Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis / Thomas W. FRAZIER in Autism, 18-5 (July 2014)  

Public ISBD [article]  inAutism > 18-5 (July 2014) . - p.571-582 Titre : Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Eric A. YOUNGSTROM, Auteur ; Rebecca EMBACHER, Auteur ; Antonio Y. HARDAN, Auteur ; John N. CONSTANTINO, Auteur ; Paul LAW, Auteur ; Robert L. FINDLING, Auteur ; Charis ENG, Auteur Article en page(s) : p.571-582 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  autism symptoms  diagnosis  prediction Index. décimale : PER Périodiques Résumé : Demographic and clinical factors may influence assessment of autism symptoms. This study evaluated these correlates and also examined whether social communication and interaction and restricted/repetitive behavior provided unique prediction of autism spectrum disorder diagnosis. We analyzed data from 7352 siblings included in the Interactive Autism Network registry. Social communication and interaction and restricted/repetitive behavior symptoms were obtained using caregiver-reports on the Social Responsiveness Scale. Demographic and clinical correlates were covariates in regression models predicting social communication and interaction and restricted/repetitive behavior symptoms. Logistic regression and receiver operating characteristic curve analyses evaluated the incremental validity of social communication and interaction and restricted/repetitive behavior domains over and above global autism symptoms. Autism spectrum disorder diagnosis was the strongest correlate of caregiver-reported social communication and interaction and restricted/repetitive behavior symptoms. The presence of comorbid diagnoses also increased symptom levels. Social communication and interaction and restricted/repetitive behavior symptoms provided significant, but modest, incremental validity in predicting diagnosis beyond global autism symptoms. These findings suggest that autism spectrum disorder diagnosis is by far the largest determinant of quantitatively measured autism symptoms. Externalizing (attention deficit hyperactivity disorder) and internalizing (anxiety) behavior, low cognitive ability, and demographic factors may confound caregiver-report of autism symptoms, potentially necessitating a continuous norming approach to the revision of symptom measures. Social communication and interaction and restricted/repetitive behavior symptoms may provide incremental validity in the diagnosis of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361313481506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Eric A. YOUNGSTROM, Auteur ; Rebecca EMBACHER, Auteur ; Antonio Y. HARDAN, Auteur ; John N. CONSTANTINO, Auteur ; Paul LAW, Auteur ; Robert L. FINDLING, Auteur ; Charis ENG, Auteur . - p.571-582. Langues : Anglais (eng) in Autism > 18-5 (July 2014) . - p.571-582 Mots-clés : autism spectrum disorder  autism symptoms  diagnosis  prediction Index. décimale : PER Périodiques Résumé : Demographic and clinical factors may influence assessment of autism symptoms. This study evaluated these correlates and also examined whether social communication and interaction and restricted/repetitive behavior provided unique prediction of autism spectrum disorder diagnosis. We analyzed data from 7352 siblings included in the Interactive Autism Network registry. Social communication and interaction and restricted/repetitive behavior symptoms were obtained using caregiver-reports on the Social Responsiveness Scale. Demographic and clinical correlates were covariates in regression models predicting social communication and interaction and restricted/repetitive behavior symptoms. Logistic regression and receiver operating characteristic curve analyses evaluated the incremental validity of social communication and interaction and restricted/repetitive behavior domains over and above global autism symptoms. Autism spectrum disorder diagnosis was the strongest correlate of caregiver-reported social communication and interaction and restricted/repetitive behavior symptoms. The presence of comorbid diagnoses also increased symptom levels. Social communication and interaction and restricted/repetitive behavior symptoms provided significant, but modest, incremental validity in predicting diagnosis beyond global autism symptoms. These findings suggest that autism spectrum disorder diagnosis is by far the largest determinant of quantitatively measured autism symptoms. Externalizing (attention deficit hyperactivity disorder) and internalizing (anxiety) behavior, low cognitive ability, and demographic factors may confound caregiver-report of autism symptoms, potentially necessitating a continuous norming approach to the revision of symptom measures. Social communication and interaction and restricted/repetitive behavior symptoms may provide incremental validity in the diagnosis of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361313481506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

Risk factors for bullying among children with autism spectrum disorders / Benjamin ZABLOTSKY in Autism, 18-4 (May 2014)  

Public ISBD [article]  inAutism > 18-4 (May 2014) . - p.419-427 Titre : Risk factors for bullying among children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin ZABLOTSKY, Auteur ; Catherine P. BRADSHAW, Auteur ; Connie M. ANDERSON, Auteur ; Paul LAW, Auteur Article en page(s) : p.419-427 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  bullying  schools  special needs Index. décimale : PER Périodiques Résumé : Although children with disabilities have been found to be at an increased risk of bullying, there are limited studies investigating predictors of bullying involvement in children with autism spectrum disorders. The current study presents findings from 1221 parents of children diagnosed with autism spectrum disorder who were selected from a national web-based registry. Parents completed a survey dedicated to the school and bullying experiences of their child, and multivariate logistic regression analyses were conducted to identify child and school risk factors for involvement as victim, bully, or bully–victim. Additional analyses examined the risk of bullying involvement based on the amount of time spent in general education classrooms. Children diagnosed with Asperger’s disorder, attending a public school or a school with a general education population, were at the greatest risk of being victimized in the past month. Children with comorbid conditions and a high level of autistic traits were the most likely to be victims, bullies, and bully–victims. Finally, children in full inclusion classrooms were more likely to be victimized than those who spend the majority of their time in special education settings. Future research studies should be invested in finding appropriate supports for children with autism spectrum disorder placed in inclusive settings. En ligne : http://dx.doi.org/10.1177/1362361313477920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Risk factors for bullying among children with autism spectrum disorders [Texte imprimé et/ou numérique] / Benjamin ZABLOTSKY, Auteur ; Catherine P. BRADSHAW, Auteur ; Connie M. ANDERSON, Auteur ; Paul LAW, Auteur . - p.419-427. Langues : Anglais (eng) in Autism > 18-4 (May 2014) . - p.419-427 Mots-clés : autism spectrum disorder  bullying  schools  special needs Index. décimale : PER Périodiques Résumé : Although children with disabilities have been found to be at an increased risk of bullying, there are limited studies investigating predictors of bullying involvement in children with autism spectrum disorders. The current study presents findings from 1221 parents of children diagnosed with autism spectrum disorder who were selected from a national web-based registry. Parents completed a survey dedicated to the school and bullying experiences of their child, and multivariate logistic regression analyses were conducted to identify child and school risk factors for involvement as victim, bully, or bully–victim. Additional analyses examined the risk of bullying involvement based on the amount of time spent in general education classrooms. Children diagnosed with Asperger’s disorder, attending a public school or a school with a general education population, were at the greatest risk of being victimized in the past month. Children with comorbid conditions and a high level of autistic traits were the most likely to be victims, bullies, and bully–victims. Finally, children in full inclusion classrooms were more likely to be victimized than those who spend the majority of their time in special education settings. Future research studies should be invested in finding appropriate supports for children with autism spectrum disorder placed in inclusive settings. En ligne : http://dx.doi.org/10.1177/1362361313477920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

The Association Between Child Autism Symptomatology, Maternal Quality of Life, and Risk for Depression / Benjamin ZABLOTSKY in Journal of Autism and Developmental Disorders, 43-8 (August 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1946-1955 Titre : The Association Between Child Autism Symptomatology, Maternal Quality of Life, and Risk for Depression Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin ZABLOTSKY, Auteur ; Connie M. ANDERSON, Auteur ; Paul LAW, Auteur Article en page(s) : p.1946-1955 Langues : Anglais (eng) Mots-clés : Parental depression  Autism spectrum  Parents  Parent stress  Quality of life Index. décimale : PER Périodiques Résumé : Parents raising children with autism spectrum disorders (ASDs) have been shown to experience high levels of stress and report a lower quality of life. The current study examined the association between child autism symptomatology, mother’s quality of life, and mother’s risk for depression in a sample of 1,110 mothers recruited from a web-based registry of families with children with an ASD. Higher autism symptomatology and a greater number of co-occurring psychiatric disorders in the child were associated with an increased risk for current treatment of maternal depression and a lower maternal quality of life. The results highlight the importance of screening for depression, particularly in mothers of children with ASD and mental health and behavioral challenges. En ligne : http://dx.doi.org/10.1007/s10803-012-1745-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206 [article] The Association Between Child Autism Symptomatology, Maternal Quality of Life, and Risk for Depression [Texte imprimé et/ou numérique] / Benjamin ZABLOTSKY, Auteur ; Connie M. ANDERSON, Auteur ; Paul LAW, Auteur . - p.1946-1955. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1946-1955 Mots-clés : Parental depression  Autism spectrum  Parents  Parent stress  Quality of life Index. décimale : PER Périodiques Résumé : Parents raising children with autism spectrum disorders (ASDs) have been shown to experience high levels of stress and report a lower quality of life. The current study examined the association between child autism symptomatology, mother’s quality of life, and mother’s risk for depression in a sample of 1,110 mothers recruited from a web-based registry of families with children with an ASD. Higher autism symptomatology and a greater number of co-occurring psychiatric disorders in the child were associated with an increased risk for current treatment of maternal depression and a lower maternal quality of life. The results highlight the importance of screening for depression, particularly in mothers of children with ASD and mental health and behavioral challenges. En ligne : http://dx.doi.org/10.1007/s10803-012-1745-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206

A Twin Study of Heritable and Shared Environmental Contributions to Autism / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 44-8 (August 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025 Titre : A Twin Study of Heritable and Shared Environmental Contributions to Autism Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur Article en page(s) : p.2013-2025 Langues : Anglais (eng) Mots-clés : Autism  Twins  Genetic  Heritability  Environment  Diagnosis Index. décimale : PER Périodiques Résumé : The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92?1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements. En ligne : http://dx.doi.org/10.1007/s10803-014-2081-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] A Twin Study of Heritable and Shared Environmental Contributions to Autism [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur . - p.2013-2025. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025 Mots-clés : Autism  Twins  Genetic  Heritability  Environment  Diagnosis Index. décimale : PER Périodiques Résumé : The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92?1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements. En ligne : http://dx.doi.org/10.1007/s10803-014-2081-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

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