESIGE in Autism, 18-4 (May 2014)  

Public ISBD [article]  inAutism > 18-4 (May 2014) . - p.447-457 Titre : Adaptation of the “ten questions” to screen for autism and other neurodevelopmental disorders in Uganda Type de document : Texte imprimé et/ou numérique Auteurs : Angelina KAKOOZA-MWESIGE, Auteur ; Keron SSEBYALA, Auteur ; Charles KARAMAGI, Auteur ; Sarah KIGULI, Auteur ; Karen SMITH, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Edwin TREVATHAN, Auteur ; Robin HANSEN, Auteur ; Daniel SMITH, Auteur ; Judith K. GRETHER, Auteur Article en page(s) : p.447-457 Langues : Anglais (eng) Mots-clés : autism spectrum disorder screening and assessment  developing countries  low- and middle-income countries  neurodevelopmental disorder screening and assessment  Uganda Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders are recognized to be relatively common in developing countries but little data exist for planning effective prevention and intervention strategies. In particular, data on autism spectrum disorders are lacking. For application in Uganda, we developed a 23-question screener (23Q) that includes the Ten Questions screener and additional questions on autism spectrum disorder behaviors. We then conducted household screening of 1169 children, 2–9 years of age, followed by clinical assessment of children who screened positive and a sample of those who screened negative to evaluate the validity of the screener. We found that 320 children (27% of the total) screened positive and 68 children received a clinical diagnosis of one or more moderate to severe neurodevelopmental disorders (autism spectrum disorder; cerebral palsy; epilepsy; cognitive, speech and language, hearing, or vision impairment), including 8 children with autism spectrum disorders. Prevalence and validity of the screener were evaluated under different statistical assumptions. Sensitivity of the 23Q ranged from 0.55 to 0.80 and prevalence for ?1 neurodevelopmental disorders from 7.7/100 children to 12.8/100 children depending on which assumptions were used. The combination of screening positive on both autism spectrum disorders and Ten Questions items was modestly successful in identifying a subgroup of children at especially high risk of autism spectrum disorders. We recommend that autism spectrum disorders and related behavioral disorders be included in studies of neurodevelopmental disorders in low-resource settings to obtain essential data for planning local and global public health responses. En ligne : http://dx.doi.org/10.1177/1362361313475848 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Adaptation of the “ten questions” to screen for autism and other neurodevelopmental disorders in Uganda [Texte imprimé et/ou numérique] / Angelina KAKOOZA-MWESIGE, Auteur ; Keron SSEBYALA, Auteur ; Charles KARAMAGI, Auteur ; Sarah KIGULI, Auteur ; Karen SMITH, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Edwin TREVATHAN, Auteur ; Robin HANSEN, Auteur ; Daniel SMITH, Auteur ; Judith K. GRETHER, Auteur . - p.447-457. Langues : Anglais (eng) in Autism > 18-4 (May 2014) . - p.447-457 Mots-clés : autism spectrum disorder screening and assessment  developing countries  low- and middle-income countries  neurodevelopmental disorder screening and assessment  Uganda Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders are recognized to be relatively common in developing countries but little data exist for planning effective prevention and intervention strategies. In particular, data on autism spectrum disorders are lacking. For application in Uganda, we developed a 23-question screener (23Q) that includes the Ten Questions screener and additional questions on autism spectrum disorder behaviors. We then conducted household screening of 1169 children, 2–9 years of age, followed by clinical assessment of children who screened positive and a sample of those who screened negative to evaluate the validity of the screener. We found that 320 children (27% of the total) screened positive and 68 children received a clinical diagnosis of one or more moderate to severe neurodevelopmental disorders (autism spectrum disorder; cerebral palsy; epilepsy; cognitive, speech and language, hearing, or vision impairment), including 8 children with autism spectrum disorders. Prevalence and validity of the screener were evaluated under different statistical assumptions. Sensitivity of the 23Q ranged from 0.55 to 0.80 and prevalence for ?1 neurodevelopmental disorders from 7.7/100 children to 12.8/100 children depending on which assumptions were used. The combination of screening positive on both autism spectrum disorders and Ten Questions items was modestly successful in identifying a subgroup of children at especially high risk of autism spectrum disorders. We recommend that autism spectrum disorders and related behavioral disorders be included in studies of neurodevelopmental disorders in low-resource settings to obtain essential data for planning local and global public health responses. En ligne : http://dx.doi.org/10.1177/1362361313475848 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

Antenatal Ultrasound and Risk of Autism Spectrum Disorders / Judith K. GRETHER in Journal of Autism and Developmental Disorders, 40-2 (February 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-2 (February 2010) . - p.238-245 Titre : Antenatal Ultrasound and Risk of Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Judith K. GRETHER, Auteur ; Cathleen K. YOSHIDA, Auteur ; Sherian XU LI, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2010 Article en page(s) : p.238-245 Langues : Anglais (eng) Mots-clés : Antenatal-ultrasound Obstetrical-ultrasound Autism Index. décimale : PER Périodiques Résumé : We evaluated antenatal ultrasound (U/S) exposure as a risk factor for autism spectrum disorders (ASD), comparing affected singleton children and control children born 1995–1999 and enrolled in the Kaiser Permanente health care system. Among children with ASD (n = 362) and controls (n = 393), 13% had no antenatal exposure to U/S examinations; case–control differences in number of exposures during the entire gestation or by trimester were small and not statistically significant. In analyses adjusted for covariates, cases were generally similar to controls with regard to the number of U/S scans throughout gestation and during each trimester. This study indicates that antenatal U/S is unlikely to increase the risk of ASD, although studies examining ASD subgroups remain to be conducted. En ligne : http://dx.doi.org/10.1007/s10803-009-0859-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=965 [article] Antenatal Ultrasound and Risk of Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Judith K. GRETHER, Auteur ; Cathleen K. YOSHIDA, Auteur ; Sherian XU LI, Auteur ; Lisa A. CROEN, Auteur . - 2010 . - p.238-245. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-2 (February 2010) . - p.238-245 Mots-clés : Antenatal-ultrasound Obstetrical-ultrasound Autism Index. décimale : PER Périodiques Résumé : We evaluated antenatal ultrasound (U/S) exposure as a risk factor for autism spectrum disorders (ASD), comparing affected singleton children and control children born 1995–1999 and enrolled in the Kaiser Permanente health care system. Among children with ASD (n = 362) and controls (n = 393), 13% had no antenatal exposure to U/S examinations; case–control differences in number of exposures during the entire gestation or by trimester were small and not statistically significant. In analyses adjusted for covariates, cases were generally similar to controls with regard to the number of U/S scans throughout gestation and during each trimester. This study indicates that antenatal U/S is unlikely to increase the risk of ASD, although studies examining ASD subgroups remain to be conducted. En ligne : http://dx.doi.org/10.1007/s10803-009-0859-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=965

Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? / Sumi HOSHIKO in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.456-463 Titre : Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? Type de document : Texte imprimé et/ou numérique Auteurs : Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur Année de publication : 2012 Article en page(s) : p.456-463 Langues : Anglais (eng) Mots-clés : epidemiology  autism  thyroid  environment  hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? [Texte imprimé et/ou numérique] / Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur . - 2012 . - p.456-463. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.456-463 Mots-clés : epidemiology  autism  thyroid  environment  hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1621-1632 Titre : Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Karen S. SMITH, Auteur ; Nila ROSEN, Auteur ; Meredith C. ANDERSON, Auteur ; Judith K. GRETHER, Auteur ; Richard B. COOLMAN, Auteur ; Stephen HARRIS, Auteur Article en page(s) : p.1621-1632 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Developmental screening  M-CHAT  ASQ  Hispanics  Children’s health Index. décimale : PER Périodiques Résumé : We implemented screening of children 16–30 months of age (n = 1,760) from a typically under-served, primarily Hispanic, population, at routine pediatric appointments using the modified checklist for autism in toddlers (M-CHAT) and Ages and Stages Questionnaire. Screen positive rates of 26 and 39 %, respectively, were higher than previous reports. Hispanics were more likely to score M-CHAT positive than non-Hispanics (adjusted OR 1.7, 95 % CI 1.2–2.4), as were those screened in Spanish. About 30 % of screen-positive children were referred for further assessment, but only half were seen. Thus screening in this population is feasible, but may require additional resources. Attention to the cultural applicability of screening instruments, as well as to explaining the results or need for additional services to parents, is critical to serve the growing Hispanic population. En ligne : http://dx.doi.org/10.1007/s10803-014-2032-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Karen S. SMITH, Auteur ; Nila ROSEN, Auteur ; Meredith C. ANDERSON, Auteur ; Judith K. GRETHER, Auteur ; Richard B. COOLMAN, Auteur ; Stephen HARRIS, Auteur . - p.1621-1632. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1621-1632 Mots-clés : Autism spectrum disorders  Developmental screening  M-CHAT  ASQ  Hispanics  Children’s health Index. décimale : PER Périodiques Résumé : We implemented screening of children 16–30 months of age (n = 1,760) from a typically under-served, primarily Hispanic, population, at routine pediatric appointments using the modified checklist for autism in toddlers (M-CHAT) and Ages and Stages Questionnaire. Screen positive rates of 26 and 39 %, respectively, were higher than previous reports. Hispanics were more likely to score M-CHAT positive than non-Hispanics (adjusted OR 1.7, 95 % CI 1.2–2.4), as were those screened in Spanish. About 30 % of screen-positive children were referred for further assessment, but only half were seen. Thus screening in this population is feasible, but may require additional resources. Attention to the cultural applicability of screening instruments, as well as to explaining the results or need for additional services to parents, is critical to serve the growing Hispanic population. En ligne : http://dx.doi.org/10.1007/s10803-014-2032-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

Autism spectrum disorders in relation to parental occupation in technical fields / Gayle C. WINDHAM in Autism Research, 2-4 (August 2009)  

Public ISBD [article]  inAutism Research > 2-4 (August 2009) . - p.183-191 Titre : Autism spectrum disorders in relation to parental occupation in technical fields Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Judith K. GRETHER, Auteur ; Karen FESSEL, Auteur Année de publication : 2009 Article en page(s) : p.183-191 Langues : Anglais (eng) Mots-clés : autism parental-occupation broader-autism-phenotype risk-factors Index. décimale : PER Périodiques Résumé : A previous study reported that fathers of children with autism spectrum disorders (ASD) were more likely to work as engineers, requiring systemizing skills, and suggesting a distinct phenotype, but alternatively this may have been related to selection biases. We conducted a population-based study to explore whether fathers, or mothers, of children with ASD are over-represented in fields requiring highly technical skills. Subjects included 284 children with ASD and 659 gender-matched controls, born in 1994 in the San Francisco Bay Area. Parental occupation and industry were abstracted verbatim from birth certificates. Engineering, computer programming, and science were examined as highly technical occupations. To limit bias by parental socio-economic status, we selected a referent group of occupations that seemed professionally similar but of a less technical nature. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for parental age, education, and child race. Mothers of cases were somewhat more likely to work in hi-tech occupations (6.7%) than mothers of controls (4.0%, P=0.07), but little difference was observed among fathers, nor for engineering separately. Compared to parents in other white collar occupations, the adjusted OR for highly technical occupations among mothers was 2.5 (95% CI: 1.2-5.3) and among fathers was 1.3 (95% CI: 0.79-2.1), with no evidence of a joint effect observed. Our results regarding maternal occupation in technical fields being associated with ASD in offspring suggest further study to distinguish parental occupation as a phenotypic marker of genetic loading vs. other social or exposure factors. En ligne : http://dx.doi.org/10.1002/aur.84 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937 [article] Autism spectrum disorders in relation to parental occupation in technical fields [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Judith K. GRETHER, Auteur ; Karen FESSEL, Auteur . - 2009 . - p.183-191. Langues : Anglais (eng) in Autism Research > 2-4 (August 2009) . - p.183-191 Mots-clés : autism parental-occupation broader-autism-phenotype risk-factors Index. décimale : PER Périodiques Résumé : A previous study reported that fathers of children with autism spectrum disorders (ASD) were more likely to work as engineers, requiring systemizing skills, and suggesting a distinct phenotype, but alternatively this may have been related to selection biases. We conducted a population-based study to explore whether fathers, or mothers, of children with ASD are over-represented in fields requiring highly technical skills. Subjects included 284 children with ASD and 659 gender-matched controls, born in 1994 in the San Francisco Bay Area. Parental occupation and industry were abstracted verbatim from birth certificates. Engineering, computer programming, and science were examined as highly technical occupations. To limit bias by parental socio-economic status, we selected a referent group of occupations that seemed professionally similar but of a less technical nature. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for parental age, education, and child race. Mothers of cases were somewhat more likely to work in hi-tech occupations (6.7%) than mothers of controls (4.0%, P=0.07), but little difference was observed among fathers, nor for engineering separately. Compared to parents in other white collar occupations, the adjusted OR for highly technical occupations among mothers was 2.5 (95% CI: 1.2-5.3) and among fathers was 1.3 (95% CI: 0.79-2.1), with no evidence of a joint effect observed. Our results regarding maternal occupation in technical fields being associated with ASD in offspring suggest further study to distinguish parental occupation as a phenotypic marker of genetic loading vs. other social or exposure factors. En ligne : http://dx.doi.org/10.1002/aur.84 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937

Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 41-10 (October 2011)  

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Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study / Lisa A. CROEN in Autism Research, 1-2 (April 2008)  

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Brief Report: Effect of Maternal Age on Severity of Autism / Alisa C. BAXTER in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

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“Communities” in Community Engagement: Lessons Learned From Autism Research in South Korea and South Africa / Roy Richard GRINKER in Autism Research, 5-3 (June 2012)  

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Head Circumferences in Twins With and Without Autism Spectrum Disorders / Wendy FROEHLICH in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

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Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving birth to a child with autism: a case-control study / Paula GOINES in Molecular Autism, (August 2011)  

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Investigation of Shifts in Autism Reporting in the California Department of Developmental Services / Judith K. GRETHER in Journal of Autism and Developmental Disorders, 39-10 (October 2009)  

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Is Infertility Associated with Childhood Autism? / Judith K. GRETHER in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

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Maternal Infection During Pregnancy and Autism Spectrum Disorders / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

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Neonatally measured immunoglobulins and risk of autism / Judith K. GRETHER in Autism Research, 3-6 (December 2010)  

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