Preserved reward outcome processing in ASD as revealed by event-related potentials / J. C. MCPARTLAND in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.16 Titre : Preserved reward outcome processing in ASD as revealed by event-related potentials Type de document : Texte imprimé et/ou numérique Auteurs : J. C. MCPARTLAND, Auteur ; M. J. CROWLEY, Auteur ; D. R. PERSZYK, Auteur ; C. E. MUKERJI, Auteur ; A. J. NAPLES, Auteur ; J. WU, Auteur ; L. C. MAYES, Auteur Article en page(s) : p.16 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Problems with reward system function have been posited as a primary difficulty in autism spectrum disorders. The current study examined an electrophysiological marker of feedback monitoring, the feedback-related negativity (FRN), during a monetary reward task. The study advanced prior understanding by focusing exclusively on a developmental sample, applying rigorous diagnostic characterization and introducing an experimental paradigm providing more subtly different feedback valence (reward versus non-reward instead of reward versus loss). METHODS: Twenty-six children with autism spectrum disorder and 28 typically developing peers matched on age and full-scale IQ played a guessing game resulting in monetary gain ("win") or neutral outcome ("draw"). ERP components marking early visual processing (N1, P2) and feedback appraisal (FRN) were contrasted between groups in each condition, and their relationships to behavioral measures of social function and dysfunction, social anxiety, and autism symptomatology were explored. RESULTS: FRN was observed on draw trials relative to win trials. Consistent with prior research, children with ASD exhibited a FRN to suboptimal outcomes that was comparable to typical peers. ERP parameters were unrelated to behavioral measures. CONCLUSIONS: Results of the current study indicate typical patterns of feedback monitoring in the context of monetary reward in ASD. The study extends prior findings of normative feedback monitoring to a sample composed exclusively of children and demonstrates that, as in typical development, individuals with autism exhibit a FRN to suboptimal outcomes, irrespective of neutral or negative valence. Results do not support a pervasive problem with reward system function in ASD, instead suggesting any dysfunction lies in more specific domains, such as social perception, or in response to particular feedback-monitoring contexts, such as self-evaluation of one's errors. En ligne : http://dx.doi.org/10.1186/1866-1955-4-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Preserved reward outcome processing in ASD as revealed by event-related potentials [Texte imprimé et/ou numérique] / J. C. MCPARTLAND, Auteur ; M. J. CROWLEY, Auteur ; D. R. PERSZYK, Auteur ; C. E. MUKERJI, Auteur ; A. J. NAPLES, Auteur ; J. WU, Auteur ; L. C. MAYES, Auteur . - p.16. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.16 Index. décimale : PER Périodiques Résumé : BACKGROUND: Problems with reward system function have been posited as a primary difficulty in autism spectrum disorders. The current study examined an electrophysiological marker of feedback monitoring, the feedback-related negativity (FRN), during a monetary reward task. The study advanced prior understanding by focusing exclusively on a developmental sample, applying rigorous diagnostic characterization and introducing an experimental paradigm providing more subtly different feedback valence (reward versus non-reward instead of reward versus loss). METHODS: Twenty-six children with autism spectrum disorder and 28 typically developing peers matched on age and full-scale IQ played a guessing game resulting in monetary gain ("win") or neutral outcome ("draw"). ERP components marking early visual processing (N1, P2) and feedback appraisal (FRN) were contrasted between groups in each condition, and their relationships to behavioral measures of social function and dysfunction, social anxiety, and autism symptomatology were explored. RESULTS: FRN was observed on draw trials relative to win trials. Consistent with prior research, children with ASD exhibited a FRN to suboptimal outcomes that was comparable to typical peers. ERP parameters were unrelated to behavioral measures. CONCLUSIONS: Results of the current study indicate typical patterns of feedback monitoring in the context of monetary reward in ASD. The study extends prior findings of normative feedback monitoring to a sample composed exclusively of children and demonstrates that, as in typical development, individuals with autism exhibit a FRN to suboptimal outcomes, irrespective of neutral or negative valence. Results do not support a pervasive problem with reward system function in ASD, instead suggesting any dysfunction lies in more specific domains, such as social perception, or in response to particular feedback-monitoring contexts, such as self-evaluation of one's errors. En ligne : http://dx.doi.org/10.1186/1866-1955-4-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

Sex Differences in Social Perception in Children with ASD / M. C. COFFMAN in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.589-599 Titre : Sex Differences in Social Perception in Children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : M. C. COFFMAN, Auteur ; L. C. ANDERSON, Auteur ; A. J. NAPLES, Auteur ; J. C. MCPARTLAND, Auteur Article en page(s) : p.589-599 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Sex differences  ERP  N170  Face perception Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is more common in males than females. An underrepresentation of females in the ASD literature has led to limited knowledge of differences in social function across the sexes. Investigations of face perception represent a promising target for understanding variability in social functioning between males and females. The current study analyzed electrophysiological brain recordings during face perception to investigate sex differences in the neural correlates of face perception and their relationship to social function. Event related potentials (ERP) were recorded from children with ASD while viewing faces, inverted faces, and houses. Relative to males, females showed attenuated response at an ERP marker of face perception, the N170. Among females, but not males, atypical face response was associated with symptom severity. Observed sex differences reflect influential differences in social information processing, and impairment in these features correlates with deficits in social information processing in females, but not males, with ASD. These findings hold significance for future treatment protocols, which should account for differences in males and females with ASD in clinical presentation and neural phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-013-2006-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Sex Differences in Social Perception in Children with ASD [Texte imprimé et/ou numérique] / M. C. COFFMAN, Auteur ; L. C. ANDERSON, Auteur ; A. J. NAPLES, Auteur ; J. C. MCPARTLAND, Auteur . - p.589-599. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.589-599 Mots-clés : Autism spectrum disorder  Sex differences  ERP  N170  Face perception Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is more common in males than females. An underrepresentation of females in the ASD literature has led to limited knowledge of differences in social function across the sexes. Investigations of face perception represent a promising target for understanding variability in social functioning between males and females. The current study analyzed electrophysiological brain recordings during face perception to investigate sex differences in the neural correlates of face perception and their relationship to social function. Event related potentials (ERP) were recorded from children with ASD while viewing faces, inverted faces, and houses. Relative to males, females showed attenuated response at an ERP marker of face perception, the N170. Among females, but not males, atypical face response was associated with symptom severity. Observed sex differences reflect influential differences in social information processing, and impairment in these features correlates with deficits in social information processing in females, but not males, with ASD. These findings hold significance for future treatment protocols, which should account for differences in males and females with ASD in clinical presentation and neural phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-013-2006-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

The N170 event-related potential reflects delayed neural response to faces when visual attention is directed to the eyes in youths with ASD / T. C. PARKER in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1347-1356 Titre : The N170 event-related potential reflects delayed neural response to faces when visual attention is directed to the eyes in youths with ASD Type de document : Texte imprimé et/ou numérique Auteurs : T. C. PARKER, Auteur ; M. J. CROWLEY, Auteur ; A. J. NAPLES, Auteur ; M. J. ROLISON, Auteur ; J. WU, Auteur ; J. A. TRAPANI, Auteur ; J. C. MCPARTLAND, Auteur Article en page(s) : p.1347-1356 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Evoked Potentials  Facial Recognition  Humans  Eeg  N170  autism  event-related potential  face perception  social neuroscience Index. décimale : PER Périodiques Résumé : Atypical neural response to faces is thought to contribute to social deficits in autism spectrum disorder (ASD). Compared to typically developing (TD) controls, individuals with ASD exhibit delayed brain responses to upright faces at a face-sensitive event-related potential (ERP), the N170. Given observed differences in patterns of visual attention to faces, it is not known whether slowed neural processing may simply reflect atypical looking to faces. The present study manipulated visual attention to facial features to examine whether directed attention to the eyes normalizes N170 latency in ASD. ERPs were recorded in 30 children and adolescents with ASD as well as 26 TD children and adolescents. Results replicated prior findings of shorter N170 latency to the eye region of the face in TD individuals. In contrast, those with ASD did not demonstrate modulation of N170 latency by point of regard to the face. Group differences in latency were most pronounced when attention was directed to the eyes. Results suggest that well-replicated findings of N170 delays in ASD do not simply reflect atypical patterns of visual engagement with experimental stimuli. These findings add to a body of evidence indicating that N170 delays are a promising marker of atypical neural response to social information in ASD. LAY SUMMARY: This study looks at how children's and adolescents' brains respond when looking at different parts of a face. Typically developing children and adolescents processed eyes faster than other parts of the face, whereas this pattern was not seen in ASD. Children and adolescents with ASD processed eyes more slowly than typically developing children. These findings suggest that observed inefficiencies in face processing in ASD are not simply reflective of failure to attend to the eyes. En ligne : http://dx.doi.org/10.1002/aur.2505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] The N170 event-related potential reflects delayed neural response to faces when visual attention is directed to the eyes in youths with ASD [Texte imprimé et/ou numérique] / T. C. PARKER, Auteur ; M. J. CROWLEY, Auteur ; A. J. NAPLES, Auteur ; M. J. ROLISON, Auteur ; J. WU, Auteur ; J. A. TRAPANI, Auteur ; J. C. MCPARTLAND, Auteur . - p.1347-1356. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1347-1356 Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Evoked Potentials  Facial Recognition  Humans  Eeg  N170  autism  event-related potential  face perception  social neuroscience Index. décimale : PER Périodiques Résumé : Atypical neural response to faces is thought to contribute to social deficits in autism spectrum disorder (ASD). Compared to typically developing (TD) controls, individuals with ASD exhibit delayed brain responses to upright faces at a face-sensitive event-related potential (ERP), the N170. Given observed differences in patterns of visual attention to faces, it is not known whether slowed neural processing may simply reflect atypical looking to faces. The present study manipulated visual attention to facial features to examine whether directed attention to the eyes normalizes N170 latency in ASD. ERPs were recorded in 30 children and adolescents with ASD as well as 26 TD children and adolescents. Results replicated prior findings of shorter N170 latency to the eye region of the face in TD individuals. In contrast, those with ASD did not demonstrate modulation of N170 latency by point of regard to the face. Group differences in latency were most pronounced when attention was directed to the eyes. Results suggest that well-replicated findings of N170 delays in ASD do not simply reflect atypical patterns of visual engagement with experimental stimuli. These findings add to a body of evidence indicating that N170 delays are a promising marker of atypical neural response to social information in ASD. LAY SUMMARY: This study looks at how children's and adolescents' brains respond when looking at different parts of a face. Typically developing children and adolescents processed eyes faster than other parts of the face, whereas this pattern was not seen in ASD. Children and adolescents with ASD processed eyes more slowly than typically developing children. These findings suggest that observed inefficiencies in face processing in ASD are not simply reflective of failure to attend to the eyes. En ligne : http://dx.doi.org/10.1002/aur.2505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

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