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Auteur Robert KEERS |
Documents disponibles écrits par cet auteur (2)
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Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study / Robert KEERS in Development and Psychopathology, 29-5 (December 2017)
[article]
Titre : Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study Type de document : Texte imprimé et/ou numérique Auteurs : Robert KEERS, Auteur ; Michael PLUESS, Auteur Article en page(s) : p.1921-1933 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324
in Development and Psychopathology > 29-5 (December 2017) . - p.1921-1933[article] Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study [Texte imprimé et/ou numérique] / Robert KEERS, Auteur ; Michael PLUESS, Auteur . - p.1921-1933.
Langues : Anglais (eng)
in Development and Psychopathology > 29-5 (December 2017) . - p.1921-1933
Index. décimale : PER Périodiques Résumé : While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses. En ligne : http://dx.doi.org/10.1017/S0954579417001493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation / Sandra MACHLITT-NORTHEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)
[article]
Titre : Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation Type de document : Texte imprimé et/ou numérique Auteurs : Sandra MACHLITT-NORTHEN, Auteur ; Robert KEERS, Auteur ; Patricia B. MUNROE, Auteur ; David M. HOWARD, Auteur ; Vassily TRUBETSKOY, Auteur ; Michael PLUESS, Auteur Année de publication : 2022 Article en page(s) : p.1140-1152 Langues : Anglais (eng) Mots-clés : Cohort Studies Depression Depressive Disorder, Major/etiology/genetics Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Humans Multifactorial Inheritance Risk Factors Schizophrenia/epidemiology/genetics Environment genetics major depressive disorder schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Whilst genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) have been established, it is unclear whether exposure to environmental risk factors is genetically confounded by passive, evocative or active gene-environment correlation (rGE). STUDY OBJECTIVE: This study aims to investigate: (a) whether the genetic risk for SCZ/MDD in children is correlated with established environmental and psychosocial risk factors in two British community samples, the 1958 National Child Development Study (NCDS) and the Millennium Cohort Study (MCS), (b) whether these associations vary between both psychopathologies, and (c) whether findings differ across the two cohorts which were born 42years apart. METHODS: Polygenic risk scores (PRS) from existing large genome-wide associations studies (GWAS) were applied to test the correlation between the child genetic risk for SCZ/MDD and known environmental risk factors. In addition, parental and child genetic data from MCS were used to distinguish between passive and evocative rGE. RESULTS: The child polygenic risk for SCZ and MDD was correlated with single parenthood in MCS. Moreover, the lack of father's involvement in child care was associated with the genetic risk for SCZ in NCDS. However, we also found associations between several indicators of low socioeconomic status and heightened genetic risk for MDD in children in both cohorts. Further, the genetic risk for MDD was associated with parental lack of interest in the child's education in NCDS as well as more maternal smoking and less maternal alcohol consumption during childhood in MCS. According to sensitivity analyses in MCS (controlling for parental genotype), more than half of our significant correlations reflected passive rGE. CONCLUSIONS: Findings suggest that several established environmental and psychosocial risk factors for SCZ and MDD are at least partially associated with children's genetic risk for these psychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1140-1152[article] Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation [Texte imprimé et/ou numérique] / Sandra MACHLITT-NORTHEN, Auteur ; Robert KEERS, Auteur ; Patricia B. MUNROE, Auteur ; David M. HOWARD, Auteur ; Vassily TRUBETSKOY, Auteur ; Michael PLUESS, Auteur . - 2022 . - p.1140-1152.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1140-1152
Mots-clés : Cohort Studies Depression Depressive Disorder, Major/etiology/genetics Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Humans Multifactorial Inheritance Risk Factors Schizophrenia/epidemiology/genetics Environment genetics major depressive disorder schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Whilst genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) have been established, it is unclear whether exposure to environmental risk factors is genetically confounded by passive, evocative or active gene-environment correlation (rGE). STUDY OBJECTIVE: This study aims to investigate: (a) whether the genetic risk for SCZ/MDD in children is correlated with established environmental and psychosocial risk factors in two British community samples, the 1958 National Child Development Study (NCDS) and the Millennium Cohort Study (MCS), (b) whether these associations vary between both psychopathologies, and (c) whether findings differ across the two cohorts which were born 42years apart. METHODS: Polygenic risk scores (PRS) from existing large genome-wide associations studies (GWAS) were applied to test the correlation between the child genetic risk for SCZ/MDD and known environmental risk factors. In addition, parental and child genetic data from MCS were used to distinguish between passive and evocative rGE. RESULTS: The child polygenic risk for SCZ and MDD was correlated with single parenthood in MCS. Moreover, the lack of father's involvement in child care was associated with the genetic risk for SCZ in NCDS. However, we also found associations between several indicators of low socioeconomic status and heightened genetic risk for MDD in children in both cohorts. Further, the genetic risk for MDD was associated with parental lack of interest in the child's education in NCDS as well as more maternal smoking and less maternal alcohol consumption during childhood in MCS. According to sensitivity analyses in MCS (controlling for parental genotype), more than half of our significant correlations reflected passive rGE. CONCLUSIONS: Findings suggest that several established environmental and psychosocial risk factors for SCZ and MDD are at least partially associated with children's genetic risk for these psychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486