Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? / Tim CADMAN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.477-485 Titre : Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? Type de document : Texte imprimé et/ou numérique Auteurs : Tim CADMAN, Auteur ; Debbie SPAIN, Auteur ; Patrick JOHNSTON, Auteur ; Ailsa RUSSELL, Auteur ; David MATAIX-COLS, Auteur ; Michael C. CRAIG, Auteur ; Quinton DEELEY, Auteur ; Dene ROBERTSON, Auteur ; Clodagh M. MURPHY, Auteur ; Nicola GILLAN, Auteur ; C. Ellie WILSON, Auteur ; Maria MENDEZ, Auteur ; Christine ECKER, Auteur ; Eileen DALY, Auteur ; James FINDON, Auteur ; Karen GLASER, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Francesca HAPPE, Auteur ; Declan MURPHY, Auteur Article en page(s) : p.477-485 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  adults  obsessive compulsive disorder  obsessive-compulsive inventory-revised  hoarding  self-report questionnaire Index. décimale : PER Périodiques Résumé : Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD?+?OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n?=?171), OCD (n?=?108), ASD?+?OCD (n?=?54) and control participants (n?=?92) completed the OCI-R. Individuals with ASD?+?OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD?+?versus –OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population. Autism Res 2015, 8: 477–485. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? [Texte imprimé et/ou numérique] / Tim CADMAN, Auteur ; Debbie SPAIN, Auteur ; Patrick JOHNSTON, Auteur ; Ailsa RUSSELL, Auteur ; David MATAIX-COLS, Auteur ; Michael C. CRAIG, Auteur ; Quinton DEELEY, Auteur ; Dene ROBERTSON, Auteur ; Clodagh M. MURPHY, Auteur ; Nicola GILLAN, Auteur ; C. Ellie WILSON, Auteur ; Maria MENDEZ, Auteur ; Christine ECKER, Auteur ; Eileen DALY, Auteur ; James FINDON, Auteur ; Karen GLASER, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Francesca HAPPE, Auteur ; Declan MURPHY, Auteur . - p.477-485. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.477-485 Mots-clés : autism spectrum disorder  adults  obsessive compulsive disorder  obsessive-compulsive inventory-revised  hoarding  self-report questionnaire Index. décimale : PER Périodiques Résumé : Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD?+?OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n?=?171), OCD (n?=?108), ASD?+?OCD (n?=?54) and control participants (n?=?92) completed the OCI-R. Individuals with ASD?+?OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD?+?versus –OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population. Autism Res 2015, 8: 477–485. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay / Joana Bisol BALARDIN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.556-566 Titre : Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay Type de document : Texte imprimé et/ou numérique Auteurs : Joana Bisol BALARDIN, Auteur ; João Ricardo SATO, Auteur ; Gilson VIEIRA, Auteur ; Yeu FENG, Auteur ; Eileen DALY, Auteur ; Clodagh M. MURPHY, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Declan MURPHY, Auteur ; Christine ECKER, Auteur Article en page(s) : p.556-566 Langues : Anglais (eng) Mots-clés : autism  Asperger syndrome  brain anatomy  intelligence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the autism spectrum has long been acknowledged, but it remains unknown whether these differences impact on the neuropathology of ASD. In this study, we aimed to compare associations between surface-based regional brain measures and general intelligence (IQ) scores in ASD individuals with and without a history of language delay. We included 64 ASD adults of normal intelligence (37 without a history of language delay and 27 with a history of language delay and 80 neurotypicals). Regions with a significant association between verbal and nonverbal IQ and measures of cortical thickness (CT), surface area, and cortical volume were first identified in the combined sample of individuals with ASD and controls. Thicker dorsal frontal and temporal cortices, and thinner lateral orbital frontal and parieto-occipital cortices were associated with greater and lower verbal IQ scores, respectively. Correlations between cortical volume and verbal IQ were observed in similar regions as revealed by the CT analysis. A significant difference between ASD individuals with and without a history of language delay in the association between CT and verbal IQ was evident in the parieto-occipital region. These results indicate that ASD subgroups defined on the basis of differential language trajectories in childhood can have different associations between verbal IQ and brain measures in adulthood despite achieving similar levels of cognitive performance. Autism Res 2015, 8: 556–566. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay [Texte imprimé et/ou numérique] / Joana Bisol BALARDIN, Auteur ; João Ricardo SATO, Auteur ; Gilson VIEIRA, Auteur ; Yeu FENG, Auteur ; Eileen DALY, Auteur ; Clodagh M. MURPHY, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Declan MURPHY, Auteur ; Christine ECKER, Auteur . - p.556-566. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.556-566 Mots-clés : autism  Asperger syndrome  brain anatomy  intelligence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the autism spectrum has long been acknowledged, but it remains unknown whether these differences impact on the neuropathology of ASD. In this study, we aimed to compare associations between surface-based regional brain measures and general intelligence (IQ) scores in ASD individuals with and without a history of language delay. We included 64 ASD adults of normal intelligence (37 without a history of language delay and 27 with a history of language delay and 80 neurotypicals). Regions with a significant association between verbal and nonverbal IQ and measures of cortical thickness (CT), surface area, and cortical volume were first identified in the combined sample of individuals with ASD and controls. Thicker dorsal frontal and temporal cortices, and thinner lateral orbital frontal and parieto-occipital cortices were associated with greater and lower verbal IQ scores, respectively. Correlations between cortical volume and verbal IQ were observed in similar regions as revealed by the CT analysis. A significant difference between ASD individuals with and without a history of language delay in the association between CT and verbal IQ was evident in the parieto-occipital region. These results indicate that ASD subgroups defined on the basis of differential language trajectories in childhood can have different associations between verbal IQ and brain measures in adulthood despite achieving similar levels of cognitive performance. Autism Res 2015, 8: 556–566. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

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