Evidence for Specificity of Motor Impairments in Catching and Balance in Children with Autism / Katarina AMENT in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.742-751 Titre : Evidence for Specificity of Motor Impairments in Catching and Balance in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Katarina AMENT, Auteur ; Amanda MEJIA, Auteur ; Rebecca BUHLMAN, Auteur ; Shannon ERKLIN, Auteur ; Brian S. CAFFO, Auteur ; Stewart MOSTOFSKY, Auteur ; Ericka WODKA, Auteur Article en page(s) : p.742-751 Langues : Anglais (eng) Mots-clés : Autism  Attention-deficit/hyperactivity disorder  Motor impairment  Specificity Index. décimale : PER Périodiques Résumé : To evaluate evidence for motor impairment specificity in autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Children completed performance-based assessment of motor functioning (Movement Assessment Battery for Children: MABC-2). Logistic regression models were used to predict group membership. In the models comparing typically developing and developmental disability (DD), all three MABC subscale scores were significantly negatively associated with having a DD. In the models comparing ADHD and ASD, catching and static balance items were associated with ASD group membership, with a 1 point decrease in performance increasing odds of ASD by 36 and 39 %, respectively. Impairments in motor skills requiring the coupling of visual and temporal feedback to guide and adjust movement appear specifically deficient in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2229-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Evidence for Specificity of Motor Impairments in Catching and Balance in Children with Autism [Texte imprimé et/ou numérique] / Katarina AMENT, Auteur ; Amanda MEJIA, Auteur ; Rebecca BUHLMAN, Auteur ; Shannon ERKLIN, Auteur ; Brian S. CAFFO, Auteur ; Stewart MOSTOFSKY, Auteur ; Ericka WODKA, Auteur . - p.742-751. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.742-751 Mots-clés : Autism  Attention-deficit/hyperactivity disorder  Motor impairment  Specificity Index. décimale : PER Périodiques Résumé : To evaluate evidence for motor impairment specificity in autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Children completed performance-based assessment of motor functioning (Movement Assessment Battery for Children: MABC-2). Logistic regression models were used to predict group membership. In the models comparing typically developing and developmental disability (DD), all three MABC subscale scores were significantly negatively associated with having a DD. In the models comparing ADHD and ASD, catching and static balance items were associated with ASD group membership, with a 1 point decrease in performance increasing odds of ASD by 36 and 39 %, respectively. Impairments in motor skills requiring the coupling of visual and temporal feedback to guide and adjust movement appear specifically deficient in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2229-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder / Daniel PETERSON in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.61-72 Titre : Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur Article en page(s) : p.61-72 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging (DTI)  neuroimaging  laterality  white matter Index. décimale : PER Périodiques Résumé : Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. En ligne : http://dx.doi.org/10.1002/aur.1413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur . - p.61-72. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.61-72 Mots-clés : diffusion tensor imaging (DTI)  neuroimaging  laterality  white matter Index. décimale : PER Périodiques Résumé : Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. En ligne : http://dx.doi.org/10.1002/aur.1413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

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