[article]
| Titre : |
Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder |
| Type de document : |
texte imprimé |
| Auteurs : |
Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur |
| Article en page(s) : |
p.61-72 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
diffusion tensor imaging (DTI) neuroimaging laterality white matter |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1413 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 |
in Autism Research > 8-1 (February 2015) . - p.61-72
[article] Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder [texte imprimé] / Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur . - p.61-72. Langues : Anglais ( eng) in Autism Research > 8-1 (February 2015) . - p.61-72
| Mots-clés : |
diffusion tensor imaging (DTI) neuroimaging laterality white matter |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1413 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 |
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Faire une suggestion Affiner la rechercheEvidence for Specificity of Motor Impairments in Catching and Balance in Children with Autism / Katarina AMENT in Journal of Autism and Developmental Disorders, 45-3 (March 2015)
