Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort / Laura TIMONEN-SOIVIO in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2780-2784 Titre : Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort Type de document : Texte imprimé et/ou numérique Auteurs : Laura TIMONEN-SOIVIO, Auteur ; Raija VANHALA, Auteur ; Heli MALM, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur Article en page(s) : p.2780-2784 Langues : Anglais (eng) Mots-clés : Syndromic autism  Chromosomal abnormalities  Autism spectrum disorder  Single gene disorders Index. décimale : PER Périodiques Résumé : We studied the association between specific congenital syndromes and autism spectrum disorders (ASD) in the large Finnish Register material. Our data include all children diagnosed with ASD (n = 4441) according to Finnish Hospital Discharge Register in 1987–2000. Four controls per each case were matched to sex, birthplace, date of birth (±30 days) and residence in Finland (n = 17,695). The prevalence of specific congenital syndromes in the Finnish Register of Congenital Malformations was evaluated among the ASD group and the controls by sex. The results of this study suggest that there is an association between several etiologically different syndromes and ASD when compared to controls without ASD. Statistically significant associations were observed with 47,XYY, Sotos syndrome, neurofibromatosis I, and syndrome not otherwise specified. Syndromes were more common among males with ASD compared to controls. These results support the previous studies of etiological heterogeneity of ASD and have importance in clinical examination, management and rehabilitation. En ligne : http://dx.doi.org/10.1007/s10803-016-2789-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort [Texte imprimé et/ou numérique] / Laura TIMONEN-SOIVIO, Auteur ; Raija VANHALA, Auteur ; Heli MALM, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur . - p.2780-2784. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2780-2784 Mots-clés : Syndromic autism  Chromosomal abnormalities  Autism spectrum disorder  Single gene disorders Index. décimale : PER Périodiques Résumé : We studied the association between specific congenital syndromes and autism spectrum disorders (ASD) in the large Finnish Register material. Our data include all children diagnosed with ASD (n = 4441) according to Finnish Hospital Discharge Register in 1987–2000. Four controls per each case were matched to sex, birthplace, date of birth (±30 days) and residence in Finland (n = 17,695). The prevalence of specific congenital syndromes in the Finnish Register of Congenital Malformations was evaluated among the ASD group and the controls by sex. The results of this study suggest that there is an association between several etiologically different syndromes and ASD when compared to controls without ASD. Statistically significant associations were observed with 47,XYY, Sotos syndrome, neurofibromatosis I, and syndrome not otherwise specified. Syndromes were more common among males with ASD compared to controls. These results support the previous studies of etiological heterogeneity of ASD and have importance in clinical examination, management and rehabilitation. En ligne : http://dx.doi.org/10.1007/s10803-016-2789-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study / Elina JOKIRANTA in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557 Titre : Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study Type de document : Texte imprimé et/ou numérique Auteurs : Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur Article en page(s) : p.2547-2557 Langues : Anglais (eng) Mots-clés : Epilepsy  Autism spectrum disorders  Intellectual disability  Gender  Age at onset  Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 [article] Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study [Texte imprimé et/ou numérique] / Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur . - p.2547-2557. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557 Mots-clés : Epilepsy  Autism spectrum disorders  Intellectual disability  Gender  Age at onset  Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240

The Association Between Autism Spectrum Disorders and Congenital Anomalies by Organ Systems in a Finnish National Birth Cohort / Laura TIMONEN-SOIVIO in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3195-3203 Titre : The Association Between Autism Spectrum Disorders and Congenital Anomalies by Organ Systems in a Finnish National Birth Cohort Type de document : Texte imprimé et/ou numérique Auteurs : Laura TIMONEN-SOIVIO, Auteur ; Andre SOURANDER, Auteur ; Heli MALM, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Raija VANHALA, Auteur Article en page(s) : p.3195-3203 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Congenital anomalies  Malformations  Birth defects Index. décimale : PER Périodiques Résumé : The aim of this study was to evaluate the association between autism spectrum disorders (ASD) with and without intellectual disability (ID) and congenital anomalies (CAs) by organ system. The sample included all children diagnosed with ASD (n = 4441) from the Finnish Hospital Discharge Register during 1987–2000 and a total of four controls per case (n = 17,695). CAs of the eye, central nervous system, and specific craniofacial anomalies were most strongly associated with ASD. Children with ASD and co-occurring ID were more likely to have CAs compared to ASD children without ID. The results suggest that some cases of ASD may originate during organogenesis, in the early first trimester of pregnancy. The results of this study may be useful for identifying prenatal etiological factors and elucidating the molecular pathogenesis of ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2477-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] The Association Between Autism Spectrum Disorders and Congenital Anomalies by Organ Systems in a Finnish National Birth Cohort [Texte imprimé et/ou numérique] / Laura TIMONEN-SOIVIO, Auteur ; Andre SOURANDER, Auteur ; Heli MALM, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Raija VANHALA, Auteur . - p.3195-3203. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3195-3203 Mots-clés : Autism spectrum disorders  Congenital anomalies  Malformations  Birth defects Index. décimale : PER Périodiques Résumé : The aim of this study was to evaluate the association between autism spectrum disorders (ASD) with and without intellectual disability (ID) and congenital anomalies (CAs) by organ system. The sample included all children diagnosed with ASD (n = 4441) from the Finnish Hospital Discharge Register during 1987–2000 and a total of four controls per case (n = 17,695). CAs of the eye, central nervous system, and specific craniofacial anomalies were most strongly associated with ASD. Children with ASD and co-occurring ID were more likely to have CAs compared to ASD children without ID. The results suggest that some cases of ASD may originate during organogenesis, in the early first trimester of pregnancy. The results of this study may be useful for identifying prenatal etiological factors and elucidating the molecular pathogenesis of ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2477-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

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