Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information / Jennifer L. HUDSON in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094 Titre : Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information Type de document : texte imprimé Auteurs : Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.1086-1094 Langues : Anglais (eng) Mots-clés : CBT  G × E  anxiety disorders  child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information [texte imprimé] / Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur . - p.1086-1094. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094 Mots-clés : CBT  G × E  anxiety disorders  child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders / Anna MCKINNON in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.763-772 Titre : The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders Type de document : texte imprimé Auteurs : Anna MCKINNON, Auteur ; Robert KEERS, Auteur ; Jonathan R.I. COLEMAN, Auteur ; Kathryn J. LESTER, Auteur ; S. Wendy ROBERTS, Auteur ; Kristian ARENDT, Auteur ; Susan M. BOGELS, Auteur ; Peter J. COOPER, Auteur ; Cathy CRESWELL, Auteur ; Catharina A. HARTMAN, Auteur ; Krister W. FJERMESTAD, Auteur ; Tina IN-ALBON, Auteur ; Kristen LAVALLEE, Auteur ; Heidi J. LYNEHAM, Auteur ; Paula SMITH, Auteur ; Richard MEISER-STEDMAN, Auteur ; Maaike H. NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Yasmin REY, Auteur ; Silvia SCHNEIDER, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Gro Janne WERGELAND, Auteur ; Thalia C. ELEY, Auteur ; Jennifer L. HUDSON, Auteur Année de publication : 2018 Article en page(s) : p.763-772 Langues : Anglais (eng) Mots-clés : Anxiety  cognitive therapy  treatment trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Several delivery formats of cognitive behaviour therapy (CBT) for child anxiety have been proposed, however, there is little consensus on the optimal delivery format. The primary goal of this study was to investigate the impact of the child's primary anxiety diagnosis on changes in clinical severity (of the primary problem) during individual CBT, group CBT and guided parent-led CBT. The secondary goal was to investigate the impact of the child's primary anxiety diagnosis on rates of remission for the three treatment formats. METHODS: A sample of 1,253 children (5-12 years; Mage = 9.3, SD = 1.7) was pooled from CBT trials carried out at 10 sites. Children had a primary diagnosis of generalised anxiety disorder (GAD), social anxiety disorder (SoAD), specific phobia (SP) or separation anxiety disorder (SAD). Children and parents completed a semistructured clinical interview to assess the presence and severity of DSM-IV psychiatric disorders at preintervention, postintervention and follow-up. Linear mixture modelling was used to evaluate the primary research question and logistic modelling was used to investigate the secondary research question. RESULTS: In children with primary GAD, SAD or SoAD, there were no significant differences between delivery formats. However, children with primary SP showed significantly larger reductions in clinical severity following individual CBT compared to group CBT and guided parent-led CBT. The results were mirrored in the analysis of remission responses with the exception that individual CBT was no longer superior to group CBT for children with a primary SP. The difference between individual and group was not significant when follow-up data were examined separately. CONCLUSIONS: Data show there may be greater clinical benefit by allocating children with a primary SP to individual CBT, although future research on cost-effectiveness is needed to determine whether the additional clinical benefits justify the additional resources required. En ligne : http://dx.doi.org/10.1111/jcpp.12872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders [texte imprimé] / Anna MCKINNON, Auteur ; Robert KEERS, Auteur ; Jonathan R.I. COLEMAN, Auteur ; Kathryn J. LESTER, Auteur ; S. Wendy ROBERTS, Auteur ; Kristian ARENDT, Auteur ; Susan M. BOGELS, Auteur ; Peter J. COOPER, Auteur ; Cathy CRESWELL, Auteur ; Catharina A. HARTMAN, Auteur ; Krister W. FJERMESTAD, Auteur ; Tina IN-ALBON, Auteur ; Kristen LAVALLEE, Auteur ; Heidi J. LYNEHAM, Auteur ; Paula SMITH, Auteur ; Richard MEISER-STEDMAN, Auteur ; Maaike H. NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Yasmin REY, Auteur ; Silvia SCHNEIDER, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Gro Janne WERGELAND, Auteur ; Thalia C. ELEY, Auteur ; Jennifer L. HUDSON, Auteur . - 2018 . - p.763-772. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.763-772 Mots-clés : Anxiety  cognitive therapy  treatment trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Several delivery formats of cognitive behaviour therapy (CBT) for child anxiety have been proposed, however, there is little consensus on the optimal delivery format. The primary goal of this study was to investigate the impact of the child's primary anxiety diagnosis on changes in clinical severity (of the primary problem) during individual CBT, group CBT and guided parent-led CBT. The secondary goal was to investigate the impact of the child's primary anxiety diagnosis on rates of remission for the three treatment formats. METHODS: A sample of 1,253 children (5-12 years; Mage = 9.3, SD = 1.7) was pooled from CBT trials carried out at 10 sites. Children had a primary diagnosis of generalised anxiety disorder (GAD), social anxiety disorder (SoAD), specific phobia (SP) or separation anxiety disorder (SAD). Children and parents completed a semistructured clinical interview to assess the presence and severity of DSM-IV psychiatric disorders at preintervention, postintervention and follow-up. Linear mixture modelling was used to evaluate the primary research question and logistic modelling was used to investigate the secondary research question. RESULTS: In children with primary GAD, SAD or SoAD, there were no significant differences between delivery formats. However, children with primary SP showed significantly larger reductions in clinical severity following individual CBT compared to group CBT and guided parent-led CBT. The results were mirrored in the analysis of remission responses with the exception that individual CBT was no longer superior to group CBT for children with a primary SP. The difference between individual and group was not significant when follow-up data were examined separately. CONCLUSIONS: Data show there may be greater clinical benefit by allocating children with a primary SP to individual CBT, although future research on cost-effectiveness is needed to determine whether the additional clinical benefits justify the additional resources required. En ligne : http://dx.doi.org/10.1111/jcpp.12872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

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