Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model / Vanessa BABINEAU in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.21-29 Titre : Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa BABINEAU, Auteur ; Cathryn Gordon GREEN, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; John LYDON, Auteur ; Meir STEINER, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Michael MEANEY, Auteur ; Ashley WAZANA, Auteur ; THE MAVAN PROJECT,, Auteur Article en page(s) : p.21-29 Langues : Anglais (eng) Mots-clés : Child development  emotional dysregulation  gene–environment interaction (GxE)  longitudinal studies  maternal depression  Prenatal Index. décimale : PER Périodiques Résumé : Background Childhood dysregulation, which reflects deficits in the capacity to regulate or control one's thoughts, emotions and behaviours, is associated with psychopathology throughout childhood and into adulthood. Exposures to adversity during the prenatal period, including prenatal depression, can influence the development of dysregulation, and a number of candidate genes have been suggested as moderators of prenatal exposure, including polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). We examined whether prenatal depression and child 5-HTTLPR interact to predict childhood dysregulation. Method Sample of N = 213 mother–child pairs from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. Mothers reported the IBQ-R at 3 and 6 months, and the ECBQ at 18 and 36 months, from which measures of dysregulation were extracted. Mothers' self-reported symptoms of depression on the CES-D at 24–36 weeks of gestation, and at 6, 12, 24 and 36 months postnatal. 5-HTTLPR genotype was extracted from buccal swabs. Mixed-model and confirmatory analyses were conducted. Results Prenatal depression and 5-HTTLPR interacted to predict dysregulation from 3 to 36 months, within a model of strong differential susceptibility. Conclusion Children with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression. En ligne : http://dx.doi.org/10.1111/jcpp.12246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model [Texte imprimé et/ou numérique] / Vanessa BABINEAU, Auteur ; Cathryn Gordon GREEN, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; John LYDON, Auteur ; Meir STEINER, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Michael MEANEY, Auteur ; Ashley WAZANA, Auteur ; THE MAVAN PROJECT,, Auteur . - p.21-29. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.21-29 Mots-clés : Child development  emotional dysregulation  gene–environment interaction (GxE)  longitudinal studies  maternal depression  Prenatal Index. décimale : PER Périodiques Résumé : Background Childhood dysregulation, which reflects deficits in the capacity to regulate or control one's thoughts, emotions and behaviours, is associated with psychopathology throughout childhood and into adulthood. Exposures to adversity during the prenatal period, including prenatal depression, can influence the development of dysregulation, and a number of candidate genes have been suggested as moderators of prenatal exposure, including polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). We examined whether prenatal depression and child 5-HTTLPR interact to predict childhood dysregulation. Method Sample of N = 213 mother–child pairs from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. Mothers reported the IBQ-R at 3 and 6 months, and the ECBQ at 18 and 36 months, from which measures of dysregulation were extracted. Mothers' self-reported symptoms of depression on the CES-D at 24–36 weeks of gestation, and at 6, 12, 24 and 36 months postnatal. 5-HTTLPR genotype was extracted from buccal swabs. Mixed-model and confirmatory analyses were conducted. Results Prenatal depression and 5-HTTLPR interacted to predict dysregulation from 3 to 36 months, within a model of strong differential susceptibility. Conclusion Children with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression. En ligne : http://dx.doi.org/10.1111/jcpp.12246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months / Cathryn Gordon GREEN in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.901-917 Titre : Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months Type de document : Texte imprimé et/ou numérique Auteurs : Cathryn Gordon GREEN, Auteur ; Vanessa BABINEAU, Auteur ; Alexia JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; Meir STEINER, Auteur ; John LYDON, Auteur ; Helene GAUDREAU, Auteur ; Jacob A. BURACK, Auteur ; Robert LEVITAN, Auteur ; Michael J. MEANEY, Auteur ; Ashley WAZANA, Auteur Article en page(s) : p.901-917 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother–infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs. any LA) and the dopamine receptor D4 gene (six to eight repeats vs. two to five repeats). Negative emotionality was extracted from the Infant Behaviour Questionnaire—Revised at 3 and 6 months and the Early Child Behavior Questionnaire at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict negative emotionality from 3 to 36 months. The results were characterized by a differential susceptibility model at 3 and 6 months and by a diathesis–stress model at 36 months. En ligne : http://dx.doi.org/10.1017/s0954579416000560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312 [article] Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months [Texte imprimé et/ou numérique] / Cathryn Gordon GREEN, Auteur ; Vanessa BABINEAU, Auteur ; Alexia JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; Meir STEINER, Auteur ; John LYDON, Auteur ; Helene GAUDREAU, Auteur ; Jacob A. BURACK, Auteur ; Robert LEVITAN, Auteur ; Michael J. MEANEY, Auteur ; Ashley WAZANA, Auteur . - p.901-917. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.901-917 Index. décimale : PER Périodiques Résumé : Abstract Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother–infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs. any LA) and the dopamine receptor D4 gene (six to eight repeats vs. two to five repeats). Negative emotionality was extracted from the Infant Behaviour Questionnaire—Revised at 3 and 6 months and the Early Child Behavior Questionnaire at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict negative emotionality from 3 to 36 months. The results were characterized by a differential susceptibility model at 3 and 6 months and by a diathesis–stress model at 36 months. En ligne : http://dx.doi.org/10.1017/s0954579416000560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312

The interplay of maternal and paternal postpartum depressive symptoms with children's internalizing and externalizing symptoms from childhood to adolescence: does socioeconomic status matter? A longitudinal cohort study / Myriam CLEMENT ; Marilyn N. AHUN ; Massimiliano ORRI ; Tina C. Montreuil ; Martin ST-ANDRÉ ; Catherine M. HERBA ; Grégory MOULLEC ; Sylvana M. CÔTÉ in Journal of Child Psychology and Psychiatry, 66-2 (February 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.225-240 Titre : The interplay of maternal and paternal postpartum depressive symptoms with children's internalizing and externalizing symptoms from childhood to adolescence: does socioeconomic status matter? A longitudinal cohort study : Journal of Child Psychology and Psychiatry Type de document : Texte imprimé et/ou numérique Auteurs : Myriam CLEMENT, Auteur ; Marilyn N. AHUN, Auteur ; Massimiliano ORRI, Auteur ; Tina C. Montreuil, Auteur ; Martin ST-ANDRÉ, Auteur ; Catherine M. HERBA, Auteur ; Grégory MOULLEC, Auteur ; Sylvana M. CÔTÉ, Auteur Article en page(s) : p.225-240 Langues : Anglais (eng) Mots-clés : Postpartum depression  maternal depression  paternal depression  internalizing problems  externalizing problems  mental health  child development  socioeconomic status Index. décimale : PER Périodiques Résumé : Background Maternal postpartum depression is an important risk factor for internalizing and externalizing problems in children. The role of concurrent paternal depression remains unclear, especially by socioeconomic status. This study examined independent and interactive associations of postpartum maternal and paternal depression with children's internalizing/externalizing symptoms throughout childhood and adolescence (ages 3.5?17?years). Methods We used data from the Québec Longitudinal Study of Child Development, a representative birth cohort (1997?1998) in Canada. Data included self-reported maternal and paternal depressive symptoms at 5?months' postpartum using the Center for Epidemiologic Studies Depression Scale. Internalizing and externalizing symptoms in children were reported by parents, teachers and children/adolescents using the Social Behaviour Questionnaire (ages 3.5?13?years) and the Mental Health and Social Inadaptation Assessment for Adolescents (ages 15?17?years). We used three-level mixed effects modelling to test associations after adjusting for confounding factors. Results With 168 single-parent families excluded, our sample consisted of 1,700 families with useable data. Of these, 275 (16.2%) families reported maternal depression (clinically elevated symptoms), 135 (7.9%) paternal depression and 39 (2.3%) both. In families with high socioeconomic status, maternal depression was associated with greater child internalizing (??=?.34; p? En ligne : https://doi.org/10.1111/jcpp.14051 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] The interplay of maternal and paternal postpartum depressive symptoms with children's internalizing and externalizing symptoms from childhood to adolescence: does socioeconomic status matter? A longitudinal cohort study : Journal of Child Psychology and Psychiatry [Texte imprimé et/ou numérique] / Myriam CLEMENT, Auteur ; Marilyn N. AHUN, Auteur ; Massimiliano ORRI, Auteur ; Tina C. Montreuil, Auteur ; Martin ST-ANDRÉ, Auteur ; Catherine M. HERBA, Auteur ; Grégory MOULLEC, Auteur ; Sylvana M. CÔTÉ, Auteur . - p.225-240. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.225-240 Mots-clés : Postpartum depression  maternal depression  paternal depression  internalizing problems  externalizing problems  mental health  child development  socioeconomic status Index. décimale : PER Périodiques Résumé : Background Maternal postpartum depression is an important risk factor for internalizing and externalizing problems in children. The role of concurrent paternal depression remains unclear, especially by socioeconomic status. This study examined independent and interactive associations of postpartum maternal and paternal depression with children's internalizing/externalizing symptoms throughout childhood and adolescence (ages 3.5?17?years). Methods We used data from the Québec Longitudinal Study of Child Development, a representative birth cohort (1997?1998) in Canada. Data included self-reported maternal and paternal depressive symptoms at 5?months' postpartum using the Center for Epidemiologic Studies Depression Scale. Internalizing and externalizing symptoms in children were reported by parents, teachers and children/adolescents using the Social Behaviour Questionnaire (ages 3.5?13?years) and the Mental Health and Social Inadaptation Assessment for Adolescents (ages 15?17?years). We used three-level mixed effects modelling to test associations after adjusting for confounding factors. Results With 168 single-parent families excluded, our sample consisted of 1,700 families with useable data. Of these, 275 (16.2%) families reported maternal depression (clinically elevated symptoms), 135 (7.9%) paternal depression and 39 (2.3%) both. In families with high socioeconomic status, maternal depression was associated with greater child internalizing (??=?.34; p? En ligne : https://doi.org/10.1111/jcpp.14051 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

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